LOCUS       NM_178547               1567 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 8 opposite
            strand (ZBTB8OS), transcript variant 1, mRNA.
ACCESSION   NM_178547
VERSION     NM_178547.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Mason,C.C., Khorashad,J.S., Tantravahi,S.K., Kelley,T.W.,
            Zabriskie,M.S., Yan,D., Pomicter,A.D., Reynolds,K.R., Eiring,A.M.,
            Kronenberg,Z., Sherman,R.L., Tyner,J.W., Dalley,B.K., Dao,K.H.,
            Yandell,M., Druker,B.J., Gotlib,J., O'Hare,T. and Deininger,M.W.
  TITLE     Age-related mutations and chronic myelomonocytic leukemia
  JOURNAL   Leukemia 30 (4), 906-913 (2016)
   PUBMED   26648538
  REMARK    GeneRIF: ARCH mutation is associated with chronic myelomonocytic
            leukemia.
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Jurkin,J., Henkel,T., Nielsen,A.F., Minnich,M., Popow,J.,
            Kaufmann,T., Heindl,K., Hoffmann,T., Busslinger,M. and Martinez,J.
  TITLE     The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA
            and controls antibody secretion in plasma cells
  JOURNAL   EMBO J 33 (24), 2922-2936 (2014)
   PUBMED   25378478
  REMARK    GeneRIF: RTCB, the catalytic subunit of the tRNA ligase complex,
            and its co-factor archease mediate XBP1 mRNA splicing both in vitro
            and in vivo.
REFERENCE   5  (bases 1 to 1567)
  AUTHORS   Popow,J., Jurkin,J., Schleiffer,A. and Martinez,J.
  TITLE     Analysis of orthologous groups reveals archease and DDX1 as tRNA
            splicing factors
  JOURNAL   Nature 511 (7507), 104-107 (2014)
   PUBMED   24870230
  REMARK    GeneRIF: archease (also called ZBTB8OS), a protein of unknown
            function, is required for full activity of the human tRNA ligase
            complex and, in cooperation with DDX1, facilitates the formation of
            an RTCB-guanylate intermediate central to mammalian RNA ligation
REFERENCE   6  (bases 1 to 1567)
  AUTHORS   Popow,J., Englert,M., Weitzer,S., Schleiffer,A., Mierzwa,B.,
            Mechtler,K., Trowitzsch,S., Will,C.L., Luhrmann,R., Soll,D. and
            Martinez,J.
  TITLE     HSPC117 is the essential subunit of a human tRNA splicing ligase
            complex
  JOURNAL   Science 331 (6018), 760-764 (2011)
   PUBMED   21311021
REFERENCE   7  (bases 1 to 1567)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   8  (bases 1 to 1567)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY151084.1 and AL033529.25.
            
            On Oct 29, 2020 this sequence version replaced NM_178547.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.106358.1,
                                           SRR18074969.1432910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000468695.6/ ENSP00000417677.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AY151084.1         35-717
            684-1567            AL033529.25        131961-132844       c
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..1567
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /note="zinc finger and BTB domain containing 8 opposite
                     strand"
                     /db_xref="GeneID:339487"
                     /db_xref="HGNC:HGNC:24094"
                     /db_xref="MIM:615891"
     exon            1..118
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..525
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein archease; archease-like protein; archease (ARCH);
                     zinc finger and BTB domain-containing opposite strand
                     protein 8"
                     /codon_start=1
                     /product="protein archease isoform 1"
                     /protein_id="NP_848642.2"
                     /db_xref="CCDS:CCDS365.2"
                     /db_xref="GeneID:339487"
                     /db_xref="HGNC:HGNC:24094"
                     /db_xref="MIM:615891"
                     /translation="MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHA
                     WGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSA
                     DEFFIPREVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPE
                     VFVIIDI"
     exon            119..143
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..265
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..348
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..401
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..438
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1567
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      536..541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /note="hexamer: AATAAA"
     polyA_site      557
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /note="major polyA site"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="ZBTB8OS"
                     /gene_synonym="ARCH; ARCH2"
ORIGIN      
        1 agagtgtcta atcctgcagt catggcgcag gaagaggaag atgttagaga ttacaatttg
       61 actgaagaac agaaggcgat caaggccaag tatccgccag tcaataggaa gtacgagtat
      121 ttggatcata cagcagatgt ccagttacac gcatggggag atactctgga ggaagcattt
      181 gagcaatgtg caatggccat gtttggttac atgacagata ctgggacagt ggagcccctc
      241 caaacagtag aagtagaaac ccaaggagat gacttacagt ctcttctgtt tcactttttg
      301 gatgaatggc tttataagtt cagtgctgat gaattcttca taccccggga agtgaaagta
      361 cttagcattg atcaaagaaa tttcaaatta cgatcaattg ggtggggaga agaattttca
      421 ttgtccaagc accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc
      481 tataatgaag agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa
      541 aagactccta cgaagaactg tttttgtttt cctcttcctt ttgagaagac actatgaatt
      601 aaattctaca gctttttttt gatatatgga aatttgtaga acagaaatat tttagttaaa
      661 gtgtgacttt cagaaaggga aaatcagggc acagccttgg tctgtgttcc ccaaatattc
      721 acactttaaa gaattcttca accccccaag ggacagttat ggtcctttga ttctctgctg
      781 tggcagtagg tgtgcctcat gcccttccag tgcaatgcaa gccctccagc ctcaccccag
      841 agaggatcac tgatgtcagc agcagcctga ggctgaatcc aggttgaaag aagaataact
      901 tgaaaaaata tatttccaca cacagaattt tgtttttctt ccaagttggt taagacatat
      961 attttgtttc tttttttttt ttttttttga gacggagtct cgctctgtag cccaggctga
     1021 agcgcagtgg tgtgagctcg gcttactgca agctccacct cccgggttca cgccattctc
     1081 ctacctcagc ctcccgagta gctgggacta taggcacccg ccaccatgcc cggctaattt
     1141 ttgtatcttt agtagagacg gggtttcact gtgttagcta ggatggtctt gatctcctga
     1201 ccttgtgatc cgcccacctt ggcctcccaa ggtactgcga ttacaggcat gagctaccat
     1261 gcccggccac aagacataga ttttctatat gcacatcaag ggaggtgctg gtttaggttg
     1321 ctataggaca gagctatcct gtattccagt tggtttttgt agagaaacaa ttagacttct
     1381 ctagatagag ccctgatttt tctctcacgc tttcagtttt ttaaaagcac taatgatatt
     1441 tcctgttttc tcataagaaa aagtcaatac tatgccttac aaagagacct ttccttctaa
     1501 tatagaattt tatttgaaag tgagtacatg tttataacta gagaataaaa ggagaatttt
     1561 tgaaaaa
//
