LOCUS       NM_152735               2715 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 9 (ZBTB9), mRNA.
ACCESSION   NM_152735
VERSION     NM_152735.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Siedlinski,M., Cho,M.H., Bakke,P., Gulsvik,A., Lomas,D.A.,
            Anderson,W., Kong,X., Rennard,S.I., Beaty,T.H., Hokanson,J.E.,
            Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators; ECLIPSE Investigators
  TITLE     Genome-wide association study of smoking behaviours in patients
            with COPD
  JOURNAL   Thorax 66 (10), 894-902 (2011)
   PUBMED   21685187
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662799.16, AK122644.1, BX488390.1 and BC014978.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152735.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014978.1, AK122644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395064.3/ ENSP00000378503.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL662799.16        106945-106947
            4-369               AK122644.1         1-366
            370-567             BX488390.1         364-561
            568-2715            BC014978.1         552-2699
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2715
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /note="zinc finger and BTB domain containing 9"
                     /db_xref="GeneID:221504"
                     /db_xref="HGNC:HGNC:28323"
     exon            1..200
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /inference="alignment:Splign:2.1.0"
     exon            201..2715
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1693
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 9"
                     /protein_id="NP_689948.1"
                     /db_xref="CCDS:CCDS4780.1"
                     /db_xref="GeneID:221504"
                     /db_xref="HGNC:HGNC:28323"
                     /translation="METPTPLPPVPASPTCNPAPRTIQIEFPQHSSSLLESLNRHRLE
                     GKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQL
                     IYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRELETSGGGISARGGNSYHALL
                     STTSSTGGWCIRSSPFQTPVQSSASTESPASTESPVGGEGSELGEVLQIQVEEEEEEE
                     EDDDDEDQGSATLSQTPQPQRVSGVFPRPHGPHPLPMTATPRKLPEGESAPLELPAPP
                     ALPPKIFYIKQEPFEPKEEISGSGTQPGGAKEETKVFSGGDTEGNGELGFLLPSGPGP
                     TSGGGGPSWKPVDLHGNEILSGGGGPGGAGQAVHGPVKLGGTPPADGKRFGCLCGKRF
                     AVKPKRDRHIMLTFSLRPFGCGICNKRFKLKHHLTEHMKTHAGALHACPHCGRRFRVH
                     ACFLRHRDLCKGQGWATAHWTYK"
     regulatory      2691..2696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /note="hexamer: AATAAA"
     polyA_site      2715
                     /gene="ZBTB9"
                     /gene_synonym="ZNF919"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccggt ctgggacgga gctgtagcgg cactgtaact gcgagggcag cgccgcgtgt
       61 gtaacggcgg gggcgtgtcg gcgggaagga caatcgggcc gggactcgcg gtgtccgggt
      121 gaccgcggct tcccgggagc agacctctgt gggcactgtg aggcggaacg gagcggcggg
      181 gcaggagctg ttctgggcag ccttcatccc gcgtggagtc tacccccaag cccttctcct
      241 cttcccaatt cttgtcacct tcgaggaggc catggaaacc ccaacacctt tgccgcctgt
      301 acccgcctcc ccgacctgca acccagcccc acggacaatc cagatcgagt tcccacagca
      361 tagctcgtct ctgctggaat ctctgaaccg ccacaggcta gagggaaagt tctgtgatgt
      421 gtccctcctg gtgcagggcc gggaacttag ggctcataaa gcagtgttag ctgctgcctc
      481 tccttacttc catgacaagc tgcttctggg ggatgcgcct cgtctcactc taccgagtgt
      541 cattgaagcc gatgccttcg aggggctgct ccagctcatt tattcagggc gtctccgcct
      601 gccactggat gctcttcctg ctcatctcct tgtggccagt ggccttcaaa tgtggcaggt
      661 agtagatcag tgctcagaaa ttcttagaga attagaaact tcaggtggtg gaatttcagc
      721 ccgtggagga aactcctacc atgcccttct ttccactaca tcctctacag gaggctggtg
      781 cattcgctct tcgcctttcc agaccccagt acagtcctct gcttctactg aaagccctgc
      841 ttccactgag agccctgtgg gaggggaggg aagtgaactg ggagaagtgc tgcaaattca
      901 ggtggaagaa gaagaggagg aggaggaaga tgatgatgat gaggaccagg ggtcagccac
      961 actctctcag actcctcagc cccagagagt atcaggggtt tttccccgtc ctcatggacc
     1021 ccacccactg cccatgactg ctactccccg aaagcttcca gagggtgaga gtgcaccact
     1081 tgagcttcct gcccctcctg cactgccccc caaaatcttc tacattaagc aggaaccctt
     1141 cgagcctaag gaggagatat caggaagcgg aactcagcct ggaggagcaa aggaggaaac
     1201 caaagtgttt tctggagggg acactgaagg gaatggggag ctagggttct tgttgccttc
     1261 agggccaggg ccaacatctg ggggaggggg tccatcctgg aaaccagtgg atcttcatgg
     1321 gaatgaaatc ctgtcagggg gtggaggacc tgggggagca ggccaggccg tgcatgggcc
     1381 tgtgaagcta ggggggacac cccctgcaga tggaaaacgc tttggttgcc tgtgtgggaa
     1441 gcggtttgca gtgaagccaa agcgtgaccg gcacatcatg ctgaccttca gccttcggcc
     1501 ttttggctgt ggcatctgca acaagcgctt caagctgaag caccatctga cagagcacat
     1561 gaagacccat gctggagccc tgcatgcctg tccccactgt ggccgtcggt tccgagtcca
     1621 tgcctgtttt ctccgccacc gggacctatg caagggccag ggctgggcca ctgcccactg
     1681 gacttacaag tgactgctga ggctatacac tagcttctag aacaagataa ccactgctgc
     1741 tgatggatac ttttccctca ctgccatggc acaccagtca tggatcttgt aatcatgcca
     1801 agagaataga tacattatgg acctcttgtt cttagatatg ggcctctcag cctggcagat
     1861 gtggaaactc aaatttctcg tcccactcca ggttttggct agccaaccct gcaggaaagt
     1921 ggtttatagg ccattcatac ttaagttgat cacttgccca tggtggacat ttttgtggtg
     1981 gtgatgtcca ttaaggaaac cagattttca attatttagt gagagaagag ttagagcaaa
     2041 agacagtggt aaatgtttta ttccgtctcc atgaggaatt gaaggagttg gtctccacct
     2101 agagatacat ttgatttaca gcttaagtaa ttcagaggct aagctctaag cttttttctc
     2161 tcattgctgg aatgatttaa gcagaagtcc ttttgtgtac ttttaaaatt gtatctttcc
     2221 aggagcccct cagattgtac cttgctttct caccaataga caccttcccg acactttttt
     2281 aatgttgtag ctgagcactt taacaagttg agcattccat gtttcattct tagaaccttc
     2341 tttaatagag ggtcttccct caacagcctg tgcctctggt ctacctttga ccaccactga
     2401 taactaatat attggtcaca atgactggaa tgtgactagt gatctcagga gatggcactg
     2461 tcctaaagtg ctgtcagggt ggcaccactg ctctctgaac aacttacctt ggtcagaggg
     2521 actcaggttt gggacagcac aagctgaagg ctggagagta acttgcatag taggaccata
     2581 cctcttcctt tcccatccca cccacatatg atagacagcc cctctgttga gatatggagg
     2641 ggacagatac tggaatcggg ggtgggactt gcagttactt aaaatttttt aataaactgt
     2701 gccctgaaac ctaaa
//
