LOCUS       NM_001010888            8269 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens zinc finger CCCH-type containing 12B (ZC3H12B), mRNA.
ACCESSION   NM_001010888 XM_293334
VERSION     NM_001010888.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8269)
  AUTHORS   Sowinska,W., Wawro,M., Biswas,D.D., Kochan,J., Pustelny,K.,
            Solecka,A., Gupta,A.S., Mockenhaupt,K., Polak,J., Kwinta,B.,
            Kordula,T. and Kasza,A.
  TITLE     The homeostatic function of Regnase-2 restricts neuroinflammation
  JOURNAL   FASEB J 37 (3), e22798 (2023)
   PUBMED   36753401
  REMARK    GeneRIF: The homeostatic function of Regnase-2 restricts
            neuroinflammation.
REFERENCE   2  (bases 1 to 8269)
  AUTHORS   Luningham,J.M., Chen,J., Tang,S., De Jager,P.L., Bennett,D.A.,
            Buchman,A.S. and Yang,J.
  TITLE     Bayesian Genome-wide TWAS Method to Leverage both cis- and
            trans-eQTL Information through Summary Statistics
  JOURNAL   Am J Hum Genet 107 (4), 714-726 (2020)
   PUBMED   32961112
  REMARK    GeneRIF: Bayesian Genome-wide TWAS Method to Leverage both cis- and
            trans-eQTL Information through Summary Statistics.
REFERENCE   3  (bases 1 to 8269)
  AUTHORS   Liang,J., Wang,J., Azfer,A., Song,W., Tromp,G., Kolattukudy,P.E.
            and Fu,M.
  TITLE     A novel CCCH-zinc finger protein family regulates proinflammatory
            activation of macrophages
  JOURNAL   J Biol Chem 283 (10), 6337-6346 (2008)
   PUBMED   18178554
  REMARK    GeneRIF: MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a,
            Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage
            activation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355606.14, AL591202.8, AL441964.4, Z83841.1 and AL050306.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 21, 2021 this sequence version replaced NM_001010888.3.
            
            Summary: The protein encoded by this gene belongs to a family of
            CCCH-type zinc finger proteins that are involved in the
            proinflammatory activation of macrophages. The exact function of
            this family member is unknown, but it is thought to function as a
            ribonuclease. [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.2632862.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA2144120 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338957.5/ ENSP00000340839.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AL355606.14        2898-3341           c
            445-513             AL591202.8         39678-39746
            514-642             AL441964.4         81809-81937
            643-812             AL441964.4         84000-84169
            813-924             Z83841.1           91563-91674         c
            925-1688            Z83841.1           858-1621            c
            1689-1828           AL050306.5         6966-7105
            1829-2063           AL050306.5         8833-9067
            2064-2170           AL050306.5         9717-9823
            2171-8269           AL050306.5         11623-17721
FEATURES             Location/Qualifiers
     source          1..8269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq11.2-q12"
     gene            1..8269
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /note="zinc finger CCCH-type containing 12B"
                     /db_xref="GeneID:340554"
                     /db_xref="HGNC:HGNC:17407"
                     /db_xref="MIM:300889"
     exon            1..444
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..513
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..642
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..812
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..924
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1688
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1081..3591
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /note="MCP-induced protein 2; zinc finger CCCH
                     domain-containing protein 12B"
                     /codon_start=1
                     /product="probable ribonuclease ZC3H12B"
                     /protein_id="NP_001010888.3"
                     /db_xref="CCDS:CCDS48131.2"
                     /db_xref="GeneID:340554"
                     /db_xref="HGNC:HGNC:17407"
                     /db_xref="MIM:300889"
                     /translation="MTATAEVETPKMEKSASKEEKQQPKQDSTEQGNADSEEWMSSES
                     DPEQISLKSSDNSKSCQPRDGQLKKKEMHSKPHRQLCRSPCLDRPSFSQSSILQDGKL
                     DLEKEYQAKMEFALKLGYAEEQIQSVLNKLGPESLINDVLAELVRLGNKGDSEGQINL
                     SLLVPRGPSSREIASPELSLEDEIDNSDNLRPVVIDGSNVAMSHGNKEEFSCRGIQLA
                     VDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRV
                     VCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDD
                     PLGRHGPSLENFLRKRPIVPEHKKQPCPYGKKCTYGHKCKYYHPERANQPQRSVADEL
                     RISAKLSTVKTMSEGTLAKCGTGMSSAKGEITSEVKRVAPKRQSDPSIRSVAMEPEEW
                     LSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLE
                     HMASMQYPPILVTNSHGTPISYAEQYPKFESMGDHGYYSMLGDFSKLNINSMHNREYY
                     MAEVDRGVYARNPNLCSDSRVSHTRNDNYSSYNNVYLAVADTHPEGNLKLHRSASQNR
                     LQPFPHGYHEALTRVQSYGPEDSKQGPHKQSVPHLALHAQHPSTGTRSSCPADYPMPP
                     NIHPGATPQPGRALVMTRMDSISDSRLYESNPVRQRRPPLCREQHASWDPLPCTTDSY
                     GYHSYPLSNSLMQPCYEPVMVRSVPEKMEQLWRNPWVGMCNDSREHMIPEHQYQTYKN
                     LCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLRAAR"
     exon            1689..1828
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2063
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2170
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..8269
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8246..8251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /note="hexamer: CATAAA"
     polyA_site      8269
                     /gene="ZC3H12B"
                     /gene_synonym="CXorf32; MCPIP2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcca gaggaggagg agcaggagga tgcagctgcg accgcggccc caagagggag
       61 ccgccgctgc tctgtggcca ggggggccca gggactggaa tcaggcctgg gggtcgcatc
      121 gctgagggga ctggtaacgg cggtccctcc agaggctcag gcctagtacc ccaggagggt
      181 ccgggccgct gggcgagcgc cttcccccca tcgcctcccc tcgtccctcc acgtcgatgg
      241 tggtgaagtt ggcggcgcca cggagcgcaa ggcaccaagc tgtctccctt gcacccagct
      301 cctctctggc cccggctgtt ggacacctgc gccgccgcct tctctcgccc gccgagccca
      361 ccccctgcgg cgggcggggg aggggctccc ccctgcaggg gctgcgtcga gcagggcgac
      421 gacggggacc ataggagagt aggggaagaa gccaagaatt gggagttttc tgctgatgat
      481 gctatgctaa gctgggcaga gagaccatgg cgagaaatag actaaatagc caagttgcaa
      541 gataccactg cttcttttaa gagtgatggg tttcccaggt gatacttgaa agaagagata
      601 acgaccacct atctccttca tcctggttac acaggaaggt aggctatgga ctccttttgg
      661 catttctgcc tcagcaacag aggataaaag tcatgttgtg atggataagt cacaaaagta
      721 aaaaatacag acgtggacta caggcctcca aagaagaatt gagcatgctg aggatcgatg
      781 ccagacattg gacatttttg aggtgttaag agatgtgcat gcttccaaca ttgtgaagat
      841 gtgtgtgctt tccagtcacc ttccaccatg actgtaagtt ttctgaggct gcccagtcat
      901 gcttcctgtt aagcctgcag aactggactg ataacatctg aacataccaa accacacagt
      961 caaactcttg caccatcgct accacgacat tttactacaa aagaatgcca ctgcatgtgg
     1021 attccaagca ggctaaaaag aaaaagaact gattagacct cagacgaccc actaaacggg
     1081 atgacggcca cagctgaggt agagacacca aaaatggaga agagtgcctc caaggaagag
     1141 aagcagcagc ctaagcagga cagcacagag cagggcaatg ctgattctga agagtggatg
     1201 agctctgaga gtgaccctga acagataagc cttaagagta gcgacaacag caagagctgc
     1261 caacctaggg atggtcagtt gaagaaaaag gagatgcact ccaagccaca ccgccagctc
     1321 tgtcgatcac cctgcctaga tcgtccaagt ttctcccaga gcagcatttt acaggatggt
     1381 aaacttgact tggagaagga ataccaagct aagatggagt ttgcgctaaa gctgggctat
     1441 gcagaggaac agattcaatc agtgctaaac aagctgggcc cagaatcact tattaatgat
     1501 gtattggcag agcttgtcag acttgggaac aaaggtgatt cagaagggca gatcaacttg
     1561 agtctgttag tgcctcgtgg gcccagctcc agagagattg caagccctga attgtctctt
     1621 gaagatgaaa tagataacag tgacaatttg aggccagttg tcattgatgg aagtaatgtg
     1681 gcaatgagcc atgggaataa agaagaattc tcctgcagag gaatacaact tgctgtggat
     1741 tggtttctag ataaaggcca taaagatatt actgtatttg tgcctgcatg gagaaaggag
     1801 caatcccgcc ctgatgcacc aattacagat caagatattc tacgaaaact ggagaaggaa
     1861 aagattcttg tcttcacacc atcccgaaga gtccaaggca ggagggttgt ctgctatgat
     1921 gaccggttca tagtcaaact ggcttttgat tctgatggca tcattgtgtc caatgataac
     1981 taccgagacc ttcaagttga aaagccagaa tggaagaagt ttatagagga gcggttgctg
     2041 atgtattctt ttgtgaatga caaatttatg cctccagatg atccattagg acgccacggc
     2101 ccaagccttg aaaatttctt aagaaagaga cccattgttc ctgagcataa gaagcaacca
     2161 tgtccttatg gcaaaaaatg cacctacggc cacaagtgca aatactacca tccggagcgg
     2221 gccaaccaac cccagcgttc ggtggctgat gagctccgca tcagtgccaa actgtccaca
     2281 gtgaaaacta tgagtgaagg caccctggcc aagtgtggca cagggatgtc tagtgccaaa
     2341 ggtgagataa cctcagaggt caaacgtgtg gcccccaagc gccaatcaga tcccagcatc
     2401 cggtctgtgg ctatggagcc tgaggaatgg ctgtccattg cccgtaagcc tgaggctagt
     2461 tctgtcccct cgcttgtgac tgccctaagt gttcccacaa tcccaccccc caaaagccat
     2521 gcagtgggtg cactcaacac ccgttcggcc agcagcccag tgccaggatc ctcccatttc
     2581 ccccaccaga aggcctcttt ggagcatatg gccagcatgc agtatcctcc catcttggtt
     2641 accaacagcc atgggacccc tattagctat gctgagcaat acccaaagtt tgaatccatg
     2701 ggggaccatg gctactattc aatgttaggt gacttctcca aactgaacat caacagcatg
     2761 cataaccgag agtattacat ggctgaagta gaccgggggg tgtatgcccg gaatcctaac
     2821 ctctgttctg acagccgtgt gagccatacc aggaatgaca actattcctc ttacaacaac
     2881 gtgtatttgg ctgtagctga tacccatcct gaaggcaatt tgaagctgca ccgctcagca
     2941 tcccagaacc gacttcagcc ttttcctcat ggttaccatg aagccttaac acgagtgcag
     3001 agctatggcc cagaggattc taagcaaggc ccccacaaac agtcagtccc ccacttagct
     3061 ctgcatgccc agcacccatc aactggaaca cgttccagct gtcctgcaga ctaccccatg
     3121 cctcccaata tccatcctgg ggcaaccccc cagccaggcc gtgccctggt gatgactcgg
     3181 atggatagca tttccgactc ccgcctctat gagagcaacc ccgtgaggca aagacgacct
     3241 cccctgtgcc gggaacagca tgccagctgg gacccgctgc cctgtacaac tgactcctat
     3301 ggctaccact cctatccctt gagtaacagc ctcatgcaac catgttatga gccagtcatg
     3361 gtacggagcg tgcctgaaaa gatggagcag ctttggagga atccttgggt tggaatgtgc
     3421 aatgattcca gggagcatat gatcccagaa caccagtatc agacctacaa gaacctctgc
     3481 aatattttcc cttctaacat cgtccttgca gtgatggaga agaatcccca cacagcagat
     3541 gcccagcaac tggcagcctt gattgttgct aagcttaggg ctgcacgttg atatgacata
     3601 gtacttattt ctttatacaa atatgaatat taatactaat aatacactaa tacaataatt
     3661 atagtaacta ataatttgtg ttgcgcttta caagttagag tgtttatatc atttaagcgc
     3721 ttaacaaccc tgtgaggtac gtcttactaa catcctcttt tatagagaag gaaggtgaag
     3781 gtcagtgaaa ttaagtggct agccagggtc acactgctag caaatgacta agtcaagaca
     3841 cacacccaag tcctctaaat ccaagtccca tgcccctttg cactgcacca tgcaggtaat
     3901 ggaggacaaa acccaggggg agaggtctag atgtaagaaa tcccagagga ttccattacc
     3961 agagttttcc tttttctctt ttcgtttctt tctttctttc tttatttttt ttttttgaga
     4021 cagaatctca ctctgttaca caggctggag tgcagtggca ctatctctgc tcactgcaac
     4081 ctccacctcc agggttcaag tgattctatg gcctcagcct cccaggtagc tgggattaca
     4141 ggcgtgcacc accatgccca gctaattttt gtatttttag tagagacgtg gtttcaccgt
     4201 gttggccagg ctggtctcaa actcctggcc tcaagtgatc cgcccacctt ggcctcctaa
     4261 agtgctggga ttacaggtgt gagccactgc gcccagccta ccagagtttt cgtagtcaca
     4321 tattctatat tacaaagtat ggatgatata tccaatttag agagcaaaag catcaggatc
     4381 agatcatatg ttgaattaac cttttaggtt ttttctaata gaaatattta aagctattta
     4441 aaagtaaatg catactttat tgcatggata tctgatcact caatctatat taatgaaact
     4501 atagggtcac attgaagctt ctagaactat attttaaagc tattattagc aattatattg
     4561 catgtatgaa tatatatatt tggtttgaga tgtgtgtgta tctctgtata accttttata
     4621 tagtgataat gagagggtag gctctacaca gtccttcgtc tatagctgta taggtcacta
     4681 atctgacttg atgattttaa gtcacatttc atagttttaa ctagttatga gagagaaatt
     4741 atatggcaat atttgaacat tgctttctta ggcaccagag caaagcaact ctgtttcctt
     4801 tgcacatttt acctgccaac atttattaac agttcttacc ttccaagtct cttcacctta
     4861 gcaaattagg gatcaggttg cagtcttctg cagagaaact gatggttaag ctcaagttcc
     4921 aagcatagta tgtgtgtgct acacaagctc agaagagttt gacaaggacc aggggactta
     4981 ctaccacaat ccacttccct tatcccagga gagatggcca aacccatgtg gcattaaatg
     5041 gtgaataaaa aagcttcact caaggaggga ctattggatg ctctttggac ttctgaccta
     5101 tgcagtattc aacatcattg gatgaaatgt aatggaggac agtgcacagc catgtatcca
     5161 ctttctcttc ctgtccaccc tttgggtaat aaggtcaatc attggtggaa cagaatttct
     5221 ctaggaaaca aaaccagggg attttatttg tggaaaaagg aagtttccaa aaggggatac
     5281 tgcatcttta ctaatagctg gctcagttac tcactttaaa tccatgcaaa gagtgcactt
     5341 gctgttaaat aattgttaaa tgagttatta gaaggcagga cttttggttt gggcgacacc
     5401 atttgcgcaa cttgtatctt gctcagggtg gaaaacttca tagctaaatg cctctagaag
     5461 aggtgtttat tgtttttttt aagctgcact aaatgaattc cctttttgaa tccattgtat
     5521 atttcaatat ttcgaaccat gatcagctca ctatttcctg agctggaact tgctaacttc
     5581 tatgatcgtt ttttcatgaa agttgagaag gccgggcctt ggccttttgt ttcttcatga
     5641 gaaggtgtga cactgcctat aaatgtttct tactgtgaaa cactctgaat gtgaggctgt
     5701 agtcagggtt gtttctggtg gtttgacaat ggcttgcatg ctgctttctg gctttctgtc
     5761 tctgtccaag ttgatcaata ctgcatctta accaatgttt cacttgagtt aaccacagct
     5821 ttacattcta tctcctatct tctgatcttc gtatacccca gcatattgaa aaagagtaaa
     5881 agtattttct atcaatcagg tagatccaca gagtgacagt tgccactgca gtgcttgcta
     5941 tttcacacaa acaccatttc ataccttcaa cttcttggac tttctaaatc ggactcgtgt
     6001 ctaaatcagg gtatttgaca atctcagatg atgctactgc ctatgtgcca gttagttcat
     6061 cttcctacca agatcatgaa tggcaccaca ctatccacta gctgtacaat ttacagagaa
     6121 gcacaagatt catcttgtca cctacaattc gtcttgaaca tgttcatatt tagtactcag
     6181 aaactgtgta agctcctccc aatacagaaa atatttttta aggcagcata tgtatttctg
     6241 atttactaaa aacgattgtc attctcctct cattcttctt tttggtatga accaaaagcg
     6301 gctaggagca atgcctcaaa taaccagaaa tgaccttttg ttgatacaaa ttgtatctct
     6361 ttttttcctg attgtataga aacaaatgta caaaactcat ctgaagctag gtttggcact
     6421 gaattttcac catgaggttt gtggcactgt gtgtcacagg gaagtagctc aggggttgtg
     6481 agggagcttt tatttctaaa gggcagtagt aatttataga caaaaacaat ttttcaaggc
     6541 ctctttatta ccactgcaca gctatcatgt gtaaaatttc aagcattata ttgcataagt
     6601 tctctttagc ctattaaatt taatatgtcc ttgcaaaagg gattttgtgt aaaaagtgtc
     6661 agtgttagtg actcatctgc aagaatctac aaatggagct atacaactat gaatacataa
     6721 atacagcatg gttcctagtt attagagaaa cattttcttt atattgaggt ctacgcactt
     6781 cttgactttc cattttgtct gtaattataa aacagcaaat aacaaagaag cattgggacc
     6841 ccctcggctg ccttgataat aaaatcaagc ttccttcatg ggactaagca tgtgtccttc
     6901 aggatactta cctctaagca ctcagcaggg gttactacaa agcgttttgt gtggttttca
     6961 aaaaacagtg tattttgcaa gaggtgcttt gtaattttaa ttatttcact gattttctga
     7021 cctcatagga agtctgtgcc tgttgaggcc ttcaattttg tagcttttct gatttttttt
     7081 cttctttttg tgattttgtt gttgttttca ttttgatcta aaggagaagt gtgaccccgg
     7141 agtggcatgg tcaatccagg gcaccctttc tgtaagacaa ctcaaaggaa aagaagcctt
     7201 ttcaaaggta atatcgagcc attgcactct ctcttaaggt gccaggtatg ggagaatgac
     7261 agatgcctta tggaaatggt ctacaaaact tttcttcttc taagtaataa aacacatagc
     7321 atgattctct ctccctctct ctctctctct ctgcccaccc cctgctagtt tccaggagaa
     7381 tacttctcta aaattcattt ttttctattt tggaataaat tatctttata cagtaattca
     7441 aacactgatt tccattaacc tttggccctg agttttcttc taacatagaa gagttcattt
     7501 tgagaggcac tcagttacca ttcaatctgt gctgtaagta tgggactttg tacaaatgcc
     7561 ctttttgagg gccaaaaatt tcaatacact ttgttctact ttgtgaacca ggtctggatc
     7621 tgcacagaga aagtaatgct gagctgtcca aagagtccgc tcaggtctcc ctcctaaccc
     7681 tcctctgcct tcccctagtt tgcttatcct cacgtctgac actgaggagt gcatagtctt
     7741 caactgaaat ggcactacag ttagttctca ttggaaacaa acaagtgtat ttctggaacc
     7801 tgctcgtcta aaatagtcaa tgcctttgta aagactcagc atattcaata tctattgtat
     7861 ggtagctagc tatatacata gattgactat ttttagtcct ggtttgtgta ttgttgagct
     7921 atagtagttt gctttatcca tttgtgggat taaacaatac tgtttaatgg ttgtaaactt
     7981 ttataaaatc tctttgggtt ttttgtttga cccaaacata atgtaagtct taatgacaaa
     8041 atacacaaag ttaaccagag gtgagtgaaa atatagccct tccccagttt tgtctgcccc
     8101 tataatgcac gtgcattgct ttgtaatatg ctctcgctag catgaatgtg ctatgactac
     8161 ttcatgaggt tttgtttcac ctataattgt gatggaaaat gctgtattgc tgacaacaat
     8221 gaactgtaac cacagttatt tactgcataa actatttgtg tactaacca
//
