LOCUS       NM_001351303            3342 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 11B (putative) (ZDHHC11B),
            transcript variant 1, mRNA.
ACCESSION   NM_001351303
VERSION     NM_001351303.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Dai,H., Wu,R., Zhang,J., Dou,R., Xu,M., Wang,J., Wang,J., Su,F. and
            Zhang,T.
  TITLE     ZDHHC11B is decreased in lung adenocarcinoma and inhibits
            tumorigenesis via regulating epithelial-mesenchymal transition
  JOURNAL   Cancer Med 12 (16), 17212-17222 (2023)
   PUBMED   37434393
  REMARK    GeneRIF: ZDHHC11B is decreased in lung adenocarcinoma and inhibits
            tumorigenesis via regulating epithelial-mesenchymal transition.
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Dzikiewicz-Krawczyk,A., Kok,K., Slezak-Prochazka,I., Robertus,J.L.,
            Bruining,J., Tayari,M.M., Rutgers,B., de Jong,D., Koerts,J.,
            Seitz,A., Li,J., Tillema,B., Guikema,J.E., Nolte,I.M., Diepstra,A.,
            Visser,L., Kluiver,J. and van den Berg,A.
  TITLE     ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic
            MYC-miR-150-MYB network in Burkitt lymphoma
  JOURNAL   Leukemia 31 (6), 1470-1473 (2017)
   PUBMED   28331227
  REMARK    GeneRIF: First, MYC downregulates miR-150 to unleash MYB from the
            miR-150-mediated repression. Second, MYC induces ZDHHC11 and
            ZDHHC11B that further ensures the maintenance of high MYB levels
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026740.6.
            
            On Apr 29, 2020 this sequence version replaced NM_001351303.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508859.8/ ENSP00000442373.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC026740.6         174842-174903       c
            63-158              AC026740.6         159009-159104       c
            159-291             AC026740.6         157566-157698       c
            292-513             AC026740.6         156872-157093       c
            514-692             AC026740.6         146140-146318       c
            693-794             AC026740.6         145172-145273       c
            795-919             AC026740.6         141307-141431       c
            920-1075            AC026740.6         138578-138733       c
            1076-1191           AC026740.6         135357-135472       c
            1192-1226           AC026740.6         131768-131802       c
            1227-1314           AC026740.6         123926-124013       c
            1315-1349           AC026740.6         120608-120642       c
            1350-1414           AC026740.6         106975-107039       c
            1415-3342           AC026740.6         100529-102456       c
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..3342
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /note="zDHHC palmitoyltransferase 11B (putative)"
                     /db_xref="GeneID:653082"
                     /db_xref="HGNC:HGNC:32962"
     exon            1..62
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            63..158
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            159..291
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1407
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /EC_number="2.3.1.225"
                     /note="zinc finger DHHC domain-containing protein 11B;
                     zinc finger DHHC-type containing 11B"
                     /codon_start=1
                     /product="probable palmitoyltransferase ZDHHC11B"
                     /protein_id="NP_001338232.1"
                     /db_xref="CCDS:CCDS87287.1"
                     /db_xref="GeneID:653082"
                     /db_xref="HGNC:HGNC:32962"
                     /translation="MDTRSGSQCSVTPEAIRNNEELVLPPRISRVNGWSLPLHYFRVV
                     TWAVFVGLSLATFRIFIPLLPHSWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRL
                     MKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINN
                     CVGSRNYWFFFSTVASATAGMLCLIAILLYVLVQYLVNPRVLRTDPRYEDVKNMNTWL
                     LFLPLFPVQVQTLIVVIIRMLVLLLDLLGLVQLGQLLIFHIYLKAKKMTTFEYLINTR
                     KEESSKHQAVRKDPYVQMDKGFLQQGAGALGSSAQGVKAKSSLLIYKCPCHFCTSVNQ
                     DGDSKAQEADDAPSTSTLGLQQETTEPMKTDSAESED"
     exon            292..513
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            514..692
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            693..794
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            795..919
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1075
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1191
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1226
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1314
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1349
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1414
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..3342
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /note="hexamer: AATATA"
     polyA_site      3342
                     /gene="ZDHHC11B"
                     /gene_synonym="DHHC-11B"
                     /note="major polyA site"
ORIGIN      
        1 gcacttggtc gcgcgcggcc gggtcgcggg ggagcctccg ctgcagttgc tgcgtctcca
       61 agaggaggag acccacccgg tggacttgag ctcgctctcc agtaagctac tcccaggctt
      121 caccacgctg ggcttcaaag acgagagaag aaacaaagtc acctttctct ccagtgccac
      181 tactgcgctt tcgatgcaga ataattcagc atttggcgac ttgaagtcgg acgagttgga
      241 gctgctctac tcagcctacg gagatgagac aggcgtgcag tgtgcgccga gatggacacc
      301 cgctccggga gccagtgttc cgtcacccca gaagccatac gcaacaatga agagctggtc
      361 ttgccgcccc gcatctccag agtgaacggc tggtcgttac ccctgcacta cttccgggtg
      421 gtgacttggg ctgtcttcgt tggcctttcc ttggccacct tcaggatctt cattcccctc
      481 ctgcctcact cgtggaaata catcgcctat gtggtgaccg gggggatctt ctcgttccac
      541 ctcgtcgtcc acctgatcgc gtcctgcatc gacccggccg actccaatgt cagactcatg
      601 aagaactatt ctcagcccat gcccctcttc gacagatcaa aacatgcaca cgtgatccag
      661 aatcagttct gccacctgtg caaggtcacc gtgaacaaga aaaccaaaca ctgcatttcc
      721 tgcaataagt gtgtgtccgg cttcgaccac cactgcaaat ggatcaacaa ctgcgtggga
      781 agccggaatt attggttctt cttcagcact gtggcctcgg ccacagctgg catgctctgc
      841 ctgatcgcca tcctgctgta tgtcctcgtc cagtacctcg tgaaccccag ggtgctccgc
      901 acggacccca ggtatgaaga tgtcaagaat atgaacacgt ggctgctgtt cctccccctg
      961 ttcccggtgc aggtgcagac tctgatagtc gtgatcatca ggatgctcgt gctcctgctg
     1021 gaccttcttg gcttggtgca gctgggccag ctgctcatct tccacatcta cctgaaggcc
     1081 aagaagatga ccacctttga gtatctcatt aatacccgca aagaagagag ttcaaaacat
     1141 caagcagtga ggaaagatcc atacgtgcaa atggacaaag gatttctcca gcaaggagct
     1201 ggcgccctgg gctcatctgc acagggagtc aaggccaaga gctccctgct gatttacaaa
     1261 tgcccatgtc acttctgcac ttcagtaaac caggacgggg attcgaaggc acaggaagca
     1321 gatgatgccc cgagtacatc tacacttggg ctgcaacaag aaacaacaga gcccatgaaa
     1381 actgacagtg ctgaaagtga agactgagat tcgggagctc aggtgcccct gtgatccagg
     1441 tcttctaccc tgaaacccca ccctccatca aggtcctgcc tgtagagtct accttgcaaa
     1501 gcctcctgct cctacccatg ctacaggcca ggaaccagag cccatcatct cagaggcccc
     1561 tggatgtcct tcgaaggaac caggaccctc agagcccagc atccatctct gtcatcatct
     1621 tcatcacacc caaagaagag ccagccttgc aggagggttt acatctccag gaagatgggc
     1681 tgccagcaac tgcagaggat gcagccacct gcttaactgt gctgtccagc cagccagcca
     1741 gctgcagggc ctcttgctgc ttaagagctg atgggccggg catgttggct cacacctgtg
     1801 agcacagtac tgggaaatgg gagcatagta ctgggaaatg ggagcacagt actgagaaat
     1861 gggagcacag tactgggaaa tggtagcaca gtactaggaa atgggatcac agtgctggga
     1921 aatgggagca cagtaatggg aaatgggagc acagtgctgg gaaatgggag cacaaagtac
     1981 tgggaaatgg gagcacagag tactggggaa taggagcaca gtactgggaa atgggagcaa
     2041 acagcactgg gagataggag tatacagcac tgggaaatgg gagcacggca ctgggaaatg
     2101 ggagcacagt actgggaaat gggagcacag tgctaggaaa tgagagcaca gttttgggaa
     2161 atgggagcac agtactggga aatatgagca cagtactggg aaatggaagc acatggcact
     2221 gggaaatagg agtatacagc actgggaaat gggagcacag tactgggaat tgggagcaca
     2281 gcactgggaa atgggagcac agtactagga aatgggagct cacagcactg ggaaatggga
     2341 acatagtact gggaaatggg agcacagtac tgggaaaggg gagcccacag tactgggaat
     2401 tgggagcaca gtactgggaa atgggagttc acagcactag gaaatgggag cacagtattg
     2461 ggaaatggga gcacagtact gggaaagggg agggcacagc actgggaaat gggagcatag
     2521 tactgggaaa gcggagcaca gtactgggaa aggggagccc atagtactgg gaaatgggag
     2581 cacagtactg gaaaatggga gctcacagca ctgggaaatg ggagcatagc attgggaaat
     2641 gggagcacag tactgggaat tgggagcaca gcgctgagaa atgggagctc acagtactgg
     2701 gaaatggagc acagtatttg gaaatgggag cacagtactg ggaaatggga gctcacagca
     2761 ctgggaaatg ggagcatagc attgggaaat gggagcacag tactgggaat tgggagcaca
     2821 gtactgggaa atgggagctc acagtactgg gaaatgggag ctcacagtac tgggaaatgg
     2881 gagcacagta ttcggaaatg ggagcacagt actgggaaat gggagctcac agcactggga
     2941 aatggagcat agcattggga aatgggagca cagtactggg aaatggaagc tcacagtcct
     3001 gggaaatggg agcatagtgc tgggaaatgg gagcacagta ctgagaaatg ggagcacagt
     3061 actgggaaat gggagcccag tactgagaaa tgggagcaca cagtactgtg aaatgggagc
     3121 acagtactgg gaaatgggag catagtactg agaaacccca gacctggatt ctgagttttt
     3181 cagtctagcc cagacttctt atcttagtag acaaaaagag tcaataccag agaaccagag
     3241 gcatcctctg tattttaatg aactctgcgt tttagtctgt ttagtagtca tattttaaaa
     3301 gataatcagt tttctaaata tatctataag ttactacatg ca
//
