LOCUS       NM_017590               5906 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 7B (ZC3H7B), mRNA.
ACCESSION   NM_017590 NM_025013
VERSION     NM_017590.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5906)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   2  (bases 1 to 5906)
  AUTHORS   Hoang,L.N., Aneja,A., Conlon,N., Delair,D.F., Middha,S.,
            Benayed,R., Hensley,M.L., Park,K.J., Hollmann,T.J., Hameed,M.R.,
            Antonescu,C.R., Soslow,R.A. and Chiang,S.
  TITLE     Novel High-grade Endometrial Stromal Sarcoma: A Morphologic
            Mimicker of Myxoid Leiomyosarcoma
  JOURNAL   Am J Surg Pathol 41 (1), 12-24 (2017)
   PUBMED   27631520
  REMARK    GeneRIF: we find that ESS with ZC3H7B-BCOR fusion constitutes a
            novel type of high-grade endometrial stromal sarcoma and shares
            significant morphologic overlap with myxoid leiomyosarcoma.
REFERENCE   3  (bases 1 to 5906)
  AUTHORS   Specht,K., Zhang,L., Sung,Y.S., Nucci,M., Dry,S., Vaiyapuri,S.,
            Richter,G.H., Fletcher,C.D. and Antonescu,C.R.
  TITLE     Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated
            Small Blue Round Cell Sarcomas
  JOURNAL   Am J Surg Pathol 40 (4), 433-442 (2016)
   PUBMED   26752546
  REMARK    GeneRIF: The present study further expands the genetic spectrum of
            small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 and
            ZC3H7B-BCOR, identified
REFERENCE   4  (bases 1 to 5906)
  AUTHORS   Antonescu,C.R., Sung,Y.S., Chen,C.L., Zhang,L., Chen,H.W.,
            Singer,S., Agaram,N.P., Sboner,A. and Fletcher,C.D.
  TITLE     Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying
            fibromyxoid tumors--molecular characterization shows genetic
            overlap with endometrial stromal sarcoma
  JOURNAL   Genes Chromosomes Cancer 53 (2), 183-193 (2014)
   PUBMED   24285434
  REMARK    GeneRIF: ZC3H7B-BCOR and MEAF6-PHF1 fusions occurred predominantly
            in S100 protein-negative and malignant ossifying fibromyxoid
            tumors.
REFERENCE   5  (bases 1 to 5906)
  AUTHORS   Panagopoulos,I., Thorsen,J., Gorunova,L., Haugom,L.,
            Bjerkehagen,B., Davidson,B., Heim,S. and Micci,F.
  TITLE     Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas
            carrying an X;22-translocation
  JOURNAL   Genes Chromosomes Cancer 52 (7), 610-618 (2013)
   PUBMED   23580382
  REMARK    GeneRIF: Reverse transciptase-PCR with the ZC3H7B forward and BCOR
            reverse primer combinations confirmed the presence of a ZC3H7-BCOR
            chimeric transcript in both ESS carrying a der(22)t(X;22) but not
            in a control ESS with t(1;6) and the MEAF6-PHF1 fusion.
REFERENCE   6  (bases 1 to 5906)
  AUTHORS   Harb,M., Becker,M.M., Vitour,D., Baron,C.H., Vende,P., Brown,S.C.,
            Bolte,S., Arold,S.T. and Poncet,D.
  TITLE     Nuclear localization of cytoplasmic poly(A)-binding protein upon
            rotavirus infection involves the interaction of NSP3 with eIF4G and
            RoXaN
  JOURNAL   J Virol 82 (22), 11283-11293 (2008)
   PUBMED   18799579
  REMARK    GeneRIF: nuclear localization of PABP-C1 not only is dependent on
            the capacity of rotavirus NSP3 to interact with eIF4G but also
            requires the interaction of NSP3 with a specific region in RoXaN
REFERENCE   7  (bases 1 to 5906)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 5906)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 5906)
  AUTHORS   Vitour,D., Lindenbaum,P., Vende,P., Becker,M.M. and Poncet,D.
  TITLE     RoXaN, a novel cellular protein containing TPR, LD, and zinc finger
            motifs, forms a ternary complex with eukaryotic initiation factor
            4G and rotavirus NSP3
  JOURNAL   J Virol 78 (8), 3851-3862 (2004)
   PUBMED   15047801
  REMARK    GeneRIF: RoXaN is capable of interacting with NSP3 and eIF4G I in
            vivo and during rotavirus infection. Domains of interaction were
            mapped.
REFERENCE   10 (bases 1 to 5906)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035659.22.
            
            On Nov 22, 2018 this sequence version replaced NM_017590.5.
            
            Summary: This gene encodes a protein that contains a
            tetratricopeptide repeat domain. The encoded protein also interacts
            with the rotavirus non-structural protein NSP3. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152558.1, BC098378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352645.5/ ENSP00000345793.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL035659.22        5103-5350
            249-307             AL035659.22        24233-24291
            308-341             AL035659.22        29142-29175
            342-539             AL035659.22        29299-29496
            540-698             AL035659.22        30784-30942
            699-779             AL035659.22        33601-33681
            780-836             AL035659.22        35749-35805
            837-879             AL035659.22        41891-41933
            880-1070            AL035659.22        42579-42769
            1071-1392           AL035659.22        43394-43715
            1393-1451           AL035659.22        44666-44724
            1452-1551           AL035659.22        46107-46206
            1552-1713           AL035659.22        46993-47154
            1714-1919           AL035659.22        49581-49786
            1920-2020           AL035659.22        51645-51745
            2021-2202           AL035659.22        52698-52879
            2203-2288           AL035659.22        55139-55224
            2289-2422           AL035659.22        59047-59180
            2423-2528           AL035659.22        59335-59440
            2529-2637           AL035659.22        59532-59640
            2638-2771           AL035659.22        59921-60054
            2772-2935           AL035659.22        60223-60386
            2936-5906           AL035659.22        60755-63725
FEATURES             Location/Qualifiers
     source          1..5906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..5906
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="zinc finger CCCH-type containing 7B"
                     /db_xref="GeneID:23264"
                     /db_xref="HGNC:HGNC:30869"
                     /db_xref="MIM:618206"
     exon            1..248
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..307
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..3188
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="ubiquitous tetratricopeptide containing protein
                     RoXaN; rotavirus X protein associated with NSP3; Rotavirus
                     'X' associated non-structural protein; rotavirus
                     'X'-associated non-structural protein"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 7B"
                     /protein_id="NP_060060.3"
                     /db_xref="CCDS:CCDS14013.1"
                     /db_xref="GeneID:23264"
                     /db_xref="HGNC:HGNC:30869"
                     /db_xref="MIM:618206"
                     /translation="MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGN
                     DLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEKAL
                     EDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELA
                     QKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSP
                     ALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLDSLSLVQ
                     GGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAAS
                     VLDALDPPGPTLDPLDLLPYSETRLDALDSFGSTRGSLDKPDSFMEETNSQDHRPPSG
                     AQKPAPSPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCK
                     RDILLGRLRSSEDQTWKRIRPRPTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEE
                     IDVWTEERKGTLNRDLLFDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKPRIIS
                     KGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSLKYSKIRQFQEHFQFDVCRHEVRYG
                     CLREDSCHFAHSFIELKVWLLQQYSGMTHEDIVQESKKYWQQMEAHAGKASSSMGAPR
                     THGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRK
                     WVSVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDM
                     QQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMMGYHCWLCGKNSNSKKQ
                     WQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQE
                     ELNEWLDRREVLKQKLAKARKDMLLCPRDDDFGKYNFLLQEDGDLAGATPEAPAAAAT
                     ATTGE"
     exon            308..341
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..539
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..698
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..779
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..836
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..879
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1070
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1392
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1451
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1551
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1713
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1919
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2020
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2202
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2288
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2422
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2528
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2637
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2771
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2935
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..5906
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5843..5848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="hexamer: AATAAA"
     polyA_site      5863
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="major polyA site"
     regulatory      5887..5892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="hexamer: AATAAA"
     polyA_site      5906
                     /gene="ZC3H7B"
                     /gene_synonym="RoXaN; ROXAN1"
                     /note="major polyA site"
ORIGIN      
        1 gagacagtgc ctccagcggg tgctgccgcg agcggccagc cgaggggctg gaaatgaaag
       61 taaagcgctc cagagccaca tggacggagc tgccggggcg gcggcgccgg gagcaggatg
      121 cggccgcccg taattaaata gcatttactc ttattattac taataataat aacgtaatca
      181 tacctctagt catagcatac catttatcgg gctcggcgca ggcccgcggg gagcgcagcc
      241 cggcggagag actgatggag aggcagaaac ggaaggcgga catcgagaaa gggctgcagt
      301 tcattcagtc gacactaccc ctaaagcaag aagaatatga ggcctttctg ctcaagctgg
      361 tgcagaatct gtttgctgag ggcaatgatc tgttccggga gaaggactat aagcaggctc
      421 tggtgcagta catggaaggg ctgaacgtgg ccgactacgc tgcctctgac caggtggccc
      481 tgccccggga gctgctgtgc aagctgcatg tcaatagggc cgcctgctac ttcaccatgg
      541 gcctgtatga gaaggcgctg gaggacagcg agaaggcgct gggcctggac agtgagagta
      601 tccgggcgtt gttccgcaag gcacgcgctc tcaatgaact gggacgccac aaggaggcct
      661 acgagtgcag cagccggtgt tccctcgccc tgccccacga tgaaagcgtg actcagcttg
      721 gtcaggagct ggcccagaaa ctggggctgc gagttcgcaa ggcgtataag aggccccagg
      781 aattggaaac cttttctctg ctcagtaacg gcactgcggc tggcgtggca gatcagggaa
      841 cttctaatgg attggggtcc atagatgaca tcgaaacaga ctgctacgtg gaccctcgag
      901 gctccccagc ccttctcccc tccacgccca cgatgcccct gttccctcac gttctggacc
      961 tgctggcccc cctggacagc agcaggaccc tccccagcac cgacagcctg gatgacttct
     1021 cagacgggga tgtctttggc ccagagctgg acaccctcct ggactcgctg tctctggtcc
     1081 agggtggcct gtctggcagc ggcgtgccta gtgagttgcc ccagctgata cccgtgttcc
     1141 ccggcgggac cccactgcta ccacctgtgg tgggtggctc catccctgtc tccagcccac
     1201 tgccccccgc ctccttcggc ttggtcatgg acccctccaa gaagctggcc gcctctgtgc
     1261 tggatgccct cgatcccccg ggccccacgc tggaccccct ggacctgctg ccgtactcgg
     1321 agacccggct ggatgcactc gacagctttg ggtcgacacg aggctccctg gacaaacctg
     1381 actccttcat ggaggagacc aactcacagg accaccgtcc ccctagcggt gctcagaaac
     1441 cagccccctc gccagagccc tgcatgccca acactgcctt gctcatcaag aaccccttgg
     1501 ctgccaccca cgagttcaag caggcctgcc agctctgcta ccccaagaca ggcccccggg
     1561 ctggcgacta cacctaccgt gagggccttg agcacaagtg caagcgggac atcctgctcg
     1621 gccggctccg gagctcggag gaccagacct ggaagcggat ccggccccgg cccactaaga
     1681 ccagcttcgt gggctcctac tacctgtgca aagacatgat taacaagcag gactgtaagt
     1741 acggggataa ctgcaccttc gcctaccatc aggaggagat cgacgtgtgg accgaggagc
     1801 ggaagggcac cctcaaccgc gacctgctct tcgacccgct ggggggtgtt aagcgcggca
     1861 gcctcaccat cgccaagctc ctgaaggagc accagggcat cttcaccttc ctctgcgaga
     1921 tctgctttga cagtaaaccc cggatcatca gcaaaggcac caaggactct ccgtctgtct
     1981 gctccaacct ggctgccaag cacagcttct acaacaacaa gtgcctggtg cacatcgtcc
     2041 gctccacctc cctcaagtac tccaagatcc gccagttcca ggagcacttc cagttcgacg
     2101 tgtgccgcca tgaggtgcgc tacggctgcc tgcgggagga cagctgccac ttcgcccaca
     2161 gcttcatcga gctcaaggtc tggctgctgc agcagtactc aggcatgacc cacgaagaca
     2221 tcgttcagga gtctaagaag tactggcagc agatggaggc gcatgcgggg aaggccagca
     2281 gcagcatggg tgctccgagg acacatgggc ccagcacctt tgacctgcag atgaagtttg
     2341 tatgtggcca gtgctggaga aacgggcagg tggtggagcc tgacaaggac ctcaagtact
     2401 gtagtgccaa ggcccggcac tgctggacca aggagcggcg ggtccttctg gtgatgtcca
     2461 aggccaagag gaaatgggtg tcagtgaggc cactgccatc cattcgtaac ttcccacagc
     2521 aatacgatct ctgcatccat gcacagaacg gccgcaagtg ccaatatgtg gggaactgct
     2581 ccttcgcaca cagcccggag gagagggaca tgtggacctt catgaaggag aacaagatcc
     2641 tggacatgca gcagacctat gacatgtggc tgaaaaaaca caacccagga aagcctggag
     2701 aagggacccc catcagttct cgggaagggg agaagcagat ccagatgccc acggactacg
     2761 cggacatcat gatgggctac cactgctggc tctgcggcaa gaacagcaac agcaagaagc
     2821 agtggcagca gcacatccag tccgagaagc acaaggagaa ggtcttcacg tccgacagtg
     2881 acgccagcgg ctgggccttc cgcttcccca tgggcgagtt ccggctctgc gacaggctcc
     2941 agaagggcaa agcctgccca gatggggaca agtgccgctg cgcccatgga caggaggagc
     3001 tcaacgagtg gctggaccgg cgcgaggtgc tgaagcagaa gttggccaag gctcgcaagg
     3061 acatgctgct gtgcccacgg gacgacgact ttggcaaata caacttcctg ctgcaagagg
     3121 acggggacct tgccggtgcc accccagaag cccctgctgc tgctgccacc gccaccactg
     3181 gggagtaggg ccaggtgttg gccgtgggtg aagtcctggg gtcagggggt ggggtggggc
     3241 cagaaggcct gatagaaggg tcagggcagg ccaggggggt ggggggccgc cctcatcagg
     3301 cagcccccag ccccctgagg ccctgtccat cttctcccca ccaccgcccc ggtgtgcgta
     3361 cccaggcgca cgtgctgcag cccccggagg ccccgctgaa acctgggctg cccttccccc
     3421 acccccacgg ctctcctggt tgaggaggga ggggcctggc tgacccctcc agcttcagcc
     3481 tccagcttta acttctgtct gctcctaatg ggggcccaaa gctcagggct ggggagcctg
     3541 gggtccccac ttgaatctcc agcaggaggg tccttctctc cctggcccgt cctcctccca
     3601 ccccctcccc ctgggggcaa atcaggacac aacagagggc agaggcccca ttagctttaa
     3661 aatgtagccc caggttggag ctgggaacac tgtactggcc acttaccctc tggggcctca
     3721 gctttccctc cggaaggctg ggaggaggtg ggctagatga tctttggagc ttaaggagtc
     3781 ccagcccttt ctctgatgcc accacctgaa ccctgctccc tcgtgggcca gtgaaaatag
     3841 actgtaggtc ctcagagcct tcagagatga tccagcccaa accccatttt gcagagagga
     3901 aaactgaggc ctagaaggga ggagtggtcc acccacggtc ccagcacaag gcagagctgg
     3961 gatgaaaaca gggctgaaaa gactcagggc caattattgg ctgagcccac ggtcccctca
     4021 gcagggatgc gatggtctct gaatcagtgt gcagctgggg tcccaggcag cgctgcctgg
     4081 gggctgggga ggggaggccc agaggagggc tggccatgtg agcaccccat gaagggaccg
     4141 ccccctccca aggatggtcc ctttgggtgc agcagcagag gtcacctcct gacatgcgct
     4201 ctgggaaagg tggcagaggg caggacacca tgagctcagg atctgtgtga ggtgtgggag
     4261 gtgggaaggg tgagggtctg ggggaatgcg gagaaaaggg aggcttgacc ccgggcacca
     4321 tgggccactc caggatggga cacggcccct ctttcttggg gacccagtat gtcctctcct
     4381 ctagacccag acatacagtt ataaccgtct gtcctagccc ctccctaatc cctggccctc
     4441 ccagctgtct gggacttcag tggaccccca gcccctgccc ccactcacca aggcctcgct
     4501 cgtccctctc gtctgacatg tctgtgtgca cccccctcct ctccacccta ccttccatca
     4561 accagggcag atccaccgtg ccctggttcc ccagacattc cagaatgccc cacatcattg
     4621 gcacaggagt ggggcagccc cggaaggaac cagggattag gctgtagggg ggtgagaagg
     4681 agagaaggga ccaccccatt cttctcaagc aaggattgcc agcgcgcgct gacacagtga
     4741 tgggctgccc agggctggag gggacgctgt tcctcccgcc gccactgccc aacctttcct
     4801 gataatcgtg gcatgcgccc tttcctcttc cctgccccac cccctggccg cagcaggcca
     4861 gcactgcaga gtttgggtgc tggtggtgtg gctgtagggg aggggagacc acacccaagg
     4921 tgggggctgt ggccatgtgt ggccgtgatg tcgatgatac tcgttttccc tgatccgtgg
     4981 tgttgcagtc cgttgtcacc agccttgttt ctagtgtgta tatatgtcgc ccccgtgatg
     5041 catatataca caggtattaa atatatcgct ctatataata ttatatatgt gtgtggtatc
     5101 caaggaatca cttttatgag ggctaaagat aaagaatttg gccagaaaat gcagccatcc
     5161 ttgtgtgatt aggagggttt caggggccac tggactattt gcaaggtgac agggactgga
     5221 gccatggctc agaggtgatt cgggcagcca gggacaggag ccaccctccc caggcccaac
     5281 tctgctagct tcccagacca cccccatcga gtgcggagag agtgggagtg ctcagggaaa
     5341 gaaggtgatt tgtatttgtc tccccgctga aaagaacagg attcaagtcc agagttttca
     5401 tcttcagcct gtgatctgtc cagggaccct tgggatctgg ggcttcctgg cctggccaga
     5461 gctggagccc ccacagggta aggaagagag agtgggaggc agagtgtgat ggggaggagg
     5521 gacaggaaga cccttttaat gatgagggta actatttcag ttgtgagcct tctagggccc
     5581 caggctggga ggctcagagg actgaatctg ggacctgtgt tccccccggc aggcagggac
     5641 aagatggcat ggcaagcatg ggggcggggt gggtggggag ggatgctgca tttctcagct
     5701 gggcagtaat caatttaatg gtcctttaaa atgtctgtgt attaaaaatt taagaatacc
     5761 acactttaat attaaatatt cataaggtct agtatcttga taataatgta gatgttttaa
     5821 taacaatttt tgtccttctt aaaataaaat gaaagaaact tgcttccctt agcctttgtt
     5881 ctagaaaata aacttgtgca ctttga
//
