LOCUS       NM_015117               3270 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 3 (ZC3H3), mRNA.
ACCESSION   NM_015117
VERSION     NM_015117.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3270)
  AUTHORS   Silla,T., Schmid,M., Dou,Y., Garland,W., Milek,M., Imami,K.,
            Johnsen,D., Polak,P., Andersen,J.S., Selbach,M., Landthaler,M. and
            Jensen,T.H.
  TITLE     The human ZC3H3 and RBM26/27 proteins are critical for
            PAXT-mediated nuclear RNA decay
  JOURNAL   Nucleic Acids Res 48 (5), 2518-2530 (2020)
   PUBMED   31950173
  REMARK    GeneRIF: three additional proteins required for Poly(A) Tail
            eXosome Targeting (PAXT) function: ZC3H3, RBM26 and RBM27 along
            with the known PAXT-associated protein, PABPN1, were identified.
REFERENCE   2  (bases 1 to 3270)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3270)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3270)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3270)
  AUTHORS   Hurt,J.A., Obar,R.A., Zhai,B., Farny,N.G., Gygi,S.P. and
            Silver,P.A.
  TITLE     A conserved CCCH-type zinc finger protein regulates mRNA nuclear
            adenylation and export
  JOURNAL   J Cell Biol 185 (2), 265-277 (2009)
   PUBMED   19364924
REFERENCE   6  (bases 1 to 3270)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3270)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 3270)
  AUTHORS   Collart,C., Remacle,J.E., Barabino,S., van Grunsven,L.A.,
            Nelles,L., Schellens,A., Van de Putte,T., Pype,S., Huylebroeck,D.
            and Verschueren,K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM148116.1, AC067930.7, D63484.1 and AA806585.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015117.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63484.1, BC038670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262577.6/ ENSP00000262577.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               BM148116.1         7-482
            477-1390            AC067930.7         76168-77081         c
            1391-3268           D63484.1           1354-3231
            3269-3270           AA806585.1         30-31               c
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3270
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /note="zinc finger CCCH-type containing 3"
                     /db_xref="GeneID:23144"
                     /db_xref="HGNC:HGNC:28972"
                     /db_xref="MIM:618640"
     exon            1..72
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2873
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /note="smad-interacting CPSF-like factor; zinc finger
                     CCCH-type domain containing 3"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 3"
                     /protein_id="NP_055932.2"
                     /db_xref="CCDS:CCDS6402.1"
                     /db_xref="GeneID:23144"
                     /db_xref="HGNC:HGNC:28972"
                     /db_xref="MIM:618640"
                     /translation="MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTY
                     HSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADHAVRPLHGARGGQ
                     PPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPR
                     EGEGEPPRGQLQPSRPTRARGTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRT
                     VSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHTDQPVPS
                     GSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAA
                     ENVCKASAGMANKVEKPQLIADPEPKPRKPATSSKPGSAPSKYKWKASSPSASSSSSF
                     RWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
                     RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCR
                     LPPSRAHLPTKEASSLHAVRTAPTSKVIKTRYRIVKKTPASPLSAPPFPLSLPSWRAR
                     RLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPS
                     DAGSRPLLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRC
                     NRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEKMPVCSYFLKGICSNS
                     NCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHR
                     TQKRHSRRAATSPAPGPSDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAA
                     PPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNRLCKLPSFIS
                     LQSSPSPGAQPRVRAPRAPLTKDSGKPLHIKPRL"
     exon            73..1390
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1587
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1741
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1929
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1972
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2131
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2201
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2333
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2518
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2841
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3270
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3251..3256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /note="hexamer: AATAAA"
     polyA_site      3270
                     /gene="ZC3H3"
                     /gene_synonym="SMICL; ZC3HDC3"
                     /note="major polyA site"
ORIGIN      
        1 ctggccggcc gtcgcggact cgggagatgg aggaaaagga gatattacgg cggcagatcc
       61 gcctactgca gggtctgatt gatgactaca aaaccctcca cggcaatgcc ccggcccctg
      121 gtaccccagc agcttctggg tggcagccac ccacttacca cagtggcaga gcctttagtg
      181 cccgctaccc tcgtccaagc cggaggggct actcttccca ccatgggcct tcgtggcgca
      241 agaaatactc cctcgtgaat cggcccccgg gaccctcaga ccctcctgcc gaccatgctg
      301 tgcggccgtt gcacggggcc cgggggggcc agcctcctgt cccgcagcag catgtccttg
      361 agagacaggt ccagctcagt cagggtcaga acgtggtcat caaagttaaa ccgccatcaa
      421 agtctggctc tgccagtgcc tcaggggccc agcggggctc tttggaagaa tttgaggaaa
      481 ccccctggag tgaccaaagg ccccgggaag gtgaaggtga gccccctcgg ggacagctgc
      541 agccctcgag gccaacaaga gccaggggga cctgcagtgt ggaagatcct cttctggtct
      601 gccagaagga gcctggtaag cccaggatgg tgaagtcagt gggcagtgtg ggcgacagcc
      661 cccgggagcc ccgccggaca gtcagtgaga gtgtgattgc cgtcaaggcg agcttcccat
      721 cctccgctct gcccccacgc actggcgtgg ccctgggccg gaagctgggt tctcattccg
      781 tggccagctg tgctccacag ctccttgggg acaggagagt agatgctggc cacacagatc
      841 agccagttcc gtctggctca gtggggggcc ccgccagacc ggcctcagga cccaggcagg
      901 cccgggaggc ctcgctggtt gtgacctgtc gaactaacaa gttccggaaa aacaactaca
      961 aatgggtggc tgcctcctcg aagagtcccc gggttgctcg gagggccctc agtcccagag
     1021 tggctgcaga gaatgtgtgc aaggcctctg ctggcatggc aaacaaggtg gagaagccgc
     1081 agctcatagc tgacccagag cccaagccca ggaagccagc cacgtcctcc aagccagggt
     1141 ctgcccccag caagtacaag tggaaggcct ccagcccctc tgcctcctcc tcttcctcct
     1201 tccgttggca gtcggaggcc agcagcaagg accatgcctc ccagctctcc ccagtcctgt
     1261 ctaggtcccc gtcgggggac agaccagcag taggacacag tggcttgaag cccctctctg
     1321 gggagacccc gctctcggct tacaaagtga agagccgcac caagatcatc cggagacgca
     1381 gcagcacaag ccttcctgga gacaagaaaa gcggcacctc acctgccgcc accgccaaga
     1441 gccacctcag cctccggcgg agacaggccc tcagggggaa gagcagccct gtcctgaaga
     1501 agacccccaa caagggcctg gtacaggtca ccacgcaccg actatgtcgc ctgccaccga
     1561 gccgggccca cctccccacc aaggaagcgt ccagcctgca tgccgtgcgg actgcaccca
     1621 ccagcaaggt gatcaagacc cgctaccgca ttgtcaagaa gacgccggcc tcgcctctca
     1681 gcgccccgcc cttccccctg tctctgccct cctggcgggc ccggcggctc tcactatcca
     1741 ggtccctggt gctgaaccgc ctgcgtccag ttgccagcgg gggtgggaaa gcccaaccgg
     1801 gctccccttg gtggcggagc aaaggctacc gctgcatcgg aggggtcctc tacaaagtat
     1861 ctgccaacaa gctctccaag acctccggcc agcccagtga tgcgggcagc aggcccctcc
     1921 tgcgcacagg ccggctggat cctgcaggca gctgtagccg ttccctggcc agccgggcag
     1981 tgcagcgcag cctggccatc atccggcagg cgcggcagcg cagggagaag aggaaggagt
     2041 actgcatgta ctacaaccgc ttcggcaggt gcaaccgtgg cgagcgctgc ccctacatcc
     2101 acgatcccga gaaggtggcc gtgtgcacca ggtttgtccg gggcacctgc aagaaaacgg
     2161 atgggacctg ccccttctcc caccatgtgt ccaaggagaa gatgccggtg tgctcctact
     2221 tcctgaaggg catctgcagc aacagcaact gtccctatag ccacgtgtac gtgtcccgca
     2281 aggccgaggt ctgcagcgac ttcctcaaag gctactgccc cctgggtgca aagtgcaaga
     2341 agaaacacac gctgctgtgc cccgactttg cccgcagggg ggcgtgtccc cgcggcgccc
     2401 agtgccagct gctccaccgt acccagaaac gccacagtcg gcgggcagcc acgtcccccg
     2461 ccccagggcc cagcgacgca accgccagga gcagggtctc ggccagccac gggcccagga
     2521 agccttcagc atcccagcgc cccaccaggc agacgcccag ctcggctgcc ctcactgcgg
     2581 ctgccgtggc tgcacctccc cactgcccag gggggtcagc ctctccctca tcctcgaagg
     2641 cttcctcctc ctcctcctcc tcctcatccc ctcccgcttc cttggaccac gaggcaccat
     2701 ctctccagga ggctgcctta gcagcagcgt gctccaacag gctctgcaag ctgccttcct
     2761 tcatctccct gcagtcctcg ccgagcccag gagcccagcc cagggtccgg gcccctaggg
     2821 cccccctcac caaggactca gggaagcctc tgcacatcaa accacgtctg tgaggacccc
     2881 agggaccggc ctgcacctac ctcagaccct catccttgga gaggaaagag gctctgtcca
     2941 ccactctacc ccacaggagg gccgcccgcc accaagcctc acctgggggc cacagggaca
     3001 ctgctctgcc tgcctggccc tcaaccttcc atgaccagcg tgtgcgcagg gcctggtctt
     3061 cctcccccaa gccaggcccc tgtccccacc ccaccacctt ccagggtgcc aggcagggct
     3121 ggcctccagg cctgtccccg actgccattg gcaacagtgg ccctgcagcc cccagccctc
     3181 cccacccagg ttttcggccc agtgaagagg ccactggcca ggcctcccag gcaggtgttt
     3241 tatgttcagc aataaaggtt ctatccgtaa
//
