LOCUS       NM_024643               3923 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger C2HC-type containing 1C (ZC2HC1C),
            transcript variant 1, mRNA.
ACCESSION   NM_024643
VERSION     NM_024643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Qiao,Y., Shao,T., Chen,Y., Chen,J., Sun,X. and Chen,X.
  TITLE     Screening of candidate genes at GLC3B and GLC3C loci in Chinese
            primary congenital glaucoma patients with targeted next generation
            sequencing
  JOURNAL   Ophthalmic Genet 44 (2), 133-138 (2023)
   PUBMED   36193031
  REMARK    GeneRIF: Screening of candidate genes at GLC3B and GLC3C loci in
            Chinese primary congenital glaucoma patients with targeted next
            generation sequencing.
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY031397.1, AK026746.1, AL049780.4 and AK223359.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024643.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.95260.1,
                                           SRR1660803.70129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524913.3/ ENSP00000435550.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                HY031397.1         65-89
            26-232              AK026746.1         25-231
            233-1220            AL049780.4         90089-91076         c
            1221-1701           AK026746.1         1218-1698
            1702-1787           AK223359.1         1187-1272
            1788-2024           AK026746.1         1785-2021
            2025-3923           AL049780.4         81766-83664         c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3923
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /note="zinc finger C2HC-type containing 1C"
                     /db_xref="GeneID:79696"
                     /db_xref="HGNC:HGNC:20354"
     exon            1..109
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /inference="alignment:Splign:2.1.0"
     exon            110..1466
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1499
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM164C; family with sequence similarity 164,
                     member C; zinc finger C2HC domain-containing protein 1C"
                     /codon_start=1
                     /product="zinc finger C2HC domain-containing protein 1C
                     isoform a"
                     /protein_id="NP_078919.2"
                     /db_xref="CCDS:CCDS41972.1"
                     /db_xref="GeneID:79696"
                     /db_xref="HGNC:HGNC:20354"
                     /translation="MAGLQRLASHLPVGVMLPHNTTEAPGPHSAKQDSYEQGDSSQQS
                     LKGHLRNNFQKQLLSNKELILDKVYTHPKWNTQTKARSYSYPHCTGISQQDPESDSQG
                     QGNGLFYSSGPQSWYPKANNQDFIPFTKKRVGVDRAFPLKPMVHRKSCSTGEAGTDGD
                     HNVYPRPPEPREFSSRNFGVRNQGNFSVVGTVLAATQAEKAVANFDRTEWVQIRRLEA
                     AGESLEEEIRRKQILLRGKLKKTEEELRRIQTQKEQAKENENGELQKIILPRSRVKGN
                     KSNTMYKPIFSPEFEFEEEFSRDRREDETWGRSQQNSGPFQFSDYRIQRLKRERLVAS
                     NNKIRDPVSEPSVEKFSPPSETPVGALQGSARNSSLSMAPDSSGSSGSIEEPQLGECS
                     HCGRKFLSFRLERHSNICSRMRGSKRKVFDSSRARAKGTELEQYLNWKGPASAKAEPP
                     QKSNWR"
     exon            1467..3923
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /note="hexamer: ATTAAA"
     polyA_site      2024
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /note="major polyA site"
     regulatory      3903..3908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /note="hexamer: AATAAA"
     polyA_site      3923
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
ORIGIN      
        1 agaagccagc tgagagcgcc tgcgcggctg tcggttgatg gggaggtcag gtctgggaaa
       61 ctaggccctg gggttttccc tgagcaggag cggtgcccga gggcctcagg cgtcagtcca
      121 ggccctgaat ggctggtctc cagcggttgg cgtcacatct gcctgtgggc gttatgctcc
      181 cacataatac aacggaagct ccagggcccc actcagccaa gcaagactct tacgaacaag
      241 gtgactcttc ccagcagtcc ttgaaggggc acctgaggaa caatttccag aagcagcttt
      301 tgagcaacaa agagttgatt ctggataaag tctatactca ccccaaatgg aacacccaaa
      361 caaaagcccg gagctactcc tatccccact gtactggaat cagccagcaa gatccagaaa
      421 gtgattccca gggccaagga aatggtttgt tttactcgtc aggccctcaa tcctggtatc
      481 ccaaagccaa taaccaggac tttatcccct ttacaaagaa acgagttgga gtggaccggg
      541 cgttcccatt gaaacccatg gtccacagga agtcgtgcag tacaggtgag gctggcactg
      601 atggggacca taatgtctac ccaaggcccc ctgagccgag agagttttca tctaggaact
      661 ttggtgtgag gaaccagggc aacttttctg tggttggtac tgttcttgct gccacgcagg
      721 cggagaaggc cgtggcaaac tttgacagga cggagtgggt gcagatccga agactagaag
      781 ctgcagggga gagcttagag gaggaaatcc gaagaaagca gattctcctg aggggaaagc
      841 tgaagaagac agaggaggaa ctcagaagga tccagacgca aaaggaacag gccaaggaaa
      901 atgaaaacgg agagctacag aaaattatac tccccaggag cagagttaaa ggtaataaaa
      961 gcaacaccat gtacaaacct atcttctccc cagaatttga gtttgaggaa gaatttagta
     1021 gagacaggag agaggatgaa acttggggac ggtctcaaca aaattcaggt ccattccagt
     1081 tctctgatta tagaatccag aggctcaaaa gggaaaggct ggtagcaagc aataataaaa
     1141 ttcgagaccc agtctcagag ccatcggtgg agaaattctc cccgccttca gaaacaccag
     1201 tcggtgcttt gcagggatcc gccagaaatt ccagcctgtc catggcacca gactcctcag
     1261 gttccagcgg ctccattgaa gagccacagc tgggtgagtg cagccactgt gggcgcaaat
     1321 tcctctcgtt caggctggag agacactcca acatctgcag caggatgcgg ggttccaaga
     1381 ggaaagtgtt tgactcctcc agggcccggg ctaagggcac agaactagag cagtacttga
     1441 actggaaggg gccagcttca gccaaggctg aacctcctca gaagagcaac tggagataga
     1501 agcatgaatc ttttatccat acgttccgcc aggctcgaga ggtccagcag gtaactgcca
     1561 aaggtggaaa ctgttcacac ttgcctccca tcctgcctgc agaaaaccca gactgcattc
     1621 agtgtcctca gtgtagccac cactttgctc ccaaggtggc tgagcaacac attcccaagt
     1681 gtaagaccat caagaactgt cttccacctc taaggaagca ttatagttga gcagacaaca
     1741 atggaaactt ttggatagtt cagaaagctc tgcttctctt cagcagtaaa tgggagtaga
     1801 atttgatgca aagcagaaag aaatcaaaca gctcccagat ctgcctgcag agctaaaatc
     1861 tgtgaggaga gagccactgc taagcagcag gaggcagaag gaagccccag cttcccacta
     1921 aattacaacc ttgggctggt atgctttatg ttattgccct cagaattgat gggtgaagac
     1981 actgaagagt catgagcagg ctccattaaa gctcttttct tgcatgcctg acttgtggtt
     2041 tgtgctagtt aagtgcctgc atctggttct gccttcttgt cactgcatgt atgttcagag
     2101 ttcctgttaa ctcttgcttt tgtagaagct ggagttatta ggatgtgttg gtgtcagagg
     2161 ggcatgatca cccagatagt aactcttata aaagataata caattttgct ataaggcatt
     2221 attaatggaa atctatcctt ggtctccctg gtgcataagc ctggccaaaa cccaatacaa
     2281 gtatgtaagg ttaaggcacc aatgtctcct aaaccttccc tatggtgtac tgtgtaataa
     2341 aggaaagatc tttatgtact ttacagggta gggatgggtg ttggggggga aacacattat
     2401 acttctctct acttgttctt ttctaatggg tttcatatgt taagaaagaa acctccattt
     2461 tagctgttag tagcactcta ctttcaaatc ggtttggcta aatgactgtt tagaggcagc
     2521 aaaatctacc atcaaagcaa gctgagacag gctggtcatg gtggctcatt cctataattc
     2581 cagcactttg ggaggctgaa gtgggaggat tgcttgaggc caggagttca agagcggcct
     2641 cgacaacaaa gcaagacccc atctcaaaac aaaacaaagc tgggacactg cacagtgtca
     2701 catgcccttg gcaattatag catagtcaac ttctatttca gagagtaaac tttgaaggga
     2761 aagggatcaa atctttttaa ttttctctgt gtagaatatt gcctagcaca agttagacct
     2821 tcaattagtg aggtctggag atttaaaatt aaacaagaag atgagtgagt cctacactag
     2881 tgaaatcaga gaactgataa gttaatgtct gcgagagtat tatcagttca gataggagtg
     2941 aagttagcac aacagataga aatcttagga ttactgttct gtattactca aattgttagt
     3001 ttaaaatact ggagaaaaac tgctcaattt gagctagtca acagggctag acagacaaca
     3061 aaatcctatt ttactaagta acaaatggcc actcactctt gctccatttc cactgcactc
     3121 cagcctggtg acctagtgag actccatctc aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa
     3181 ttgggctaac agatcagacc aatttgaaat gtgagttaag gctttagcgg tgaagctgca
     3241 ggacacaggc tgggaaaaaa tcctatatat ttaaatagga gcacacattt ctttgcactc
     3301 tttttaattg ttccaaagga aaggaggtat cacataataa agctttatgg ttagcccctt
     3361 aaggaaacct cacacagaga taatggatat ttaacctaat aggtacattc cctaggcaag
     3421 ttcaatgaaa tgtacacttt aagtgggaat gtaaaccagt acattgcaat agatggcaag
     3481 agtaagctgt ggccaaggtc acaaaatggc aacatgtgga ttgctttgct ccacagatgt
     3541 tttatttcgc tggcctagca ttcataatat gatctgacat ttaaaaactg ggatatggaa
     3601 catctcttga aaaactggaa gttctggaaa cactgggcca gcaacccgca tggcacaaat
     3661 tgggtggggt ttagaatcag atgctcctcc agatgggaat ggtagcacca gaccactgca
     3721 gtctcacttg gcctgcttca cttctttacc ttatctgcct ggtaccacag gcacttggat
     3781 ttgggatcgc tggatgttag taaggtcata gatccgggcc ctccagagag aacaaattgt
     3841 tgttatatgt ggggagtgct ttctaaaaag gaagcagttg tttgctctca ttttgctaaa
     3901 gaaataaaac aatagtcaat gcc
//
