LOCUS       NM_016478               1889 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger C3HC-type containing 1 (ZC3HC1),
            transcript variant 1, mRNA.
ACCESSION   NM_016478
VERSION     NM_016478.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Gunkel,P., Iino,H., Krull,S. and Cordes,V.C.
  TITLE     ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket,
            Resident in a State of Reciprocal Dependence with TPR
  JOURNAL   Cells 10 (8), 1937 (2021)
   PUBMED   34440706
  REMARK    GeneRIF: ZC3HC1 Is a Novel Inherent Component of the Nuclear
            Basket, Resident in a State of Reciprocal Dependence with TPR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Jafaripour,S., Sasanejad,P., Dadgarmoghaddam,M. and Sadr-Nabavi,A.
  TITLE     ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery
            Disease and Large Artery Ischemic Stroke
  JOURNAL   Crit Rev Eukaryot Gene Expr 29 (4), 351-361 (2019)
   PUBMED   31679296
  REMARK    GeneRIF: Data show that common variants in A disintegrin and
            metalloproteinase with thrombospondin motifs 7 protein (ADAMTS7)
            and zinc finger, C3HC-type containing 1 protein (ZC3HC1) genes
            contribute to an increased risk for both coronary artery disease
            (CAD) and large artery ischemic stroke (LA atherosclerotic) IS.
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Dichgans,M., Malik,R., Konig,I.R., Rosand,J., Clarke,R.,
            Gretarsdottir,S., Thorleifsson,G., Mitchell,B.D., Assimes,T.L.,
            Levi,C., O'Donnell,C.J., Fornage,M., Thorsteinsdottir,U.,
            Psaty,B.M., Hengstenberg,C., Seshadri,S., Erdmann,J., Bis,J.C.,
            Peters,A., Boncoraglio,G.B., Marz,W., Meschia,J.F., Kathiresan,S.,
            Ikram,M.A., McPherson,R., Stefansson,K., Sudlow,C., Reilly,M.P.,
            Thompson,J.R., Sharma,P., Hopewell,J.C., Chambers,J.C., Watkins,H.,
            Rothwell,P.M., Roberts,R., Markus,H.S., Samani,N.J., Farrall,M. and
            Schunkert,H.
  CONSRTM   METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium;
            International Stroke Genetics Consortium
  TITLE     Shared genetic susceptibility to ischemic stroke and coronary
            artery disease: a genome-wide analysis of common variants
  JOURNAL   Stroke 45 (1), 24-36 (2014)
   PUBMED   24262325
  REMARK    Review article
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Lopez-Mejias,R., Genre,F., Garcia-Bermudez,M., Corrales,A.,
            Gonzalez-Juanatey,C., Llorca,J., Miranda-Filloy,J.A.,
            Rueda-Gotor,J., Blanco,R., Castaneda,S., Martin,J. and
            Gonzalez-Gay,M.A.
  TITLE     The ZC3HC1 rs11556924 polymorphism is associated with increased
            carotid intima-media thickness in patients with rheumatoid
            arthritis
  JOURNAL   Arthritis Res Ther 15 (5), R152 (2013)
   PUBMED   24286297
  REMARK    GeneRIF: Results indicate that ZC3HC1 rs11556924 polymorphism is
            associated with subclinical atherosclerosis in rheumatoid
            arthritis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Illert,A.L., Zech,M., Moll,C., Albers,C., Kreutmair,S., Peschel,C.,
            Bassermann,F. and Duyster,J.
  TITLE     Extracellular signal-regulated kinase 2 (ERK2) mediates
            phosphorylation and inactivation of nuclear interaction partner of
            anaplastic lymphoma kinase (NIPA) at G2/M
  JOURNAL   J Biol Chem 287 (45), 37997-38005 (2012)
   PUBMED   22955283
  REMARK    GeneRIF: Data show that cell cycle-dependent phosphorylation of
            nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is
            mediated by extracellular signal-regulated kinase 2 (ERK2).
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Klitzing,Cv., Huss,R., Illert,A.L., Froschl,A., Wotzel,S.,
            Peschel,C., Bassermann,F. and Duyster,J.
  TITLE     APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is
            regulated by its association with Skp1
  JOURNAL   PLoS One 6 (12), e28998 (2011)
   PUBMED   22205987
  REMARK    GeneRIF: phosphorylated NIPA is degraded in late mitosis in an
            APC/C(Cdh1)-dependent manner
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Bassermann,F., von Klitzing,C., Munch,S., Bai,R.Y., Kawaguchi,H.,
            Morris,S.W., Peschel,C. and Duyster,J.
  TITLE     NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic
            entry
  JOURNAL   Cell 122 (1), 45-57 (2005)
   PUBMED   16009132
  REMARK    GeneRIF: The NIPA protein is a human F-box-containing protein that
            defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic
            entry.
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Ouyang,T., Bai,R.Y., Bassermann,F., von Klitzing,C., Klumpen,S.,
            Miething,C., Morris,S.W., Peschel,C. and Duyster,J.
  TITLE     Identification and characterization of a nuclear interacting
            partner of anaplastic lymphoma kinase (NIPA)
  JOURNAL   J Biol Chem 278 (32), 30028-30036 (2003)
   PUBMED   12748172
  REMARK    GeneRIF: NIPA has an antiapoptotic role in NPM-ALK-mediated
            signaling events
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087071.2 and AC073320.8.
            
            On Jul 19, 2019 this sequence version replaced NM_016478.4.
            
            Summary: This gene encodes an F-box-containing protein that is a
            component of an SCF-type E3 ubiquitin ligase complex that regulates
            the onset of cell division. The G2/M transition in the cell cycle
            requires the interaction of the proteins cyclin B1 and
            cyclin-dependent kinase 1. The activated ubiquitin ligase complex
            targets the protein cyclin B1 for degradation, preventing this
            transition to mitosis. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000190.1, AK022373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358303.9/ ENSP00000351052.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC087071.2         18649-18802         c
            155-266             AC087071.2         16461-16572         c
            267-417             AC087071.2         8379-8529           c
            418-501             AC087071.2         6892-6975           c
            502-629             AC073320.8         83449-83576
            630-784             AC073320.8         86166-86320
            785-1028            AC073320.8         87972-88215
            1029-1241           AC073320.8         88755-88967
            1242-1448           AC073320.8         89953-90159
            1449-1889           AC073320.8         93746-94186
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..1889
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /note="zinc finger C3HC-type containing 1"
                     /db_xref="GeneID:51530"
                     /db_xref="HGNC:HGNC:29913"
                     /db_xref="MIM:619746"
     exon            1..154
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1517
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear interacting partner of anaplastic lymphoma kinase
                     (ALK); nuclear-interacting partner of ALK; hematopoietic
                     stem/progenitor cell protein 216"
                     /codon_start=1
                     /product="zinc finger C3HC-type protein 1 isoform 1"
                     /protein_id="NP_057562.3"
                     /db_xref="CCDS:CCDS34753.1"
                     /db_xref="GeneID:51530"
                     /db_xref="HGNC:HGNC:29913"
                     /db_xref="MIM:619746"
                     /translation="MAAPCEGQAFAVGVEKNWGAVVRSPEGTPQKIRQLIDEGIAPEE
                     GGVDAKDTSATSQSVNGSPQAEQPSLESTSKEAFFSRVETFSSLKWAGKPFELSPLVC
                     AKYGWVTVECDMLKCSSCQAFLCASLQPAFDFDRYKQRCAELKKALCTAHEKFCFWPD
                     SPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRPEDLKTMCLTEDKISLLL
                     HLLEDELDHRTDERKTTIKLGSDIQVHVTACILSVCGWACSSSLESMQLSLITCSQCM
                     RKVGLWGFQQIESSMTDLDASFGLTSSPIPGLEGRPERLPLVPESPRRMMTRSQDATF
                     SPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPTTRTRPVTRSMGTGDTPGLEV
                     PSSPLRKAKRARLCSSSSSDTSSRSFFDPTSQHRDWCPWVNITLGKESRENGGTEPDA
                     SAPAEPGWKAVLTILLAHKQSSQPAETDSMSLSEKSRKVFRIFRQWESLCSC"
     exon            155..266
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            267..417
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            418..501
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            502..629
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            630..784
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1028
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1241
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1448
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1889
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /note="hexamer: AATAAA"
     polyA_site      1889
                     /gene="ZC3HC1"
                     /gene_synonym="HSPC216; NIPA"
                     /note="major polyA site"
ORIGIN      
        1 ggaccaagat ggcggcgccc tgtgagggac aagcgtttgc cgtaggggtt gaaaagaatt
       61 ggggtgcagt agttcgctcc ccagaaggga ccccccagaa aatccggcag ctgatagatg
      121 aggggattgc cccggaagag ggaggcgtgg acgcgaagga cacgtctgcc acatcccagt
      181 cagttaatgg atcaccccaa gcggaacaac cttcattgga atctacaagc aaagaagcct
      241 tctttagcag agtggaaaca ttttcttctt tgaaatgggc aggtaagccc tttgagctgt
      301 ctccactcgt ctgtgcaaaa tatggctggg tcacagtgga atgtgatatg ctcaagtgct
      361 ctagctgtca agcttttctc tgtgccagtt tacaaccagc ttttgacttt gacagatata
      421 agcaacgatg tgctgagctg aagaaagcct tgtgtactgc ccatgagaag ttctgtttct
      481 ggccagacag cccatcccca gaccgatttg ggatgttgcc cctggatgag cctgctattc
      541 ttgttagtga attcctagat cgttttcaaa gcctttgtca cttggacctc cagcttcctt
      601 ccctaaggcc ggaggacttg aaaactatgt gcttgacaga agacaagatc agtcttctcc
      661 tacacttgct tgaagatgaa cttgatcacc gaactgatga gagaaaaact acaatcaaat
      721 taggctcaga catccaagtc cacgtcactg cctgtattct ctctgtgtgt ggctgggcgt
      781 gtagttcctc tttggaatcc atgcagctct ccctgataac atgttcgcaa tgtatgagga
      841 aggtggggct ctggggcttc cagcagattg aatcgtccat gactgacctg gatgcatcct
      901 ttggcctgac cagctcccca atcccaggcc ttgaggggcg accagagcgc ttacctctgg
      961 tgcctgaatc tcctcggagg atgatgaccc ggagccagga tgccactttc tccccaggct
     1021 cagagcaggc tgaaaagagc cctggtccca ttgtctctcg aactcggagc tgggactctt
     1081 ccagtcctgt tgaccgtcct gagccagagg ctgctagccc caccaccaga actcgcccag
     1141 tgacccgaag catgggaaca ggagacaccc ctggcctgga ggtaccatct agccctctgc
     1201 ggaaagccaa gcgagctcgc ctctgctcct ccagcagttc ggacacatct tcccgaagct
     1261 tctttgatcc cacctctcag catagagact ggtgcccttg ggtgaatatc acacttggca
     1321 aagaaagcag ggagaatggt ggaactgaac cagatgccag cgccccagca gagccaggct
     1381 ggaaagcagt gctgaccatc ctcttggcgc acaaacagtc tagccagcca gctgaaacgg
     1441 actccatgag tctctctgag aaatcaagga aagtattccg aatatttcgg cagtgggaat
     1501 ctctgtgctc atgctgaaga tactccagcg ccttcctgga gatagctgga atgagagtga
     1561 ctttttgaaa aattaaggct gagttccttt cggtcagctg acactaagtt tttcctgttc
     1621 tgggttaatc ataaggagcc ccctgccata gcaaaggcag tgagtgtcaa ctatctgcat
     1681 ctggctgaga gagacccgtt tcctttcagg gatgtggaca gggtaagggc agcaagcatg
     1741 gttctgttaa aggagtgtgg gattaacaga ctagaaggaa gactaaggac ctgaccaccc
     1801 atttcagcat cttcaatgtg gagcagtgtt ctgaggactc ttctatccta ggactatgac
     1861 agtgtgtatt aataaaatat ttgctaaga
//
