LOCUS       NM_018471               2032 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 15 (ZC3H15), mRNA.
ACCESSION   NM_018471
VERSION     NM_018471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Hou,J., Xu,M., Gu,H., Pei,D., Liu,Y., Huang,P., Chang,H. and Cui,H.
  TITLE     ZC3H15 promotes glioblastoma progression through regulating EGFR
            stability
  JOURNAL   Cell Death Dis 13 (1), 55 (2022)
   PUBMED   35027542
  REMARK    GeneRIF: ZC3H15 promotes glioblastoma progression through
            regulating EGFR stability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Li,Q., Hou,J., Guo,C., Zhang,Y., Liu,L., Hu,H., Shi,S., Ji,Y.,
            Guo,L., Shi,Y., Liu,Y. and Cui,H.
  TITLE     ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in
            Melanoma
  JOURNAL   Biomed Res Int 2021, 8305299 (2021)
   PUBMED   34988227
  REMARK    GeneRIF: ZC3H15 Correlates with a Poor Prognosis and Tumor
            Progression in Melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Capalbo,G., Muller-Kuller,T., Dietrich,U., Hoelzer,D., Ottmann,O.G.
            and Scheuring,U.J.
  TITLE     Inhibition of X4-tropic HIV type 1 replication by knockdown of the
            cellular protein LEREPO4
  JOURNAL   AIDS Res Hum Retroviruses 26 (10), 1155-1161 (2010)
   PUBMED   20925576
  REMARK    GeneRIF: down-regulation of LEREPO4 expression caused a significant
            inhibition of HIV replication
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Ishikawa,K., Akiyama,T., Ito,K., Semba,K. and Inoue,J.
  TITLE     Independent stabilizations of polysomal Drg1/Dfrp1 complex and
            non-polysomal Drg2/Dfrp2 complex in mammalian cells
  JOURNAL   Biochem Biophys Res Commun 390 (3), 552-556 (2009)
   PUBMED   19819225
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Gregory,R.C., Lord,K.A., Panek,L.B., Gaines,P., Dillon,S.B. and
            Wojchowski,D.M.
  TITLE     Subtraction cloning and initial characterization of novel
            epo-immediate response genes
  JOURNAL   Cytokine 12 (7), 845-857 (2000)
   PUBMED   10880228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL040058.1 and BC021102.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018471.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.288403.1, AF289586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337859.11/ ENSP00000338788.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL040058.1         105-316
            213-2032            BC021102.1         127-1946
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..2032
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /note="zinc finger CCCH-type containing 15"
                     /db_xref="GeneID:55854"
                     /db_xref="HGNC:HGNC:29528"
                     /db_xref="MIM:619704"
     exon            1..198
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1404
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /note="DRG family-regulatory protein 1; likely ortholog of
                     mouse immediate early response erythropoietin 4"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 15"
                     /protein_id="NP_060941.2"
                     /db_xref="CCDS:CCDS42791.1"
                     /db_xref="GeneID:55854"
                     /db_xref="HGNC:HGNC:29528"
                     /db_xref="MIM:619704"
                     /translation="MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIK
                     AVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKS
                     VVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEE
                     VVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLK
                     KDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMER
                     RKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDL
                     SLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNEREGT
                     ENGAIDAVPVDENLFTGEDLDELEEELNTLDLEE"
     exon            199..300
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            301..412
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            413..565
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            566..657
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            658..840
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            841..987
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1089
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1213
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2032
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /note="hexamer: AATAAA"
     polyA_site      2032
                     /gene="ZC3H15"
                     /gene_synonym="DFRP1; HT010; LEREPO4; MSTP012"
                     /note="major polyA site"
ORIGIN      
        1 gactcgcttt ccgtgcggtg cggcgagtga ggccccggtc ttcctcctcg tcctgccgca
       61 gggccagaac ccctgacggt attcagctgc gcgtaagtct ggccggtgcc atctgtctcc
      121 gcaatgcccc ccaagaaaca ggctcaggcc gggggcagca aaaaggcgga gcaaaaaaag
      181 aaggagaaga ttatcgaaga caaaactttc ggtttgaaga ataagaaagg agcaaagcaa
      241 cagaagttta tcaaggctgt cacacatcaa gttaaatttg gtcaacaaaa tccacgtcag
      301 gtagcacaga gtgaagctga aaagaaattg aagaaggatg acaagaagaa agaattgcag
      361 gagctaaatg agctgttcaa acctgtagtt gctgctcaaa aaataagtaa aggtgcagat
      421 cccaagtctg tagtatgtgc attcttcaag caaggacagt gtactaaagg agataagtgt
      481 aagttctccc atgacttgac tctggagaga aaatgtgaaa agcgaagtgt ttacattgat
      541 gcaagagatg aagaacttga aaaagatact atggataatt gggatgagaa aaagctggaa
      601 gaagtagtga acaagaagca cggtgaggcg gaaaagaaaa aaccaaaaac tcaaatagtg
      661 tgcaagcatt tcctggaagc tattgaaaac aacaagtatg gctggttttg ggtatgccct
      721 ggagggggtg atatttgcat gtatcgtcat gcacttcctc ctggatttgt gttgaaaaaa
      781 gataaaaaga aagaagagaa agaagatgaa atttcattag aagatctaat tgagagagag
      841 cgttctgccc taggtccaaa tgttaccaaa atcactctag aatcttttct tgcctggaag
      901 aaaaggaaaa gacaagaaaa gattgataaa cttgaacaag atatggaaag aaggaaagct
      961 gacttcaaag cagggaaagc actagtgatc agtggtcgtg aagtgtttga atttcgtcct
     1021 gaactggtca atgatgatga tgaggaagca gatgataccc gctacaccca gggaacaggt
     1081 ggtgatgagg ttgatgattc agtgagtgta aatgacatag atttaagcct gtacatccca
     1141 agagatgtag atgaaacagg tattactgta gccagtcttg aaagattcag cacatatact
     1201 tcagataaag atgaaaacaa attaagtgaa gcttctggag gtagggctga aaatggtgaa
     1261 agaagtgact tggaagagga caacgagagg gagggaacgg aaaatggagc cattgatgct
     1321 gttcctgttg atgaaaatct tttcactgga gaggatttgg atgaactaga agaagaatta
     1381 aatacacttg atttagaaga atgacaccaa acacatcgct gaaaaaatta agtcagctca
     1441 gcacgagttg aaattgacta cattaatttc tttccaccta gaatcaacag gatgtttatt
     1501 tcctatgctg attctggagg agttaacctc ctgcaaaaaa ggcatcttgt ccctacatct
     1561 tctcttctga ctttggctac atctcatagt aagttcagag tagttcatga taaattgaaa
     1621 atataatggt cattgcagaa aatgattgat gttgtaactg tccacccaag taagaagtgt
     1681 atctgccttt ccatcttttg gttttcattt gggcatgtgc tattaccaga aacaacaaac
     1741 ttatatttaa aatacccttc atttgacaca gtttttaatg agtgatttaa tttcctctgt
     1801 atttgtatgt ttagaagact gcctaaaaca tgagcactgt acttcataaa ggaaactgcg
     1861 tatgcagatt cagtattgtg tatctttgga caattagatg gacatttaaa atggaacttc
     1921 ttttatctga caggatcagc tacaatgccc tgtgttaaat tgtttaaaag tttccctttt
     1981 cttttttgcc aataaagttg taaataaaga ccatcataca ttaaaatcca aa
//
