LOCUS       NM_033114               1808 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger CCHC-type and RNA binding motif containing
            1 (ZCRB1), mRNA.
ACCESSION   NM_033114
VERSION     NM_033114.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Tan,Y.W., Hong,W. and Liu,D.X.
  TITLE     Binding of the 5'-untranslated region of coronavirus RNA to zinc
            finger CCHC-type and RNA-binding motif 1 enhances viral replication
            and transcription
  JOURNAL   Nucleic Acids Res 40 (11), 5065-5077 (2012)
   PUBMED   22362731
  REMARK    GeneRIF: Using small interfering RNA against MADP1, defective viral
            RNA synthesis was observed in the knockdown cells, therefore
            indicating the importance of the protein in coronaviral RNA
            synthesis.
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Wang,H., Gao,M.X., Li,L., Wang,B., Hori,N. and Sato,K.
  TITLE     Isolation, expression, and characterization of the human ZCRB1 gene
            mapped to 12q12
  JOURNAL   Genomics 89 (1), 59-69 (2007)
   PUBMED   16959469
  REMARK    GeneRIF: The 5'-flanking region contains an enhancer core motif and
            binding sites for AP-1, AP-2, and LF-A1. ZCRB1 is characterized by
            an RNA-binding motif and a CCHC zinc finger motif.
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
            Elbashir,S., Tuschl,T. and Luhrmann,R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB062361.1, BC022543.1 and
            BI666919.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033114.3.
            
            Summary: Pre-mRNA splicing is catalyzed by the spliceosome.
            U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5'
            splice site and branch-point sequence. U11 and U12 snRNPs are
            components of U12-type spliceosome and function as a molecular
            bridge connecting both ends of the intron. The protein encoded by
            this gene contains a RNA recognition motif. It was identified as
            one of the protein components of U11/U12 snRNPs. This protein and
            many other U11/U12 snRNP proteins are highly conserved in organisms
            known to contain U12-type introns. These proteins have been shown
            to be essential for cell viability, suggesting the key roles in
            U12-type splicing. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022543.1, SRR1660803.213590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266529.8/ ENSP00000266529.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-862               AB062361.1         37-898
            863-1063            BC022543.1         874-1074
            1064-1077           BI666919.1         638-651
            1078-1808           BC022543.1         1089-1819
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1808
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="zinc finger CCHC-type and RNA binding motif
                     containing 1"
                     /db_xref="GeneID:85437"
                     /db_xref="HGNC:HGNC:29620"
                     /db_xref="MIM:610750"
     exon            1..171
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            172..257
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..827
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="U11/U12 snRNP 31K; zinc finger CCHC-type and RNA
                     binding motif 1; U11/U12-31K; U11/U12 snRNP 31 kDa
                     protein; U11/U12 small nuclear ribonucleoprotein 31 kDa
                     protein"
                     /codon_start=1
                     /product="zinc finger CCHC-type and RNA-binding
                     motif-containing protein 1"
                     /protein_id="NP_149105.3"
                     /db_xref="CCDS:CCDS8740.1"
                     /db_xref="GeneID:85437"
                     /db_xref="HGNC:HGNC:29620"
                     /db_xref="MIM:610750"
                     /translation="MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKD
                     KDTRKSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYF
                     DKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKAPEPEEEIEEVEESEDEGE
                     DPALDSLSQAIAFQQAKIEEEQKKWKPSSGVPSTSDDSRRPRIKKSTYFSDEEELSD"
     exon            258..286
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            287..398
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            399..506
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            507..619
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            620..695
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1808
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="hexamer: AATAAA"
     polyA_site      1128
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="major polyA site"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="hexamer: AGTAAA"
     polyA_site      1735
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
                     /note="hexamer: ATTAAA"
     polyA_site      1808
                     /gene="ZCRB1"
                     /gene_synonym="MADP-1; MADP1; RBM36; SNRNP31; ZCCHC19"
ORIGIN      
        1 aaacagtcgg gaagaagcac cgtggctgct attatctgct ctccgcgcct gacccctccc
       61 aggactcgtg atgccaaggc cgctgcgagc ggctacgaag agtcggggtt gagccccagc
      121 tgagccgagg gctcgcactc ttctggtctc ccaggcccaa cccacctgaa gaaatgagtg
      181 gtggattggc tccaagtaag agcacagtgt atgtatccaa cttgcctttt tccctgacaa
      241 acaatgactt gtaccggata ttttccaagt atggcaaagt tgtaaaggtt accatcatga
      301 aagataaaga taccaggaag agtaaagggg ttgcatttat tttatttttg gataaagact
      361 ctgcacaaaa ctgtaccagg gcaataaaca acaaacagtt atttggtaga gtgataaaag
      421 caagcattgc tattgacaat ggaagagcag ctgagttcat ccgaaggcga aactactttg
      481 ataaatctaa gtgttatgaa tgtggggaaa gtggacactt aagttatgcc tgtccgaaaa
      541 atatgctcgg agaacgtgag cctccaaaga agaaagaaaa aaagaaaaaa aagaaagctc
      601 ctgaaccaga agaagaaatt gaggaagtag aagaaagtga agatgaaggg gaggatcctg
      661 ctcttgacag cctcagtcag gccatagcat tccagcaagc caaaattgaa gaagaacaaa
      721 aaaaatggaa acccagttca ggagtcccct caacatcaga tgattcaaga cgcccaagga
      781 taaagaaaag cacatatttc agtgatgagg aagaacttag tgattaaaat cttgccccag
      841 cacagtaata aaaatcaaga tttgttagta acaatcttga agagctaatt ttaataaaaa
      901 taagaaaaat taatactatc atgttaatac tattattgtc atcccaagaa aaaagatatt
      961 ttaaaaattt atttgaaaag ttcattataa gggctttatt catgcctgat ttgtttacat
     1021 gaggacttct gaaattaatc cttaaaacaa acttcctgaa gaccgaaaag ttgaatgatt
     1081 tattgttact tatattaata aacttttcaa gagaattttg tctttaaata tgggtgtttt
     1141 gtcatcatat ttcttgtagc tttatcccaa tctggataaa ttgtaaatac ctataaaata
     1201 aattataaat acctataaaa tataaagtaa catagctcta aaaggcttaa aatcaaacac
     1261 aggtgttatt tgtctgccct acccatagca ccaaattcca ttccctagaa gaaactactt
     1321 acatgtgcac acatgtagct aaataaagta catatatttc agtcacttaa taaaagaata
     1381 aaggagaatt attcaatctc ttatacttct cctaccttcc tcaatattcc caatgtggct
     1441 gtattaaaaa tttgggggaa tccatatata tcttttttaa taaccaagta aatacttttc
     1501 atttctgagc caaggaatat gctatgatta cgttttttcc tagagttaat aattgtctat
     1561 tttttttcca tgtattgtct ttgtatttat gactaaatct tcccattctg tctgcaggtg
     1621 ggtatatggt aatgggatta gagagccttt aattttctgc tttgtatatt tctatattgt
     1681 ttaactttgt aagaatgccc attacttttt taactagtaa aagcaataga aataagttaa
     1741 tactatcata gtaatattat tattgtcatc ccaagaaaaa atatattaaa aagatatttg
     1801 aaatttca
//
