LOCUS       NM_153367               4930 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 24 (ZCCHC24), mRNA.
ACCESSION   NM_153367
VERSION     NM_153367.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4930)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
REFERENCE   2  (bases 1 to 4930)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4930)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4930)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133481.14 and BC053564.1.
            
            On May 17, 2019 this sequence version replaced NM_153367.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028617.1, SRR1660809.139533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372336.4/ ENSP00000361411.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AL133481.14        95056-95153         c
            99-1368             BC053564.1         1-1270
            1369-4930           AL133481.14        31854-35415         c
FEATURES             Location/Qualifiers
     source          1..4930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..4930
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /note="zinc finger CCHC-type containing 24"
                     /db_xref="GeneID:219654"
                     /db_xref="HGNC:HGNC:26911"
     exon            1..430
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..910
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /note="zinc finger, 3CxxC-type 8; zinc finger, CCHC domain
                     containing 24"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 24"
                     /protein_id="NP_699198.2"
                     /db_xref="CCDS:CCDS7359.1"
                     /db_xref="GeneID:219654"
                     /db_xref="HGNC:HGNC:26911"
                     /translation="MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEP
                     TAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASPYGSLNNIA
                     DGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPY
                     QGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQ
                     SKEHPQHLCEKCKVLGYYCRRVQ"
     exon            431..631
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /inference="alignment:Splign:2.1.0"
     exon            632..796
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /inference="alignment:Splign:2.1.0"
     exon            797..4930
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4906..4911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /note="hexamer: ATTAAA"
     polyA_site      4930
                     /gene="ZCCHC24"
                     /gene_synonym="C10orf56; Z3CXXC8"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggggg aggcggcggc agcggcagcg gctgcgggca gcgcgcgggg cgcagggcgc
       61 ggggcgatca ccgtcggggc tcgggaggcg ggcagtgggc acaggctccc cggtgcccgc
      121 ccctccgctg cggagggggg ccgcgagcgg gcggccgggg aggggccggc accgccgcca
      181 caaaatgagc ctgctgtcgg ccatcgacac gagcgccgcc tcggtgtacc agcccgccca
      241 gctgctcaac tgggtctacc tgtcgctgca ggacacgcac caggctagcg ccttcgatgc
      301 cttccggccc gagccgaccg ccggcgccgc acccccggag ctggccttcg gcaagggccg
      361 ccccgagcag ctgggctcgc ccctgcactc cagctatctc aacagcttct tccagctgca
      421 gcgcggagag gcgctgagca acagtgtgta caagggcgcc tcaccctatg gctccctcaa
      481 caacatcgcc gatggcctca gctccctcac cgagcacttc tcagacctga ccctcacctc
      541 cgaggctcgc aagcccagca agcggccccc acccaactac ctgtgccacc tgtgcttcaa
      601 caaaggacac tacatcaagg actgccccca ggcacgcccc aaaggcgagg gcctgactcc
      661 ataccagggc aaaaagcgct gcttcggcga gtacaagtgt cccaagtgca agagaaaatg
      721 gatgagcggg aactcctggg ccaacatggg gcaggagtgc atcaagtgcc acatcaacgt
      781 gtatccacac aagcagagac ccctggagaa gcccgacggc ctggacgtgt ccgaccagag
      841 caaggagcac ccgcagcacc tctgcgagaa gtgcaaggtc ctgggctact actgccgtcg
      901 cgtgcagtga cgggctgccc gcccgcaccc agagccaccc cccgccagcc cgaggagacg
      961 ctgcttccct gtgctactcc gaggggctgc gtgtcgccct gtgcatgggg tgccctcgca
     1021 ggcctgcggg gctgggccgg gggctcttag cgtccttgtc ttgtgtgtgt tgacaaacag
     1081 tgttactgac attgctgccc cccacaggcc agggaaagca gggagtctgg ggctttttgc
     1141 aggcgggcct ggggtctcag tggaggggac aaaggcaagc aaaagcccat gtccaggagc
     1201 cctgggtgtc cccacaggct cgcctctgag agcctctttg gggtgagcag ccttgtattg
     1261 gccacaggtg cactaaattg actgtgaatc ccaaacctcc ccagaccagc caggccgcct
     1321 gcccccaccc agaaccttcc ggtttgccct gtatggaaag ccactctcag aaatccctct
     1381 ttcctgagtc agcaatcgtg gcaaggggac atgtgttcca acagcggctg gggagtggac
     1441 ctctctgtcc cttgcccacc ttaagcccca aatccagacc ccctctgaca tcactggcat
     1501 tgcacctggg tgtgcccccc tccccacgct atggacccag ataggagggg ttaggcatgg
     1561 gggaggcaca gaatgctgga gagatgcgtc ctggtgaacg tggggcagcc cctcccacga
     1621 cccccaccag actgccttag gttttgtcag ccccactccc tttccttccc ctctgcctcc
     1681 cacccactct gggggtccac atcaagatag ctgggcccag tgtggaagcc cagcgtgtct
     1741 gttccagcag aaaggacaca agcctggtgt tctggagacc tcggctcaag tctttgccct
     1801 gctgccgacg cattgtgtca ccttgggcaa ggacttcgca tctccaggcc tcagtttccc
     1861 cattagttaa atgacagcat aacactagag agcagagggc ccatttcagc tctgttgttc
     1921 tgggattcag gctggccggt gctgtgtcct ggagctttat ttggggagtt tcacccagaa
     1981 tggtgggaga aacctcccag gtgccaggta ccccgcatcg tgacccttca cttggtgtct
     2041 taggaagtca agctgaggga tgctgagtcc tcccctgctg gcccctgcag ccccagccct
     2101 gcttttcatc ccccacccct gcaaacatgg aggagccccc tccttctcac ctcggtctcc
     2161 tagcccctga catggagaac cctgagacaa gccacagaac ccctcttttc taaaatggag
     2221 acaataattt cctacctccc aagggagcag agaggcctcg tggcacgtcc gtggccaggg
     2281 agcccactgt cctggctggc ggcgggatcg tgcgctcctc tgtctcccgg atgagaagcc
     2341 ccgtttccat ggtcttgacc cttcctttct cccggctgtc agaactgggt ctcttgattt
     2401 tgcccctaca ttatgcctct gtgggaaaaa aaaaaaatca gaccaagaaa tgagcctgaa
     2461 attcagtgtt taccatggct caaggatgcc catctggtgt ccagttgcct tttgtattca
     2521 aatgaaaatg ctttgtacaa ctgaggagtt acagtgaagt gttaaccagg ggtccaggga
     2581 gcgagttgaa aagatggagt gagtgtattt gcagccaggg agctgcaggg tggatttgag
     2641 gggccatacc ctctgagcac ttaaaaaagg tatttgctcc aggccaggca gcaggctgtg
     2701 gacacccttg ccaccactgg ggactgccac tgaggactcc ccgagcacgt tgttccccgt
     2761 cttctccaag gtgttgaggt gagctggggt tggccccggc ccaggcttct gtcccaagga
     2821 gaagctgcca ctgacagtca tcctaccgca ctgctaaaga gaatgttcgc agtggtgggc
     2881 ggcgtgcctg tgccaaccct tccagggacc cggccatggg ggaccttggc ccaaggatgc
     2941 ctggggcctg ccagctgtgc tgcaaaggtg gggggcccac accctaaaac taacccaggc
     3001 cccagaccac tggaggccag ggcttccctg cacgggctaa ggggagttgg gatatcaccc
     3061 caaagtgacc ttgccagtga gctgttcagc aggtagccac tgccctgcca tctgtgcaga
     3121 gccagccacc ttgggggctg gggttcccgc tttgaggccc accttccata ctccccttga
     3181 ctcggctctg gctgaactgg ggaactctct tgtggtcagc aaagcccctg ccatgcaggc
     3241 caggtgccat tgagaattaa gtgctcagag ggccaggagc ccaggggatg ggaaagtgtg
     3301 tggttttagt acgttcaaaa gggacaatcg cttgcagttg gtagatctag cgatctagtt
     3361 gggagataat ggtgtttacc ccatatgaag tattcaatag ttctacttgt gaatttgtat
     3421 ttattttgag ttatacttga cacagaattc cttttttaaa aaaatatgtg tgtattttgg
     3481 aaaaaaaatt catagatgtt aaaatttctg catggttacc agtttttctc acaacactga
     3541 atttggtagc ttttcccgaa aaaatcttca cagtaatttt ttgtctgtat atatttgagg
     3601 gccttttttt aaaaaaaaaa aaagaaaaga aaaatataat tgtttgattt ttgagattaa
     3661 aacaaacaaa aagagaggca ttttcaaaat ttcagaactt tcaggagggc aagagaatat
     3721 caaacaaaga tttctggaag tattttgcca accttctggt tgagctgcaa gaaaatattt
     3781 atggtgagaa cttttctgtt tcccgttatt gggtttttgg ttggtttttg tttgtttttt
     3841 actatgcttt ggtctgtaaa aatatgcaac tgaactacat tcagaaggaa atattgtcta
     3901 catagaatat tatatgaagt tggtacataa ttctgatgag gaaaaaaaat ctttgcaatt
     3961 ctttaagcca tattgttgtt tttctgtgtt gttttccctg gatgaaaata tcagtattaa
     4021 gtagacagca tattattcaa gtgtttagac ttattaatat gttcttgtcc tgtatttata
     4081 catatgtgta ttttggaaag tattgccttt tttaagggaa gctataattc gatacatagt
     4141 gaaaaaggga atggtgaccc ctttgtgcct cttccactga ggataacaaa cagcattgta
     4201 atccattctc ttgcaccttc ttcttcttat cttgttatta cggttttatt aattttgtag
     4261 agggacaggg agtgggcaag gggaagaagc agcttatttg actaaccagc ccctctgtgg
     4321 tccaccagcg tcttggcttg gtgggagggc tctcaatcag cagggcccca ggagggaaga
     4381 agaagtgggg caaagcctgg cctcgccgct cgggagcttt gccatctgag ccacgcctcc
     4441 tccaggccat gctccttgaa cttggaaatg tcaaccggag cccttacacc agccctccag
     4501 catctaatag acttgaatct actctaaacg aatatttaat ccaacctcac tacattgtag
     4561 ctcagtccaa cgactaaccc tgaaatgggg gtgttccagc cttcagcgag atggccaagc
     4621 ggtcccctgg gggctgtggc agcgggctta tccttctctg ttgccaacct tgccgtccga
     4681 cctcctccgc ccccatgcgg tgaccccgtc cgtgtctgtg tctgtccata cgtgtgagtc
     4741 cagctaaaaa gacaaaacag aacccgtggg cccagctcgg aaggtgcgtg gagaaggctc
     4801 cgacgtctcc gaagtgcagc ccttgggatg gcattccgtt gtgtgcctta ttcctggaga
     4861 atctgtatac ggctcgccta tagaaatata gcctcttcat gctgtattaa aaggactttt
     4921 aaaagcaaaa
//
