LOCUS       NM_017742               5937 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 2 (ZCCHC2),
            transcript variant 1, mRNA.
ACCESSION   NM_017742 NM_032724
VERSION     NM_017742.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5937)
  AUTHORS   Guffanti,A., Iacono,M., Pelucchi,P., Kim,N., Solda,G., Croft,L.J.,
            Taft,R.J., Rizzi,E., Askarian-Amiri,M., Bonnal,R.J., Callari,M.,
            Mignone,F., Pesole,G., Bertalot,G., Bernardi,L.R., Albertini,A.,
            Lee,C., Mattick,J.S., Zucchi,I. and De Bellis,G.
  TITLE     A transcriptional sketch of a primary human breast cancer by 454
            deep sequencing
  JOURNAL   BMC Genomics 10, 163 (2009)
   PUBMED   19379481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC064801.10, BC006340.1, DN997998.1, AB051531.1, AK000288.1,
            BU675299.1, FN169762.1, BQ001246.1 and AA903206.1.
            
            On May 17, 2019 this sequence version replaced NM_017742.5.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269499.10/ ENSP00000269499.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               AC064801.10        91031-91624
            595-1148            BC006340.1         5-558
            1149-1367           DN997998.1         7-225
            1368-2298           AB051531.1         1-931
            2299-2299           AC064801.10        138161-138161
            2300-2817           AB051531.1         933-1450
            2818-3825           AK000288.1         76-1083
            3826-4000           AB051531.1         2459-2633
            4001-4216           AK000288.1         1259-1474
            4217-4636           BU675299.1         15-434
            4637-4980           AB051531.1         3269-3612
            4981-5024           FN169762.1         34-77
            5025-5121           BQ001246.1         7-103               c
            5122-5425           AA903206.1         1-304               c
            5426-5937           AB051531.1         4056-4567
FEATURES             Location/Qualifiers
     source          1..5937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..5937
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /note="zinc finger CCHC-type containing 2"
                     /db_xref="GeneID:54877"
                     /db_xref="HGNC:HGNC:22916"
                     /db_xref="MIM:620095"
     exon            1..1339
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..3937
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /note="zinc finger, CCHC domain containing 2"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 2"
                     /protein_id="NP_060212.4"
                     /db_xref="CCDS:CCDS45880.1"
                     /db_xref="GeneID:54877"
                     /db_xref="HGNC:HGNC:22916"
                     /db_xref="MIM:620095"
                     /translation="MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPP
                     PPPPPPAGPSRGPLPPPPPPRGLGPPVAGGAAAGAGMPGGGGGPSAALREQERVYEWF
                     GLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGP
                     LADFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAE
                     DERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHPAFSFHQ
                     RVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAP
                     IPQDGLTVAPHRAQREAVHIEKIMLKGVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQ
                     ELQEFLLKLPKELSSETFDKTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQ
                     SQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHAIIHKK
                     HTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSAE
                     KRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDVNLDIGSG
                     HDTCGETSSESYSSPSSPRHDGRESFESEEEKDRDTDSNSEDSGNPSTTRFTGYGSVN
                     QTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAP
                     KPADGKTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPST
                     FLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGS
                     FPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPA
                     SYPLPGSPLAAGVLPSQNSSVLSTAATSPQPASAGISQAQATVPPAVPTHTPGPAPSP
                     SPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSCGRRCSCGTNGNLQLN
                     SYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDP
                     VMGSQANYGMQQMAGFGRFYPVYPAPNVVANTSGSGPKKNGNVSCYNCGVSGHYAQDC
                     KQSSMEANQQGTYRLRYAPPLPPSNDTLDSAD"
     exon            1340..1451
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1528
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1600
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1713
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1808
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1892
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1950
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2086
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2151
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2246
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2375
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..3869
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..5937
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5919..5924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /note="hexamer: AATAAA"
     polyA_site      5937
                     /gene="ZCCHC2"
                     /gene_synonym="C18orf49"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcac ccagccgctc cgtcctcacc ggctcgcgag ggaacagctc aggcaccgcc
       61 gccccggctc agcgcggacg gcggagagag ggaggcggaa ggaggacacc ctcgctcgct
      121 tgctcccacc cgcacccggg ctcccagaac cggcgaggag cccaggggga ggagccgtcg
      181 cgggcacgcc ccgcccccag cccgggaaga cgacgccagc gaccccgccg gccggccacc
      241 gcccccctcg ccggccgaga cccgcccccg gccccggccc tcccccggcg gcatggaggg
      301 gccccgctcc tgacggccgc gccgccgcct cggcccgtgc tccacctcgc ggcccctccc
      361 gcccgccccc gctcgcatgt ctgcgccgcc ctagccgagg atgctgagga tgaagctgcc
      421 gctgaagcca acgcaccccg cggagccgcc gcccgaggcg gaggagcccg aggcggacgc
      481 gcggccgggc gcgaaggcgc cttcgcgccg ccgccgcgac tgccgccccc cgccgccgcc
      541 gccgccgccc gcgggcccgt cgcggggccc tctgccgccg ccgccgccgc cccggggact
      601 cgggccgcct gttgctggtg gagcggcggc gggggcgggt atgccgggcg gcggcggggg
      661 gccctcggcg gcgctgcgcg agcaggagcg ggtatacgag tggttcgggc tggtgctggg
      721 ctcggcgcag cgcctggagt tcatgtgcgg gctgctggac ctgtgcaacc cgctggagct
      781 gcgcttcctt ggctcgtgcc tggaggacct ggcgcgcaag gactaccact acctgcgcga
      841 ctcggaggcc aaggccaacg gcctctcgga cccggggccg ctggccgact tccgagagcc
      901 cgcggtgcgc tcgcgcctca tcgtctacct ggcgctgctg ggctcggaga accgggaggc
      961 cgctggccgt ctgcaccgcc tgctacccca ggtggactcg gtgctcaaaa gcctgcgcgc
     1021 ggcccggggc gagggctcgc ggggcggcgc ggaggacgag cgcggcgagg acggcgacgg
     1081 cgagcaggac gccgagaagg acggctcagg cccggaaggc ggcattgtgg agccccgggt
     1141 cggcggcggg cttggctcca gggcccagga ggaactgctg ctgctcttca ccatggcctc
     1201 gctgcacccg gctttctcct tccaccagcg ggtcaccctg agggaacact tggagaggct
     1261 ccgcgccgcg ctccgcgggg gccccgagga cgcggaggtg gaggtagagc cgtgcaagtt
     1321 tgccggcccc agggcccaga acaactctgc tcatggtgat tacatgcaaa ataacgagag
     1381 cagcttaata gagcaagctc caatacctca ggacggactt accgtggcac ctcacagagc
     1441 tcagcgagaa gctgtacaca ttgagaagat aatgttgaaa ggagtccaga gaaaaagagc
     1501 tgacaaatac tgggagtaca ctttcaaagt aaattggtct gatctttcag tcacaacagt
     1561 aacaaaaacc caccaagaac tacaggaatt tctactgaag cttccaaagg aactgtcttc
     1621 agagactttt gacaagacca tcttaagagc cctgaatcag ggttccttga aaagggagga
     1681 acggcgacat cctgacctag agcccatcct aaggcagcta ttttcaagtt catcacaagc
     1741 ttttctacaa agtcagaaag tacacagctt ctttcagtcc atatcatcag actccctaca
     1801 cagtatcaat aacttacaat cctctctgaa gacttctaag atattagaac acttaaaaga
     1861 agacagctct gaagcttcaa gtcaagaaga agatgtgttg cagcatgcca taatccacaa
     1921 gaagcatact gggaaaagtc ccattgtgaa caatattggt acaagttgtt ctccattgga
     1981 tgggcttacc atgcaatatt ctgaacagaa tggaattgtg gattggagga agcaaagctg
     2041 taccaccatt caacacccag agcactgtgt gacctcggct gaccagcatt ctgctgaaaa
     2101 acggagttta tcttcaataa ataagaagaa aggaaagcca caaacagaaa aggagaaaat
     2161 taagaaaact gacaacagat tgaatagtag aataaatggt attagactct ccactcctca
     2221 gcatgcccat ggtggtactg tgaaagatgt gaatttggac attggctctg gacatgacac
     2281 atgtggagaa acatcttcag agagttacag ttctccatct agtccccgac atgatggaag
     2341 agaaagtttt gaaagtgaag aagagaaaga cagagacaca gacagcaatt ctgaggattc
     2401 tgggaatcca tcaacaacta ggtttacagg ttacggttct gtcaaccaga ctgtcactgt
     2461 caagccacct gttcaaattg cttcactagg aaatgagaat ggaaaccttt tagaagatcc
     2521 cttaaactca cccaagtatc agcatatttc ttttatgcca acgttacact gtgtcatgca
     2581 caatggtgcc cagaagtctg aagttgtcgt tcctgcaccc aaacccgctg atggcaaaac
     2641 catagggatg cttgttccta gtcctgttgc tatttctgca ataagggagt ctgcaaattc
     2701 aacccctgtt ggaatactag ggccaacagc ttgcactgga gaatcggaaa agcaccttga
     2761 gttactggct tcccctttac ctattccatc aaccttcctt ccacacagta gtactcccgc
     2821 tttgcatctt acagttcaga ggctaaagtt gccaccacca cagggatctt ctgagagctg
     2881 cacagttaac atcccacaac aaccacccgg aagcctgagc atcgcatcac caaacactgc
     2941 ctttattcct atccataacc caggtagttt cccaggctct cctgttgcta ccacggaccc
     3001 catcacaaaa tctgcatccc aagtggtagg actcaatcaa atggtgcctc aaattgaggg
     3061 aaacacaggg acagtccctc agcctaccaa tgtgaaggta gttcttccag cagctggcct
     3121 ctcagctgct cagccaccag cttcctaccc cttaccaggc tctccccttg ctgccggcgt
     3181 gttacccagc cagaactcca gtgtgctcag cacagcagca acttctcccc agccagcgag
     3241 cgcaggtatc agccaggccc aggcaactgt tcctcctgca gttcctaccc acaccccagg
     3301 ccctgccccg agcccaagcc ctgccttgac acacagtacc gcgcagagtg acagcacctc
     3361 ttacatcagt gctgtgggga acacgaacgc taatgggaca gtagtgccac cgcagcagat
     3421 gggctcaggt ccttgtggtt cttgtgggcg aaggtgcagc tgtgggacca atggaaacct
     3481 tcagctaaat agttactatt atcctaatcc aatgcctgga ccaatgtacc gagtcccttc
     3541 attctttact ctgccatcca tttgcaatgg cagctacctc aaccaagcac atcagagcaa
     3601 tggaaaccaa cttccttttt ttctgcctca gactccatat gcaaatggac tggtacatga
     3661 cccagtcatg gggagccaag ccaactatgg catgcagcag atggcaggat ttgggagatt
     3721 ctatcctgta tatccagcac ctaacgtagt tgccaacacc agtggttcgg ggcccaagaa
     3781 gaatgggaat gtctcatgtt acaattgtgg tgtaagcgga cactatgcac aggactgtaa
     3841 gcagtcgtcc atggaggcca atcaacaagg cacttacaga ctgagatacg cacctcccct
     3901 ccccccttct aatgatacgt tggattctgc agactgaaac gagtaaagct tgcctactta
     3961 atacactcaa gtgtggggag tcatggggtg tggaggggag gaaaggaaag gtattttgtt
     4021 tctttgtcta tacatttcct agatttctat gcagttggga tttttcattt ctcttgtacc
     4081 aatgtccaaa acaagaaaga atgcaatgct tttgagcctc tggtctcctg gttcaacaac
     4141 aggcttatat gtatgataca tgtaatttaa accttcagac aaacttaaat gttggtgcgt
     4201 gctttttttt ttttttttac actgaatact tgctgtgtgc aatgtttact gaatctttaa
     4261 aactgtgtat ttgacctttt ttttacaaca ctggtgacag tcatatggtt ttgaaaaaaa
     4321 aaagaaattt tgcttcttcc cagcttttct cactttcacc ctaaacgaca cttcctcccc
     4381 agccagcctc actctgtctc cggcccgcag caggagcagc cagcagtgca ttcaccccac
     4441 ttttgtaaac tgctctgcat ataaaccaag ggcagaatgt ttcaccctga tcttatggga
     4501 ggaatcaaac tcccaaaata gtgtgtatat atgtaataaa cagcgtcacg taaatacata
     4561 tatgcagtgc ttgttgtcca aatagaaatg aaaataagtg gaagagagag gaagaagtca
     4621 aaccatatga aactgaaaaa atatgacgta cgaaatggac aaaaagcttt ttctgaaacc
     4681 aactttttac ttccatcatc cttttttagc ctgttgcttc agagagacac aaagtgaaca
     4741 cactggtgtg aatgtcgctc tctgtgtgct tgtgtttgta atgaaagtct acagccaatt
     4801 ttacttgtct accaccgtgt tgtgctcaaa gagacactac ttgagtgaag atttcttctt
     4861 tccctgtacc agctgttaca gtgttacgtt gtgtttaaaa tgtgtatggt ttattgcaat
     4921 ctgaacagag ctatgggttt ctaccataag tcaggttgtt tgttccctaa cctgtctctc
     4981 atagcaaagt cacttttata acagtttacc actatgcttg attataatgt gaaaggcgga
     5041 attctgagtg tgttaagatg gtattaatca tgtcggtgtc atgtcactaa gtttaatgct
     5101 gctgttttta aaaaaaaaaa aaagtttttt taaaaagcca atctatgtac taaattgctt
     5161 ccaggtaatt tttgatttcc taaagtgcac tgaggttatc tggaagattg ggtgtatttt
     5221 ttggtgactg ctgcattcat cagcaatgaa cagtttccac tgtatagtcc taggggtcag
     5281 ggggtggggg tttcattttc cattcctcag cacagagcag aaatgataga tttttattgt
     5341 ttggagtaac gttggtatgc agcagaggaa cgtaaacatt tggtcttggt tcagaagcct
     5401 aacagattgc tagacaagag aaaaaacttg aagaaaaaag aagcttaatt tcatgcttca
     5461 taagtagcat ttatatttat agcaccaatg tacattttga aactttcttt caggggtggg
     5521 agttatgggg aaggggtggg tgtgaagggg tagatgaaag ctttaattta gaaagaaagt
     5581 tcaagtaaag gaaattattt tgattaaata tattttattt gatctgggta tttttggacc
     5641 acattattaa attaattgtt aagctgcagt tgagttgttc aagtgagagt tttgataagc
     5701 cacttatggg ccgcgttgtg aatcacttgc cagttgtact ttatggagct tattttatga
     5761 tttaaaatac tgtactgtac ataggaggta tgttaccttc tccttatttg tatgtttacc
     5821 atatactttg atatttgaaa tgttatgtac tggaaaggcc acttatattt ctagaacaga
     5881 ttggatttta tgcaaccttt tttccttgaa ttaacagcaa taaaaaaatg aaaaaca
//
