LOCUS       NM_001330564            8024 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 13 (ZC3H13),
            transcript variant 2, mRNA.
ACCESSION   NM_001330564 XM_005266308
VERSION     NM_001330564.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8024)
  AUTHORS   Fu,M., Chen,Y. and Shi,X.
  TITLE     ZC3H13 Accelerates Keloid Formation by Mediating N6-methyladenosine
            Modification of HIPK2
  JOURNAL   Biochem Genet 62 (3), 1857-1871 (2024)
   PUBMED   37752292
  REMARK    GeneRIF: ZC3H13 Accelerates Keloid Formation by Mediating
            N[6]-methyladenosine Modification of HIPK2.
REFERENCE   2  (bases 1 to 8024)
  AUTHORS   Huang,L., Chen,G., He,J. and Wang,P.
  TITLE     ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous
            cell carcinoma cells through m6A-dependent modification
  JOURNAL   Tissue Cell 84, 102187 (2023)
   PUBMED   37536262
  REMARK    GeneRIF: ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal
            squamous cell carcinoma cells through m6A-dependent modification.
REFERENCE   3  (bases 1 to 8024)
  AUTHORS   Zhu,D., Liu,G., Song,Y., Li,S., Yang,S., Hu,D. and Li,P.
  TITLE     Enterovirus 71 VP1 promotes 5-HT release by upregulating the
            expression of ERICH3 and methyltransferase ZC3H13
  JOURNAL   Virus Res 318, 198843 (2022)
   PUBMED   35660571
  REMARK    GeneRIF: Enterovirus 71 VP1 promotes 5-HT release by upregulating
            the expression of ERICH3 and methyltransferase ZC3H13.
REFERENCE   4  (bases 1 to 8024)
  AUTHORS   Lin,X., Wang,F., Chen,J., Liu,J., Lin,Y.B., Li,L., Chen,C.B. and
            Xu,Q.
  TITLE     N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes
            cervical cancer stemness and chemoresistance
  JOURNAL   Mil Med Res 9 (1), 19 (2022)
   PUBMED   35418160
  REMARK    GeneRIF: N(6)-methyladenosine modification of CENPK mRNA by ZC3H13
            promotes cervical cancer stemness and chemoresistance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8024)
  AUTHORS   Wu,S., He,G., Liu,S., Cao,Y., Geng,C. and Pan,H.
  TITLE     Identification and validation of the N6-methyladenosine RNA
            methylation regulator ZC3H13 as a novel prognostic marker and
            potential target for hepatocellular carcinoma
  JOURNAL   Int J Med Sci 19 (4), 618-630 (2022)
   PUBMED   35582419
  REMARK    GeneRIF: Identification and validation of the N6-methyladenosine
            RNA methylation regulator ZC3H13 as a novel prognostic marker and
            potential target for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8024)
  AUTHORS   Oldmeadow,C., Mossman,D., Evans,T.J., Holliday,E.G., Tooney,P.A.,
            Cairns,M.J., Wu,J., Carr,V., Attia,J.R. and Scott,R.J.
  TITLE     Combined analysis of exon splicing and genome wide polymorphism
            data predict schizophrenia risk loci
  JOURNAL   J Psychiatr Res 52, 44-49 (2014)
   PUBMED   24507884
  REMARK    GeneRIF: This study identified ZC3H13 significantly associated loci
            with a biologically plausible role in schizophrenia.
REFERENCE   7  (bases 1 to 8024)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   8  (bases 1 to 8024)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 8024)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8024)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA498537.1, AY283618.1, BC032425.1, CN262326.1, CN262335.1,
            AB020660.1, AK074924.1, AL445232.5 and AI640521.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001330564.1.
            
            Transcript Variant: This variant (2), as well as variants 1 and
            7-9, encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.780438.1,
                                           SRR18074969.551753.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000679008.1/ ENSP00000503994.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               DA498537.1         16-399
            385-1593            AY283618.1         104-1312
            1594-2507           BC032425.1         483-1396
            2508-4550           AY283618.1         2227-4269
            4551-4639           CN262326.1         500-588
            4640-5301           CN262335.1         86-747
            5302-6819           AB020660.1         2846-4363
            6820-7275           AK074924.1         3592-4047
            7276-7276           AL445232.5         89664-89664         c
            7277-8022           AK074924.1         4048-4793
            8023-8024           AI640521.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..8024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..8024
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="zinc finger CCCH-type containing 13"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
     exon            1..343
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            344..469
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..5362
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger CCCH domain-containing protein 13"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform 1"
                     /protein_id="NP_001317493.1"
                     /db_xref="CCDS:CCDS91804.1"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
                     /translation="MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRN
                     WLKTGNCLYGNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQK
                     RNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDY
                     VHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKS
                     PKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIAL
                     GKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSS
                     SSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR
                     SPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDR
                     EPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR
                     DREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGR
                     VPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER
                     RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRE
                     RERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERE
                     RERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRD
                     DRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDD
                     KNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKV
                     SSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE
                     DDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG
                     PRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATAT
                     TPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNT
                     TNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSG
                     RLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS
                     TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ
                     REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRT
                     FESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERT
                     ESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPL
                     DVIDVDWSGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQR
                     LLEKPKDADNLFEHELGALNMAALLRKEERASLLSNLGPCCKALCFRRDSAIRKQLVK
                     NEKGTIKQAYTSAPMVDNELLRLSLRLFKRKTTCHAPGHEKTEDNKLSQSSIQQELCV
                     S"
     exon            470..579
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            580..691
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            692..800
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            801..940
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1098
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1296
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1607
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2072
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2264
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2820
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2924
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..4148
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4673
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4826
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..5027
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            5028..5191
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..8024
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6021..6026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="hexamer: AATAAA"
     polyA_site      6041
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="major polyA site"
     regulatory      8002..8007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="hexamer: AATAAA"
     polyA_site      8024
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /note="major polyA site"
ORIGIN      
        1 aaacctctga cttccggcgg cattttgagg cggtcctcct agcggcctgg tagtgttttt
       61 gttgcctttt cttaatctac aatctcttcg ttatttttct tcctgcgacc cagtttcgct
      121 tgaccctgga gaggcggcgg gcgggttggt tctgcttctc agccatcccg ggggctcctc
      181 gctagccaag agccggttcc cgggagccgc gcgcgcatcg ctttctcctc gtcgtcgtcc
      241 tcctgggtcc aggcgcgggg acagagtcgc ctcccccgct cctcggagcg gcggcggcgg
      301 tggtgcctcc ggactgcact tgcgaaggga gcttggggag gaatagtaca aaatgtcaaa
      361 aattagaagg aaggtcacag tggaaaatac caagactata tctgatagca catcccgaag
      421 acccagtgta tttgagaggc ttggacccag cactggcagt acagcagaga cacagtgccg
      481 taactggctg aagactggca actgcctcta tggaaacaca tgtagattcg tacatggccc
      541 ttcacctcgt ggtaaaggtt atagcagcaa ttatagaagg tcaccagaaa gacctacagg
      601 ggatcttaga gaaagaatga agaacaagcg ccaagacgtg gacactgagc cccagaaacg
      661 aaatacagag gagtcatcct cacctgttag gaaagaatct tcaagaggga gacataggga
      721 aaaggaagac ataaaaatca ctaaggaaag aactccagaa agtgaagaag aaaatgtaga
      781 atgggaaact aatagagatg attctgacaa tggagatatt aattatgatt atgttcatga
      841 attgtcattg gaaatgaagc gtcagaagat acagagggaa ttaatgaagc tggaacaaga
      901 aaacatggag aagagagaag aaattatcat taaaaaggag gtttcaccag aagtggttag
      961 atcaaaattg tccccgtcac cttctctaag aaagtctagc aaatctccga agcgaaaatc
     1021 aagcccgaag tcgtcttcag ctagcaagaa agataggaag acatctgcag tatcttctcc
     1081 cctgttggac cagcagagaa attcaaaaac caaccaaagt aaaaagaaag gaccacgtac
     1141 tcctagtcca ccccctccta taccagaaga tatcgctctg gggaaaaaat acaaagaaaa
     1201 atataaagta aaagacagga tagaagaaaa aacaagagat ggaaaggaca gaggacgaga
     1261 ttttgaacga caaagagaaa agagagacaa gccaaggtct acttccccag caggacagca
     1321 tcattctcct atatcttcta gacatcactc atcttcctca caatcaggat catctattca
     1381 aagacattct ccttctcctc gtcgaaaaag aactccttca ccatcttatc agcggacact
     1441 aactccacct ttacgacgct ctgcctctcc ttatccttca cattctttgt cgtctcccca
     1501 gagaaagcag agtcctccaa gacatcgctc tccaatgcga gagaaaggga gacatgatca
     1561 tgaacgaact tcacagtctc atgatcgacg ccatgaaagg agggaagata ctaggggcaa
     1621 acgagacaga gaaaaggact caagagaaga acgagaatat gaacaggatc agagctcttc
     1681 tagagaccac agagatgaca gagaacctcg agatggtcgg gatcggagag atgccagaga
     1741 tactagggac cgaagggaac taagagactc cagagacatg cgggactcaa gggagatgag
     1801 agattatagc agagatacca aagagagccg tgatcccaga gattctcggt ccactcgtga
     1861 tgcccatgac tacagggacc gtgaaggtcg agatactcat cgaaaggagg atacatatcc
     1921 agaagaatcc cggagttatg gccgaaacca tttgagagaa gaaagttctc gtacggaaat
     1981 aaggaatgag tccagaaatg agtctcgaag tgaaattaga aatgaccgaa tgggccgaag
     2041 tagggggagg gttcctgagt tacctgaaaa gggaagtcga ggctcaagag gttctcaaat
     2101 tgatagtcac agtagtaata gcaactatca tgacagctgg gaaactcgaa gtagctatcc
     2161 tgaaagagat agatatcctg aaagagacaa cagagatcaa gcaagggatt cttcctttga
     2221 gagaagacat ggagagcgag accgtcgtga caacagagag agagatcaaa gaccaagctc
     2281 accaattcga catcagggaa ggaatgacga gcttgagcgt gatgaaagaa gagaggaacg
     2341 aagagtagac agagtggatg ataggagaga tgaaagggct agagagagag atcgggaacg
     2401 agaacgagac agggagcggg agagagagag ggaacgtgaa cgggatcggg aaagagaaaa
     2461 agagagagaa ctagaaagag agcgtgctag ggaacgggag agagaaagag aaaaagagag
     2521 agatcgtgaa agggatagag accgagacca cgatcgagag cgggaaagag agagggaacg
     2581 agacagggaa aaagaacggg aacgagaaag agaagagaga gagagggaga gagagcgaga
     2641 acgggagaga gagcgagagc gagaacggga acgagaaaga gcgagagaaa gggataaaga
     2701 acgagaacgc caaagggatt gggaagacaa agacaaagga cgagatgacc gcagagaaaa
     2761 gcgagaagag atccgagaag ataggaatcc aagagatgga catgatgaaa gaaaatcaaa
     2821 gaagcgctat agaaatgaag ggagtcccag ccctagacag tccccgaagc gccggcgtga
     2881 acattctccg gacagtgatg cctacaacag tggagatgat aaaaatgaaa aacacagact
     2941 cttgagccaa gttgtacgac ctcaagaatc tcgttctctt agtccctcgc acctcacaga
     3001 agacagacag ggtagatgga aagaggagga tcgtaaacca gaaaggaaag agagttcaag
     3061 gcgctacgaa gaacaggaac tcaaggagaa agtttcttct gtagataaac agagagaaca
     3121 gacagaaatc ctggaaagct caagaatgcg tgcacaggac attataggac accaccagtc
     3181 tgaagatcga gagacatctg atcgagctca tgatgaaaac aagaagaaag caaaaattca
     3241 aaagaaacca attaagaaaa agaaagagga tgatgttgga atagagaggg gtaacataga
     3301 gacaacatct gaagatggtc aagtattttc accaaaaaaa ggacagaaaa agaaaagcat
     3361 tgaaaaaaaa cgtaaaaaat ccaaaggtga ttctgatatt tctgatgaag aagcagccca
     3421 gcaaagtaag aagaaaagag gcccacggac tccccctata acaactaaag aggaattggt
     3481 tgaaatgtgc aatggtaaga atggtattct agaggactcc cagaaaaaag aagatacagc
     3541 attcagtgac tggtctgatg aggatgtccc tgaccgtaca gaggtgacag aagcagagca
     3601 tactgccacc gccacgactc ctggtagtac cccttctcct ctatcttctc ttcttcctcc
     3661 tccaccgcct gtggctactg ccactgctac aactgtgcct gcaactcttg ctgccactac
     3721 tgctgctgcc gccacctctt tcagcacatc tgccatcact atttccacct ctgccacccc
     3781 caccaatacc accaataata cttttgccaa tgaagactca cacagaaaat gccacagaac
     3841 acgagtagaa aaagtagaga cgcctcacgt gactatagaa gatgcacagc atcgcaagcc
     3901 tatggatcaa aagaggagca gcagcctcgg gagcaatcgg agtaaccgta gtcatacgtc
     3961 tggtcgtctt cgctccccat ccaatgattc agcccatcga agtggagatg accaaagtgg
     4021 tcgaaagaga gtactgcaca gtggctcaag agatagagaa aaaacaaaaa gcctggaaat
     4081 cacaggagag agaaaatcta ggattgatca gttaaagcgt ggagaaccca gtcgaagtac
     4141 ttcttcagat cgccaggatt caagaagcca tagttcaaga agaagttctc cagagtcaga
     4201 tcgacaggtc cattcaagat ctgggtcatt tgatagcaga gacaggcttc aagaacgaga
     4261 tcgatatgaa cacgacagag agcgcgagag agagaggaga gatacgaggc agagagaatg
     4321 ggaccgagat gctgataaag attggccacg caacagggat cgagatagat tgcgagaacg
     4381 agaacgagag agagaacgag acaaaaggag agacttggat agggaaagag agagactaat
     4441 ttctgattct gttgaaaggg acagggacag agacagagac agaacttttg agagttctca
     4501 aatagagtct gtgaaacgct gtgaagcaaa actggaaggt gaacatgaaa gggatctaga
     4561 aagcacttcc cgagactctc tagccttgga taaagagaga atggataaag atctgggatc
     4621 tgtgcaggga tttgaagaaa caaataaatc cgagagaact gagagtctgg aagcaggaga
     4681 tgacgagtcc aagttagatg atgcacattc attaggctct ggtgctggag aaggatacga
     4741 gccaatcagt gatgacgaac tagatgaaat tctggcaggt gatgcagaaa agagggagga
     4801 ccaacaggat gaggagaaga tgccagatcc cttagatgtg atagatgtgg attggtctgg
     4861 tcttatgcca aagcatccaa aagaaccacg agagcctggg gctgcactct taaaattcac
     4921 acctggagct gttatgctaa gagttgggat ttctaaaaag ttggcaggtt ctgaactctt
     4981 tgccaaagtc aaagaaacat gtcagagact tttagaaaaa cccaaagatg cagacaatct
     5041 ctttgaacat gaattggggg ctctcaatat ggctgcatta ctacgaaaag aagaaagagc
     5101 aagtcttctt agtaatcttg gcccatgttg taaggcgttg tgcttcagac gggattctgc
     5161 aattcgaaag cagcttgtta aaaatgagaa gggcaccata aaacaagctt acacgagtgc
     5221 tccaatggta gacaatgaat tacttcgatt gagtcttcgg ttatttaagc ggaagactac
     5281 ttgccatgct ccaggacatg aaaagactga agataataaa ctttcacagt ccagtatcca
     5341 acaggaactg tgtgtgtctt aagaccgaag ttcaatatgg tatttttggt actgtcttcc
     5401 ttcagcagtg catattcttt tgcaaagttc tttggtttga caagcattag tgacaaaggc
     5461 agaaaagatt tatcagccat gctaaaagag tgaagaattt tgatctttag agacactagt
     5521 tttggccaac ttaagatttt acgttaattt ttacatagta tttgacactc atgcaaaata
     5581 atgtgaaaac atctagattt agtagtttat tctgcgcctt ttgttaaaac tgaagatttt
     5641 ggaaaatggt tgtcactgct cttccagcct atgaatattt ttgtgaaatg gaaccatgga
     5701 tttatgtctg gatcatccat acagaaccaa caattttatt caaaaacaat gtgttcatca
     5761 aagtaattgc tcacattgtg cagtactatg ttgtacagac cacgtgaaag ggaatgctgg
     5821 tctagctggc gtggtatgtt tataggcgaa tttcagcaga aggaagccaa aatagttttt
     5881 tccttttgaa agttttttaa aaattatttc atgggtcttt tttttaatta atatgtgtgc
     5941 attgttacaa tgtatgttgg atgtcttttg accctaaatg ctttttttgt tatcagagat
     6001 tgtgtactat ttttattttt aataaatgta tcttcccttt ccttgtttta gatttacttt
     6061 gctcttcgtt aatcttattc ctgatgatct agaacattag tcatcaacat tacatgtttc
     6121 atgcttcaga tattttactg cttgtgtcct tattgttgga cagctttaaa cagagttgat
     6181 gtacttcaaa tatagctcat tgatacttaa ggcatcttct tggaatgtgg cttttgaaga
     6241 aaaaaattac tcaaagcaaa tcaagagtta acaaacctaa cgtaacctga ggtttaatat
     6301 tctactatca tattttttag agctataact tttgattata ttaaactgcc tccagctgta
     6361 ctatgtaaaa cagatttact tttaaaaatt acagtatacc tgctttgttc tatatgtata
     6421 tgtttaactc atgaagtgga ctcttagaag gatttgaaat ggactctggc cacagaattt
     6481 gtgagcagac agtagtagtg ataataataa aagaaggcaa tcaaaattta attttatcat
     6541 gccctctcac aggtttgtgt tataattgta agcccatatt acttgtgtta gtagttttgt
     6601 ctctataggt aacataatga cagtggtgta aagtttctgt tcaagaaaca tatgttgtaa
     6661 agttacttta tacaagatac ctgccaaagg aaatggtctt actttcaaat gactttgaaa
     6721 gcatgtataa ttgcaaacag agcaggagaa gactttaatc agaatttcct tgtgtccttt
     6781 tcctttacta agtgttttga ataaagaaaa aaaaaatgta tgacctcaga gaatgaatac
     6841 ccttcaggaa gccacttcct gattttagtg gataatattg ttctctgtag cacaaagatt
     6901 taaagtccta gaatttctaa tcctagttct cagaattgta gaatatgaca aaaataatgg
     6961 tttccccatt tgtccactga cttcagggat atttcacaag ttatttattt atagaatgaa
     7021 aactatgtag ttaaatctgt cattcagtta aacctgttgt ctttcagttt gaaatctttt
     7081 tgttatgtat gttgcaaaag aaaatttaga actattcctt tgttcactca gtcacagcat
     7141 tcagagcttt atgtttccag tggaaatgta ctgttcagtc tcaatttctt ttaattcaac
     7201 cattctcagt attagtaaca tatacctata aaatttttct aaagcaaaat ttttgattga
     7261 atttctcata aaagctcttg gaccataatt aaagtctcag ttaaactggt attcccgaaa
     7321 aacaatcttc cagtctataa attgtttgct agtacaatta aaaggtcatc tatctcataa
     7381 ctgacggctc aggtctgtcc agttgccata attgcacaac tggattccag ctgctggtaa
     7441 taaggaattg tgtagataga taaagggcaa gagtatgtct gcaatccaaa ataaatgaga
     7501 gttaacacat aattagcctt ttgattattt tggcagctat cctcaccatt tagtaaaggg
     7561 tatactaaca atacccaact ttatttaaca aagttttgta agcataccta agtagtaact
     7621 tgatatgctg aaaaatctga cctgtcactt cgcttcactc tgaccagtaa ttgcagattg
     7681 tcgtcaccat cctagcctat gactacatta ggattttatg acttattaac ttgaaaatct
     7741 gttctgtaag tggcattggt agaatctccc actttgctcc tcactgtcca attgtgtaaa
     7801 gattaaggta catactattg ttggtgatgc ttttacacct caacttgcta ttttaaaagg
     7861 ttatatgaac ccctcccact tttaaggata ttccctttta ctgattttcc tagctaaaat
     7921 tatatagcca tctttctaaa tattgtattt aaatctgatc taggacttgc cttattttat
     7981 catttttctt taataatctc caataaactt tctttattca ttaa
//
