LOCUS       NM_016010               3310 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger C2HC-type containing 1A (ZC2HC1A),
            transcript variant 1, mRNA.
ACCESSION   NM_016010
VERSION     NM_016010.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3310)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3310)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3310)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3310)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA137885.1, AK313723.1, BU075578.1 and AC100854.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016010.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1091442.1,
                                           SRR1660809.62369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263849.9/ ENSP00000263849.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               DA137885.1         43-552
            511-725             AK313723.1         511-725
            726-1062            BU075578.1         2-338               c
            1063-3310           AC100854.2         5593-7840           c
FEATURES             Location/Qualifiers
     source          1..3310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..3310
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /note="zinc finger C2HC-type containing 1A"
                     /db_xref="GeneID:51101"
                     /db_xref="HGNC:HGNC:24277"
     exon            1..76
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1038
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM164A; family with sequence similarity 164,
                     member A; zinc finger C2HC domain-containing protein 1A"
                     /codon_start=1
                     /product="zinc finger C2HC domain-containing protein 1A
                     isoform 1"
                     /protein_id="NP_057094.2"
                     /db_xref="CCDS:CCDS6223.1"
                     /db_xref="GeneID:51101"
                     /db_xref="HGNC:HGNC:24277"
                     /translation="MEGLEENGGVVQVGELLPCKICGRTFFPVALKKHGPICQKTATK
                     KRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALK
                     EGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKG
                     KPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSGKVSSSSSSLGNK
                     LQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDC
                     ASSLNGGNIKGIEGHSPGNLPKFCHECGTKYPVEWAKFCCECGIRRMIL"
     exon            77..153
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            154..270
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            271..412
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            413..564
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            565..664
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            665..764
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            765..872
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     exon            873..3310
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
     regulatory      3288..3293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /note="hexamer: AATAAA"
     polyA_site      3310
                     /gene="ZC2HC1A"
                     /gene_synonym="C8orf70; CGI-62; FAM164A"
                     /note="major polyA site"
ORIGIN      
        1 agagctgggc ggtggcgggc gctgctgaag gagtctcgct gagctcgagg aggtggcgcg
       61 atggagggac tggaagagaa tggaggtgtt gtccaagttg gagaattgtt accttgcaag
      121 atttgtggaa gaacattctt tccagtagca ttaaaaaaac atggacccat ttgccagaag
      181 actgcaacta aaaaacggaa gacttttgat tcaagcagac agagagctga aggaactgat
      241 attccaacag taaaacctct caaaccgagg ccagaaccac caaagaaacc atctaattgg
      301 agaaggaaac atgaagaatt cattgctacc ataagagcag ctaaaggcct tgatcaggcc
      361 ctcaaagagg gtggcaaact tcctcctcct cctccacctt cttatgatcc tgattatatt
      421 caatgtccat attgtcagag gagattcaat gaaaatgcag ctgatagaca tataaatttc
      481 tgtaaagaac aggcagcacg tattagtaat aaagggaaat tttctacaga taccaaagga
      541 aaaccaactt ctcggacaca ggtgtataag ccacccgcac ttaaaaagtc aaattctcct
      601 ggaactgcat catcaggatc ttcacgatta ccgcagccaa gtggcgctgg caaaactgtt
      661 gtaggtgttc cttcaggtaa agtgtcttca agtagcagct ctttgggaaa caaacttcag
      721 accttatctc cctctcataa agggatagca gcccctcatg caggagctaa tgtcaaaccc
      781 cgaaattcca caccacctag tttggcaaga aatcctgccc caggtgtgct tacaaacaaa
      841 agaaaaacat atactgagag ctacatagcc aggccagatg gggactgtgc atcttccctt
      901 aatggtggaa atattaaagg cattgaagga cattcacctg gaaacttacc aaaattctgc
      961 catgagtgtg ggactaaata ccctgtagaa tgggccaaat tttgctgtga atgtggcatt
     1021 cgaagaatga ttctatgaat agaatctcaa aaaaaaaaaa aagccaagtt cagagtttat
     1081 gattattgct gcttggacag ctagagcaca tcctctagtt agtttgtgct aaaaatactc
     1141 gaaataccat ttccagttaa ttttgaagtg taatcttttg gctatataat gtgtgtatgt
     1201 ttatatgtgt acatatactg tatataataa atatctgata ccccagactg tgtcattcaa
     1261 ggaaatattc acttatctgt cagaaaataa tttcaaatgg aacaattaat ttaggtgtta
     1321 cttttctgtt gttgttaaag cacgttaagt acatttccac aaactctcat actctagtgc
     1381 ttagcccttc aagctttagg ataagtataa ctttgagcaa aaaatttgga taaacatttg
     1441 tattattggt gcctatcttc agatagtatc atagtaggat agatgctggg aattttgtaa
     1501 ttaaagagaa cagttttagt taccattagg tatgttaagg tcactcctgt agagcatgtc
     1561 aacaaattat ttcataaatc cgaaaaacta agagaaaaaa aaacccctct attagttacg
     1621 taatttaaac atcttacttg ttttgtaaaa gtgtaattat gcaatttcct tttcaaatac
     1681 acaagactaa aaatacaaat ctatcttgtt ctatttataa ctgatttttt ttagttctgt
     1741 atgtattcgt tgaacatatt tttttacttc caattgtttt tccagatttc acttttcctc
     1801 tttttccata acccgtgaag atagttttaa tttgctagtt cattttttgc tgtatttgaa
     1861 aatgtaatta tttaatatag aaggcacaga attccctgca aaatcttaca tgtttaaaaa
     1921 catataattt tttgtatctg aatttagaat aaatcatttt aatgcatctt aaatcacgtc
     1981 acctaatcat aatagttgtg gtaactaatc attagtgcag agcatgcaga taaaaaatat
     2041 ttgaattttt ttttcttgga agtacatgta gttatgagta ggttaagaga atatctaatt
     2101 ttcctactct ttttttcatc tttagcattt aatgttgaaa caccattcac gtcacattaa
     2161 ggacccactg aaaatgtatt gttttaatgc ataattgact tacctaatta aacatacaca
     2221 caaatttaat tatttttttc tctttaacct gatcacgaca cagctcttaa tcattgtcac
     2281 tttcagtata tcatagtagt tagtagtaga ttgccttgat ggcagtaatt ctgtagtaat
     2341 ttctattcaa tcaaacctaa gagagctttg atcttactgt aaaggtacaa acaaatctct
     2401 tatataattc ctagcttttt tttttgttta tgattctgat caactataag acacaatgta
     2461 aagaattgtg gcttataatt tatctgaaat ttattagctt agtttagttt gggcaggagt
     2521 tacaaactta ataggaattg tcattttact tacagtttat ttcctgatta gttgttaatt
     2581 tttttcccct cagttatctt tattcagtct tattggtcaa aacaaagaaa caaatagtcc
     2641 atcaactaaa ataagctgta atgaatttag aagatgaatg catatattag atttccattt
     2701 aaatcacttc tgttataaat catataaaga actttaaact tgttttatct aatactgagc
     2761 actgtttttt tgtcaagtat ttttttaaga ccacataatt ctttttgtct gctcaaggaa
     2821 aggatagata aataattggc acacatttgt ttctcactga attttacagt agtaaattaa
     2881 tgttataatg taccacatgg agatgagttg gtaagaaatc atctagttcc agagcccaga
     2941 gattataaac agtaggtgaa atagatttat gacttacgaa atatgttgtg acaatatatt
     3001 taaatgcatt tttatattac ttgcatattc tcacattgat ttgtgcaata gttcagtttt
     3061 aaaaaaaatc ttcctatgca tcatgtattt tatttttatt tattttcaca agtatttgac
     3121 agtatggtag aataaaagat gattgtaaga ttaaaaatgt aaaaattgct tatgtattat
     3181 tctgaattgt gttaggttga aaaagatgat tgtggtgact attatttctt gtccactatt
     3241 tgttttttgt tttttcacca ataatgtctt catatttgaa cctattcaat aaagacatga
     3301 agcataaaaa
//
