LOCUS       NM_001131035            1580 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 9 (ZCCHC9),
            transcript variant 2, mRNA.
ACCESSION   NM_001131035
VERSION     NM_001131035.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Shi,X., Jiang,B., Liu,H. and Fan,C.
  TITLE     ZCCHC9 promotes proliferation and invasion of lung cancer through
            regulating the JNK pathway
  JOURNAL   J Cell Biochem 120 (6), 10596-10604 (2019)
   PUBMED   30644129
  REMARK    GeneRIF: Cytoplasmic ZCCHC9 could promote the proliferation and
            invasion of non-small cell lung cancer through the JNK pathway.
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Zhou,A., Zhou,J., Yang,L., Liu,M., Li,H., Xu,S., Han,M. and
            Zhang,J.
  TITLE     A nuclear localized protein ZCCHC9 is expressed in cerebral cortex
            and suppresses the MAPK signal pathway
  JOURNAL   J Genet Genomics 35 (8), 467-472 (2008)
   PUBMED   18721783
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG776648.1, CB126982.1, BC032736.1, AI961614.1 and AC008411.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001131035.1.
            
            Transcript Variant: This variant (2) has an alternate splice site,
            which results in a shorter 5' UTR, as compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.608006.1,
                                           SRR5189658.94325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407610.8/ ENSP00000385047.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BG776648.1         5-43
            40-629              CB126982.1         1-590
            630-1424            BC032736.1         571-1365
            1425-1430           AI961614.1         12-17               c
            1431-1580           AC008411.5         44113-44262
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..1580
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /note="zinc finger CCHC-type containing 9"
                     /db_xref="GeneID:84240"
                     /db_xref="HGNC:HGNC:25424"
                     /db_xref="MIM:620382"
     exon            1..112
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     exon            113..513
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..945
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /note="protein phosphatase 1, regulatory subunit 41; zinc
                     finger, CCHC domain containing 9"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 9"
                     /protein_id="NP_001124507.1"
                     /db_xref="CCDS:CCDS4054.1"
                     /db_xref="GeneID:84240"
                     /db_xref="HGNC:HGNC:25424"
                     /db_xref="MIM:620382"
                     /translation="MTRWARVSTTYNKRPLPATSWEDMKKGSFEGTSQNLPKRKQLEA
                     NRLSLKNDAPQAKHKKNKKKKEYLNEDVNGFMEYLRQNSQMVHNGQIIATDSEEVREE
                     IAVALKKDSRREGRRLKRQAAKKNAMVCFHCRKPGHGIADCPAALENQDMGTGICYRC
                     GSTEHEITKCKAKVDPALGEFPFAKCFVCGEMGHLSRSCPDNPKGLYADGGGCKLCGS
                     VEHLKKDCPESQNSERMVTVGRWAKGMSADYEEILDVPKPQKPKTKIPKVVNF"
     exon            514..664
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     exon            665..757
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     exon            758..826
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1580
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /note="hexamer: AATAAA"
     polyA_site      1430
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /note="major polyA site"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
                     /note="hexamer: AATAAA"
     polyA_site      1580
                     /gene="ZCCHC9"
                     /gene_synonym="PPP1R41"
ORIGIN      
        1 actatgtgct tccggtctcc aataccgcag gagggcggtc ttccccggct cgccaactcg
       61 gctgctctgg gggattcgtg cgcggtaaga agctgcgcgg tagcgcggtg aggtaccact
      121 gatgaaatta tgaccaggtg ggcccgagtt agtaccacat ataacaagag acccttgcct
      181 gcaacatcat gggaggacat gaagaaggga tcctttgagg gaacaagcca aaacctacca
      241 aagcgtaaac aacttgaagc caataggcta tccctcaaaa atgatgcacc ccaagcaaaa
      301 cataaaaaga acaaaaagaa aaaagagtac ttaaatgaag atgtgaatgg attcatggaa
      361 tacctaagac agaattcaca gatggttcac aatgggcaaa ttatagcaac agacagtgag
      421 gaagtaaggg aagaaattgc agttgcttta aagaaagaca gtcgacggga aggaagaaga
      481 ttaaaaagac aagcggcaaa gaaaaatgca atggtgtgtt tccattgtag aaaacctggt
      541 catggaattg cagattgccc cgccgccctt gaaaatcaag acatgggcac tgggatatgt
      601 tacaggtgtg ggtccacaga gcacgaaata accaagtgta aggctaaagt agacccggct
      661 cttggcgaat ttccttttgc aaaatgtttt gtttgtggag aaatggggca cctgtctaga
      721 tcttgtcctg ataatcccaa aggactctat gctgatggtg gcggttgcaa actttgtggc
      781 tctgtggaac atttaaagaa agattgccct gaaagtcaga attcagagcg aatggtcaca
      841 gttggtcgct gggcaaaggg aatgagtgca gactatgaag aaattttgga tgtacctaaa
      901 ccgcaaaaac ccaaaacaaa aatacctaaa gttgttaatt tttgataaca gctagcacta
      961 tcatgagtta ctacctcatt gttactttct aaaccaggcc cgcttcacga gttagagttg
     1021 agctcccctg tagccaggac tatgctgtag atatcagtat gatctgggtg tggccaaaaa
     1081 caattttctt tattctgtct atcaaatagt acttctacca ctgtttggag aaaattgaag
     1141 aaaagaataa gatgattaaa tgaattctct aaaagaacat attttaagag acagaactta
     1201 gacataacca agtagttgta tacctgattg taacaatcat cttttataaa agcaaaatta
     1261 tgcataaatg taaaacaccc ctaaacaaag ggaacaaatg aatttttggt tatattgttt
     1321 tcttggctca aagtatcaat ttattattat aatagaaatt tataagttgc tagaaagtct
     1381 atatttttaa agtacggaat aaaaatatgt tttctattaa gcaatagaaa tatttttgtg
     1441 tataattttt ctgaatactt gattctcgat tgaaatatcc attgttcgtt aatatccatg
     1501 taacaatccc attggaaaca agattttttt tgaatcctag atgagaataa acagggattt
     1561 ggtttttgtt ttagttttga
//
