LOCUS       NM_019028               2406 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 13 (ZDHHC13), transcript
            variant 1, mRNA.
ACCESSION   NM_019028
VERSION     NM_019028.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2406)
  AUTHORS   Sun,Y., Li,X., Yin,C., Zhang,J., Liang,E., Wu,X., Ni,Y.,
            Arbesman,J., Goding,C.R. and Chen,S.
  TITLE     AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress
            Melanomagenesis
  JOURNAL   Cancer Res 83 (7), 1062-1073 (2023)
   PUBMED   36701140
  REMARK    GeneRIF: AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and
            Suppress Melanomagenesis.
REFERENCE   2  (bases 1 to 2406)
  AUTHORS   Shen,L.F., Chen,Y.J., Liu,K.M., Haddad,A.N.S., Song,I.W.,
            Roan,H.Y., Chen,L.Y., Yen,J.J.Y., Chen,Y.J., Wu,J.Y. and Chen,Y.T.
  TITLE     Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and
            Metabolism in Liver
  JOURNAL   Sci Rep 7 (1), 2182 (2017)
   PUBMED   28526873
  REMARK    GeneRIF: this is the first study to demonstrate that defects in
            ZDHHC13, a PAT, leads to phenotypes in mice, including
            non-thyroidal hypermetabolism, mitochondrial dysfunction, and
            abnormal lipid metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2406)
  AUTHORS   Sanders,S.S. and Hayden,M.R.
  TITLE     Aberrant palmitoylation in Huntington disease
  JOURNAL   Biochem Soc Trans 43 (2), 205-210 (2015)
   PUBMED   25849918
  REMARK    GeneRIF: This suggests that altered HIP14-HTT and HIP14L-HTT
            interactions in the presence of the HD mutation reduces
            palmitoylation and promotes mislocalization of HTT and other
            HIP14/HIP14L substrates
            Review article
REFERENCE   4  (bases 1 to 2406)
  AUTHORS   Sanders,S.S., Mui,K.K., Sutton,L.M. and Hayden,M.R.
  TITLE     Identification of binding sites in Huntingtin for the Huntingtin
            Interacting Proteins HIP14 and HIP14L
  JOURNAL   PLoS One 9 (2), e90669 (2014)
   PUBMED   24651384
  REMARK    GeneRIF: Data show that deletion of huntingtin protein (HTT) amino
            acids 1-427 abolishes the interaction of HTT with palmitoyl
            acyltransferases huntingtin interacting protein 14 (HIP14) and
            huntingtin interacting protein 14-like (HIP14L).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2406)
  AUTHORS   Saleem,A.N., Chen,Y.H., Baek,H.J., Hsiao,Y.W., Huang,H.W.,
            Kao,H.J., Liu,K.M., Shen,L.F., Song,I.W., Tu,C.P., Wu,J.Y.,
            Kikuchi,T., Justice,M.J., Yen,J.J. and Chen,Y.T.
  TITLE     Mice with alopecia, osteoporosis, and systemic amyloidosis due to
            mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase
  JOURNAL   PLoS Genet 6 (6), e1000985 (2010)
   PUBMED   20548961
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2406)
  AUTHORS   Huang,K., Sanders,S., Singaraja,R., Orban,P., Cijsouw,T.,
            Arstikaitis,P., Yanai,A., Hayden,M.R. and El-Husseini,A.
  TITLE     Neuronal palmitoyl acyl transferases exhibit distinct substrate
            specificity
  JOURNAL   FASEB J 23 (8), 2605-2615 (2009)
   PUBMED   19299482
REFERENCE   7  (bases 1 to 2406)
  AUTHORS   Goytain,A., Hines,R.M. and Quamme,G.A.
  TITLE     Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual
            functions, palmitoyl acyltransferase and Mg2+ transport
  JOURNAL   J Biol Chem 283 (48), 33365-33374 (2008)
   PUBMED   18794299
  REMARK    GeneRIF: huntingtin interacting protein genes, HIP14 and HIP14L,
            encode Mg2+ transport proteins that are regulated by their innate
            palmitoyl acyltransferases thus fulfilling the characteristics of
            'chanzymes.'
REFERENCE   8  (bases 1 to 2406)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   9  (bases 1 to 2406)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 2406)
  AUTHORS   Singaraja,R.R., Hadano,S., Metzler,M., Givan,S., Wellington,C.L.,
            Warby,S., Yanai,A., Gutekunst,C.A., Leavitt,B.R., Yi,H.,
            Fichter,K., Gan,L., McCutcheon,K., Chopra,V., Michel,J.,
            Hersch,S.M., Ikeda,J.E. and Hayden,M.R.
  TITLE     HIP14, a novel ankyrin domain-containing protein, links huntingtin
            to intracellular trafficking and endocytosis
  JOURNAL   Hum Mol Genet 11 (23), 2815-2828 (2002)
   PUBMED   12393793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB097014.1 and BC056152.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019028.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036020.1, BC056152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446113.7/ ENSP00000400113.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2405              AB097014.1         22-2426
            2406-2406           BC056152.1         2429-2429
FEATURES             Location/Qualifiers
     source          1..2406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..2406
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /note="zDHHC palmitoyltransferase 13"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
     exon            1..109
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1951
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin interacting protein HIP3RP; HIP14-related
                     protein; zinc finger, DHHC domain containing 13; probable
                     palmitoyltransferase ZDHHC13; DHHC-13; putative
                     MAPK-activating protein PM03; zinc finger DHHC-type
                     palmitoyltransferase 13; putative NF-kappa-B-activating
                     protein 209; zinc finger DHHC domain-containing protein
                     13; huntingtin-interacting protein 14-related protein;
                     zinc finger DHHC-type containing 13"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC13 isoform 1"
                     /protein_id="NP_061901.2"
                     /db_xref="CCDS:CCDS44550.1"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
                     /translation="MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPL
                     IEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYI
                     SKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQ
                     HMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQN
                     TPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMR
                     ANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLF
                     PRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFY
                     KTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVA
                     RYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWT
                     YLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMK
                     QTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAREKVLRSV"
     exon            110..255
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            256..378
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..456
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            457..601
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            602..666
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            667..829
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            830..955
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1089
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1190
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1315
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1378
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1472
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1556
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1714
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1812
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2406
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /note="hexamer: AATAGA"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /note="major polyA site"
     polyA_site      2406
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgacc caaggcgggc tggcgggctg gcggcagtcg ctacttgcct agtagcctca
       61 gccgctgtgg gctcctgggg agatggaggg gccggggctg ggctcgcagt gcaggaatca
      121 cagccatggc ccccaccctc caggatttgg tcgatatggc atctgtgcac atgaaaacaa
      181 agaacttgcc aatgcaagag aagctcttcc tcttatagag gactctagta actgtgacat
      241 tgtcaaagct actcaatacg gaatttttga acgatgtaaa gagttggtag aagcaggata
      301 tgatgtcagg caaccagata aagaaaatgt gtcgcttctt cattgggctg ctattaacaa
      361 cagactggat cttgtaaagt tttatatttc aaaaggtgct gttgtagatc agttgggtgg
      421 agatttaaat tcaactcctc ttcactgggc catccgacaa ggacatttac ctatggtcat
      481 attattactc cagcatggtg cagaccccac tcttattgat ggagagggat tcagcagcat
      541 ccacctggca gtattgtttc aacacatgcc tattatagca tatctcatct caaagggaca
      601 gagtgtgaat atgacagatg taaatgggca gacacctctc atgttatcag ctcacaaagt
      661 aattgggcca gaaccaactg gatttctttt aaagtttaat ccttctctca atgtggttga
      721 taaaatacac caaaacactc cacttcactg ggcagttgca gcaggaaatg ttaatgcagt
      781 tgataagctt ttggaagctg gttctagcct ggatatccag aatgttaagg gagaaacacc
      841 tcttgatatg gctctacaaa acaaaaatca gctcattatt catatgctaa aaacagaagc
      901 caaaatgaga gccaaccaaa agttcagact ttggaggtgg ctgcagaaat gcgagctctt
      961 cctgctgctg atgctttctg tgattaccat gtgggctatt ggatacatat tggacttcaa
     1021 ttcagattct tggcttttaa aaggatgtct tctagtaaca ctgttttttc tgacatcttt
     1081 gtttccaagg ttcttggttg ggtataagaa ccttgtatac ttaccaacag cctttctgct
     1141 aagttctgtt ttttggatat ttatgacttg gttcatctta ttttttcctg atttagcagg
     1201 agcccctttc tatttcagtt tcattttcag catagtagcc tttctatact ttttctataa
     1261 gacttgggca actgatccag gcttcactaa ggcttctgaa gaagaaaaga aagtgaatat
     1321 catcaccctt gcagaaactg gctctctgga cttcagaaca ttttgtacat catgtcttat
     1381 aaggaagcca ttaaggtcac tccactgcca tgtatgcaac tgctgtgtgg ctcgatatga
     1441 tcaacactgc ctgtggactg gacggtgcat aggttttggc aaccatcact attacatatt
     1501 cttcttgttt ttcctttcca tggtatgtgg ctggattata tatggatctt tcatctattt
     1561 gtccagtcat tgtgccacaa cattcaaaga agatggatta tggacttacc tcaatcagat
     1621 tgtggcctgt tccccttggg ttttatatat cttgatgcta gcaactttcc atttctcatg
     1681 gtcaacattt ttattattaa atcaactctt tcagattgcc tttctgggcc tgacctccca
     1741 tgagagaatc agcctgcaga agcagagcaa gcatatgaaa cagacgttgt ccctcaggaa
     1801 gacaccatac aatcttggat tcatgcagaa cctggcagat ttctttcagt gtggctgctt
     1861 tggcttggtg aagccctgtg tggtagattg gacatcacag tacaccatgg tctttcaccc
     1921 agccagggag aaggttcttc gctcagtatg aagaaaagca acccaaaact ctcaatctga
     1981 tttgtttttg tttatgtcga tgccctgtag tttgaaagtg aagtaaagat ttagaattca
     2041 cctaagtcca aaggaaaaca cgtggttttt aaagccatta ggtaaaaaaa gttctcaata
     2101 aaggcattac aattttttag gtttagaaag atggactttt ctgataaatc ttggcagaca
     2161 tctaaaaaaa aaaccatatt tttcacaaga aaatgcaagt tacttttttt ggaaataata
     2221 ctcactgatt atggataaaa tggaatattt tcagatacta tattggctgt ttcaaaatag
     2281 tactattctt taaacttgta atttttgcta agttatttgt ctttgttgta tctataaata
     2341 tgtaaaaaat atttaaatag atgtacctgt tttgctttca cacttaataa aaaatttttt
     2401 tttgta
//
