LOCUS       NM_001323627            2252 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 1 (ZDHHC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001323627 XM_005255914
VERSION     NM_001323627.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Zhang,Q., Du,Z., Zhou,W., Li,W., Yang,Q., Yu,H. and Liu,T.
  TITLE     ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via
            IGF2BP1 Palmitoylation
  JOURNAL   Cancer Gene Ther 31 (9), 1427-1437 (2024)
   PUBMED   39069526
  REMARK    GeneRIF: ZDHHC1 downregulates LIPG and inhibits colorectal cancer
            growth via IGF2BP1 Palmitoylation.
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Tang,J., Peng,W., Feng,Y., Le,X., Wang,K., Xiang,Q., Li,L.,
            Wang,Y., Xu,C., Mu,J., Xu,K., Ji,P., Tao,Q., Huang,A., Deng,C.X.,
            Lin,Y. and Xiang,T.
  TITLE     Cancer cells escape p53's tumor suppression through ablation of
            ZDHHC1-mediated p53 palmitoylation
  JOURNAL   Oncogene 40 (35), 5416-5426 (2021)
   PUBMED   34282274
  REMARK    GeneRIF: Cancer cells escape p53's tumor suppression through
            ablation of ZDHHC1-mediated p53 palmitoylation.
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Le,X., Mu,J., Peng,W., Tang,J., Xiang,Q., Tian,S., Feng,Y., He,S.,
            Qiu,Z., Ren,G., Huang,A., Lin,Y., Tao,Q. and Xiang,T.
  TITLE     DNA methylation downregulated ZDHHC1 suppresses tumor growth by
            altering cellular metabolism and inducing oxidative/ER
            stress-mediated apoptosis and pyroptosis
  JOURNAL   Theranostics 10 (21), 9495-9511 (2020)
   PUBMED   32863941
  REMARK    GeneRIF: DNA methylation downregulated ZDHHC1 suppresses tumor
            growth by altering cellular metabolism and inducing oxidative/ER
            stress-mediated apoptosis and pyroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Feng,T. and Zhu,X.
  TITLE     Genome-wide searching of rare genetic variants in WTCCC data
  JOURNAL   Hum Genet 128 (3), 269-280 (2010)
   PUBMED   20549515
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   10 (bases 1 to 2252)
  AUTHORS   Putilina,T., Wong,P. and Gentleman,S.
  TITLE     The DHHC domain: a new highly conserved cysteine-rich motif
  JOURNAL   Mol Cell Biochem 195 (1-2), 219-226 (1999)
   PUBMED   10395086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY054038.1, U90653.2, BM724650.1, BX111231.1 and AC009061.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001323627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1731199.1,
                                           SRR14038194.3174015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000565726.3/ ENSP00000459264.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                HY054038.1         19-59
            42-1225             U90653.2           1-1184
            1226-1803           BM724650.1         49-626
            1804-1985           BX111231.1         14-195              c
            1986-2252           AC009061.10        90556-90822         c
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2252
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /note="zDHHC palmitoyltransferase 1"
                     /db_xref="GeneID:29800"
                     /db_xref="HGNC:HGNC:17916"
     exon            1..307
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            308..354
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1794
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /EC_number="2.3.1.225"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger, DHHC domain containing 1; probable
                     palmitoyltransferase ZDHHC1; zinc finger protein 377; zinc
                     finger DHHC domain-containing protein 1; DHHC
                     domain-containing cysteine-rich protein 1; zinc finger
                     DHHC-type containing 1"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC1 isoform 2"
                     /protein_id="NP_001310556.1"
                     /db_xref="CCDS:CCDS92175.1"
                     /db_xref="GeneID:29800"
                     /db_xref="HGNC:HGNC:17916"
                     /translation="MYKMNICNKPSNKTAPEKSVWTAPAQPSGPSPELQGQRSRRNGW
                     SWPPHPLQIVAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVS
                     IDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGF
                     DHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFE
                     VLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKL
                     TTYEYIVQHRPPQEAKGVHRELESCPPKMRPIQEMEFYMRTFRHMRPEPPGQAGPAAV
                     NANPSQFLATRGQAEPPPPSSPDTLALPPRIRPQKKRKRRVYKVRTSETSDPASGPRA
                     PSRRSSSSTDSADASPVHAAGPAGAYHSASAESVDEIPVAQTRLGSAALAAPRGRGRQ
                     PTLARQARAPAVFVSPSSGEPRAPGGREAGLA"
     exon            355..597
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            598..773
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            774..875
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1000
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1159
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1272
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1355
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1449
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1510
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..2252
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="ZDHHC1"
                     /gene_synonym="C16orf1; DHHC-1; HSU90653; ZNF377"
                     /note="major polyA site"
ORIGIN      
        1 agcgccggac gaggcccagc cagtctgggt ctggcctggc cgcccctcca gcctgctgga
       61 gccggagccg gagccggagc cggagccgga gccggagcca gagccagagc tcgaggactc
      121 accggcccag tctccgtccg ggatggggcc ccgctcccgg gcgcgttgcc gcccagtccc
      181 ggggaccgtc cctaccgcga gggtctgagg cgcggctgcc ccggggaggg tggaaggcca
      241 ggcgtggggc ccgaacctct ggctgacttt ggcagggccc atctggcacg gcctccgcgg
      301 cgcgcagctg ttttcaagtc agcaaacatt tactgaggat ctactatgta caagatgaac
      361 atctgcaaca agccctccaa caagacggcc cctgagaaga gtgtgtggac ggcaccggca
      421 cagcccagcg gaccctcccc tgagctgcag ggccagcgat cccgccggaa tgggtggagc
      481 tggccccctc acccgctcca gattgtggcc tggctgctgt acctcttctt tgctgtgatc
      541 ggctttggga tccttgttcc cctcctgcct caccactggg tgcccgctgg ctacgcttgc
      601 atgggcgcca tctttgctgg ccaccttgtg gtgcacctga ccgccgtctc catcgatcca
      661 gcagatgcca acgtgcggga caagagctat gcggggcccc tgcccatctt caaccgaagc
      721 cagcacgcac atgtcattga agacctgcac tgcaacttgt gcaacgtgga tgtgagcgct
      781 cgctccaagc actgcagcgc ctgcaacaag tgcgtgtgcg gtttcgacca ccactgcaag
      841 tggctcaaca actgtgtggg cgagcggaac taccggctct ttctacacag tgttgcatcc
      901 gctttactgg gcgtcctgct cctggtgctg gtggccacat atgtcttcgt ggagttcttt
      961 gtcaacccca tgcgtctgcg caccaaccga cactttgaag tcctgaagaa tcacacggat
     1021 gtgtggttcg tgttcctgcc tgccgccccc gtggagaccc aggcccctgc catcctggcc
     1081 ctggccgccc tgctcatcct tctgggcctc ctgtccacag ccctcctggg gcacctgctc
     1141 tgcttccaca tttatctcat gtggcacaag ctcaccacct atgagtacat cgtgcagcac
     1201 cgcccaccac aggaggccaa gggggttcac agggagctcg agtcatgtcc tcccaagatg
     1261 cggcccattc aggagatgga gttctacatg cggaccttca gacatatgcg cccagagccc
     1321 cctggccagg ccgggccagc agcagtgaat gccaatccct cccagtttct tgccacccgt
     1381 ggccaagcgg aacctccacc accctcttcc ccagacactc tcgccctgcc tccccggatc
     1441 cgaccccaga aaaagaggaa gaggcgcgtg tataaagtgc gaacgtctga gacctcggat
     1501 ccggcgtcgg ggcctagggc ccccagccgc cgctccagct cgtcgacgga ttccgcggac
     1561 gccagccctg tgcacgccgc tggccctgcc ggcgcctacc actcggcgtc ggcagagtcc
     1621 gtggacgaga ttccagtggc gcagacgcgc ctgggcagcg ccgctctggc cgccccgcgg
     1681 ggccggggcc gacagcccac gctggcgcgg caggcgcgtg cgcccgccgt tttcgtgagc
     1741 ccgagcagcg gcgagcccag ggcgccgggc ggccgggagg ctggtctggc ttagctgggc
     1801 cgagaggccg gagggccgag ttagagcggc cggcctgact ctctatgcaa caccccatcc
     1861 ttgccgcacc gagtgcactt taggggcccc tacggccggc gggatcggcc tccctccccc
     1921 acgactcagc aatacccgcc ccaccggctg tgatgctcca ataaactttt ttatgctttt
     1981 gcggacgtcg cgcttacttt cttaatggca ggggccacgg gccatccaga agcccgaccc
     2041 tggccagtgg accgggggcg gggaggaggt ccctgtatag taggtagcca cccaggctgc
     2101 cctgtggagg tgctcacgtg cggctcgtgg ttaggaaagg ccttagaagg cggcctggag
     2161 gaggttattt ttcttaaaga tgggctttgc actgggaggc cgagagaaag caggctttgg
     2221 gctccgaaag cagcagtggg cgctgaggct gc
//
