LOCUS       NM_015168               6143 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 4 (ZC3H4), mRNA.
ACCESSION   NM_015168 XM_028253 XM_942694
VERSION     NM_015168.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6143)
  AUTHORS   Park,K., Zhong,J., Jang,J.S., Kim,J., Kim,H.J., Lee,J.H. and Kim,J.
  TITLE     ZWC complex-mediated SPT5 phosphorylation suppresses divergent
            antisense RNA transcription at active gene promoters
  JOURNAL   Nucleic Acids Res 50 (7), 3835-3851 (2022)
   PUBMED   35325203
  REMARK    GeneRIF: ZWC complex-mediated SPT5 phosphorylation suppresses
            divergent antisense RNA transcription at active gene promoters.
REFERENCE   2  (bases 1 to 6143)
  AUTHORS   Estell,C., Davidson,L., Steketee,P.C., Monier,A. and West,S.
  TITLE     ZC3H4 restricts non-coding transcription in human cells
  JOURNAL   Elife 10, e67305 (2021)
   PUBMED   33913806
  REMARK    GeneRIF: ZC3H4 restricts non-coding transcription in human cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6143)
  AUTHORS   Austenaa,L.M.I., Piccolo,V., Russo,M., Prosperini,E., Polletti,S.,
            Polizzese,D., Ghisletti,S., Barozzi,I., Diaferia,G.R. and Natoli,G.
  TITLE     A first exon termination checkpoint preferentially suppresses
            extragenic transcription
  JOURNAL   Nat Struct Mol Biol 28 (4), 337-346 (2021)
   PUBMED   33767452
  REMARK    GeneRIF: A first exon termination checkpoint preferentially
            suppresses extragenic transcription.
            GeneRIF: ZC3H4 controls termination of extragenic transcription in
            human and mouse cells. Cells depleted of ZC3H4 show greatly
            enhanced synthesis of long and spliced extragenic transcripts.
REFERENCE   4  (bases 1 to 6143)
  AUTHORS   Wen,W., Zheng,W., Okada,Y., Takeuchi,F., Tabara,Y., Hwang,J.Y.,
            Dorajoo,R., Li,H., Tsai,F.J., Yang,X., He,J., Wu,Y., He,M.,
            Zhang,Y., Liang,J., Guo,X., Sheu,W.H., Delahanty,R., Guo,X.,
            Kubo,M., Yamamoto,K., Ohkubo,T., Go,M.J., Liu,J.J., Gan,W.,
            Chen,C.C., Gao,Y., Li,S., Lee,N.R., Wu,C., Zhou,X., Song,H.,
            Yao,J., Lee,I.T., Long,J., Tsunoda,T., Akiyama,K., Takashima,N.,
            Cho,Y.S., Ong,R.T., Lu,L., Chen,C.H., Tan,A., Rice,T.K.,
            Adair,L.S., Gui,L., Allison,M., Lee,W.J., Cai,Q., Isomura,M.,
            Umemura,S., Kim,Y.J., Seielstad,M., Hixson,J., Xiang,Y.B.,
            Isono,M., Kim,B.J., Sim,X., Lu,W., Nabika,T., Lee,J., Lim,W.Y.,
            Gao,Y.T., Takayanagi,R., Kang,D.H., Wong,T.Y., Hsiung,C.A.,
            Wu,I.C., Juang,J.M., Shi,J., Choi,B.Y., Aung,T., Hu,F., Kim,M.K.,
            Lim,W.Y., Wang,T.D., Shin,M.H., Lee,J., Ji,B.T., Lee,Y.H.,
            Young,T.L., Shin,D.H., Chun,B.Y., Cho,M.C., Han,B.G., Hwu,C.M.,
            Assimes,T.L., Absher,D., Yan,X., Kim,E., Kuo,J.Z., Kwon,S.,
            Taylor,K.D., Chen,Y.D., Rotter,J.I., Qi,L., Zhu,D., Wu,T.,
            Mohlke,K.L., Gu,D., Mo,Z., Wu,J.Y., Lin,X., Miki,T., Tai,E.S.,
            Lee,J.Y., Kato,N., Shu,X.O. and Tanaka,T.
  TITLE     Meta-analysis of genome-wide association studies in East
            Asian-ancestry populations identifies four new loci for body mass
            index
  JOURNAL   Hum Mol Genet 23 (20), 5492-5504 (2014)
   PUBMED   24861553
REFERENCE   5  (bases 1 to 6143)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 6143)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 6143)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 6143)
  AUTHORS   Hall,T.M.
  TITLE     Multiple modes of RNA recognition by zinc finger proteins
  JOURNAL   Curr Opin Struct Biol 15 (3), 367-373 (2005)
   PUBMED   15963892
  REMARK    Review article
REFERENCE   9  (bases 1 to 6143)
  AUTHORS   Brown,R.S.
  TITLE     Zinc finger proteins: getting a grip on RNA
  JOURNAL   Curr Opin Struct Biol 15 (1), 94-98 (2005)
   PUBMED   15718139
  REMARK    Review article
REFERENCE   10 (bases 1 to 6143)
  AUTHORS   Hartwig,A.
  TITLE     Zinc finger proteins as potential targets for toxic metal ions:
            differential effects on structure and function
  JOURNAL   Antioxid Redox Signal 3 (4), 625-634 (2001)
   PUBMED   11554449
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008755.8, AB028987.2, AW603637.1, CN300565.1, AK125279.1 and
            AK074282.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015168.1.
            
            Summary: This gene encodes a member of a family of CCCH
            (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins.
            These zinc finger domains, which coordinate zinc finger binding and
            are characterized by three cysteine residues and one histidine
            residue, are nucleic acid-binding. Other family members are known
            to function in post-transcriptional regulation. [provided by
            RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028987.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253048.10/ ENSP00000253048.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC008755.8         140584-140607       c
            25-1156             AB028987.2         1-1132
            1157-1315           AW603637.1         382-540             c
            1316-1342           CN300565.1         94-120
            1343-4565           AB028987.2         1319-4541
            4566-5471           AK125279.1         2354-3259
            5472-6143           AK074282.1         1362-2033
FEATURES             Location/Qualifiers
     source          1..6143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..6143
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /note="zinc finger CCCH-type containing 4"
                     /db_xref="GeneID:23211"
                     /db_xref="HGNC:HGNC:17808"
                     /db_xref="MIM:619498"
     exon            1..57
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            58..223
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..3974
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 4"
                     /protein_id="NP_055983.1"
                     /db_xref="CCDS:CCDS42582.1"
                     /db_xref="GeneID:23211"
                     /db_xref="HGNC:HGNC:17808"
                     /db_xref="MIM:619498"
                     /translation="MEAAPGTPPPPPSESPPPPSPPPPSTPSPPPCSPDARPATPHLL
                     HHRLPLPDDREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRR
                     LKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSP
                     PYAPSHQQYPPSHATPLPKKAYSKMDSKSYGMYEDYENEQYGEYEGDEEEDMGKEDYD
                     DFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGGD
                     HPEDEEDFYEEEMDYGESEEPMGDDDYDEYSKELNQYRRSKDSRGRGLSRGRGRGSRG
                     RGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDEDMGDGGGGSYRSRDHDKPHQQSDKKG
                     KVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKL
                     YHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLP
                     KPPPGVGLLPTPPRPPGPQAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPMPVHEPLS
                     PQQLQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPM
                     GGPMHPDMHPDMHPDMHPDMHADMHADMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHS
                     GMMPPIPPAQNFYENFYQQQEGMEMEPGLLGDAEDYGHYEELPGEPGEHLFPEHPLEP
                     DSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEEERARRLAESSKQDRENE
                     EGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPPASVGELSSSGLGDPRLQKGHPTG
                     SRLADPRLSRDPRLTRHVEASGGSGPGDSGPSDPRLARALPTSKPEGSLHSSPVGPSS
                     SKGSGPPPTEEEEGERALREKAVNIPLDPLPGHPLRDPRSQLQQFSHIKKDVTLSKPS
                     FARTVLWNPEDLIPLPIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGAS
                     TDSSTQGANLPDFELLSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDS
                     TASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGI
                     SLYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPFVRKSALEQPETGKA
                     GADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQT
                     PKTGSGSPFAGNSPAREGEQDAASLKDVFKGFDPTASPFCQ"
     exon            224..443
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..554
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            555..777
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            778..932
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1029
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1169
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1280
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1392
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1502
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1864
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2208
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2460
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..6143
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6118..6123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /note="hexamer: ATTAAA"
     polyA_site      6143
                     /gene="ZC3H4"
                     /gene_synonym="C19orf7"
                     /note="major polyA site"
ORIGIN      
        1 gggcttcatc gcttctccgg aaacctccga ctctcggcac ctggcctcca gctttcggaa
       61 ctatggaggc cgcgcccggg acccccccgc cgccgccatc agagtcgccg ccgccgccat
      121 cgccgccgcc gccatcaacg ccttcgcctc ctccgtgttc ccccgacgcc cgcccggcca
      181 ccccgcacct cctccaccac cgcctcccgc tccctgacga cagggaagat ggagagttgg
      241 aagaaggtga attggaagat gatggggcag aggagaccca ggatacctcc ggagggcctg
      301 agagaagccg gaaagaaaag ggggagaagc atcacagtga ttcggatgag gagaagtccc
      361 acaggagact gaagcggaaa cggaagaaag agcgggagaa agagaaaagg aggtcgaaga
      421 agaggaggaa atccaagcac aaacgccatg cttcttctag cgatgacttc tctgacttct
      481 cagatgactc ggatttcagc cccagtgaga aaggtcaccg caagtacaga gagtacagcc
      541 ccccatatgc gccgtcccac cagcagtacc ccccatcgca tgccacgccc ctgcccaaga
      601 aggcatactc caagatggac agcaagagtt atggcatgta cgaggactac gagaatgagc
      661 agtatgggga atatgagggc gacgaggagg aggacatggg caaggaggac tatgacgact
      721 tcaccaaaga gctgaaccag taccggcgtg ccaaggaggg cagcagccgc ggccgaggca
      781 gccgaggccg gggccggggc tacaggggcc gaggaagccg tggaggatcg cgaggccgcg
      841 gcatgggcag gggcagccga ggcaggggca gaggctctat gggaggagac cacccggagg
      901 atgaagagga tttctacgag gaagagatgg actatggaga gagtgaggag ccaatgggag
      961 acgacgacta tgacgagtac tccaaggagc tgaaccagta ccgccgctcc aaggacagcc
     1021 gaggccgagg gctaagtcga ggccgtggca ggggctcccg aggtcgaggg aaaggaatgg
     1081 gtcggggccg aggccgaggt ggcagccgag gagggatgaa caagggcgga atgaacgatg
     1141 acgaagactt ctatgacgag gacatgggcg acggtggtgg tggaagctac cggagtcgtg
     1201 accatgacaa gccccaccag cagtcggaca agaaaggcaa agtcatttgc aagtacttcg
     1261 tggaagggcg ctgcacctgg ggagaccact gtaattttag ccatgacatc gaactcccaa
     1321 agaagcgaga actgtgcaag ttttacatca ctggattttg cgccagagct gagaactgcc
     1381 cttatatgca cggtgatttc ccgtgtaagc tgtaccacac cactgggaac tgcatcaatg
     1441 gtgacgactg catgttttcc cacgaccctc tgaccgaaga gacgagggag ctcttggata
     1501 agatgttggc cgatgatgca gaagcaggtg ccgaggatga gaaggaggtg gaggaactga
     1561 agaagcaggg catcaacccc ctgcccaaac cgccccctgg tgtgggcctc ctgcccaccc
     1621 ctcctcggcc ccctggcccg caggctccaa cctctcccaa cggcaggccc atgcagggtg
     1681 gccccccgcc cccgccccct ccccctcccc caccgcccgg gccccctcag atgcccatgc
     1741 cggtgcatga gccactgtcc ccgcagcagc tgcagcagca ggacatgtac aacaagaaga
     1801 tcccctcctt gtttgagatc gtggtgcggc ccacgggaca gctggctgag aagctgggtg
     1861 tgaggttccc tggacccggt ggacccccag ggccaatggg ccctgggccc aacatgggac
     1921 ccccagggcc aatgggcggt ccaatgcatc ctgacatgca ccccgacatg cacccggaca
     1981 tgcaccctga catgcacgca gacatgcacg cagacatgcc gatgggccct ggcatgaatc
     2041 ctggcccacc catgggccct ggcggccctc caatgatgcc ctacggccct ggagactccc
     2101 cacattctgg aatgatgccc cctatcccgc cagcccagaa cttctatgaa aacttctacc
     2161 agcagcagga gggcatggag atggagcccg gactcctggg ggatgcagag gactacgggc
     2221 actacgaaga gctgccaggg gagcctgggg agcacctctt ccctgagcac cctctggagc
     2281 ccgacagctt ctctgaggga gggcccccag gccggccgaa gccaggcgcc ggtgtccctg
     2341 acttcctgcc ctcagcccag agggccctgt acctgaggat ccagcagaag cagcaggagg
     2401 aggaggagag agcgaggagg ctggctgaga gcagcaagca ggaccgggag aatgaggaag
     2461 gtgacaccgg aaactggtac tcaagtgatg aggatgaggg tggaagcagt gtcacctcca
     2521 tcctgaagac cttgaggcag cagacgtcca gccgaccccc ggcttcagtt ggggagctga
     2581 gcagcagtgg gctgggggac ccccgcctcc agaagggaca ccccacagga agccggctgg
     2641 ctgaccctcg cctcagccgg gaccccagac tcacccgcca tgtggaggct tctggcgggt
     2701 ctggcccagg tgattcggga ccctccgatc ctcggctggc tcgcgccctg cccacctcca
     2761 agcccgaagg cagccttcat tccagccctg tgggccccag cagttccaag gggtctgggc
     2821 cgcccccaac ggaggaggag gaaggggagc gggccctgcg ggagaaggcc gtgaacattc
     2881 ccctggaccc actccccggg caccctctgc gggacccacg gtcacagctg cagcagttca
     2941 gccacatcaa gaaggacgtg accctgagca agcccagctt cgcccgcacc gtgctctgga
     3001 atcccgagga cctgatcccc ctacccatcc ccaagcagga cgcagtgccc cccgtgcccg
     3061 cggccctgca atccatgccc accctggacc cccggctgca ccgcgctgcc acggcagggc
     3121 cccccaacgc ccggcagcgc ccgggcgcct ccacggattc cagcacacag ggcgccaacc
     3181 tccccgactt tgaacttctg tctcgcatcc tcaagacagt caatgccacc ggctcctcgg
     3241 ccgcccccgg ttccagcgac aaacccagtg acccccgggt gcggaaggcc cccaccgacc
     3301 ctcggctgca gaaacccaca gactctacgg cctcctcccg ggctgccaag cccggccctg
     3361 ctgaggcgcc ctctcccacc gccagcccga gtggggatgc ctccccacca gccaccgctc
     3421 cctacgaccc ccgcgtgctg gcggccggtg gactgggcca gggcggaggg ggcgggcaga
     3481 gcagtgtgct gagcggtatc agcctctacg acccgaggac tcccaacgcg gggggcaaag
     3541 ccacagagcc ggctgctgac acgggtgccc agcccaaggg tgctgagggc aatggcaaga
     3601 gctcggcctc caaggctaag gagcccccgt tcgtccgcaa gtctgccctg gaacagccag
     3661 agacagggaa ggccggtgct gatgggggca cccccacgga cagatacaac agctacaacc
     3721 ggccccggcc caaggctgct gcagcccccg ctgccaccac cgccacccca ccccccgagg
     3781 gtgccccacc ccagcccggg gtgcacaacc tgcccgtgcc caccctcttc gggacggtga
     3841 agcagacacc caagacgggc tcaggaagcc catttgctgg gaacagtccg gcccgcgagg
     3901 gtgagcagga tgcggcatcc ctgaaggatg tttttaaagg cttcgacccc acggcctccc
     3961 ccttttgcca gtagtgtcca gccagagctg cggctccagc cacccttcct agggtggcat
     4021 tcagggcagc acccagggta gggaacttgg gggcaagggg aggcaggctg ggtgttcctt
     4081 ttttcttttc tttttctttt gctttccgtc tcttttattt ttttttaaag tagtactttc
     4141 tttgagattt gtaaattgta tataaccatc ttaagttctg gtcagtgtgg cgggctcagg
     4201 ggctcctgct gagcaaaccg actcatgccc gcaaacctgt gaactttcgc cagtgcctgg
     4261 cctcagactc tgtgggctct gcgtggccgg gccttgctgg aggcccagtg ggttttctgg
     4321 gcaaagcatg gccccttttc cccaggacaa agggaacagt tggtgtctgg gaaggtattg
     4381 aacgctcctc accctgtgcc cgaagagacc cggaaccaag accatggcag ggcctgcgtg
     4441 gaagcaggtc caggcgtttc tagaacccta gggtgcacca tcactgtctt ttcagtgcag
     4501 gctgtaacaa cccactcagg agacagtgag agtgaaaagg tattaaggaa aaagccccca
     4561 gcggcactat gggggctccc tggcgcatgc ctgctcctgt ccctggatta ccacacgtgc
     4621 cctccctgcc accctccgtc tagagcaagc ggatgccccc cagcctgcag cagaagcctc
     4681 cacagtgaga actggaccca aaggtagtgg gggccggtgt ggggcagagt cctgaagagc
     4741 cacctctagg aggcagcccc taggagcacg cacgttctgt cagtattacc ccacctgtcc
     4801 tatcaggtgg gccacaccct gcttgcccac accagggtct gtcctggtcc tcaagccacg
     4861 cacccgctat gcctgcactg cagcccagcc ccggacagct ccaggatccg tgcagtggct
     4921 gcgccgccag gccccaacaa tggggaccct ggggtggctc ctggccaagt gttctctgtt
     4981 ttcctcgcac ctccttacac tgtgtgacct gcagggcatg aggtattgat gtgttcgggt
     5041 ttcctttccc aagccagcag atgcaggtgt tccaaggtgt gttgctctgt gggatttgtg
     5101 gacacttaag aaacggactg agtgggaacc ctgcagccag gggatgggga gcctctgctc
     5161 cccccatgct cccaccctgg ctgagggcca gcctcatctg cagagccctg gaggaggccc
     5221 acctatggac acagcccgag agatgggcgc aaggggtgct gggggaggcc tgctatcctg
     5281 cctctgggcc acttgagggg cctcaggaag tgtgtgcttg tggctgcatc tgcccgtctc
     5341 cctggcccac catgtggctg caggccaagc tcttcattgc tgaccatgaa gagacctagt
     5401 tacctgccaa gggattcccc ttccctcctc ctcagggtgg ggtgaacaag gctcctatcc
     5461 caccccaccc caaaaagaga aaaatgaaaa actcatagtt tggagccagg aggcagggtg
     5521 tcctacaggg ctgcacagcc ctgaggggtc agtgctggga tctggttggt tggtttgtct
     5581 ttttgtcttt tttttttttt ttttttttac acaatcatta atgagatttg tcttcagcca
     5641 ccagtgttgg ccttgaagca gagggcacag cccttggtgt ttgtaaaata agtatgaata
     5701 cacagtgtgg cagtgttgtg gtttttgttg ttgtttttcc tctccttttg agaattttct
     5761 tttgtaaaag aaaaatattt tttaaaccga aatctgtgga tgaaatagaa gctggagccc
     5821 tcctcttgga atattcagcc taagaacctc ataggactat gaattcaccc gaaattctca
     5881 tttgccatca ggccgagctt ttaaagaaaa attgttctct aaccaggatt gtaacaaaag
     5941 tgtaaatact gtttcagagt tgagagttgg tggtgcaaat atgtatataa tgaactgtat
     6001 ttttacaatg atcgccgcat gactatttca cacccttttt atactccata tctgtcttcc
     6061 agaaacgtca cctgcctttc tcctgtggtc tcttaatcca gtaattgtat tactgccatt
     6121 aaaggatgca gttattttaa aaa
//
