LOCUS       NM_032799               1146 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 12 (ZDHHC12), transcript
            variant 5, mRNA.
ACCESSION   NM_032799
VERSION     NM_032799.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Wang,L., Cai,J., Zhao,X., Ma,L., Zeng,P., Zhou,L., Liu,Y., Yang,S.,
            Cai,Z., Zhang,S., Zhou,L., Yang,J., Liu,T., Jin,S. and Cui,J.
  TITLE     Palmitoylation prevents sustained inflammation by limiting NLRP3
            inflammasome activation through chaperone-mediated autophagy
  JOURNAL   Mol Cell 83 (2), 281-297 (2023)
   PUBMED   36586411
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Dejanovic,B., Semtner,M., Ebert,S., Lamkemeyer,T., Neuser,F.,
            Luscher,B., Meier,J.C. and Schwarz,G.
  TITLE     Palmitoylation of gephyrin controls receptor clustering and
            plasticity of GABAergic synapses
  JOURNAL   PLoS Biol 12 (7), e1001908 (2014)
   PUBMED   25025157
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL441992.17.
            
            On Nov 23, 2018 this sequence version replaced NM_032799.4.
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 5' coding region, compared to variant 1. It encodes isoform
            5 which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.431333.1,
                                           SRR5189661.123557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372663.9/ ENSP00000361748.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AL441992.17        24580-24713         c
            135-271             AL441992.17        23024-23160         c
            272-349             AL441992.17        22595-22672         c
            350-516             AL441992.17        22237-22403         c
            517-1146            AL441992.17        21459-22088         c
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1146
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /note="zDHHC palmitoyltransferase 12"
                     /db_xref="GeneID:84885"
                     /db_xref="HGNC:HGNC:19159"
     exon            1..134
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..838
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /EC_number="2.3.1.225"
                     /note="isoform 5 is encoded by transcript variant 5;
                     probable palmitoyltransferase ZDHHC12; zinc finger protein
                     400; zinc finger DHHC domain-containing protein 12; zinc
                     finger DHHC-type containing 12; DHHC domain-containing
                     cysteine-rich protein 12; zinc finger DHHC-type
                     palmitoyltransferase 12"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC12 isoform 5"
                     /protein_id="NP_116188.3"
                     /db_xref="CCDS:CCDS6909.1"
                     /db_xref="GeneID:84885"
                     /db_xref="HGNC:HGNC:19159"
                     /translation="MAPWALLSPGVLVRTGHTVLTWGITLVLFLHDTELRQWEEQGEL
                     LLPLTFLLLVLGSLLLYLAVSLMDPGYVNVQPQPQEELKEEQTAMVPPAIPLRRCRYC
                     LVLQPLRARHCRECRRCVRRYDHHCPWMENCVGERNHPLFVVYLALQLVVLLWGLYLA
                     WSGLRFFQPWGQWLRSSGLLFATFLLLSLFSLVASLLLVSHLYLVASNTTTWEFISSH
                     RIAYLRQRPSNPFDRGLTRNLAHFFCGWPSGSWETLWAEEEEEGSSPAV"
     exon            135..271
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /inference="alignment:Splign:2.1.0"
     exon            272..349
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /inference="alignment:Splign:2.1.0"
     exon            350..516
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1146
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /note="hexamer: TATAAA"
     polyA_site      1146
                     /gene="ZDHHC12"
                     /gene_synonym="DHHC-12; ZNF400"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttcttc cgggtggggc cccgggccga ggcgatggcg ccctgggcgc tcctcagccc
       61 tggggtcctg gtgcggaccg ggcacaccgt gctgacctgg ggaatcacgc tggtgctctt
      121 cctgcacgat accgagctgc ggcaatggga ggagcagggg gagctgctcc tgcccctcac
      181 cttcctgctc ctggtgctgg gctccctgct gctctacctc gctgtgtcac tcatggaccc
      241 tggctacgtg aatgtgcagc cccagcctca ggaggagctc aaagaggagc agacagccat
      301 ggttcctcca gccatccctc ttcggcgctg cagatactgc ctggtgctgc agcccctgag
      361 ggctcggcac tgccgtgagt gccgccgttg cgtccgccgc tacgaccacc actgcccctg
      421 gatggagaac tgtgtgggag agcgcaacca cccactcttt gtggtctacc tggcgctgca
      481 gctggtggtg cttctgtggg gcctgtacct ggcatggtca ggcctccggt tcttccagcc
      541 ctggggtcag tggttgcggt ccagcgggct cctgttcgcc accttcctgc tgctgtccct
      601 cttctcgttg gtggccagcc tgctcctcgt ctcgcacctc tacctggtgg ccagcaacac
      661 caccacctgg gaattcatct cctcacaccg catcgcctat ctccgccagc gccccagcaa
      721 ccccttcgac cgaggcctga cccgcaacct ggcccacttc ttctgtggat ggccctcagg
      781 gtcctgggag accctctggg ctgaggagga ggaagagggc agcagcccag ctgtttaggg
      841 ttgctggagg ccgggctacc gtcttgtgcc tgaaaaccac ggggcctgtc cccagctggg
      901 gtgagcgctc agagggcctg gggccctcac tcctgcccac gcctcccaga ccccagaacg
      961 gagcttcaag tcagacagat ccctgccttg gtgggcagtt ctgccttcca aggaagaagg
     1021 ggaagaaaag gacctgtggg tggctcaggc ccaagcagac cccgggctcc accccagccc
     1081 cgcccaggct gctgccagtg cacactttta caaatttaat ataaagcaag tccagtctta
     1141 aaaaga
//
