LOCUS       NM_014153               3805 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 7A (ZC3H7A), mRNA.
ACCESSION   NM_014153
VERSION     NM_014153.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3805)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 3805)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3805)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3805)
  AUTHORS   Newton-Cheh,C., Eijgelsheim,M., Rice,K.M., de Bakker,P.I., Yin,X.,
            Estrada,K., Bis,J.C., Marciante,K., Rivadeneira,F.,
            Noseworthy,P.A., Sotoodehnia,N., Smith,N.L., Rotter,J.I.,
            Kors,J.A., Witteman,J.C., Hofman,A., Heckbert,S.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Psaty,B.M., Lumley,T., Larson,M.G. and
            Stricker,B.H.
  TITLE     Common variants at ten loci influence QT interval duration in the
            QTGEN Study
  JOURNAL   Nat Genet 41 (4), 399-406 (2009)
   PUBMED   19305408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA160892.1, BC046363.1 and AY163807.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014153.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046363.1, SRR11853564.10389.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355758.9/ ENSP00000347999.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               DA160892.1         1-107
            108-3602            BC046363.1         1-3495
            3603-3805           AY163807.1         3632-3834
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..3805
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /note="zinc finger CCCH-type containing 7A"
                     /db_xref="GeneID:29066"
                     /db_xref="HGNC:HGNC:30959"
                     /db_xref="MIM:619819"
     exon            1..135
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            136..237
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3085
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /note="zinc finger CCCH-type domain containing 7;
                     zinc-finger protein AY163807"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 7A"
                     /protein_id="NP_054872.2"
                     /db_xref="CCDS:CCDS10550.1"
                     /db_xref="GeneID:29066"
                     /db_xref="HGNC:HGNC:30959"
                     /db_xref="MIM:619819"
                     /translation="MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVR
                     NLFNEGNDVYREHDWNNSISQYTEALNIADYAKSEEILIPKEIIEKLYINRIACYSNM
                     GFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVI
                     KLTQELAQKLGFKIRKAYVRAELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPV
                     VSLPAPSFSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTMPEAFLD
                     DGDMVLGDELDDLLDSAPETNETVMPSALVRGPLQTASVSPSMPFSASLLGTLPIGAR
                     YAPPPSFSEFYPPLTSSLEDFCSSLNSFSMSESKRDLSTSTSREGTPLNNSNSSLLLM
                     NGPGSLFASENFLGISSQPRNDFGNFFGSAVTKPSSSVTPRHPLEGTHELRQACQICF
                     VKSGPKLMDFTYHANIDHKCKKDILIGRIKNVEDKSWKKIRPRPTKTNYEGPYYICKD
                     VAAEEECRYSGHCTFAYCQEEIDVWTLERKGAFSREAFFGGNGKINLTVFKLLQEHLG
                     EFIFLCEKCFDHKPRMISKRNKDNSTACSHPVTKHEFEDNKCLVHILRETTVKYSKIR
                     SFHGQCQLDLCRHEVRYGCLREDECFYAHSLVELKVWIMQNETGISHDAIAQESKRYW
                     QNLEANVPGAQVLGNQIMPGFLNMKIKFVCAQCLRNGQVIEPDKNRKYCSAKARHSWT
                     KDRRAMRVMSIERKKWMNIRPLPTKKQMPLQFDLCNHIASGKKCQYVGNCSFAHSPEE
                     REVWTYMKENGIQDMEQFYELWLKSQKNEKSEDIASQSNKENGKQIHMPTDYAEVTVD
                     FHCWMCGKNCNSEKQWQGHISSEKHKEKVFHTEDDQYCWQHRFPTGYFSICDRYMNGT
                     CPEGNSCKFAHGNAELHEWEERRDALKMKLNKARKDHLIGPNDNDFGKYSFLFKDLN"
     exon            238..277
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            278..475
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..634
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            635..715
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            716..754
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            755..788
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1072
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1277
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1342
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1529
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1691
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1888
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1989
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2171
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2248
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2382
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2488
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2597
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2731
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2895
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3805
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /note="hexamer: AATAAA"
     polyA_site      3805
                     /gene="ZC3H7A"
                     /gene_synonym="HSPC055; ZC3H7; ZC3HDC7"
                     /note="major polyA site"
ORIGIN      
        1 gctgccgccg ccgctaaccg agggagagct gcgagcgagc acccaggccc cgccgccgcc
       61 gccgccaccg ctgcccgcct gccgccgccc gcctccgcct gccttctgcc gccggccggc
      121 gcgtcgtccc cacagattgc tcatttagaa agtggatgtg tgggataaca tgtccaatgt
      181 gtccgaggag agaagaaaaa ggcagcagaa cattaaggaa ggactgcagt ttatacagtc
      241 accgctgtca tatccaggaa cacaggagca atatgcggta tatttgcgtg ctctcgtgag
      301 aaatcttttt aatgaaggaa atgacgttta tcgggaacat gattggaaca actcgataag
      361 ccagtacacg gaagccttga atatagctga ttatgcaaaa tctgaagaaa ttttaatccc
      421 caaagaaata attgaaaaac tatatataaa tcgtattgcc tgctattcta atatgggttt
      481 ccatgataaa gttttggagg actgcaatat agtcctcagt ttaaatgcca gtaactgcaa
      541 agctctgtat cggaaatcta aggctttaag tgatttagga agatacaaaa aggcttacga
      601 tgctgtagca aagtgctcct tagcagtgcc tcaggatgag catgtaataa aactaactca
      661 agaactagct cagaaattgg gatttaaaat aagaaaagcg tatgtcagag ctgagctctc
      721 attaaaatca gttcctgggg atggggctac caaggctttg aaccattctg tggaagatat
      781 tgagccagat ttattaactc caaggcaaga agcagttcct gttgtctctt taccggcacc
      841 cagtttttct catgaagttg gaagtgagct ggcctcagtt cctgttatgc ccttaacttc
      901 tattttgcca ctacaagtgg aagagagcgc tctgccatct gcagtgctgg caaatggagg
      961 aaagatgccc ttcactatgc cagaagcttt tctagatgat ggagatatgg tccttggaga
     1021 tgaactagat gacctgcttg attctgcacc tgaaactaat gaaactgtta tgccgtcagc
     1081 tttagtcaga ggaccccttc agacagccag tgtctctcct agcatgccct tttcggcatc
     1141 gctgttagga accttaccca ttggtgcgag gtatgctcct ccaccctcct tctcagaatt
     1201 ttatccacct ttgacttcat ccttagaaga tttttgttct tctttaaatt cattttcaat
     1261 gagtgaatcc aaacgagatc tgtccacctc aacttctaga gagggaacac cgcttaacaa
     1321 cagtaattct tcccttttac ttatgaatgg accaggtagt ttgtttgctt cagagaattt
     1381 cctgggaatt tcaagtcagc ctagaaatga ctttggaaac ttttttggaa gtgcagttac
     1441 caaaccatct tcatcagtga ctccaagaca tcccctcgaa ggaacccatg aattgagaca
     1501 agcttgccag atctgttttg taaaatcagg ccctaagtta atggatttca cttaccatgc
     1561 taacatagat cataagtgta agaaagatat tttaatcggt aggataaaga atgttgaaga
     1621 taaatcatgg aaaaaaatac gtccaagacc aacaaaaaca aattatgaag gaccatatta
     1681 tatatgtaaa gatgttgctg ctgaggagga atgtagatat tcaggccact gcacgtttgc
     1741 ttattgccaa gaggagatag atgtgtggac actggagcgg aaaggagcat tcagccggga
     1801 ggctttcttt ggcggcaatg gaaagattaa ccttactgtg ttcaaacttc tccaggagca
     1861 tcttggggaa tttatattcc tttgtgagaa atgttttgat cataagccta gaatgataag
     1921 taaaagaaat aaagataatt ctactgcttg ttctcacccg gttacaaagc atgagtttga
     1981 agacaataag tgccttgtcc acattttgcg agagacaaca gtaaaatact ccaaaatacg
     2041 ttcttttcat ggtcagtgtc agcttgattt atgtcgacat gaagttcggt atggctgttt
     2101 aagggaagat gagtgctttt atgcccatag tcttgtggaa ctgaaagtct ggataatgca
     2161 aaatgaaaca ggtatctcac atgatgctat tgctcaagag tctaaacgat attggcagaa
     2221 tttggaagca aatgtacctg gagcgcaggt acttggtaat caaataatgc ctggatttct
     2281 taatatgaag ataaagtttg tgtgcgccca gtgtctgaga aacggtcaag tcattgaacc
     2341 agacaaaaac agaaaatatt gtagtgcaaa agcaaggcat tcgtggacca aagaccggcg
     2401 tgcgatgaga gtgatgtcta ttgaacgtaa gaagtggatg aacatccgtc ctctccccac
     2461 aaagaaacaa atgcctttac agtttgatct gtgcaaccat attgcttctg ggaaaaaatg
     2521 tcaatatgtt ggaaactgtt cctttgctca tagtcctgag gaaagagaag tttggactta
     2581 catgaaggag aatgggatac aagatatgga gcaattttac gaactatggc tcaagagtca
     2641 aaaaaatgaa aaaagtgaag acatagccag tcagtcaaac aaggaaaatg gaaaacaaat
     2701 tcacatgcca acagattatg ctgaagttac agtggacttt cactgctgga tgtgtgggaa
     2761 aaactgcaac agtgagaagc agtggcaggg ccacatctcc tccgagaagc acaaagagaa
     2821 ggttttccac accgaggacg accagtactg ctggcagcac cgcttcccaa caggctattt
     2881 cagtatttgt gataggtata tgaatggcac ctgcccagaa ggaaacagct gtaaatttgc
     2941 acatggaaat gccgaacttc atgaatggga agaaagaaga gatgccctaa agatgaagct
     3001 caacaaagca cgaaaagatc acttaattgg cccaaatgat aatgactttg gaaaatatag
     3061 ttttttgttt aaagatttaa actaatatgc tggcttttat gtatgatacc taatcagagc
     3121 attgaccaga aaaattgaaa gtgttctgag gcacatagca gaggagctgc agatttcctg
     3181 cttgtattgg cgtatatcgt tcctcctgag cagcaaccca cagtaggtag gaaaatgggc
     3241 tgtttcacag gcctggccac gctctcacgg aaccactggc atcagatggt gaagtgactg
     3301 ctacccggtt gccatctgtt gaacagactt ttggatgaag tgtgttgggg aagaggataa
     3361 ggttatatct aggacaactc tttgagttgg tccttcatat aagaatcgtg acggtaagag
     3421 aataaacact tgtactggga tcagaataca tgatggatga aattctttac atgttttagc
     3481 agaatgaatt tgtttaatat aataaagttt gctacttatc tgtatgtagg ttgctaaaaa
     3541 ggattttctt aactcagatt ttaagccaaa taaccattta acactagtat ttgttaaatg
     3601 gggtattttt ctgtatttgt atgtttcact ataataaggg aattaaggat aatgtgcatt
     3661 gagaatattt tgaaaaataa ttgactcaaa ttttatttct tggtcttttg ctgtttaaat
     3721 gatgattttg aaagattaaa cctgtactgt tggtattgtg ttagtgtatg gaccaatact
     3781 gcctgtaata aagattttat atata
//
