LOCUS       NM_001300816            2189 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger CCHC-type containing 10 (ZCCHC10),
            transcript variant 1, mRNA.
ACCESSION   NM_001300816 XM_005272024
VERSION     NM_001300816.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Ohira,T., Kojima,H., Kuroda,Y., Aoki,S., Inaoka,D., Osaki,M.,
            Wanibuchi,H., Okada,F., Oshimura,M. and Kugoh,H.
  TITLE     PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA
            transcription
  JOURNAL   PLoS One 14 (8), e0217605 (2019)
   PUBMED   31404068
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Ning,Y., Hui,N., Qing,B., Zhuo,Y., Sun,W., Du,Y., Liu,S., Liu,K.
            and Zhou,J.
  TITLE     ZCCHC10 suppresses lung cancer progression and cisplatin resistance
            by attenuating MDM2-mediated p53 ubiquitination and degradation
  JOURNAL   Cell Death Dis 10 (6), 414 (2019)
   PUBMED   31138778
  REMARK    GeneRIF: ZCCHC10 exerts its tumor-suppressive effects by
            stabilizing the p53 protein and can be used a potential prognostic
            marker and therapeutic target in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2189)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   7  (bases 1 to 2189)
  AUTHORS   Yu,X., Noll,R.R., Romero Duenas,B.P., Allgood,S.C., Barker,K.,
            Caplan,J.L., Machner,M.P., LaBaer,J., Qiu,J. and Neunuebel,M.R.
  TITLE     Legionella effector AnkX interacts with host nuclear protein
            PLEKHN1
  JOURNAL   BMC Microbiol 18 (1), 5 (2018)
   PUBMED   29433439
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2189)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   9  (bases 1 to 2189)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK300543.1, BC022443.1 and AK000101.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001300816.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.437468.1, BC022443.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000509437.6/ ENSP00000423276.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK300543.1         24-27
            5-1074              BC022443.1         1-1070
            1075-2189           AK000101.1         1008-2122
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2189
                     /gene="ZCCHC10"
                     /note="zinc finger CCHC-type containing 10"
                     /db_xref="GeneID:54819"
                     /db_xref="HGNC:HGNC:25954"
     exon            1..53
                     /gene="ZCCHC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..591
                     /gene="ZCCHC10"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCHC domain-containing protein 10; zinc finger,
                     CCHC domain containing 10"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 10
                     isoform 1"
                     /protein_id="NP_001287745.1"
                     /db_xref="CCDS:CCDS75301.1"
                     /db_xref="GeneID:54819"
                     /db_xref="HGNC:HGNC:25954"
                     /translation="MATPMHRLIARRQAFDTELQPVKTFWILIQPSIVISEANKQHVR
                     CQKCLEFGHWTYECTGKRKYLHRPSRTAELKKALKEKENRLLLQQSIGETNVERKAKK
                     KRSKSVTSSSSSSSDSSASDSSSESEETSTSSSSEDSDTDESSSSSSSSASSTTSSSS
                     SDSDSDSSSSSSSSTSTDSSSDDEPPKKKKKK"
     exon            54..119
                     /gene="ZCCHC10"
                     /inference="alignment:Splign:2.1.0"
     exon            120..281
                     /gene="ZCCHC10"
                     /inference="alignment:Splign:2.1.0"
     exon            282..323
                     /gene="ZCCHC10"
                     /inference="alignment:Splign:2.1.0"
     exon            324..2189
                     /gene="ZCCHC10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC10"
                     /note="hexamer: AATAAA"
     polyA_site      1071
                     /gene="ZCCHC10"
                     /note="major polyA site"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC10"
                     /note="hexamer: AATAAA"
     polyA_site      1994
                     /gene="ZCCHC10"
                     /note="major polyA site"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZCCHC10"
                     /note="hexamer: AATAAA"
     polyA_site      2189
                     /gene="ZCCHC10"
                     /note="major polyA site"
ORIGIN      
        1 gaccgcgcta agatggcgac tcccatgcat cggctaatag cccggagaca agcattcgac
       61 acagagttgc agcctgtcaa gaccttttgg atcctgattc agccatccat cgttattagt
      121 gaagcaaata agcaacatgt aagatgtcag aaatgcttgg aatttggaca ttggacttat
      181 gaatgcacag gaaaaagaaa atacctacat aggccctcaa ggacagcaga actaaagaaa
      241 gctttaaaag aaaaagaaaa cagattatta ttgcaacaaa gcattggaga aaccaatgta
      301 gaaagaaagg ccaagaaaaa aaggtctaag agtgtaacca gttccagtag cagtagcagt
      361 gacagttctg ccagtgattc ttcatcagag agtgaagaaa catctacctc ttcctcctca
      421 gaggacagtg acactgatga aagctcctct agttcctcat cctcagcctc ctccacaacc
      481 tcttcctcct cctctgattc agactcagat tccagctctt ccagtagcag tagcaccagc
      541 acagatagca gctctgacga tgaaccacca aagaagaaga aaaagaaata gagttgctcc
      601 attcatattg gactgatgga ctgaaaacat tgatgtgatt cttgaaaggg aatttagaat
      661 atgttaaggc caagtaggtt aactggtgaa catttctaga attcaaaagt ttctaaatgt
      721 tttacattgt aagagcatag agaatattaa taatggctta tagagagaga cttttatttg
      781 aagggtgaat cttgtttttt ttatctttaa aatatatctc tagaacttaa agctgaaatc
      841 tgcaaatctg tttgtgtgat gaaactatct tttctctctg tgaaataaat gccatacttt
      901 gttatatatg ttagtggtat gtatcagaca tattttcagg atggtgcgtc aggatatctg
      961 gcagtggatt tctaatgctt ttggctgtat gttatgtaag atttaatatg ttgttactgt
     1021 aagcttagga gttttcctac tattaataaa tgtgctctat ttttacattt atgttcagaa
     1081 agttatctga ctttttgtcc taagtggtat gttcaaggag cctattaata tatttatagt
     1141 ttttgaatgc tgtaagtttc aaattgctgt gttacgtcat tcattttctt ctggttcctt
     1201 aagtttttca agttatcctt ttctgaggaa aattattcta gaggaaccta aaaagggaca
     1261 aaaaaattga aacttcttag gagtctaatc ttggtgcctt ctgttaaaag tcagtgtatc
     1321 agaaaagaaa gcagccatgt aagaggctaa cttaaataga agtgctagaa atatctttgt
     1381 gtattaacat gcaataaaag gtaccattca aagcaggggg aaaggtagga agaagaggta
     1441 atttttactg aaaattaggg caatgttggt cgccttttat taaaagcttt ttttaagctt
     1501 tcataaagat tgctttttgc tatttttgaa aatatggtat tatagtttgt atggtaactg
     1561 gtcatatatg acagtctact gcatatatat gaatgactag gattaatctg gtgtgtttac
     1621 ataggatata catagttgaa atctagcatg aaaggttaaa aaggagatac tgcacaatat
     1681 ttcttaaaag taaaatgctg ttattgtgat gagtctttgg tttaacatca cagtattctg
     1741 tgatgtcttt ttaacttttt ggaaagaggt atcatttgta gaaaaaattt gatttgggtt
     1801 aaatataggt ttttaaaact ataaatgttg tcttttttat atttttatga aaaagcagta
     1861 gaaaattact tttgaagaaa acaggctatt taaatattga aatatatgta tgttgtgagt
     1921 ttaaggagcc tgtaattgtc agttttacaa aaccatctgt gttcaatggt tgtaaataaa
     1981 ttctcaaaac atcatttcaa aggctgccta cagaatatta tcacttgaca gatagagtta
     2041 ataaattacc aatcaggcac attttataat gtttgtctct gtaaaggtaa tattagcagt
     2101 taaagaacac ggatgagaaa agaatgtgtt acataggttg catcacttgc agttaaataa
     2161 aactcacaat ttgtgctcac aagcttaaa
//
