LOCUS       NM_016505               1568 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 17 (ZCCHC17),
            transcript variant 3, mRNA.
ACCESSION   NM_016505
VERSION     NM_016505.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1568)
  AUTHORS   Cortese,G.P., Bartosch,A.M.W., Xiao,H., Gribkova,Y., Lam,T.G.,
            Argyrousi,E.K., Sivakumar,S., Cardona,C. and Teich,A.F.
  TITLE     ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of
            synaptic proteins and hyperexcitability
  JOURNAL   J Neuropathol Exp Neurol 83 (7), 626-635 (2024)
   PUBMED   38630575
  REMARK    GeneRIF: ZCCHC17 knockdown phenocopies Alzheimer's disease-related
            loss of synaptic proteins and hyperexcitability.
REFERENCE   2  (bases 1 to 1568)
  AUTHORS   Bartosch,A.M.W., Youth,E.H.H., Hansen,S., Wu,Y., Buchanan,H.M.,
            Kaufman,M.E., Xiao,H., Koo,S.Y., Ashok,A., Sivakumar,S., Soni,R.K.,
            Dumitrescu,L.C., Lam,T.G., Ropri,A.S., Lee,A.J., Klein,H.U.,
            Vardarajan,B.N., Bennett,D.A., Young-Pearse,T.L., De Jager,P.L.,
            Hohman,T.J., Sproul,A.A. and Teich,A.F.
  TITLE     ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive
            Resilience in Alzheimer's Disease
  JOURNAL   J Neurosci 44 (3), e2324222023 (2024)
   PUBMED   38050142
  REMARK    GeneRIF: ZCCHC17 Modulates Neuronal RNA Splicing and Supports
            Cognitive Resilience in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1568)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1568)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1568)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1568)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1568)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   8  (bases 1 to 1568)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 1568)
  AUTHORS   Chang,W.L., Lee,D.C., Leu,S., Huang,Y.M., Lu,M.C. and Ouyang,P.
  TITLE     Molecular characterization of a novel nucleolar protein, pNO40
  JOURNAL   Biochem Biophys Res Commun 307 (3), 569-577 (2003)
   PUBMED   12893261
  REMARK    GeneRIF: molecular cloning and characterization; it is localized to
            nucleoli of diverse cultured cells, with some concentration in the
            granular component of nucleoli
REFERENCE   10 (bases 1 to 1568)
  AUTHORS   Gueydan,C., Wauquier,C., De Mees,C., Huez,G. and Kruys,V.
  TITLE     Identification of ribosomal proteins specific to higher eukaryotic
            organisms
  JOURNAL   J Biol Chem 277 (47), 45034-45040 (2002)
   PUBMED   12202495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001929.1, AK302343.1, BC050609.1 and AK307478.1.
            
            On Feb 27, 2020 this sequence version replaced NM_016505.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, and uses an alternate start codon, compared to
            variant 1. The encoded isoform (c) has a distinct and shorter
            N-terminus, compared to isoform a. Both variants 3 and 4 encode
            isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007446.2, AK001929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344147.10/ ENSP00000343557.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-960               AK001929.1         1-960
            961-1184            AK302343.1         914-1137
            1185-1416           BC050609.1         1175-1406
            1417-1568           AK307478.1         1320-1471
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1568
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /note="zinc finger CCHC-type containing 17"
                     /db_xref="GeneID:51538"
                     /db_xref="HGNC:HGNC:30246"
                     /db_xref="MIM:619744"
     exon            1..44
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            45..165
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..825
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /note="isoform c is encoded by transcript variant 3;
                     putative S1 RNA binding domain protein; nucleolar protein
                     40; nucleolar protein of 40 kDa; pnn-interacting nucleolar
                     protein; zinc finger CCHC domain-containing protein 17;
                     zinc finger, CCHC domain containing 17"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 17
                     isoform c"
                     /protein_id="NP_057589.2"
                     /db_xref="CCDS:CCDS341.1"
                     /db_xref="GeneID:51538"
                     /db_xref="HGNC:HGNC:30246"
                     /db_xref="MIM:619744"
                     /translation="MNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGLV
                     HRTHMSSCRVDKPSEIVDVGDKVWVKLIGREMKNDRIKVSLSMKVVNQGTGKDLDPNN
                     VIIEQEERRRRSFQDYTGQKITLEAVLNTTCKKCGCKGHFAKDCFMQPGGTKYSLIPD
                     EEEEKEEAKSAEFEKPDPTRNPSRKRKKEKKKKKHRDRKSSDSDSSDSESDTGKRARH
                     TSKDSKAAKKKKKKKKHKKKHKE"
     exon            166..223
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            224..324
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            325..416
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            417..517
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            518..663
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1568
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /note="hexamer: ACTAAA"
     polyA_site      1568
                     /gene="ZCCHC17"
                     /gene_synonym="HSPC251; pNO40; PS1D"
                     /note="major polyA site"
ORIGIN      
        1 gtttagttca gcgcagcgac tcggggacct ggagctgacg cctagacact tgtattagct
       61 ttaatagaag agaaatggag gagccataga atattaagga tgaattcagg aaggcctgag
      121 accatggaaa acttgcctgc tctctacact attttccaag gagaggttgc tatggtgaca
      181 gactatgggg cctttatcaa aatcccaggc tgtcggaagc aaggtctggt ccatcgaact
      241 catatgtcat cctgtcgggt ggataagccc tctgagatag tagatgttgg agataaagtg
      301 tgggtgaagc ttattggccg agagatgaaa aatgatagaa taaaagtatc cctctccatg
      361 aaggttgtca atcaagggac tgggaaagac cttgatccca acaatgttat cattgagcaa
      421 gaagagaggc ggaggcgatc cttccaggat tacactgggc agaagatcac ccttgaggct
      481 gtcttgaaca ctacctgcaa gaagtgtggc tgtaaaggcc actttgcaaa agattgtttc
      541 atgcaaccag gtgggactaa atactctctg atacctgatg aggaagagga aaaggaagag
      601 gcaaagtcag cagagtttga gaagcctgac cctacaagga atccttctag aaaaagaaag
      661 aaggagaaga agaaaaagaa acatagagat aggaagtcat ctgactctga cagctcagac
      721 tctgagagtg atacaggcaa gagggcaagg cacacatcaa aagacagcaa ggcagcaaag
      781 aagaagaaaa agaagaagaa gcacaagaag aagcacaagg agtgagagta taaagagtgt
      841 agggggtggt tgagagtaag aaaccaggag ccttgtgcct tgagactcct ggaaagactc
      901 aatagtgaga atatagcctc ccaccccatt aacttcgctc ccatgggaga tggcttcccc
      961 tcatgcaaca ggcaggtttg ggagttagag gtcaaaagca gctgcctgaa tgagttgttg
     1021 tttccttatc actcctggtc cctttgcaag tgaaccctgc agctcaccca ttcattcacc
     1081 caacttcctt cattcagcag gaggtcctat taccctctcc agctgccact gccagagctg
     1141 gattcctgta aaggagtcca ggctagagcc acagagactg ttgtggaggt gagttcggct
     1201 gtagttagag tgattggacc cttcctattg gtctgtcctg ggccaactgg tgggtgatct
     1261 ctgctgcatc caacatggga gcagagactg gcagcaggag gggggaacat ggtgagaagt
     1321 ggtgctcact tttcccattc ctcctaacat agttctacta tgctagaagt ggcatccagc
     1381 ggccacagct agaaaacagt ctgcagtgtg acttaacttg tgtattgcat tccagcagac
     1441 cactgaacca gacagcgaag ccaagatcat tgttctactt tgtatttact actgtgtgaa
     1501 tcagttgatt ctacttcagg tccttgctta aattcctgtc actaaatgga aatgtgtttg
     1561 gttttaaa
//
