LOCUS       NM_198046               1977 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 16 (ZDHHC16), transcript
            variant 5, mRNA.
ACCESSION   NM_198046
VERSION     NM_198046.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Liu,Z., Jing,C. and Zhang,W.
  TITLE     METTL3-mediated m6A modification enhances ZDHHC16 expression in
            nonsmall- cell lung cancer patients, attenuating ferroptosis by
            suppressing CREB ubiquitination
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (2), 30-37 (2024)
   PUBMED   38430044
  REMARK    GeneRIF: METTL3-mediated m6A modification enhances ZDHHC16
            expression in nonsmall- cell lung cancer patients, attenuating
            ferroptosis by suppressing CREB ubiquitination.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Fan,X., Sun,S., Yang,H., Ma,H., Zhao,C., Niu,W., Fan,J., Fang,Z.
            and Chen,X.
  TITLE     SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor
            Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced
            DNA Damage
  JOURNAL   Int J Radiat Oncol Biol Phys 113 (3), 648-660 (2022)
   PUBMED   35192890
  REMARK    GeneRIF: SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal
            Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing
            Radiation-Induced DNA Damage.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Abrami,L., Dallavilla,T., Sandoz,P.A., Demir,M., Kunz,B.,
            Savoglidis,G., Hatzimanikatis,V. and van der Goot,F.G.
  TITLE     Identification and dynamics of the human ZDHHC16-ZDHHC6
            palmitoylation cascade
  JOURNAL   Elife 6, e27826 (2017)
   PUBMED   28826475
  REMARK    GeneRIF: human ZDHHC6, which modifies key proteins of the
            endoplasmic reticulum, is controlled by an upstream
            palmitoyltransferase, ZDHHC16, revealing the first palmitoylation
            cascade.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Zhou,T., Li,J., Zhao,P., Liu,H., Jia,D., Jia,H., He,L., Cang,Y.,
            Boast,S., Chen,Y.H., Thibault,H., Scherrer-Crosbie,M., Goff,S.P.
            and Li,B.
  TITLE     Palmitoyl acyltransferase Aph2 in cardiac function and the
            development of cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15666-15671 (2015)
   PUBMED   26644582
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Zhang,F., Di,Y., Li,J., Shi,Y., Zhang,L., Wang,C., He,X., Liu,Y.,
            Wan,D., Huo,K. and Gu,J.
  TITLE     Molecular cloning and characterization of human Aph2 gene, involved
            in AP-1 regulation by interaction with JAB1
  JOURNAL   Biochim Biophys Acta 1759 (11-12), 514-525 (2006)
   PUBMED   17123647
  REMARK    GeneRIF: APH2 contains a zf-DHHC domain (148-210aa), which is
            involved in protein-protein or protein-DNA interaction.
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Li,B., Cong,F., Tan,C.P., Wang,S.X. and Goff,S.P.
  TITLE     Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has
            pro-apoptotic activity
  JOURNAL   J Biol Chem 277 (32), 28870-28876 (2002)
   PUBMED   12021275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC399731.1, AK297962.1, AJ294945.1 and BM678689.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198046.2.
            
            Transcript Variant: This variant (5) represents the longest
            transcript. Variants 1 and 5 encode the same isoform (1), which is
            the longest isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1126740.1,
                                           SRR3476690.833613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393760.6/ ENSP00000377357.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DC399731.1         45-195
            152-209             AK297962.1         152-209
            210-1973            AJ294945.1         88-1851
            1974-1977           BM678689.1         16-19               c
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..1977
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /note="zDHHC palmitoyltransferase 16"
                     /db_xref="GeneID:84287"
                     /db_xref="HGNC:HGNC:20714"
                     /db_xref="MIM:616750"
     exon            1..179
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            180..359
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            360..607
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1498
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 5; zinc
                     finger, DHHC domain containing 16; Abl-philin 2; probable
                     palmitoyltransferase ZDHHC16; zinc finger DHHC
                     domain-containing protein 16; zinc finger DHHC-type
                     containing 16; zinc finger DHHC-type palmitoyltransferase
                     16"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC16 isoform 1"
                     /protein_id="NP_932163.1"
                     /db_xref="CCDS:CCDS7460.1"
                     /db_xref="GeneID:84287"
                     /db_xref="HGNC:HGNC:20714"
                     /db_xref="MIM:616750"
                     /translation="MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKV
                     CLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCV
                     LPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKC
                     IYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGS
                     WDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSS
                     VALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFL
                     GVDTGRHWLTRVLLPSSHLPHGNGMSWEPPPWVTAHSASVMAV"
     exon            608..802
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            803..891
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            892..920
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1054
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1102
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1188
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1312
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1383
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1977
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="ZDHHC16"
                     /gene_synonym="APH2; DHHC-16"
                     /note="major polyA site"
ORIGIN      
        1 gtggttgagg atgggctggc ggcgggtccg ggtccgctgc ctggcgctgc gggcggcggg
       61 ccatggtggt ttggattgag ccgggcccgg ccggggcgcc gagtcggagg gggtggcagt
      121 gagcggcggc agaggctacg gggctcggtt tggctgactg gggagtcggc aggcggcagg
      181 tcttttgtgg ggatgagcca gggtgcaagg agagtacaat actccagtta ccgaattgaa
      241 accatccctg cagtggagca gcctcctcca gtttctgttg ggttttgagc tacctgttaa
      301 ataagtcagt gggattgtca aggacaaagc cctccctggc tgcctcaggg caaaatcagg
      361 aaccatgcga ggccagcgga gcctgctgct gggcccggcc cgcctctgcc tccgcctcct
      421 tctgctgctg ggttacaggc gccgctgtcc acctctactc cggggtctag tacagcgctg
      481 gcgctacggc aaggtctgcc tgcgctccct gctctacaac tcctttgggg gcagtgacac
      541 cgctgttgat gctgcctttg agcctgtcta ctggctggta gacaacgtga tccgctggtt
      601 tggagtggtg ttcgtggtcc tggtgatcgt gctgacaggc tccattgtag ctatcgccta
      661 cctgtgtgtc ctgcctctca tcctccgaac ctactcagtg ccacgactct gctggcattt
      721 cttctatagc cactggaatc tgatcctgat tgtcttccac tactaccagg ccatcaccac
      781 tccgcctggg tacccacccc agggcaggaa tgatatcgcc accgtctcca tctgtaagaa
      841 gtgcatttac cccaagccag cccgaacaca ccactgcagc atctgcaaca ggtgtgtgct
      901 gaagatggat caccactgcc cctggctaaa caattgtgtg ggccactata accatcggta
      961 cttcttctct ttctgctttt tcatgactct gggctgtgtc tactgcagct atggaagttg
     1021 ggaccttttc cgggaggctt atgctgccat tgagaaaatg aaacagctcg acaagaacaa
     1081 actacaggcg gttgccaacc agacttatca ccagacccca ccacccacct tctcctttcg
     1141 agaaaggatg actcacaaga gtcttgtcta cctctggttc ctgtgcagtt ctgtggcact
     1201 tgccctgggt gccctaactg tatggcatgc tgttctcatc agtcgaggtg agactagcat
     1261 cgaaaggcac atcaacaaga aggagagacg tcggctacag gccaagggca gagtatttag
     1321 gaatccttac aactacggct gcttggacaa ctggaaggta ttcctgggtg tggatacagg
     1381 aaggcactgg cttactcggg tgctcttacc ttctagtcac ttgccccatg ggaatggaat
     1441 gagctgggag ccccctccct gggtgactgc tcactcagcc tctgtgatgg cagtgtgagc
     1501 tggactgtgt cagccacgac tcgagcactc attctgctcc ctatgttatt tcaagggcct
     1561 ccaagggcag cttttctcag aatccttgat caaaaagagc cagtgggcct gccttagggt
     1621 accatgcagg acaattcaag gaccagcctt tttaccactg cagaagaaag acacaatgtg
     1681 gagaaatctt aggactgaca tccctttact caggcaaaca gaagttccaa ccccagacta
     1741 ggggtcaggc agctagctac ctaccttgcc cagtgctgac ccggacctcc tccaggatac
     1801 agcactggag ttggccacca cctcttctac ttgctgtctg aaaaaacacc tgactagtac
     1861 agctgagatc ttggcttctc aacagggcaa agataccagg cctgctgctg aggtcactgc
     1921 cacttctcac atgctgctta agggagcaca aataaaggta ttcgattttt aaagata
//
