LOCUS       NM_020119               7177 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing, antiviral 1
            (ZC3HAV1), transcript variant 1, mRNA.
ACCESSION   NM_020119
VERSION     NM_020119.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7177)
  AUTHORS   Sabir,A.J., Le,N.P.K., Singh,P.P. and Karniychuk,U.
  TITLE     Endogenous ZAP affects Zika virus RNA interactome
  JOURNAL   RNA Biol 21 (1), 1-10 (2024)
   PUBMED   39183472
  REMARK    GeneRIF: Endogenous ZAP affects Zika virus RNA interactome.
REFERENCE   2  (bases 1 to 7177)
  AUTHORS   Wu,Q., Zhong,Z., Zhou,C., Cao,Q., Su,G. and Yang,P.
  TITLE     Association of ZC3HAV1 single nucleotide polymorphisms with the
            susceptibility of Vogt-Koyanagi-Harada Disease
  JOURNAL   BMC Med Genomics 16 (1), 113 (2023)
   PUBMED   37221558
  REMARK    GeneRIF: Association of ZC3HAV1 single nucleotide polymorphisms
            with the susceptibility of Vogt-Koyanagi-Harada Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7177)
  AUTHORS   Ly,P.T., Xu,S., Wirawan,M., Luo,D. and Roca,X.
  TITLE     ZAP isoforms regulate unfolded protein response and epithelial-
            mesenchymal transition
  JOURNAL   Proc Natl Acad Sci U S A 119 (31), e2121453119 (2022)
   PUBMED   35881805
  REMARK    GeneRIF: ZAP isoforms regulate unfolded protein response and
            epithelial- mesenchymal transition.
REFERENCE   4  (bases 1 to 7177)
  AUTHORS   Afrasiabi,A., Alinejad-Rokny,H., Khosh,A., Rahnama,M., Lovell,N.,
            Xu,Z. and Ebrahimi,D.
  TITLE     The low abundance of CpG in the SARS-CoV-2 genome is not an
            evolutionarily signature of ZAP
  JOURNAL   Sci Rep 12 (1), 2420 (2022)
   PUBMED   35165300
  REMARK    GeneRIF: The low abundance of CpG in the SARS-CoV-2 genome is not
            an evolutionarily signature of ZAP.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7177)
  AUTHORS   Okudera,M., Odawara,M., Arakawa,M., Kawaguchi,S., Seya,K.,
            Matsumiya,T., Sato,R., Ding,J., Morita,E. and Imaizumi,T.
  TITLE     Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human
            Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like
            Receptor 3 Agonist
  JOURNAL   Neuroimmunomodulation 29 (4), 349-358 (2022)
   PUBMED   34937041
  REMARK    GeneRIF: Expression of Zinc-Finger Antiviral Protein in hCMEC/D3
            Human Cerebral Microvascular Endothelial Cells: Effect of a
            Toll-Like Receptor 3 Agonist.
REFERENCE   6  (bases 1 to 7177)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 7177)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 7177)
  AUTHORS   Bick,M.J., Carroll,J.W., Gao,G., Goff,S.P., Rice,C.M. and
            MacDonald,M.R.
  TITLE     Expression of the zinc-finger antiviral protein inhibits alphavirus
            replication
  JOURNAL   J Virol 77 (21), 11555-11562 (2003)
   PUBMED   14557641
REFERENCE   9  (bases 1 to 7177)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
  REMARK    GeneRIF: ZAP, TIPARP and FLJ22693 proteins with TPH, WW and
            PARP-like domains constitute the TIPARP family.
REFERENCE   10 (bases 1 to 7177)
  AUTHORS   Gao,G., Guo,X. and Goff,S.P.
  TITLE     Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc
            finger protein
  JOURNAL   Science 297 (5587), 1703-1706 (2002)
   PUBMED   12215647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018644.6, BC040956.1,
            BX647974.1, AC083868.3 and BX571742.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020119.3.
            
            Summary: This gene encodes a CCCH-type zinc finger protein. This
            antiviral protein inhibits viral replication by recruiting cellular
            RNA degradation machineries to degrade viral mRNAs. The encoded
            protein plays an important role in the innate immune response
            against multiple DNA and RNA viruses, including Ebola virus, HIV
            and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep
            2021].
            
            Transcript Variant: This variant encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX571742.1, SRR1660805.28723.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000242351.10/ ENSP00000242351.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC018644.6         60770-60770         c
            2-366               BC040956.1         1-365
            367-849             BX647974.1         2-484
            850-850             AC018644.6         35066-35066         c
            851-3360            BX647974.1         486-2995
            3361-6979           AC083868.3         140823-144441       c
            6980-7172           BX571742.1         6965-7157
            7173-7177           AC083868.3         140625-140629       c
FEATURES             Location/Qualifiers
     source          1..7177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..7177
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /note="zinc finger CCCH-type containing, antiviral 1"
                     /db_xref="GeneID:56829"
                     /db_xref="HGNC:HGNC:23721"
                     /db_xref="MIM:607312"
     exon            1..697
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..3098
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCCH-type antiviral protein 1; zinc finger CCCH
                     domain-containing protein 2; ADP-ribosyltransferase
                     diphtheria toxin-like 13; zinc finger CCCH-type, antiviral
                     1; inactive Poly [ADP-ribose] polymerase 13"
                     /codon_start=1
                     /product="zinc finger CCCH-type antiviral protein 1
                     isoform 1"
                     /protein_id="NP_064504.2"
                     /db_xref="CCDS:CCDS5851.1"
                     /db_xref="GeneID:56829"
                     /db_xref="HGNC:HGNC:23721"
                     /db_xref="MIM:607312"
                     /translation="MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVA
                     GPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSE
                     RNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQ
                     ICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDI
                     CNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSP
                     DQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENG
                     SQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQ
                     TPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKST
                     SSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHD
                     SEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHL
                     CSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEE
                     KDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRR
                     PTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEY
                     VRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESIC
                     SNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNIT
                     YTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTEDKACVIS"
     exon            698..833
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1086
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1860
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1962
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2086
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2261
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2382
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2485
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2576
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2707
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2838
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..7177
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6491
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /note="major polyA site"
     regulatory      7154..7159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
                     /note="hexamer: AATAAA"
     polyA_site      7177
                     /gene="ZC3HAV1"
                     /gene_synonym="ARTD13; FLB6421; PARP13; ZAP; ZC3H2;
                     ZC3HDC2"
ORIGIN      
        1 gcttttagtt tctcttcttt ctaaagaagg ctcgcggagc ccggctggag aacctcaccc
       61 tcgccgagcc tagaaccgag agggggccac cccaggcggt caccagcaga tttgcccgcg
      121 cgttctcttt ctttccaccc agttgccctt gcggccggct gtaaacctgc cactaggacc
      181 cggtcggtga gatctagcct cttgacctga gagccgagag tggatcgctg ggctgggcta
      241 acggcgacgg agagcgcgcc ctcgctgact ccgggcgcgc ccagcagtag caccgcccgc
      301 gcccgcccct ggacacttgt aagtttcgat ttccgatttc cgcggaaccg agtcccgcgc
      361 cgcggcagag ccagcacagc cagcgcgcca tggcggaccc ggaggtgtgc tgcttcatca
      421 ccaaaatcct gtgcgcccac gggggccgca tggccctgga cgcgctgctc caggagatcg
      481 cgctgtctga gccgcagctc tgtgaggtgc tgcaggtggc cgggcccgac cgctttgtgg
      541 tgttggagac cggcggcgag gccgggatca cccgatcggt ggtggccacc actcgagccc
      601 gggtctgccg tcgcaagtac tgccagagac cctgcgataa cctgcatctc tgcaaactca
      661 acttgctggg ccggtgcaac tattcgcagt ccgagcggaa tttatgcaaa tattctcatg
      721 aggttctctc agaagagaac ttcaaagtcc tgaaaaatca cgaactctct ggactgaaca
      781 aagaggaatt agcagtgctc ctcctccaaa gtgatccttt ttttatgccc gagatatgca
      841 aaagttataa gggagagggt cggcagcaga tttgtaacca gcagccaccg tgttcaagac
      901 tccacatctg tgaccacttc acccgaggga actgtcgttt tcccaactgc ctccggtccc
      961 ataacctgat ggacagaaag gtgctggcca tcatgaggga gcacgggctg aaccccgacg
     1021 tggtccagaa catccaggac atctgcaaca gcaagcacat gcagaagaat cccccagggc
     1081 ccagagctcc ttcttcacat cgtagaaaca tggcatatag ggctagaagc aagagtagag
     1141 atcggttctt tcagggcagc caagaatttc ttgcgtctgc ttcagcgtct gctgagaggt
     1201 cctgcacacc tagtccagat cagatcagcc acagggcttc cctggaggac gcgcctgtgg
     1261 acgatctcac ccgcaagttc acgtatctgg ggagtcagga tcgcgctcgg cctccctcag
     1321 gctcgtccaa ggctactgat cttggaggaa caagtcaggc cgggacaagc cagaggtttt
     1381 tagagaacgg cagtcaagag gacctcttgc atggaaatcc aggcagcact taccttgctt
     1441 ccaattcaac atcagccccc aactggaaga gcctcacatc ctggacgaat gaccaaggcg
     1501 ccaggagaaa gactgtgttt tctcccacgc tacctgccgc ccgctcttct cttggctctc
     1561 tgcaaacacc tgaagctgtg accaccagaa agggcacagg cttgctttcc tcagactaca
     1621 ggatcatcaa tggcaaaagt ggaactcagg acatccagcc tggccctctt tttaataata
     1681 atgctgatgg agtggccaca gatataactt ctaccagatc cttaaattac aaaagcacta
     1741 gcagcggtca cagagaaata tcatcaccta ggattcagga tgctggacct gcttcccgag
     1801 atgtccaggc cactggcaga atcgcagatg atgctgaccc aagagtagca cttgttaacg
     1861 attctttatc tgatgtcaca agtaccacat cttctagggt ggatgatcat gactcagagg
     1921 aaatttgtct tgaccatctg tgtaagggtt gtccgcttaa tggtagctgc agcaaagtcc
     1981 acttccatct gccttaccgg tggcagatgc ttattggtaa aacctggacg gactttgagc
     2041 acatggagac gatcgagaaa ggctactgta accccggaat ccacctctgt tctgtaggaa
     2101 gttatacaat caattttcgg gtaatgagtt gtgattcctt tcccatccga cgcctctcca
     2161 ctccttcttc tgtcaccaag ccagccaatt ctgtcttcac caccaaatgg atttggtatt
     2221 ggaagaatga atctggcaca tggattcagt atggagaaga gaaagacaaa cggaaaaatt
     2281 caaacgtcga ctcttcatac ctggagtctc tctatcaatc ctgtccgagg ggagttgtgc
     2341 catttcaggc gggctcacgg aactatgagc tgagtttcca agggatgatt cagacaaaca
     2401 tagcttccaa aactcaaaag gatgtcatca gaagaccaac atttgtgcct cagtggtatg
     2461 tgcagcagat gaagagaggg ccagaccatc agccagcaaa gacctcgtca gtgtctttaa
     2521 ctgcgacctt tcgtcctcag gaggactttt gcttcctatc ctcaaagaaa tataagttgt
     2581 cagagatcca tcacctacat ccagaatatg tcagagtaag tgagcatttt aaagcttcca
     2641 tgaaaaattt caagattgaa aagataaaga agatcgagaa ctcagagctc ctggataaat
     2701 ttacatggaa gaaatcgcag atgaaggaag aaggaaaact cctattttat gcgacaagcc
     2761 gtgcctatgt ggaatctatc tgttcgaata attttgacag tttcctacat gaaactcatg
     2821 aaaacaaata cggaaaagga atttactttg caaaagatgc catctattcc cacaaaaatt
     2881 gcccgtatga tgccaaaaac gtcgttatgt ttgtagccca agttctggtt ggaaagttta
     2941 ctgaaggaaa tataacgtac acgagccctc ctccacagtt cgacagctgt gtggatacca
     3001 gatcgaatcc ctccgttttt gtcatctttc agaaagatca ggtttaccca caatatgtga
     3061 ttgaatatac tgaagacaaa gcctgcgtga ttagttagaa ccgatgaata cagcgtcaga
     3121 aggatgccat aaccattctg ttcctttaca gaactaaatt gccgcagaca ggagttaaag
     3181 ttttatattt tcctgctcag ttatctaatg tcttagatca gtggtcccca aattttgcta
     3241 catattagaa tcatctggga ggttttaaac aaattctgat gcccaggttg caccccatgc
     3301 caatgaaatc atttctgggc gtcagcgcca ggcagttgta tttttttttt tttttttttt
     3361 tttgagactg aatctcactc catcgtccag gctggagtgc agtggcgcga tctcggctca
     3421 ctgcaacctc tgcctcccgg gttcaagcaa ttctcctgcc tcagcctccc gagtagctgg
     3481 aactacaggc acacactgcc gcgcccagct aattttttgt attttttagt agagacaggg
     3541 tttcactgtg ttgcccaggc tggtctcaaa ctcctgagct caggcaatct gcccgccttg
     3601 gcctcccaaa gtgctaggat tacaggtatg agccaccatg cccggctggc agttgtattt
     3661 tttaaagccc ttctgatgat tccaatgtgt tggaaagttt accttgtctc agatgtaact
     3721 ggtaaaggct gatttctaaa ttttctgtaa ttgcagcaac ctttctctcc tgtctaccct
     3781 tttagtttac tgtatgccat ggttttgttt tggttacatt gaaagaaagt taatttggaa
     3841 aatttgggag aaatctaatc atgcctatta aggatgtaag acattacagc cttagaagaa
     3901 agattgtgaa aagctgggga gaaaatgctt aaggacatgc taggggaaaa aaaagtaaaa
     3961 ttgaagtgct attgcagaca tggctgcagt actgtacctt atcattctga tgaaactgat
     4021 ttggagcacc cttttcttta tcgctacatt tatttagggg acaaactcca tccaggttga
     4081 ctctctctgg aatgcggtaa taagagctgg caagtaaggc tcagagagaa gcaaccaact
     4141 ggagttaatt gcccatttgg gctctttgta taattatggc aaagtagaca tttatgttct
     4201 aattaatatg attacagaga aggctttttc tcaggtcagg cttttcatga aagtattttg
     4261 agaacaatga attgcaataa ccagcttcac acaagcataa ctgataaacg cgagtgctat
     4321 tgtagtcttg gcaagtgagc caagaaccta ggagcagggc cattcctact gaaggacggg
     4381 ccccctacgg agatgaaatt tgtttcctgg tgagcacaga atcagaacaa agaacaatat
     4441 cccaaagagg ccctgtgtct accaggagct tctttttcca aatgtaatgg attatgtgga
     4501 attgtagtgc catcggtttt tacttagagc ccttgacgtg cttggaccaa tatttccttc
     4561 cttcttatga accaggtttt tccttctgat tttccctttt caacattcct taccagtcac
     4621 caaagtttcc tgttataatt tcttttagca gacaagttat aagtcagatt taattagcat
     4681 cagagttgat tttatattag tcagattttg gatcatcaca gagatctcca caactccttg
     4741 gcttaaacag ctccaccggt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tagttttttt
     4801 agagtagagt tattttctgg gagagttact acaaatgctt attctcattg acttatttct
     4861 ttcatggtaa ctttcgtttt ggagtgttca ttttctgaac ttgaccctca cattgtaggg
     4921 gtgcagtttg tccaactctt tccaacagcc cattagacac cactagctgg atatttcaca
     4981 ggcatctttg attcaatatg tccaaagtgg aactctccat ctacctccct cacatgaacc
     5041 tgttcctctc tcaggatctg tatgtaagtg aaaagcatca ccatctaccc attggctcaa
     5101 gcagaaatct ggaagtcatc tttgactcct tcctctccct cctgataaac atctaagcag
     5161 tttctaagtc tagttttacc tcttaaatat ctctgttccc ttctaagttg tttgctgtgt
     5221 tttcttcaga gcaagaaggt tatatttttt aaaatttact tagtaatgca cattcaaaac
     5281 acacatcaag tcttcaggat aaagttcaaa accgctgtca tggccccatg tgatctctcc
     5341 ctcccctacc cctctatcat ttagtttctt ctgcgcaagc cactctggct tcctttcagt
     5401 tttgtggttc ccatttttag ctagttcagt ggttttcaat gggcatttct gccttttttt
     5461 ttctaaacga caaatagaaa tacatcttct ttattatcct ccaaatccaa ttcagaggta
     5521 atatgctcca cctacacaca attttagaaa taaattaaaa attaaataaa actaatatga
     5581 acataaagag gaaataaaag gtacctaact tgggcacagc tgtaactgaa gacctaatga
     5641 agtagtcaga tgcttacaac tatttataat gcatcaattt gaacttagaa ggtaggagat
     5701 cagatcatat gtgggaaaat gtaaaagcag ggatatcagt gggcattaga ataaaaacta
     5761 gggatacaat aacttctttg catatgacaa tacttatttg tatataagag aaagaacgaa
     5821 ataaccttta ttgaaataaa gatactatgc aagaaaatgt acagttgtcg aagtggagaa
     5881 aatgaggata tattcttgca gacgagctat aggtcataca tgaatgtcta gtgagacatt
     5941 caaaattcgt atagggtgca gagtaatttc ttattgtgag gaactgtcca atgtattgca
     6001 agatgttctg catacttggc tctcacatac taaatgctag tagcgccccc acccccacgc
     6061 ccagtcacgg tgacaaccac aaaccctatc agatctattc acctttttca gagcagatat
     6121 tttgtaacat tctctttgct gacctgaaat gactcataga taatacaatc tacttacaca
     6181 catgaatttc ttaaaaaaat caatttaatg ccctaactct cttattaagg agaaatagaa
     6241 aagaagaaat ttataatgaa aagaagatga atttcattat gtaaacgctc aggcatgact
     6301 acgctgtttg aaacagacag atgtttactc ttccttgtaa tgagtaggtt tggatttaag
     6361 agccgattag aggctacttc ctgtaaacaa gtacaggaaa atgaaactag acgggtgggg
     6421 gacactagaa tgaaaaccag tgttagggta aagacaaaac agactatgta cataatctgt
     6481 atatgggaaa agaaagagcg aaattacctt acttaaggat aataggacaa gacaaattac
     6541 agattgtctc agagaaaaca aatgagttac tctctcggac aagctgtagg tcctacctaa
     6601 atgtccagca ggacattaga cagtcgtaca gggtacagaa taattcttcg ttgtgtggca
     6661 ctaacccaca cactgcagga catcgttctc cctggctgca tccactcagt gctgggagta
     6721 gtccccagtt attatgaaac caccaataac ccactgacca cagtgagaac cactgatttt
     6781 ttccactgac ctactgaata tctagcatcc ttagattggc tcaactgtta ctttcctaag
     6841 gagtccttct acagaatagg tcagatcttg gcctcccaaa ccccttattt ttaaaatact
     6901 ttgcgccttg ctttgataat ttgtattatg tatccaaact gaaattatct gctttctgca
     6961 ttagaatgta agccccctga gggttgagtc agtctgtctt gtttgctgtg ccacgcctga
     7021 tgcccagccc agcagcatgc tttgtacact gatatattgg gtaaattttg ttgaataaat
     7081 taagctcaac tatttgtatt tcaatagttg agttgtattg cttcctgttc ttcaagctta
     7141 atttgaactg tctaataaaa agaagtaatt aatttgg
//
