LOCUS       NM_033390               8776 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 12C (ZC3H12C),
            transcript variant 1, mRNA.
ACCESSION   NM_033390 XM_370654 XM_931631 XM_938482
VERSION     NM_033390.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8776)
  AUTHORS   Liu,B., Huang,J., Ashraf,A., Rahaman,O., Lou,J., Wang,L., Cai,P.,
            Wen,J., Anwaar,S., Liu,X., Ni,H., Ganguly,D., Zhao,J. and Yang,C.Y.
  TITLE     The RNase MCPIP3 promotes skin inflammation by orchestrating
            myeloid cytokine response
  JOURNAL   Nat Commun 12 (1), 4105 (2021)
   PUBMED   34215755
  REMARK    GeneRIF: The RNase MCPIP3 promotes skin inflammation by
            orchestrating myeloid cytokine response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8776)
  AUTHORS   Chaudhry,M., Wang,X., Bamne,M.N., Hasnain,S., Demirci,F.Y.,
            Lopez,O.L. and Kamboh,M.I.
  TITLE     Genetic variation in imprinted genes is associated with risk of
            late-onset Alzheimer's disease
  JOURNAL   J Alzheimers Dis 44 (3), 989-994 (2015)
   PUBMED   25391383
  REMARK    GeneRIF: The Gene-based analyses revealed four significant
            associations in the WT1, ZC3H12C, DLGAP2, and GPR1 genes at p <
            0.05. in this study.
REFERENCE   4  (bases 1 to 8776)
  AUTHORS   Liu,L., Zhou,Z., Huang,S., Guo,Y., Fan,Y., Zhang,J., Zhang,J.,
            Fu,M. and Chen,Y.E.
  TITLE     Zc3h12c inhibits vascular inflammation by repressing NF-kappaB
            activation and pro-inflammatory gene expression in endothelial
            cells
  JOURNAL   Biochem J 451 (1), 55-60 (2013)
   PUBMED   23360436
  REMARK    GeneRIF: Thus Zc3h12c is an endogenous inhibitor of
            TNFalpha-induced inflammatory signalling in HUVECs and might be a
            therapeutic target in vascular inflammatory diseases.
REFERENCE   5  (bases 1 to 8776)
  AUTHORS   Liang,J., Wang,J., Azfer,A., Song,W., Tromp,G., Kolattukudy,P.E.
            and Fu,M.
  TITLE     A novel CCCH-zinc finger protein family regulates proinflammatory
            activation of macrophages
  JOURNAL   J Biol Chem 283 (10), 6337-6346 (2008)
   PUBMED   18178554
  REMARK    GeneRIF: MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a,
            Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage
            activation.
REFERENCE   6  (bases 1 to 8776)
  AUTHORS   Vasan,R.S., Larson,M.G., Aragam,J., Wang,T.J., Mitchell,G.F.,
            Kathiresan,S., Newton-Cheh,C., Vita,J.A., Keyes,M.J.,
            O'Donnell,C.J., Levy,D. and Benjamin,E.J.
  TITLE     Genome-wide association of echocardiographic dimensions, brachial
            artery endothelial function and treadmill exercise responses in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S2 (2007)
   PUBMED   17903301
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8776)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001889.5, AB096241.1, AL832893.1 and AP000901.5.
            
            On Nov 23, 2018 this sequence version replaced NM_033390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295437.1, SRR1803614.237135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278590.8/ ENSP00000278590.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AP001889.5         95341-95381
            42-1275             AB096241.1         810-2043
            1276-7533           AL832893.1         160-6417
            7534-8776           AP000901.5         22373-23615
FEATURES             Location/Qualifiers
     source          1..8776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..8776
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /note="zinc finger CCCH-type containing 12C"
                     /db_xref="GeneID:85463"
                     /db_xref="HGNC:HGNC:29362"
                     /db_xref="MIM:615001"
     exon            1..41
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2672
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MCP-induced protein 3; probable ribonuclease ZC3H12C; zinc
                     finger CCCH domain-containing protein 12C"
                     /codon_start=1
                     /product="probable ribonuclease ZC3H12C isoform 1"
                     /protein_id="NP_203748.1"
                     /db_xref="CCDS:CCDS44727.1"
                     /db_xref="GeneID:85463"
                     /db_xref="HGNC:HGNC:29362"
                     /db_xref="MIM:615001"
                     /translation="MPGGGSQEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGH
                     LYVESTDPQLSPAVPWSTVENPSMDTVNVGKDEKEASEENASSGDSEENTNSDHESEQ
                     LGSISVEPGLITKTHRQLCRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVR
                     EYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINTI
                     TRETSSLESQRSESPMQEIVTDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDW
                     FLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCY
                     DDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLG
                     RHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAM
                     SRNTAAKTANEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLP
                     TKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPSMMMAT
                     KNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERRFSLDTDYRISSVAS
                     DCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENLKCQHMHPHSRLNPQPFLQNFHD
                     PLTRGQSYSHEEPKFHHKPPLPHLALHLPHSAVGARSSCPGDYPSPPSSAHSKAPHLG
                     RSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERPGYGIDAYGYRQTYSLPDN
                     STQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRI
                     VMKRNPHMTDAQQLAAAILVEKSQLGY"
     exon            42..793
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..933
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1168
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1275
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..8776
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8749..8754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /note="hexamer: ATTAAA"
     polyA_site      8776
                     /gene="ZC3H12C"
                     /gene_synonym="MCPIP3"
                     /note="major polyA site"
ORIGIN      
        1 gctttctcgc ggggctggct atgccgggtg gcggctccca ggaatacggg gtgctttgca
       61 ttcaggaata cagaaaaaac agcaaagtgg agtcaagtac acgtaacaac ttcatgggct
      121 tgaaggatca cctagggcat gacctcggcc acctttatgt ggagagcact gacccacagt
      181 taagtccagc tgtaccttgg tcaacagtag aaaacccaag tatggatacc gttaatgtgg
      241 ggaaggatga aaaagaggcg tctgaagaga atgcaagctc tggtgactct gaagaaaaca
      301 caaattctga tcatgagtca gaacaattgg gtagcatttc agtagagcca ggcttgataa
      361 ctaagactca cagacagctc tgcaggtctc cctgtttaga gcctcacata ctcaagcgca
      421 atgaaatttt gcaagacttt aaacctgaag agtcccagac tacatccaag gaagcaaaga
      481 aaccacctga tgtggtgcga gaataccaaa caaaactgga gtttgcactt aagttaggtt
      541 attctgaaga acaggttcag cttgtactaa acaaacttgg tactgatgct ttaatcaatg
      601 atattttggg agaacttgtc aaacttggaa ataaaagtga ggctgatcaa acggttagta
      661 caattaacac tataacacgg gaaacttctt ccctggaatc tcagaggtct gaatctccaa
      721 tgcaagagat tgtaacagat gatggtgaaa atctgagacc aatagttatt gatggcagca
      781 atgtggcaat gagccatgga aacaaagaag tattttcctg cagaggaata aaattggcag
      841 tggattggtt tttggaaaga ggccacaaag acattacagt ttttgttcct gcttggagga
      901 aagagcaatc ccgacctgat gctctcatta cagatcagga aattttacgt aaattagaga
      961 aggagaaaat cctggtgttc acgccatccc ggcgagtcca ggggaggaga gtggtgtgct
     1021 atgacgacag gttcatcgtg aagctggctt ttgagtcgga cggtatcatt gtgtccaatg
     1081 ataactacag ggacttggct aatgagaagc cagaatggaa gaagttcata gatgaacgat
     1141 tattaatgta ttcatttgtc aatgacaagt tcatgccccc tgatgaccct cttggcagac
     1201 atggccccag tctggataat tttctgagga agaaacctat tgttcctgaa cacaaaaagc
     1261 agccttgtcc atatggaaag aagtgtacct atggacacaa gtgcaaatat taccatcccg
     1321 aaaggggcag tcagccacag cggtcagtgg ctgatgaact ccgtgccatg tctagaaata
     1381 cggcagccaa aactgcaaac gaaggaggac tggtgaaaag caacagtgtt ccttgtagca
     1441 ccaaggctga tagcacttct gatgtcaaac gaggtgctcc aaagaggcaa tcagatccaa
     1501 gcataaggac acaagtctac caagacctag aagaaaagct tcccaccaaa aacaaattgg
     1561 aaaccaggtc tgtaccttcc ttagttagca tcccagctac ttctactgca aaaccccaaa
     1621 gcactacatc tttaagcaat ggccttccat ctggagttca tttcccacct caggatcaaa
     1681 gaccacaggg acaatatcct tcaatgatga tggcaaccaa aaatcatgga acgccaatgc
     1741 cttatgaaca gtatccaaaa tgtgactcac ctgtcgacat cggatattat tccatgttga
     1801 atgcatactc aaatctgagt ctctcaggcc cacgaagccc tgaaaggcgt ttctccttag
     1861 acacagatta tagaataagt tccgtagctt ctgactgcag cagtgaaggg agcatgagct
     1921 gtgggagcag tgactcctac gtgggttaca atgaccggtc ctatgtcagc tcccccgacc
     1981 cacagctaga ggagaatttg aagtgtcaac acatgcaccc tcacagccgc cttaatcctc
     2041 aaccgttcct gcagaatttc cacgacccct taaccagagg gcaaagttac agtcacgaag
     2101 aaccaaagtt ccatcacaag cctcctcttc cgcacctggc tctgcacctg ccgcactccg
     2161 ctgtgggcgc ccggtccagc tgtcctggcg actacccctc tcctccaagt tcagcacact
     2221 ctaaggcacc acacctaggg aggtccttgg tggccacgag aatagacagc atctctgact
     2281 ctcgacttta tgacagttct ccttcacgac aaagaaagcc ttattcccgc caggaaggcc
     2341 tgggaagctg ggagaggcca ggctatggga tcgacgccta tgggtaccgg cagacttatt
     2401 ccttgcccga taactccaca cagccgtgtt atgagcagtt caccttccag agcctccctg
     2461 agcaacagga gccagcctgg cggatcccat actgtggaat gccgcaagat cccccgaggt
     2521 atcaagacaa ccgagaaaag atttatatca atttgtgcaa catcttcccc cctgaccttg
     2581 tgagaattgt catgaaaagg aatcctcaca tgacagacgc ccagcagctc gccgcagcca
     2641 ttttagtgga gaaatcccag ctgggttatt gaaagatgat gcatctttgt ggtgtttagt
     2701 agttttttgt tcagctcaaa tgctgaggga ggtttgctac aatagcacat gtgatctcct
     2761 tctcagcaag gaggttatat agtatccatt tatgtgaaat actgtatcat ggaatctgta
     2821 tgtatagccc cacatggtgg aagtatcacg ggattgcttt acatttaaac tttttttttt
     2881 taacatttcc tttttaaagc tatatccttg gctggaaatt tttccagttt gatttaatag
     2941 atgtatctgt gatctttgat attaatcttt ggtgcatcag gggtttatat gcagcacttt
     3001 ttatccttgt tttgtgtttt attaacttgg tgtttgtcta tcaattgcaa gcaattacaa
     3061 taccttcaga atgtgggaca tttgactaga cctagcaaac tgttttttcg agccaagctt
     3121 agttagactc ttttacagct ttttaagtta tttttatttg gggaaagtgg gcttctttgt
     3181 gctataatca ttatttatag aaacaaagtt atactacagc actgacttta tattttaaac
     3241 agaatgtaag ttaccagttt tatgttgaaa tgtgttacag tatatatata ttagaatgat
     3301 ttacaatatg gcacttttcg atgtgttatt tttgtttgga tttttttttc tgttaagaaa
     3361 ttagttaatt taatatggtc aatttaaaag aaagcagatg caatcaatgg aaaaatgttt
     3421 ccatttttta aaaatgaata aggcaaaagc tgtaactgtt acaggttaga gctttgttat
     3481 ccagctatga tgtgcttctt gacagtagaa gtggaattga attcctagat ttccattaac
     3541 ctgtattttt aatatgtctg tctttttgtt ttggggcaca acaatactgg ataaaataac
     3601 cctttcacag cacttgcctg tttttaatga atctaattat tcacaatgca acttttatat
     3661 ttaacatact ctttagcttt cctgctattt atcaaggctg gcctgaggtg ggtttatgtg
     3721 ttgaggttat gcaacatttc ttgatactgc actatagaga aatggtgatg gaggagttgt
     3781 aaatggtaac ttaaaatttt tgtaagatat tgtatatttt ccattttcct gaaggtagtt
     3841 ttcttggggg ggcctgttat attattaagg ccagactctt gccacaaata gtgtagtttt
     3901 agatacagac taaggtctgt tctagtatta gtaagggata tttctggttt caaagtcatg
     3961 ggttttgcta gtggtgaata catttctgcg gagtagaaga tagattttgc agtcagtggc
     4021 agacagttgt gtgattgaca tcacttgact gttgcgtcca ggttttgaat tgtacttcac
     4081 gtaacagatg cattcagatc tttttctgta gtctgcttag atgccctggc tattctgatt
     4141 atcctacatg ctacagtttg aagtgaagcc ctgaaaaacc agaaagtacc ttttactgtt
     4201 gatacaaatt gtatcttttt aactataaga actattttga tttgtagatc tagttaaaac
     4261 acaagtatgt aactatgatt agacttttgg gcaacatttt atcccttatt taaatacaaa
     4321 tttttaaagt aaaattgagg tctagaatag attagaaaat aaaaataaca atttagataa
     4381 atagaaatgt ctgtcttagt tttatataat atattaaaac acagtaaata aatttattgg
     4441 cattttcttt ctcctaaaac ttacctagtg tgaacttaaa ataaaggtaa aatgctgcct
     4501 gaaaataatg tccaagcacc tttgactagg ataacatttt cactacttgt gtgacactgt
     4561 gtgttgcacg aagtaggatt tgggtataca gtaaatgctt ctaaaaggca ttgtgcatat
     4621 tgacataacc aataatctga accgtgttca gcaaacttaa ttcaggaaag tggtattcta
     4681 cacaattatt gctgttgtgt ttgaaatgag tgtggcactc atctgtatcc agaaataata
     4741 tgggtgaggc cacacaaccc attctgagtg gtgtctgtct gaaagcaacc ctactcgcat
     4801 gtgaaattgt tctccttgat ttggtcacta taaagcaagt ttaaatgtag aggctaactc
     4861 agtgccaaaa acagggttac aaatgtgtag tatcttttat tttagtcata ttctaagact
     4921 tctttttagt atgaaatcac ttttaaatta tacatgtagg ttttgcttcc attttcttca
     4981 ttttaccatt ttaattattt gaacattcgc caaattttac atttatttaa atgagatctt
     5041 aggtgagatg tgtgtgacac tttgaatttg accttcttgt gttattagct gactatttgt
     5101 cattgcctca tggattttaa attatgggaa aatagtgtag ccagctgcca cctctactga
     5161 agtgagtagc tctgaactac ccacactaaa tccttcagtg taattaatta tgagtttaaa
     5221 aatagcagtt ttcttatgtg aagaggacag tttgtcccct ttttttgaag caccgatgtt
     5281 gcgttcagag ctgtagaatg agataattgg cagactttag gtacagcaaa ttcttactta
     5341 tctaaagcaa taagtcaaag gagtccatca ttaaattaaa tccatagctg atcacaagcc
     5401 ttcattttag ccaaaacttt ctctctaacc aaatctttta ccagacttgc taataaataa
     5461 ccagagagat gtgttaataa gtgaagttgc cagaaatggt caactgatcg gaaaaaaaag
     5521 gattcagact ggagtatttt gcccctgaat aattgacagt tgactgtgct ttacacagta
     5581 actagccagt ctgttgtctc tgtgtcttag tccagaggga atagtaccca attggccaaa
     5641 tactggccct tagtatctcc tcctttcttg catgggatac agacgttttc agtcttgttt
     5701 ttatgatctc tctctatatc ctgataagag tttgtcattg acttacacat ttggaagaaa
     5761 tgcacaccag tgtaatatat ttgatactgg tggaaacttg aactttgtgt ttttatgaaa
     5821 attcatttat gagaatatgt aatataactg aagagtattt tatgtatatc tatatacaca
     5881 aatatgtatt tgttatgagg tattaaaaac aggggttggg gggagtgctt ctgatggcta
     5941 acttttctct aattaaacta tgtttctttg agttgtgaac gaccgagtct ggggtctgga
     6001 cggccaatga taagatttag aaccacttgg atggaaagca gttcttcact ggttttattc
     6061 ttggtatttt caaagaatta ttttgatatt tttaatagaa tgtgtaattt taaaatacac
     6121 aaaaaactta aagtagtatt gattatacaa ataattattt aacatgtctt atggatgtat
     6181 ctatatgtat atagacagta atatatttat aaaacaaata tactttgctt atgttatagc
     6241 tcttagtttg tgacaggtgg gaggatggct ctgggtgtgt gtgtgtgtgt gtgtgtgtgt
     6301 gtgtgtgtgt gtgtgttttg aaaactctca agctgttttc cctctgattt acaatggtat
     6361 ttactttaaa gtatgtttgg ttttcattat tctttttgct ctccaacttc cttattcaag
     6421 ataaaataag acatacagtt ttctggccat tctgttggtg tgtggtgcac ccattttatt
     6481 gtcatctaac tcctggagaa ttcccacgtg acctgaaatc aaacagattc tggctggaca
     6541 tatgcttatg ttccaaatat attaaagatg ttaattcagc taacagttaa gtttccaagg
     6601 tatacaccaa caaataaaat gaggtattaa aaagagatgg attacacaca tgcattagaa
     6661 taagagaaaa cagtagtgtt aataaaagta aagaaacata cactatctta gccccctagg
     6721 gcaggggttg actttttctg taaaggatca gatagtaaat aatacaggaa tcatatggac
     6781 ttcaaatgcc attgtaaaaa ctactcagct ctgcctttag agcataagaa cagccacaga
     6841 taacatgtaa attagtgtgg ctgtgttcca ataaaacttt atttacagaa acgggaagcc
     6901 ggtcagattg ggcctgtggg ccataatttg ctgatctcaa gcagtaaatc ctggtatatg
     6961 ttaatagaag aaatcataat tgcatttcag ttgacattaa aagaaaatct ggtagttttt
     7021 gatgtccttc aaaagaggat tgttagacat tgatgttaaa gcatcttaat tcatttgagt
     7081 tttcttacct gtttacaccc attatttatt agagatattt cttgtgttta accacaaaaa
     7141 aaagcactct gttaaaatgt tttaatatgt attgaatttc tttcataaac ttttcatttc
     7201 tgttgataaa tgggaatccc ttaccaacct tttgtttttt aaaagtctca tagaccaaaa
     7261 aaaatctgtt gcagcattta attagccaca gatacatttt ggctgcattt accagttaca
     7321 tttttccatt ggttttggct tctaataaat aacatatctg ccattcttta aaaatgattt
     7381 taaagaagat aaatatattg taatttcaca tgctatagct ttattctgta agattaaaaa
     7441 ttgtgactag tataattgta gctataatgt gagtggcatg ttacaatgta actctttatg
     7501 agaaataaaa tgtatctctg ctttgtctgt ccagatcttt aggattttta gatgccttgg
     7561 gactgtcctt ggtgaatgat attcttcata tgatcatatg taattttgaa ttcgttggaa
     7621 gtacacgctg ctgagcatgt ttattcacag tgctttatac cgggtgttgc atcagtaatc
     7681 attttcataa gaacatttaa acagcatgaa catcatcatc cacttaaata gttaaacttt
     7741 cttttaaaat tggaatgcaa ctgtaggttt taacaatgtt tattgttttt taagtggtta
     7801 ctttgttttt ccttaatact ttctgttaac ttaattatta ctcctgttgc agtgttactg
     7861 ttatgtatta gaagtggctt ttccccctaa gatccttagt cttttaaaga caatttaagg
     7921 tattggccat ttggcagtag aaaatgtgca tgttttaact tggttttata aaatctgtaa
     7981 tgtttcactt cttgaaccat gtaccaaatt tgccaatttt ctgtccaagt gtttcagatg
     8041 aataacaaaa cgctgttcat tgaagctttc gccacctttc ttaaagcagc gtatgttcca
     8101 agggaaaaag gcattgaaaa gcaatcgttt gtttttatga agaataggtg ttcagattcc
     8161 ttcagttttt ttgaaattag aaatttctta ccttatgtga aatattcaca aacgtgcaca
     8221 cttctgcaga gacaaagcat ttcactgcac gtgtaccagg ttattgattt tatcttttcc
     8281 tttcagggtt ttgtcctccc aaaccagagt catatgctgc tagtagaatt ttttatttga
     8341 tcctgcgaac ttttcttata ggaaaagtaa ggcaaaggat gtgtagtgca accatctgat
     8401 aaactagtgt gattgtattt atcctctgtt ctgtgtattt ctgtaatgga atctttacaa
     8461 ttcccaaaac ggtattttag acctactgga aatctgtatc gaaacagcta tgtgattctg
     8521 ccactgagaa aaaaaaaatt tttaattcgt ttttcttatg ctggtttgtt tttctttaat
     8581 gaagaaattg atctcatatg gcatcataga tgctaaataa ataaaagcat catacttctc
     8641 tagtttgcct gcattcagtg gctaacatta tgagcattgt gtaagataaa cacatggtca
     8701 gtatcaatgt aaatgttaga gccatgatta attcctatga aaattgaaat taaatgtcaa
     8761 agacaactag acataa
//
