LOCUS       NM_207360               5744 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 12D (ZC3H12D), mRNA.
ACCESSION   NM_207360 XM_291154 XM_941985
VERSION     NM_207360.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5744)
  AUTHORS   Ye,J., Fu,Y., Wang,Z. and Yu,J.
  TITLE     Long non-coding RNA FOXP4-AS1 facilitates the biological functions
            of hepatocellular carcinoma cells via downregulating ZC3H12D by
            mediating H3K27me3 through recruitment of EZH2
  JOURNAL   Cell Biol Toxicol 38 (6), 1047-1062 (2022)
   PUBMED   34545456
  REMARK    GeneRIF: Long non-coding RNA FOXP4-AS1 facilitates the biological
            functions of hepatocellular carcinoma cells via downregulating
            ZC3H12D by mediating H3K27me3 through recruitment of EZH2.
REFERENCE   2  (bases 1 to 5744)
  AUTHORS   Wawro,M., Kochan,J., Krzanik,S., Jura,J. and Kasza,A.
  TITLE     Intact NYN/PIN-Like Domain is Crucial for the Degradation of
            Inflammation-Related Transcripts by ZC3H12D
  JOURNAL   J Cell Biochem 118 (3), 487-498 (2017)
   PUBMED   27472830
  REMARK    GeneRIF: overexpression of ZC3H12D increases the turnover rate of
            transcripts containing ZC3H12A 3'UTR.
REFERENCE   3  (bases 1 to 5744)
  AUTHORS   Zhang,H., Wang,W.C., Chen,J.K., Zhou,L., Wang,M., Wang,Z.D.,
            Yang,B., Xia,Y.M., Lei,S., Fu,E.Q. and Jiang,T.
  TITLE     ZC3H12D attenuated inflammation responses by reducing mRNA
            stability of proinflammatory genes
  JOURNAL   Mol Immunol 67 (2 Pt B), 206-212 (2015)
   PUBMED   26059755
  REMARK    GeneRIF: The data indicated that ZC3H12D could suppress both the
            initial inflammation storm and chronic inflammation by targeting
            the mRNA of cytokines as well as NF-kappaB and c-fos.
REFERENCE   4  (bases 1 to 5744)
  AUTHORS   Huang,S., Liu,S., Fu,J.J., Tony Wang,T., Yao,X., Kumar,A., Liu,G.
            and Fu,M.
  TITLE     Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex
            but Act Independently in Regulation of Interleukin-6 mRNA
            Degradation
  JOURNAL   J Biol Chem 290 (34), 20782-20792 (2015)
   PUBMED   26134560
  REMARK    GeneRIF: MCPIP1 and MCPIP4 form a complex but they act
            independently in regulation of IL-6 mRNA degradation.
REFERENCE   5  (bases 1 to 5744)
  AUTHORS   Minagawa,K., Wakahashi,K., Kawano,H., Nishikawa,S., Fukui,C.,
            Kawano,Y., Asada,N., Sato,M., Sada,A., Katayama,Y. and Matsui,T.
  TITLE     Posttranscriptional modulation of cytokine production in T cells
            for the regulation of excessive inflammation by TFL
  JOURNAL   J Immunol 192 (4), 1512-1524 (2014)
   PUBMED   24415781
REFERENCE   6  (bases 1 to 5744)
  AUTHORS   Dolmans,G.H., Werker,P.M., Hennies,H.C., Furniss,D., Festen,E.A.,
            Franke,L., Becker,K., van der Vlies,P., Wolffenbuttel,B.H.,
            Tinschert,S., Toliat,M.R., Nothnagel,M., Franke,A., Klopp,N.,
            Wichmann,H.E., Nurnberg,P., Giele,H., Ophoff,R.A. and Wijmenga,C.
  CONSRTM   Dutch Dupuytren Study Group; German Dupuytren Study Group;
            LifeLines Cohort Study; BSSH-GODD Consortium
  TITLE     Wnt signaling and Dupuytren's disease
  JOURNAL   N Engl J Med 365 (4), 307-317 (2011)
   PUBMED   21732829
REFERENCE   7  (bases 1 to 5744)
  AUTHORS   Minagawa,K., Katayama,Y., Nishikawa,S., Yamamoto,K., Sada,A.,
            Okamura,A., Shimoyama,M. and Matsui,T.
  TITLE     Inhibition of G(1) to S phase progression by a novel zinc finger
            protein P58(TFL) at P-bodies
  JOURNAL   Mol Cancer Res 7 (6), 880-889 (2009)
   PUBMED   19531561
REFERENCE   8  (bases 1 to 5744)
  AUTHORS   Liang,J., Wang,J., Azfer,A., Song,W., Tromp,G., Kolattukudy,P.E.
            and Fu,M.
  TITLE     A novel CCCH-zinc finger protein family regulates proinflammatory
            activation of macrophages
  JOURNAL   J Biol Chem 283 (10), 6337-6346 (2008)
   PUBMED   18178554
  REMARK    GeneRIF: MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a,
            Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage
            activation.
REFERENCE   9  (bases 1 to 5744)
  AUTHORS   Minagawa,K., Yamamoto,K., Nishikawa,S., Ito,M., Sada,A.,
            Yakushijin,K., Okamura,A., Shimoyama,M., Katayama,Y. and Matsui,T.
  TITLE     Deregulation of a possible tumour suppressor gene, ZC3H12D, by
            translocation of IGK@ in transformed follicular lymphoma with
            t(2;6)(p12;q25)
  JOURNAL   Br J Haematol 139 (1), 161-163 (2007)
   PUBMED   17854321
REFERENCE   10 (bases 1 to 5744)
  AUTHORS   Wang,M., Vikis,H.G., Wang,Y., Jia,D., Wang,D., Bierut,L.J.,
            Bailey-Wilson,J.E., Amos,C.I., Pinney,S.M., Petersen,G.M., de
            Andrade,M., Yang,P., Wiest,J.S., Fain,P.R., Schwartz,A.G.,
            Gazdar,A., Minna,J., Gaba,C., Rothschild,H., Mandal,D., Kupert,E.,
            Seminara,D., Liu,Y., Viswanathan,A., Govindan,R., Anderson,M.W. and
            You,M.
  TITLE     Identification of a novel tumor suppressor gene p34 on human
            chromosome 6q25.1
  JOURNAL   Cancer Res 67 (1), 93-99 (2007)
   PUBMED   17210687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031133.1.
            
            On May 17, 2019 this sequence version replaced NM_207360.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157832.1, SRR9304713.267523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409806.8/ ENSP00000386616.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AL031133.1         9771-9972
            203-577             AL031133.1         20172-20546
            578-717             AL031133.1         32815-32954
            718-952             AL031133.1         37885-38119
            953-1059            AL031133.1         42063-42169
            1060-5744           AL031133.1         43306-47990
FEATURES             Location/Qualifiers
     source          1..5744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..5744
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /note="zinc finger CCCH-type containing 12D"
                     /db_xref="GeneID:340152"
                     /db_xref="HGNC:HGNC:21175"
                     /db_xref="MIM:611106"
     exon            1..202
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            203..577
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1856
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /note="tumor suppressor TFL; Zinc finger CCCH
                     domain-containing protein 12D; transformed follicular
                     lymphoma"
                     /codon_start=1
                     /product="probable ribonuclease ZC3H12D"
                     /protein_id="NP_997243.2"
                     /db_xref="CCDS:CCDS47500.2"
                     /db_xref="GeneID:340152"
                     /db_xref="HGNC:HGNC:21175"
                     /db_xref="MIM:611106"
                     /translation="MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTG
                     SRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMS
                     HGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQA
                     VLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRL
                     LMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYH
                     PERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPAR
                     GSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLP
                     SPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRS
                     VWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLA
                     RLILLVQRCQSAGAPLGKP"
     exon            578..717
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            718..952
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1059
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..5744
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4891..4896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /note="hexamer: AATAAA"
     polyA_site      4911
                     /gene="ZC3H12D"
                     /gene_synonym="C6orf95; dJ281H8.1; MCPIP4; p34; TFL"
                     /note="major polyA site"
ORIGIN      
        1 agctgaacgt gactgtggcg tgcaggaagt ggagcattgg catgaagtgg ctcctagtgg
       61 ctgcttggcg cacgccagct gccctcctct gactccagtg gcacctgggg gcctggcctc
      121 actgacggga gaacattggc gtgaaggctg ctggcgactg ggccagcatt cattgtgaag
      181 accggaggga cacaccctgc tgctcatgtc tgcagggctc tgagaggagg aagcctgggg
      241 caggacctgc gccagtggcc gctgggcaca gcatggagca ccccagcaag atggaattct
      301 tccagaagct gggctatgac cgggaggatg tgctccgggt gttgggcaag ctgggcgagg
      361 gcgccctggt caacgacgtg ctgcaggagc ttatccgcac gggcagccgc ccgggtgccc
      421 tggagcaccc ggctgcaccc aggctagtgc ctcggggctc ctgtggggtc ccggactctg
      481 cccagcgtgg cccggggaca gccctggaag aggacttcag aaccctggcc agttctctgc
      541 gacccatagt gattgatggc agcaacgtgg cgatgagcca tggaaataaa gaaaccttct
      601 cttgccgggg aatcaagctg gctgttgact ggttcaggga cagaggacac acctacatca
      661 aagtttttgt tccatcctgg aggaaggacc caccaagagc tgacacccct atcagagagc
      721 agcacgtgct ggcggagctg gagcggcagg cggtgctggt gtacacgccg tcccgcaagg
      781 tgcacggcaa gcgcctggtc tgctacgacg accgctacat cgtgaaggtg gcctacgagc
      841 aggacggcgt catcgtctcc aacgacaact accgggacct gcagagcgag aaccccgagt
      901 ggaagtggtt catcgagcag aggctgctca tgttctcctt cgtcaacgac cggttcatgc
      961 cgcctgatga ccccctgggc cgccatggac cctccctgag caacttcctg agcaggaagc
     1021 cgaagccccc agagccatcc tggcagcatt gtccttatgg caagaaatgc acctatggca
     1081 tcaagtgcaa gttctaccac ccggagaggc cgcaccacgc gcaactggcg gtggccgacg
     1141 agctccgcgc caagacaggg gcccggcctg gcgcgggcgc cgaggagcag cggccaccga
     1201 gagccccggg cggctccgca ggagcccggg cggccccccg ggaaccattt gcgcacagcc
     1261 tcccgccggc gcgggggtcc ccggacctgg ccgccctgcg agggagcttc tctcggctgg
     1321 ccttcagcga cgacctgggg cccctggggc cgcctctccc ggtccccgcc tgcagcctca
     1381 cgccccgact gggcgggccc gactgggtgt ccgcgggcgg ccgggtgcca ggcccgctca
     1441 gcctccctag cccggagagc cagttctccc cgggcgacct cccgcctccg cccggcctgc
     1501 agctccagcc gcggggcgaa caccgcccta gggacctgca cggcgacttg ctttccccgc
     1561 gcaggccacc cgacgacccg tgggcccgtc caccccgctc cgaccgcttc cctgggcgct
     1621 ccgtctgggc ggagccggcc tggggcgacg gcgccactgg gggactttca gtgtacgcga
     1681 ccgaggacga cgagggggac gcgcgcgccc gggctcgcat cgcgctctac agcgtcttcc
     1741 cgcgtgacca ggtggaccgc gtgatggccg cgttcccgga gctctcagac ctcgccaggc
     1801 tcatcctcct ggtacagaga tgccagagcg cgggggcgcc cctgggcaag ccctaaggga
     1861 ccaacacgca cttgcaggga atggcccagc ctcgccttgc gtcttggacg ggtggacctg
     1921 tggttgccag cctggacctg agtgggccca tcatggtgcc cccttttctt taaagatggt
     1981 cagggaagcc tgcttcctcc tcctgagcgg ggttgtgggg gcctggtggc acttggtgat
     2041 cctcactgag gccggggcct gctgcgggga ggtccaccca cttccgtgga gggaatgatt
     2101 ttccatgtgc acggagactg cgggtccaag ctgcagtaga acccacaagt gggtcacaaa
     2161 atcaatttag tgggtcacca ccacaaacac agtggactgg gacagggcaa agcgcaccct
     2221 gtgccatcag gctgagtctg aactcttgtt acctatcctg tgtccccacc cccttggcag
     2281 ccatgtaact aacctcaatg tgggtcgtag tcagaagttt aaaaaagact atgaatgctc
     2341 ttgaatttca ttgcttcagg taatgtttga aatatgtagt caggtggcca ggggaggttt
     2401 gctatctgga agttttcatg ttagctattg ctaaccccac ccgcaagggc agcccagcct
     2461 ccaggtgtgg gctctcctgt gctctgaatt gtgtggctgt cctatgctgg ggacaagtgg
     2521 taggagcgct ttgtcccagg gccaccttct ggggccttca cacacatacc cccaccacac
     2581 aaacacacac acacacacac acacacacac acagtctatc atacatgtac atactcacac
     2641 acaccacaca gacacatact gtttggctaa gggttaagta tctccaatat tttattagcc
     2701 atccatcatg gcagtttcca gaataggctt tctactgtac cagctgagct gccttctttt
     2761 acttcttctt cttcttcttt ttttaaacag acagagtctc ggcccggcat ggtggctcat
     2821 gcctgtaatc ccagcacttt ggaaggctga ggcaggcaga tcacttgagg tcaggagttc
     2881 gagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa aaatttagcc
     2941 aggcatggtg gcatacacct gtagtcccag ctactcagga ggctgaggca ggagaatcac
     3001 ttgaacctgg gaggcggagg ttgcagtgag ttgagatcat gccactgcac tccagcctgg
     3061 gcagcagagc gagactccgt cttaaaaaaa aaaaaaagac agagtctcac tctgtcactc
     3121 tgtctggagt atagtagtgt gatcatagct cactgcagcc tcaaactcct ggattcaagt
     3181 gatccccctg cctcagcctc ctgagtaact gggactgtaa acatgacagc cgcacttcac
     3241 agttacactg gggctggatg agtcaggact tttgctctca aatctacagg tgggttagga
     3301 gaaaactgac atgagctcag tcagagttta ttgccacctt cctggtgccg tttcttctag
     3361 ccagctactg ctctgggttt gaggagaaag ggcctactca tttgcaatgg ctaagaagtg
     3421 agatggtgct gccagagtgc cgacccccga atcctcaggg gccctggcct ctcctggcag
     3481 catccaccca ttctggttac catgccagcc ctccagacta tggctcattt gttcactaga
     3541 gggcttggta gcttggcagt ttggggaaag cgggaggcac ttcccagggg aagaccagag
     3601 aagaccagcc cccagcccca caaacttcct gcagcctgct ggtgcagagg gaactcttgc
     3661 cagtttacta ccagatttca tgagatgttg gcaggcctgg ggggcacctc agggagagtg
     3721 cgttcccagc cctttcattc atggtaaatg acacccctgg ggcatacagt gatgttaggt
     3781 ttttctctga aacttctttg atcttttaaa accagattct tagcatggat tgagccagat
     3841 ctgttcctta cccccttttt ccaaagagga cggtgcaccc acaattttac cataacatat
     3901 tgggatctca ggcctgaaga tgacccattc tttgtaaata agttggattt tcctcataat
     3961 atgtgtgggt ttttttggtg ggggaggagg gggcagggtt ccgctctgtc atctgtcacc
     4021 caggctggag tgcagtagtg caatcagggc tcactgcagc tttgacttcc caggctcaag
     4081 caatccttgt gcctcagcct cctgagtagc tgggactaca gttgtgccac cacgtccagc
     4141 taattttttc tattttttgt aaagacccaa agcgttggga ttacaggcat gagccacctc
     4201 aacgggcctt tatttttttt attttaattt ttattattat tatttttgaa acggagtctc
     4261 gctctgtcac ccaggctgga gtgcagtggc gcaatcttgg ctcactacat gctccactgc
     4321 ctcccaggtt catgccattc tcctgcctca gcctcccaag tagctgggac tacaggcgcc
     4381 cgccaccaca tctggctaac tttttgtatt tttagtagag atggggtttc accgtgttag
     4441 ccaggatggt ctcgatctcc tgaccttgtg atccccgcct cagcctccca aagtgctggg
     4501 attataggcg tgagccaccg cgcctggccc cgggccttta tttttatttt taaccttttg
     4561 acaagacacg ctttctatta gagctgcttt ttgtctccct ggttcgattt cctgatgtag
     4621 aatcattgtg ttgctgattt ttcagttgaa aatgtttaaa ctgcttcctt tgagaacaag
     4681 tttgagtttt agtaagctgt aaagctgttt tatttgattc actgtgaata agacaagtac
     4741 aaaaaaaaaa gtgaaaacac agcacatttc aagtgtaatc ccctttggaa tttttccaaa
     4801 gtcttagtat atgtctttgt gacagaaaaa catagatggg acaggtaaat gaaatgttcc
     4861 tagttgcata gctgttaacc atgcttcaaa aataaatcat tttttaccac acctggattc
     4921 tttattgtca aattgtctat tagtttctcc tactggcttt cccctagatt ggtctgttct
     4981 gttaaaaatt gtgggtttag actgggcacg atggctcatg tctgtaatcc cagcactttg
     5041 gtgggcttca tgagttcagg agttcgagac cagcctggtc aacctggtga gaccctgtct
     5101 ctactaaaaa tacaaaaatt agctgggtcc gtggtggggc acacctgtaa tcccagttgc
     5161 tcgggaggct gaggcaggag aatcaccttg aacccaggag gcagaggttg tagtgagctg
     5221 agactgtgcc actgcgctct gcactccagc ctgagcgaca gagtgagact ctgtctcaaa
     5281 aaacaaaaaa aagtaggcgt gaagaagact gaggttgtgg ccagtctcag cagccgcagt
     5341 tctgtgttgt tccacctggg gggatgtgag gggctcaaat ccaccttttc caggagaagc
     5401 agtgaggcca tggcaaggac ctccctttgc tggatgtgca gcaggcagtt cccaaggaca
     5461 caggctgctt gcccatttcc tagacttcta aaatcctcat tatagaacta tgaagccatc
     5521 tcatagaagc tgctcttctt gttcaaacat gcagcagagc tctcctcgac tgatcaaacc
     5581 agaggctgtt gccatcttgg gtttgccctg aggcagcctt cccagaggcc tctggaaggg
     5641 ggtttggggt agaactgtag aatgtcaggg gttgaggagt agaagcaaga caagccactc
     5701 taattggcat tcttccaaat aaaatggatc cagctttggt ttga
//
