LOCUS       NM_001040432            3357 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger CW-type and PWWP domain containing 2
            (ZCWPW2), transcript variant 1, mRNA.
ACCESSION   NM_001040432 XR_001029 XR_001030 XR_001229 XR_001230
VERSION     NM_001040432.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Cavassim,M.I.A., Baker,Z., Hoge,C., Schierup,M.H., Schumer,M. and
            Przeworski,M.
  TITLE     PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1
            and ZCWPW2
  JOURNAL   Proc Natl Acad Sci U S A 119 (9) (2022)
   PUBMED   35217607
  REMARK    GeneRIF: PRDM9 losses in vertebrates are coupled to those of
            paralogs ZCWPW1 and ZCWPW2.
REFERENCE   2  (bases 1 to 3357)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3357)
  AUTHORS   Liu,Y., Tempel,W., Zhang,Q., Liang,X., Loppnau,P., Qin,S. and
            Min,J.
  TITLE     Family-wide Characterization of Histone Binding Abilities of Human
            CW Domain-containing Proteins
  JOURNAL   J Biol Chem 291 (17), 9000-9013 (2016)
   PUBMED   26933034
REFERENCE   4  (bases 1 to 3357)
  AUTHORS   Perry,J. and Zhao,Y.
  TITLE     The CW domain, a structural module shared amongst vertebrates,
            vertebrate-infecting parasites and higher plants
  JOURNAL   Trends Biochem Sci 28 (11), 576-580 (2003)
   PUBMED   14607086
  REMARK    Review article
REFERENCE   5  (bases 1 to 3357)
  AUTHORS   Kaneko,M., Kato,Y., Horiuchi,H. and Osawa,M.
  TITLE     Molecular characterization of a human monoclonal antibody to B
            antigen in ABO blood type
  JOURNAL   Immunol Lett 86 (1), 45-51 (2003)
   PUBMED   12600744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098616.2, DB451817.1, BC094696.1, BU508346.1, AC093142.2 and
            DB306158.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001040432.3.
            
            Transcript Variant: This variant (1). Variants 1 and 2 encode the
            same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094696.1, SRR1660807.215908.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383768.7/ ENSP00000373278.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC098616.2         26698-27125         c
            429-448             DB451817.1         1-20
            449-2141            BC094696.1         1-1693
            2142-2811           BU508346.1         49-718
            2812-2812           AC093142.2         4361-4361           c
            2813-2838           BU508346.1         720-745
            2839-3357           DB306158.1         9-527               c
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1"
     gene            1..3357
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="zinc finger CW-type and PWWP domain containing 2"
                     /db_xref="GeneID:152098"
                     /db_xref="HGNC:HGNC:23574"
     exon            1..483
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..603
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..948
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..1687
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger CW-type PWWP domain protein 2; zinc finger, CW type
                     with PWWP domain 2; zinc finger CW-type and PWWP domain 2"
                     /codon_start=1
                     /product="zinc finger CW-type PWWP domain protein 2
                     isoform a"
                     /protein_id="NP_001035522.1"
                     /db_xref="CCDS:CCDS33723.1"
                     /db_xref="GeneID:152098"
                     /db_xref="HGNC:HGNC:23574"
                     /translation="MDKEKLDVKIEYCNYAMDSSVENMYVNKVWVQCENENCLKWRLL
                     SSEDSAKVDHDEPWYCFMNTDSRYNNCSISEEDFPEESQLHQCGFKIVYSQLPLGSLV
                     LVKLQNWPSWPGILCPDRFKGKYVTYDPDGNVEEYHIEFLGDPHSRSWIKATFVGHYS
                     ITLKPEKCKNKKKWYKSALQEACLLYGYSHEQRLEMCCLSKLQDKSETHDKVAALVKK
                     RKQTSKNNIEKKKPKFRKRKRKAILKCSFENVYSDDALSKENRVVCETEVLLKELEQM
                     LQQALQPTATPDESEEGHGEEINMGEKLSKCSPEAPAGSLFENHYEEDYLVIDGIKLK
                     AGECIEDITNKFKEIDALMSEF"
     exon            949..1108
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1226
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1273
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1332
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1400
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1525
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..3357
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="hexamer: AATAAA"
     polyA_site      2141
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="major polyA site"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="hexamer: AATAAA"
     polyA_site      3148
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="major polyA site"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="hexamer: GATAAA"
     polyA_site      3266
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="major polyA site"
     regulatory      3334..3339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="hexamer: TATAAA"
     polyA_site      3357
                     /gene="ZCWPW2"
                     /gene_synonym="ZCW2"
                     /note="major polyA site"
ORIGIN      
        1 gaagacaccg ccgcttccac agcgaaggga gctgctccgg gcacgtcgcg gagggagtcc
       61 catttcttct gactcggcag gagcccggga cgttctggaa ggagggacga gccgaggcag
      121 gaggggccgg gccgacgcga gagaaggccc gttacccagc aatacgcgcg cgagacccag
      181 gcccgccgtc gggaccagca cgggccggag ggaggggaag cactccggaa agtgattgga
      241 agtgtggatg agctctcagc cggaaaaggg gctgccgctg tccgcgggct cggcgccagg
      301 gacgcgcgag gaaaccggaa gtcaggcccg agggagctgg gagggcgtta gcgaagccag
      361 gttcggtcgt gggggtgggg aagtgcagga gtggcgcgcg gcgtactaca tgtcccgtga
      421 gcctccgcgg cgggacgggg cggggccgcg ggacgccagg aggcggaggc ggagtggagt
      481 tagattcatc ccagtagaac gcctgcctct ttagtgacta cagacctcac ttcccttctc
      541 tggagttttg gagtctattt tcttcatgga attttgctag gaacaaaaga aaagtctaac
      601 tccattaaat gccttaatgg ataaagaaaa attggatgtt aagattgaat attgtaacta
      661 tgcaatggat tcctcagtgg aaaacatgta tgtaaacaaa gtgtgggttc aatgtgagaa
      721 tgaaaattgt ttgaaatgga gattgttatc aagtgaggat tcagccaagg ttgatcatga
      781 tgaaccatgg tactgcttca tgaacactga ttcaagatat aataactgct caatttctga
      841 agaagacttc cctgaagagt ctcagcttca tcagtgtgga tttaagattg tctattcaca
      901 gctccctctt ggaagcctgg ttttggtaaa attacagaat tggccaagtt ggccaggaat
      961 actttgccct gaccgtttta aagggaaata tgtaacttat gacccggatg gaaatgttga
     1021 agagtatcac atagaattcc tgggcgatcc ccattcaaga tcatggataa aggcaacatt
     1081 cgttggacat tatagtatca cattaaagcc agaaaagtgt aagaataaaa agaagtggta
     1141 taaaagtgca ctacaagaag catgtctact ctatggatat tctcatgagc aaagactgga
     1201 aatgtgctgc ctatcaaaac tacaagataa atccgaaaca catgacaaag ttgctgcact
     1261 ggtcaagaaa aggaagcaga cttctaaaaa taatattgaa aagaagaagc ccaaatttag
     1321 aaaaaggaaa aggaaagcaa ttttaaaatg ctcttttgaa aatgtttatt ctgatgatgc
     1381 cttatcaaag gagaacaggg ttgtctgtga gacggaagtt ttactaaaag agctggagca
     1441 aatgctgcag caagcactgc aacccacagc cacacctgat gaatcagaag aaggacatgg
     1501 agaggaaata aatatgggag aaaagttatc taaatgcagc ccagaagctc ctgcaggcag
     1561 tctgtttgaa aaccactatg aagaggacta tcttgtaatt gatgggataa aattaaaagc
     1621 tggagaatgt attgaggata taactaataa atttaaagaa atagatgctt tgatgtctga
     1681 gttttagaac attatacatt tttcaaatta attataaaaa tattggcatc tttatattta
     1741 tccaaagtta aaactttaaa aatgtttagt gaaataggta taaattatac caaagtttat
     1801 atttgcggta actttctact tcatattttg agaatggcca tgatttttag agccagtcaa
     1861 atggtattta agttagtgtt aaaaatttag aattaaaaaa ccctgatatt tgtatttata
     1921 tatttcttgt ttgccttaat ttttaaatgg tttgtgaaat ttgcctaaca aacatatgtt
     1981 ttacaatgat tgtttaggcc ctttgttcaa aaatggataa cttaaaatgg ctggccaagc
     2041 tattataatt ctcagaggta attcaaatct aataaactta gagaatgtat atttgcagtg
     2101 gaatcaaact attacaaaat aaaaggaaat aattttttaa ataattgttt aatagagttg
     2161 aaacttttcc taaaaagcaa aatttcactt gctacttcta ctggaatcag ttatttcaac
     2221 catggtaccc aaaactgact gcttaataga gtctctggga gattttggaa gatcaaaatc
     2281 ctggaccctt ccctgctgaa tcagtgtctt tggaggtatc atcaggaaga tggaaaaatg
     2341 taatttaaag tgtatagaga gaagttaaac atattgatta taagaaatct aacaatatag
     2401 aaagtaaaaa ctcatcattt ttcagggatt ctcatgaaca gttttagtag atatccttct
     2461 agatatgtgt gggcattcac acctatcttt agttcctgct ctatctcttt ctggtggtac
     2521 ggggtgggga aaagggcatt ccaagcacat aaaaaccaaa gcttgaggag agaagaagtg
     2581 cacgagagca tcaccacagc ggtgaatttt attgtgagtt gcctcatatt gctttaacaa
     2641 ggaggcagca catgtctaga tattaaaaac aaataagaca ccaaacaacc aacgtgtcac
     2701 tcattgagtg ggttgcttct tttaagtatt tttagattct atgataatta cgtagagtgg
     2761 agagtggaga tagactcaca acggtgaaat atcttatttg tcaaagtaaa gtatgtatgt
     2821 atttctgtct tccttgtttt cctcatgtat tccttagcat tctgatattg tgtcatagga
     2881 tgttgagttg taaagcctat ctgggttcat attttacata ctagcttgtc ttaagtcata
     2941 taaccagtaa atagaaggcc tggaagttga gtacatctct gtcaggttcc agatcccatg
     3001 ccattgatta tcatctataa tgtcttgatg aagcttttaa ctagctgggt ggtggaatga
     3061 taatctagtt tcctcatatg taaaatgggg atggaactat gcaaaccaag cactgttgtg
     3121 aggaataaat gagatatttt ttgtgaaagt ggtttgtaaa tcaatttgat cttctgttta
     3181 ctctttgcaa agagaaccaa gtatgtgttt aaatatattg caattaataa ttactgagat
     3241 aaaatgtaac tatacatttg aaatgatcag ttttctttct gttatatcat ttaatctact
     3301 actcatcaat atcagagttc tttctttctc atttataaaa ttaatctttg gaaacca
//
