LOCUS       NM_015144               8079 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 14 (ZCCHC14), mRNA.
ACCESSION   NM_015144 NM_032909
VERSION     NM_015144.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8079)
  AUTHORS   Li,Y. and Lemon,S.M.
  TITLE     Biochemical analysis of the host factor activity of ZCCHC14 in
            hepatitis A virus replication
  JOURNAL   J Virol 98 (4), e0005724 (2024)
   PUBMED   38501662
  REMARK    GeneRIF: Biochemical analysis of the host factor activity of
            ZCCHC14 in hepatitis A virus replication.
REFERENCE   2  (bases 1 to 8079)
  AUTHORS   Zhao,D., Chen,H., Zhong,J., Zhou,X., Zhang,J. and Zhang,Y.
  TITLE     circRNA-ZCCHC14 affects the chondrogenic differentiation ability of
            peripheral blood-derived mesenchymal stem cells by regulating GREM1
            through miR-181a
  JOURNAL   Sci Rep 13 (1), 2889 (2023)
   PUBMED   36804426
  REMARK    GeneRIF: circRNA-ZCCHC14 affects the chondrogenic differentiation
            ability of peripheral blood-derived mesenchymal stem cells by
            regulating GREM1 through miR-181a.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8079)
  AUTHORS   Li,Y., Misumi,I., Shiota,T., Sun,L., Lenarcic,E.M., Kim,H.,
            Shirasaki,T., Hertel-Wulff,A., Tibbs,T., Mitchell,J.E.,
            McKnight,K.L., Cameron,C.E., Moorman,N.J., McGivern,D.R.,
            Cullen,J.M., Whitmire,J.K. and Lemon,S.M.
  TITLE     The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 119 (28), e2204511119 (2022)
   PUBMED   35867748
  REMARK    GeneRIF: The ZCCHC14/TENT4 complex is required for hepatitis A
            virus RNA synthesis.
REFERENCE   4  (bases 1 to 8079)
  AUTHORS   Shi,X., Han,X., Cao,Y., Li,C. and Cao,Y.
  TITLE     ZCCHC14 regulates proliferation and invasion of non-small cell lung
            cancer through the MAPK-P38 signalling pathway
  JOURNAL   J Cell Mol Med 25 (3), 1406-1414 (2021)
   PUBMED   33345444
  REMARK    GeneRIF: ZCCHC14 regulates proliferation and invasion of non-small
            cell lung cancer through the MAPK-P38 signalling pathway.
REFERENCE   5  (bases 1 to 8079)
  AUTHORS   Kim,D., Lee,Y.S., Jung,S.J., Yeo,J., Seo,J.J., Lee,Y.Y., Lim,J.,
            Chang,H., Song,J., Yang,J., Kim,J.S., Jung,G., Ahn,K. and Kim,V.N.
  TITLE     Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs
            via mixed tailing
  JOURNAL   Nat Struct Mol Biol 27 (6), 581-588 (2020)
   PUBMED   32451488
  REMARK    GeneRIF: Viral hijacking of the TENT4-ZCCHC14 complex protects
            viral RNAs via mixed tailing.
REFERENCE   6  (bases 1 to 8079)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 8079)
  AUTHORS   Hyrina,A., Jones,C., Chen,D., Clarkson,S., Cochran,N., Feucht,P.,
            Hoffman,G., Lindeman,A., Russ,C., Sigoillot,F., Tsang,T.,
            Uehara,K., Xie,L., Ganem,D. and Holdorf,M.
  TITLE     A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor
            Required for Hepatitis B Surface Antigen Production
  JOURNAL   Cell Rep 29 (10), 2970-2978 (2019)
   PUBMED   31801065
  REMARK    GeneRIF: A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host
            Factor Required for Hepatitis B Surface Antigen Production.
REFERENCE   8  (bases 1 to 8079)
  AUTHORS   Li,D.L., Ye,L., Gao,L. and Cheng,H.W.
  TITLE     Plasma concentration of ZCCHC14 contributes to prognostic efficacy
            in intracerebral hemorrhage patients
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (19), 8533-8539 (2019)
   PUBMED   31646585
  REMARK    GeneRIF: Plasma concentration of ZCCHC14 contributes to prognostic
            efficacy in intracerebral hemorrhage patients.
REFERENCE   9  (bases 1 to 8079)
  AUTHORS   Traylor,M., Malik,R., Nalls,M.A., Cotlarciuc,I., Radmanesh,F.,
            Thorleifsson,G., Hanscombe,K.B., Langefeld,C., Saleheen,D.,
            Rost,N.S., Yet,I., Spector,T.D., Bell,J.T., Hannon,E., Mill,J.,
            Chauhan,G., Debette,S., Bis,J.C., Longstreth,W.T. Jr., Ikram,M.A.,
            Launer,L.J., Seshadri,S., Hamilton-Bruce,M.A., Jimenez-Conde,J.,
            Cole,J.W., Schmidt,R., Slowik,A., Lemmens,R., Lindgren,A.,
            Melander,O., Grewal,R.P., Sacco,R.L., Rundek,T., Rexrode,K.,
            Arnett,D.K., Johnson,J.A., Benavente,O.R., Wasssertheil-Smoller,S.,
            Lee,J.M., Pulit,S.L., Wong,Q., Rich,S.S., de Bakker,P.I.,
            McArdle,P.F., Woo,D., Anderson,C.D., Xu,H., Heitsch,L., Fornage,M.,
            Jern,C., Stefansson,K., Thorsteinsdottir,U., Gretarsdottir,S.,
            Lewis,C.M., Sharma,P., Sudlow,C.L., Rothwell,P.M.,
            Boncoraglio,G.B., Thijs,V., Levi,C., Meschia,J.F., Rosand,J.,
            Kittner,S.J., Mitchell,B.D., Dichgans,M., Worrall,B.B. and
            Markus,H.S.
  CONSRTM   METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics
            Network, Neurology Working Group of the CHARGE Consortium;
            International Stroke Genetics Consortium
  TITLE     Genetic variation at 16q24.2 is associated with small vessel stroke
  JOURNAL   Ann Neurol 81 (3), 383-394 (2017)
   PUBMED   27997041
  REMARK    GeneRIF: ZCCHC14 expression is associated with small vessel
            disease.
REFERENCE   10 (bases 1 to 8079)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092720.4, AC105429.3 and AC010531.8.
            
            On Jul 16, 2019 this sequence version replaced NM_015144.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011151.2, AK289682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000671377.2/ ENSP00000499622.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1356              AC092720.4         22091-23446         c
            1357-1480           AC105429.3         14600-14723
            1481-1554           AC105429.3         41530-41603
            1555-1626           AC105429.3         50850-50921
            1627-1736           AC105429.3         54015-54124
            1737-1831           AC105429.3         54854-54948
            1832-1886           AC105429.3         55830-55884
            1887-2169           AC105429.3         56989-57271
            2170-2261           AC010531.8         174882-174973       c
            2262-2389           AC010531.8         174020-174147       c
            2390-2530           AC010531.8         172661-172801       c
            2531-3991           AC010531.8         171122-172582       c
            3992-8079           AC010531.8         165854-169941       c
FEATURES             Location/Qualifiers
     source          1..8079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..8079
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /note="zinc finger CCHC-type containing 14"
                     /db_xref="GeneID:23174"
                     /db_xref="HGNC:HGNC:24134"
                     /db_xref="MIM:620697"
     exon            1..1356
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     CDS             787..4047
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /note="zinc finger, CCHC domain containing 14"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 14"
                     /protein_id="NP_055959.2"
                     /db_xref="CCDS:CCDS10961.2"
                     /db_xref="GeneID:23174"
                     /db_xref="HGNC:HGNC:24134"
                     /db_xref="MIM:620697"
                     /translation="MVEKRCPLQRDGVYRWFSELPSPQRVEFLCGLLDLCIPLELRFL
                     GSCLEDLARKDYHSLRDSEIKANNPADLGSLTNLTDEVVRSKLLVSLALLGSEQREAA
                     GVLYRTLTHIDSIIHNYGLQLNEGRTGDEFLLLFTMASNHPAFSFHQKQVLRQELTQI
                     QSSLNGGGGHGGKGAPGPGGALPTCPACHKITPRTEAPVSSVSNSLENALHTSAHSTE
                     ESLPKRPLGKHSKVSVEKIDLKGLSHTKNDRNVECSFEVLWSDSSITSVTKSSSEVTE
                     FISKLCQLYPEENLEKLIPCLAGPDAFYVERNHVDLDSGLRYLASLPSHVLKNDHVRR
                     FLSTSSPPQQLQSPSPGNPSLSKVGTVMGVSGRPVCGVAGIPSSQSGAQHHGQHPAGS
                     AAPLPHCSHAGSAGSALAYRTQMDTSPAILMPSSLQTPQTQEQNGILDWLRKLRLHKY
                     YPVFKQLSMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSERRCLNPSAPPLV
                     TSSGVARVPPTSHVGPVQSGRGSHAAELRVEVEQPHHQLPREGSSSEYSSSSSSPMGV
                     QAREESSDSAEENDRRVEIHLESSDKEKPVMLLNHFTSSSARPTAQVLPVQNEASSNP
                     SGHHPLPPQMLSAASHITPIRMLNSVHKPERGSADMKLLSSSVHSLLSLEERNKGSGP
                     RSSMKVDKSFGSAMMDVLPASAPHQPVQVLSGLSESSSMSPTVSFGPRTKVVHASTLD
                     RVLKTAQQPALVVETSTAATGTPSTVLHAARPPIKLLLSSSVPADSAISGQTSCPNNV
                     QISVPPAIINPRTALYTANTKVAFSAMSSMPVGPLQGGFCANSNTASPSSHPSTSFAN
                     MATLPSCPAPSSSPALSSVPESSFYSSSGGGGSTGNIPASNPNHHHHHHHQQPPAPPQ
                     PAPPPPGCIVCTSCGCSGSCGSSGLTVSYANYFQHPFSGPSVFTFPFLPFSPMCSSGY
                     VSAQQYGGGSTFPVVHAPYSSSGTPDPVLSGQSTFAVPPMQNFMAGTAGVYQTQGLVG
                     SSNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRPGTFRLKYAPPAESLDSTD"
     exon            1357..1480
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1554
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1626
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1736
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1831
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1886
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2169
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2261
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2389
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2530
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..3991
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..8079
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8039..8044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /note="hexamer: AGTAAA"
     regulatory      8059..8064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /note="hexamer: AATAAA"
     polyA_site      8066
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
     polyA_site      8079
                     /gene="ZCCHC14"
                     /gene_synonym="BDG-29; BDG29"
                     /note="major polyA site"
ORIGIN      
        1 acttctgctg atcccggccg cccgtcagcc gcgagcgcga cgatccctcc gctcctcggc
       61 cggcgcctcc tccgccgtcg ccgtcgccgt cgccgtcgcc gtcgccgccg ccgccgcgct
      121 cgggcccgga tccgtccgcc gcgcgggagc agcaaggccg gcaagtcccg gccggatccc
      181 tccgcgcctc ccgccgcgcg tccctccccc tccagcgtcc gtttcgcggc cgcggccccc
      241 agcgctcccc aggcggcgac gccgcgcccg cggcccgggg taacggccgg cctgggcgga
      301 ggcgcgggcg gcggcgacgg catggccggg gcggctccgt cggggggcgg cccgcagtga
      361 cagaccctgc ggcgcggggg gagatggggg cggccgcctc ccgggcgacg acgacgacga
      421 cgacgaggag cagccgccgc cgccgccgcg caccggccgc cgctgggcac gggcgcgggg
      481 aaggcgcctc cccgtgagcg gggggcccga ggccgctcgc cgcccccggc cgccccggcc
      541 gccccgggcc cccccggcgc cccgcgcgcg cccgcccgcc ggcccctgac gggagccttg
      601 cccggccccg gtccccgccc ccgccccggc gcccgcccgg cccgcggcgc ccgcgcgccc
      661 tcgcccggac ccggccccgg cccgcgcgtc cccggtcccg gcgcgccccg gccgcggccc
      721 ccggcgcccc ccggccgccc ccgcgcggtc cccggccccg ggtcgcggcg cggcgcgggc
      781 ggcagcatgg tggagaagcg ctgcccgctg cagagggacg gcgtgtaccg ctggttctcg
      841 gagctgccgt cgccgcagcg cgtggagttc ctgtgcggcc tgctggacct gtgcatcccg
      901 ctcgagcttc gcttcctcgg ctcgtgcctg gaggacctgg cccgcaagga ctaccactcg
      961 ctgcgcgact cggagatcaa ggccaacaac ccggccgacc tgggcagcct caccaacctg
     1021 acggacgagg tggtgcgcag caagctgctg gtgtcgctgg cgctgctggg ctcggagcag
     1081 cgcgaggcgg cgggcgtgct ctaccgcacg ctcacgcaca tcgactccat catccacaac
     1141 tacgggctgc agcttaacga gggccgcacg ggcgatgagt tcctgctgct gttcaccatg
     1201 gcctccaacc acccggcctt cagcttccac cagaagcagg tgctgcgcca ggagctcacg
     1261 cagatccaga gcagcctgaa cggcggcggg ggccacggcg gcaagggcgc gcccgggccg
     1321 ggcggcgcgc tgcccacttg cccagcctgc cacaagatca ctccaagaac tgaggcccct
     1381 gtcagcagtg tcagtaatag tttggagaat gccctgcaca catcagcaca ttccacggag
     1441 gagtcgctgc ccaagaggcc cttaggaaaa cacagcaaag tgagtgttga aaagatagac
     1501 ctgaagggat tatcacacac aaaaaatgac agaaatgttg aatgttcctt tgaggtcttg
     1561 tggtctgatt cttcaataac atcagtaacc aaatcttcct ctgaagtgac ggaatttatt
     1621 tcaaagctat gtcagctcta tcctgaagag aacttggaga aactcattcc ttgcttagct
     1681 ggtccggacg cattttatgt ggagcgaaac cacgtggatc tggactcagg cctgaggtac
     1741 ctggcctcat taccttctca cgtgttgaaa aatgaccatg tcaggaggtt tctcagcact
     1801 tcctctcccc cacagcagct tcagagtcca agtcctggca atccctccct ttctaaagta
     1861 ggtaccgtga tgggcgtgtc tggaaggcct gtgtgtggag tggctggtat cccgtcctcg
     1921 cagagcggag cccagcacca cgggcagcac ccggccggct ccgccgcccc cttgcctcac
     1981 tgctcccatg cgggcagcgc gggctcagcc ctggcctacc ggacccagat ggacacatca
     2041 cctgccatcc tcatgccttc cagtctgcag acccctcaga cccaggagca gaatgggatt
     2101 ctagactggc ttaggaaact gcgtttgcac aagtattacc ccgtctttaa gcagctctcc
     2161 atggagaagt ttttgagcct tactgaagaa gatctgaata aatttgagtc tcttaccatg
     2221 ggggcaaaga agaagctcaa gacccagctg gagctggaaa aggagaagtc agagagacgg
     2281 tgcctgaacc cctcggcccc gccgctggtc accagcagtg gtgtggctcg agtgcccccc
     2341 accagccacg tcgggcccgt gcagtcgggg cggggcagcc atgcagcaga gctgcgggtg
     2401 gaagtggagc agccccatca ccagctgccc cgggaaggca gttcctcgga gtactccagc
     2461 tcctcctcca gccccatggg ggtacaggcc cgggaagaga gctccgacag cgctgaggag
     2521 aatgacagac gtgtggagat tcacttggag agctctgaca aggagaagcc ggtgatgctg
     2581 ctgaatcact tcacttccag ttccgccaga cccacggccc aggttctccc tgtgcagaat
     2641 gaggccagct ccaatccatc aggccaccac cccctgcccc cgcagatgct gagcgcagcc
     2701 tcacacatca cacccatccg catgctgaat tccgtgcaca agccggaaag agggagcgcg
     2761 gacatgaagc tcctctcgtc ttctgtgcac tcacttttgt ctctagaaga aaggaataaa
     2821 ggatctggac caagaagcag catgaaagtg gacaagagct ttggcagcgc catgatggac
     2881 gtgctgcccg cgtccgcacc ccaccagcct gtgcaggtcc tctctgggct ttcggagagc
     2941 agctccatgt cacccacagt ctcctttggt ccccggacca aagtcgtgca tgcatccacg
     3001 ctggacaggg tgctgaagac agcacagcaa ccggccctgg tcgtggagac cagcacggcc
     3061 gccacgggga cgcccagcac agtcctccac gccgcccgtc cgcccatcaa actgctgctg
     3121 tcgtcatctg ttcctgctga ttctgccatt tctgggcaaa cttcctgtcc taataatgtg
     3181 caaataagtg tgccccctgc aataataaac ccccggactg ctctgtacac agccaacacc
     3241 aaagttgcct tttctgcaat gagcagtatg ccagtgggcc ccctgcaggg tggcttctgt
     3301 gcaaacagca acactgcctc tcccagcagc cacccctcca cgtcctttgc caacatggcc
     3361 acgttgccca gctgcccagc ccccagctcc agcccggcgc tgtcctccgt ccctgaaagc
     3421 agtttctata gcagcagtgg cggtggcggc tccacaggaa acattcctgc ctcgaatccg
     3481 aaccaccacc accaccacca ccatcagcag cccccggcac ccccgcagcc cgccccaccc
     3541 ccgccaggct gcattgtgtg cacgtcctgt ggctgcagcg gcagctgcgg ctcgagtggc
     3601 ctgactgtca gctacgccaa ctacttccag cacccgttct ccggtccgtc cgtgttcacc
     3661 ttccccttct tgcccttcag tcccatgtgc agcagcggct acgtcagcgc ccagcagtac
     3721 ggcggcggct ccaccttccc cgtcgtgcac gccccttaca gcagcagcgg gaccccagac
     3781 cctgtcctga gtgggcagtc cacgtttgcc gtgccaccca tgcagaactt catggcaggg
     3841 acagcagggg tgtaccagac ccaaggactg gtgggcagta gcaatggttc cagtcacaaa
     3901 aagagcggga acctatcttg ttacaactgc ggggccactg gtcaccgcgc ccaggactgc
     3961 aaacagccgt ccatggactt caaccggcca ggtactttta ggttgaaata cgcccctcca
     4021 gcagaaagtc tggactccac agattgatat ttttctctgg caacagaacg ttattaagcc
     4081 atggagacat aaggaaaatt aaatacaaaa ctgagaagtc tagttgctgt tgagcttaat
     4141 ctttttaatc caaaggtgct ttacttttcc tagactggat agaaaatcta gcgtagaagt
     4201 gcatcaaact cgatttattg ccaaaaccct agattggagc ttggtgtcag aactcgccta
     4261 gtgggcatct ctgtggctgg tgagatcggc cacctccact tttggttgca gtgcagagac
     4321 gccatgtctc ccgaagagca ttgccatcac tggccctcct aggctcacac gtcaattcca
     4381 gggcagctac acgtggtctg aatcgagaac cgagcttgga gttctccaag tggagttcca
     4441 cccgccggac tcctgacacc cctgggctag ggaaaatgtc gactttgttt tgttctgttc
     4501 ctaaagtgat tagcactaat ctctgggatt tttaaggatt gcactacaga agaatgtacc
     4561 ctgatgtaaa tctctgcggt tctgggagcc aaactcctct gagaacagtc agtgcaagag
     4621 actccaataa tccatattga aagagtcagc accagcagag gctactcgac ttaggacgca
     4681 acagaggttt tagtatttcc ttccctcctc caagcacttg tagcagtttc aggtttttaa
     4741 tttttttctg caaataaatc taaactacgt tattaaatag aaatagttta ctcgcaacaa
     4801 cttaatttct aagggtccaa gtcccagaga atccatagtc gtcaaagctt tgagagtatc
     4861 tttcttccca gccagtcagt ggctttgagc cctatcttcc actacaaatg acctctcgag
     4921 gggggacggc gacagcgcgg ctctgtgagt ggctgtgagg atgctgcacg tcctcagcag
     4981 agtttgcaag ttgctttatc tcccacgggc tccccaagaa cctccaaccc cgaggcttat
     5041 cgctagcgga ttcacacctg agacagacat ttcaacaatg atacagtcct gtcatttatc
     5101 agcaaaagat tgggaatttt ctcctgtcaa cttcttttgt attaggctgt gtattgatag
     5161 ttaattccgt taaaaattac ttggaaaaca gtgggaagtg gtaggactct ggaagaggcc
     5221 acacacccga gagctgcgag atctgtgcaa gtctggtttt ggttaggtag taataaaagt
     5281 cctcactgta gatctctaaa tttcaaccca cggaaatgaa agccttttgt ctgaaattta
     5341 cggacttaaa tcttcaaggt taaagggaat tttctgctca aataatactc ttatcgaaaa
     5401 tgctaaagtc ttcaatgtta aaatactgat tggtaaaatc ttgcagttgg gattttgcag
     5461 ttggatattt attttaaaaa aaattataat attcagacta ttcttaaaat gggacaatca
     5521 gcctcatgaa aaattgatgt aaatcagaag aataccctag aatgaggcct tgtgatgtga
     5581 gcgttcaatt tgaagagcag ttcctaactt catagaaact aaagcagaaa gttgttacat
     5641 tttttttatg acaggctttt agtagaattt tttagtttta ttttagttga attttatttc
     5701 tatgcaatgc agaattaaca gacctcttct cctcatggta cacagtatta cagtgttgaa
     5761 gtaatggtga tgcttattac aacagctatt taggggaatg ttacgttgat ctcttaaatt
     5821 gtaaacacta caaaatgtca aaataatgag aactgacaca actttgcctt aaagagtact
     5881 agactggacc ttctcatatt acgtttaagg aagacttaga gtgttcattg atgtttacga
     5941 ttttaatatt tctgaaggcc attacagtgg cctggatatg tgctgaaagc caaactttta
     6001 aattttttgg tttttttaag caaagaaata ttttaaataa atcctatttc aacactgaaa
     6061 ttgttgaaaa ccgtctcata acaaaaggaa aaaacattgg aatttttgtt ttagtggtca
     6121 gtatagggga atgaaagcgt ctgttgttac ccacgtaact attttgataa gtattagagg
     6181 ttaaccttaa atccagcaaa acattaaaac agaaactttt caacttggag cctgccattc
     6241 agcgttgagg tagatgagtt ccgacactgt cacggctgtg ttcccagcag cgaaggcctc
     6301 tgcggagctg ccagtcgtct tgaacgtgca tgggcggcgt gtgacatctc cagggaggcc
     6361 gtccgaagtc gagaatcgtc agctgtaagt aggagctaca cagcgcagag aaaatggaac
     6421 cacccatccg tgaggcctct ttccggaggg agccgcacac ttggacttga gagtttgcca
     6481 gcagcgagct cggatgcatc tctccaaaag ccaccaaggt cggcgcgtct gaagagcgtt
     6541 ttgcggtcat cagacttcct catctgaaaa cacagaacat actgaccctt tcaagtactt
     6601 agtcattttc ctgaaagtgt ggtctgtttc agaatgctgt ggcaaccagg taggtgtggc
     6661 actggccatg tgccacgtct ttgccctttg tagtctgtca gatattaaag tttctaaccc
     6721 tgttttttta atctccaaga atggggaaag tggaatgtag agatggaagc agaacgtgat
     6781 gtttggatac aacagctatt taatcctttt ttatttttta agcaaaacac tcagttttct
     6841 accttatttt ctaatgttga tttcatggta atactgacag ttggaagtgt ttaacataaa
     6901 aactcattgc taaagagcac tgaggaaatg ggagctagcg cacttgtaat aaaaataaag
     6961 acaaaatatt ttcttgaatg catatatgtg attgggtatt ttaaaaacca gtatcatctg
     7021 tcatctccaa aagattacag gagtcagctt gttaatacag tagtgttagt aggttctgta
     7081 tttttaattc agtacttaga attctaggtc ctttattgcc caaagtcagc acagttagtt
     7141 tataccacag actctgtctt ggggcacagt agtggggcgg ggtagtgact ttgcctaaac
     7201 atcacccagc tggaacagag gctgagcggg gctttaggca cttgccagat gggaactggg
     7261 ttgcaccctc cttgctccct gtcattttct tgtcactctt cctgcttccc agtgttttat
     7321 tttatgcctt gctcgttgta catcatgatg actgatggtc ttcaaggttg tgaggaaagc
     7381 cgtctccctg cttgactcga ctgctgtccc agaggagagt cctgtgcgac ctgagcgggg
     7441 gtggctgcca tttccagcat gcaggtgact tccaaagaat gagtcaggtg gcactgaaag
     7501 ccatgggttc tgaagaggcg aatttgttga aaagtcccaa gggtctgaat gaaagcatct
     7561 ttaatcaaca ctcaacactc gcaatattct agaaaaccat atactgtgct ggttgaggcc
     7621 aaaggttaac attgctccac tgttcaccaa ggaagggggc agtggccatc cgccgcggcc
     7681 tcacgtgcgt tgtaacaagc cctcatcaca tgtgtgagtc ttacgtgcac aaaaagagaa
     7741 ggctttggta ctgaaactgg acaccttgtg tactcgatac cttcacagct tctattggac
     7801 atattttctt tttaggaatg aaggaaaatt ctcccatttt tgagccattc ttttgtcaat
     7861 tctacaaaat tgcatgtaac tttataaata tttttaaaag atatagtttt gtaaatattt
     7921 aatattccgc taatttgatt ttgaattgta aatgtcaagt attctgtttt tggggttttt
     7981 atgttttatt atactttgtt aaaaaggaca aattgtacat ttttagaatg tttttatgag
     8041 taaatttaat gtactgaaaa taaaaatttt aaaaaaggc
//
