LOCUS       NM_024786               2606 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 11 (ZDHHC11), transcript
            variant 2, mRNA.
ACCESSION   NM_024786 XM_940764
VERSION     NM_024786.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Liu,Y., Zhao,X., Seitz,A., Hooijsma,A.A., Ravanbakhsh,R.,
            Sheveleva,S., de Jong,D., Koerts,J., Dzikiewicz-Krawczyk,A., van
            den Berg,A., Ziel-Swier,L.J.Y.M. and Kluiver,J.
  TITLE     Circular ZDHHC11 supports Burkitt lymphoma growth independent of
            its miR-150 binding capacity
  JOURNAL   Sci Rep 14 (1), 8730 (2024)
   PUBMED   38627588
  REMARK    GeneRIF: Circular ZDHHC11 supports Burkitt lymphoma growth
            independent of its miR-150 binding capacity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Hu,D., Zou,H., Chen,W., Li,Y., Luo,Z., Wang,X., Guo,D., Meng,Y.,
            Liao,F., Wang,W., Zhu,Y., Wu,J. and Li,G.
  TITLE     ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the
            Envelope Protein
  JOURNAL   Viruses 15 (1), 144 (2023)
   PUBMED   36680184
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Liu,Y., Zhou,Q., Zhong,L., Lin,H., Hu,M.M., Zhou,Y., Shu,H.B. and
            Li,S.
  TITLE     ZDHHC11 modulates innate immune response to DNA virus by mediating
            MITA-IRF3 association
  JOURNAL   Cell Mol Immunol 15 (10), 907-916 (2018)
   PUBMED   29429998
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Dzikiewicz-Krawczyk,A., Kok,K., Slezak-Prochazka,I., Robertus,J.L.,
            Bruining,J., Tayari,M.M., Rutgers,B., de Jong,D., Koerts,J.,
            Seitz,A., Li,J., Tillema,B., Guikema,J.E., Nolte,I.M., Diepstra,A.,
            Visser,L., Kluiver,J. and van den Berg,A.
  TITLE     ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic
            MYC-miR-150-MYB network in Burkitt lymphoma
  JOURNAL   Leukemia 31 (6), 1470-1473 (2017)
   PUBMED   28331227
  REMARK    GeneRIF: First, MYC downregulates miR-150 to unleash MYB from the
            miR-150-mediated repression. Second, MYC induces ZDHHC11 and
            ZDHHC11B that further ensures the maintenance of high MYB levels
            GeneRIF: ZDHHC11 and ZDHHC11B are novel targets of miR-150 with a
            key role in maintaining elevated levels of the MYB oncogene
            required for the high proliferation rate of Burkitt lymphoma cells.
REFERENCE   6  (bases 1 to 2606)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   7  (bases 1 to 2606)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   8  (bases 1 to 2606)
  AUTHORS   Yamamoto,Y., Chochi,Y., Matsuyama,H., Eguchi,S., Kawauchi,S.,
            Furuya,T., Oga,A., Kang,J.J., Naito,K. and Sasaki,K.
  TITLE     Gain of 5p15.33 is associated with progression of bladder cancer
  JOURNAL   Oncology 72 (1-2), 132-138 (2007)
   PUBMED   18025801
  REMARK    GeneRIF: data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may
            become a potential biomarker identifying high-risk patients with
            disease progression in bladder cancer.
REFERENCE   9  (bases 1 to 2606)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   10 (bases 1 to 2606)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122719.2, AC010427.5 and AC026740.6.
            
            On Feb 26, 2021 this sequence version replaced NM_024786.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023215.1, BC032000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283441.13/ ENSP00000283441.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               AC122719.2         33686-34291         c
            607-785             AC122719.2         31787-31965         c
            786-887             AC122719.2         30819-30920         c
            888-1012            AC122719.2         26905-27029         c
            1013-1168           AC122719.2         23800-23955         c
            1169-1284           AC122719.2         20670-20785         c
            1285-1319           AC010427.5         65813-65847         c
            1320-1407           AC010427.5         57204-57291         c
            1408-1442           AC010427.5         53901-53935         c
            1443-1530           AC010427.5         51565-51652         c
            1531-1565           AC010427.5         46801-46835         c
            1566-1630           AC026740.6         191274-191338       c
            1631-2606           AC026740.6         185779-186754       c
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2606
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /note="zDHHC palmitoyltransferase 11"
                     /db_xref="GeneID:79844"
                     /db_xref="HGNC:HGNC:19158"
     exon            1..606
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1623
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /EC_number="2.3.1.225"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger, DHHC domain containing 11; palmitoyltransferase
                     ZDHHC11; zinc finger DHHC-type containing 11; probable
                     palmitoyltransferase ZDHHC11; DHHC-11; zinc finger protein
                     399; zinc finger DHHC domain-containing protein 11"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC11 isoform 2"
                     /protein_id="NP_079062.1"
                     /db_xref="CCDS:CCDS3857.1"
                     /db_xref="GeneID:79844"
                     /db_xref="HGNC:HGNC:19158"
                     /translation="MDTRSGSQCSVTPEAILNNEKLVLPPRISRVNGWSLPLHYFQVV
                     TWAVFVGLSSATFGIFIPFLPHAWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRL
                     MKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINN
                     CVGSRNYWFFFSTVASATAGMLCLIAILLYVLVQYLVNPGVLRTDPRYEDVKNMNTWL
                     LFLPLFPVQVQTLIVVIIGMLVLLLDFLGLVHLGQLLIFHIYLKAKKMTTFEYLINNR
                     KEESSKHQAVRKDPYVQMDKGVLQQGAGALGSSAQGVKAKSSLLIHKHLCHFCTSVNQ
                     DGDSTAREGDEDPCPSALGAKARNSRLICRRLCQFSTRVHPDGGSMAQEADDAPSIST
                     LGLQQETTEPMKTDSAESED"
     exon            607..785
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            786..887
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1168
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1284
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1319
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1407
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1442
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1530
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1565
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1630
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2606
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /note="hexamer: AATATA"
     polyA_site      2606
                     /gene="ZDHHC11"
                     /gene_synonym="ZNF399"
                     /note="major polyA site"
ORIGIN      
        1 gtgaacgggt tgtgggacct gtcgctgtgt gggggctgtc gagcactccc cagaacgtaa
       61 caaatcctca ggggaactga tgggcggtcg cgcgggcact gggtcctcca caccctggag
      121 agccgttttc cgttgccact cggctctggc cggggtcaca ttctgcagca tgtctgttca
      181 ttcccctggg cggggccctg caccgactcc agcccagccc ctgctccctc tgcggggaac
      241 gtggccccag gcagtgctgg gccattggct gtcagtgctg gtcctggcgg ctgcattccc
      301 agtccccttg gtctctgtga cagtgggcgg ggccggccct cccaggatct gacggcgcag
      361 gtcctcccct tctgtgtcct gcagatggac acccgctccg ggagccagtg ttccgtcacc
      421 ccagaagcca tactcaataa tgaaaagctg gtcttgccgc cccgcatctc cagagtgaac
      481 ggctggtcgt tacccctgca ctacttccag gtggtgacct gggctgtctt cgtgggcctt
      541 tcctcggcca ccttcgggat cttcattccc ttcctgcctc acgcgtggaa atacattgcc
      601 tacgtggtga ccggggggat cttctcgttc cacctcgtcg tccacctgat cgcgtcctgc
      661 atcgacccgg ccgactccaa tgtcagactc atgaagaact attctcagcc catgcccctc
      721 ttcgacagat caaaacatgc acacgtgatc cagaatcagt tctgccacct gtgcaaggtc
      781 accgtgaaca agaaaaccaa acactgcatt tcctgcaata agtgtgtgtc cggcttcgac
      841 caccactgca aatggatcaa caactgcgtg ggaagccgga attattggtt cttcttcagc
      901 actgtggcct cggccacagc tggcatgctc tgcctgatcg ccatcctgct gtatgtcctc
      961 gtccagtacc tcgtgaaccc cggggtgctc cgcacggacc ccaggtatga agatgtcaag
     1021 aatatgaaca cgtggctgct gttcctcccc ctgttcccgg tgcaggtgca gaccctgata
     1081 gtcgtgatca tcgggatgct cgtgctcctg ctggactttc ttggcttggt gcacctgggc
     1141 cagctgctca tcttccacat ctacctgaag gccaagaaga tgaccacctt tgagtatctc
     1201 attaataacc gcaaagaaga gagttcaaaa catcaagcag tgaggaaaga tccatacgtg
     1261 caaatggaca aaggagttct ccagcaagga gctggcgccc tgggctcatc tgcacaggga
     1321 gtcaaagcca agagctccct gctgattcac aagcacttat gtcacttctg cacttcagta
     1381 aaccaggatg gggattcgac ggcacgggaa ggggatgaag acccgtgtcc atctgcactt
     1441 ggagccaagg ccaggaactc ccggctgatt tgcaggcgcc tgtgtcagtt ctccactcgt
     1501 gtacacccag acgggggctc gatggcacag gaagcagatg atgccccgag tatatctaca
     1561 cttgggctgc aacaagaaac aacagagccc atgaaaactg acagtgctga aagtgaagac
     1621 tgagattcag gagctcaggt gcccctgtga tccaggtctt ctaccctgaa accccaccct
     1681 ccatcaaggt cctgcctgta gagtctacct tgcaaagcct cctgctccta cccatgctac
     1741 aggccaggaa ccagagccca tcatctcaga ggcccctgga tgtccttcga aggaaccagg
     1801 accctcagag cccagcatcc atctctgtca tcatcttcat cacacccaaa gaagagccag
     1861 ccttgcagga gggtttacat ctccaggaag atgggctgcc agcaactgca gaggatgcag
     1921 ccacctgctt aactgtgctg tccagccagc cagccagctg cagggcctct tgctgcttaa
     1981 gagctgatgg gccgggcatg ttggctcaca cctgtgagca cagtactggg aaatgggagc
     2041 acagtactag gaaatgggag cacagtactg ggaaatggga gcacagtact gggaaatggg
     2101 ggctcacagc actgcaaaat gggagcacag tattgggaaa tgggagcaca gtactgggaa
     2161 gtgggagcac agtactgaga agtgggagca cagtactgag aaatgggagt acactactga
     2221 gaaatgggag cacagtactg ggaaatgggc atacagtact gagaaatggg agcacacagt
     2281 actgggaaat gggagcacag tactgggaaa tgggagccca cagtactggg aaaggggagt
     2341 tcacagtact cggaaatggg agcatagtac tgggaaatgg gagcacagta ctgggaaatg
     2401 ggagcatagt actgggaaac cccagacctg gattctgagt ttttcagcct agcccagact
     2461 tcttatctta gtagacaaaa agagtcaata ccagagaacc agaggcatcc tctgtatttt
     2521 aatgaactct gcattttaat ctgtttagta gtcatttttt aaaagataat cagttttcca
     2581 aatatatcta taagttacta cgtgca
//
