LOCUS       NM_001318841            4909 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C),
            transcript variant 1, mRNA.
ACCESSION   NM_001318841 XM_005258227
VERSION     NM_001318841.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4909)
  AUTHORS   An,X., Wu,W., Yang,L., Dong,J., Liu,B., Guo,J., Chen,J., Guo,B.,
            Cao,W. and Jiang,Q.
  TITLE     ZBTB7C m6A modification incurred by METTL3 aberration promotes
            osteosarcoma progression
  JOURNAL   Transl Res 259, 62-71 (2023)
   PUBMED   37121538
  REMARK    GeneRIF: ZBTB7C m6A modification incurred by METTL3 aberration
            promotes osteosarcoma progression.
REFERENCE   2  (bases 1 to 4909)
  AUTHORS   Chen,X., Jiang,Z., Wang,Z. and Jiang,Z.
  TITLE     The prognostic and immunological effects of ZBTB7C across cancers:
            friend or foe?
  JOURNAL   Aging (Albany NY) 13 (9), 12849-12864 (2021)
   PUBMED   33946045
  REMARK    GeneRIF: The prognostic and immunological effects of ZBTB7C across
            cancers: friend or foe?
REFERENCE   3  (bases 1 to 4909)
  AUTHORS   Prokopenko,D., Hecker,J., Kirchner,R., Chapman,B.A., Hoffman,O.,
            Mullin,K., Hide,W., Bertram,L., Laird,N., DeMeo,D.L., Lange,C. and
            Tanzi,R.E.
  TITLE     Identification of Novel Alzheimer's Disease Loci Using Sex-Specific
            Family-Based Association Analysis of Whole-Genome Sequence Data
  JOURNAL   Sci Rep 10 (1), 5029 (2020)
   PUBMED   32193444
  REMARK    GeneRIF: Identification of Novel Alzheimer's Disease Loci Using
            Sex-Specific Family-Based Association Analysis of Whole-Genome
            Sequence Data.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4909)
  AUTHORS   Hur,M.W., Yoon,J.H., Kim,M.Y., Ko,H. and Jeon,B.N.
  TITLE     Kr-POK (ZBTB7c) regulates cancer cell proliferation through
            glutamine metabolism
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (8), 829-838 (2017)
   PUBMED   28571744
  REMARK    GeneRIF: Repression of Kr-POK inhibited tumor growth.
REFERENCE   5  (bases 1 to 4909)
  AUTHORS   Du,R., Zhou,J., Lorenzano,S., Liu,W., Charoenvimolphan,N., Qian,B.,
            Xu,J., Wang,J., Zhang,X., Wang,X., Berndt,A., Devan,W.J.,
            Valant,V.J., Wang,J., Furie,K.L., Rosand,J., Rost,N.,
            Friedlander,R.M., Paigen,B. and Weiss,S.T.
  TITLE     Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as
            Susceptibility Genes to Ischemic Injury
  JOURNAL   Stroke 46 (12), 3514-3522 (2015)
   PUBMED   26542693
  REMARK    GeneRIF: ZBTB7C genetic variations were significant for
            susceptibility to ischemic injury in cerebral ischemia.
REFERENCE   6  (bases 1 to 4909)
  AUTHORS   Niu,N., Schaid,D.J., Abo,R.P., Kalari,K., Fridley,B.L., Feng,Q.,
            Jenkins,G., Batzler,A., Brisbin,A.G., Cunningham,J.M., Li,L.,
            Sun,Z., Yang,P. and Wang,L.
  TITLE     Genetic association with overall survival of taxane-treated lung
            cancer patients - a genome-wide association study in human
            lymphoblastoid cell lines followed by a clinical association study
  JOURNAL   BMC Cancer 12, 422 (2012)
   PUBMED   23006423
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4909)
  AUTHORS   Jeon,B.N., Kim,M.K., Choi,W.I., Koh,D.I., Hong,S.Y., Kim,K.S.,
            Kim,M., Yun,C.O., Yoon,J., Choi,K.Y., Lee,K.R., Nephew,K.P. and
            Hur,M.W.
  TITLE     KR-POK interacts with p53 and represses its ability to activate
            transcription of p21WAF1/CDKN1A
  JOURNAL   Cancer Res 72 (5), 1137-1148 (2012)
   PUBMED   22253232
  REMARK    GeneRIF: our findings define KR-POK as a transcriptional repressor
            with a pro-oncogenic role that relies upon binding to p53 and
            inhibition of its transactivation function.
REFERENCE   8  (bases 1 to 4909)
  AUTHORS   Zhou,M., Maitra,S.R. and Wang,P.
  TITLE     Adrenomedullin and adrenomedullin binding protein-1 protect
            endothelium-dependent vascular relaxation in sepsis
  JOURNAL   Mol Med 13 (9-10), 488-494 (2007)
   PUBMED   17932560
  REMARK    GeneRIF: Adm and APM-1 protect endothelium-dependent vascular
            relaxation in sepsis.
REFERENCE   9  (bases 1 to 4909)
  AUTHORS   Reuter,S., Bartelmann,M., Vogt,M., Geisen,C., Napierski,I.,
            Kahn,T., Delius,H., Lichter,P., Weitz,S., Korn,B. and Schwarz,E.
  TITLE     APM-1, a novel human gene, identified by aberrant co-transcription
            with papillomavirus oncogenes in a cervical carcinoma cell line,
            encodes a BTB/POZ-zinc finger protein with growth inhibitory
            activity
  JOURNAL   EMBO J 17 (1), 215-222 (1998)
   PUBMED   9427755
REFERENCE   10 (bases 1 to 4909)
  AUTHORS   Reuter,S., Delius,H., Kahn,T., Hofmann,B., zur Hausen,H. and
            Schwarz,E.
  TITLE     Characterization of a novel human papillomavirus DNA in the
            cervical carcinoma cell line ME180
  JOURNAL   J Virol 65 (10), 5564-5568 (1991)
   PUBMED   1716694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AM988839.1, BM983365.1 and AC105042.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001318841.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM988839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590800.6/ ENSP00000467877.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4312              AM988839.1         40-4351
            4313-4313           BM983365.1         18-18               c
            4314-4909           AC105042.7         95811-96406         c
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..4909
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="zinc finger and BTB domain containing 7C"
                     /db_xref="GeneID:201501"
                     /db_xref="HGNC:HGNC:31700"
                     /db_xref="MIM:616591"
     exon            1..158
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /inference="alignment:Splign:2.1.0"
     exon            159..383
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /inference="alignment:Splign:2.1.0"
     exon            384..445
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1669
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..2321
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="zinc finger and BTB domain containing 36;
                     B230208J24Rik; zinc finger and BTB domain-containing
                     protein 36; affected by papillomavirus DNA integration in
                     ME180 cells protein 1; zinc finger protein 857C"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     7C"
                     /protein_id="NP_001305770.1"
                     /db_xref="CCDS:CCDS32830.1"
                     /db_xref="GeneID:201501"
                     /db_xref="HGNC:HGNC:31700"
                     /db_xref="MIM:616591"
                     /translation="MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQE
                     YRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAG
                     NVKHILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEE
                     EEDDDDDTEDFADQENLPDPQDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGH
                     LGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMD
                     SGPLDLVIKNRKIKEEEKEELPPPPPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAY
                     LNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPY
                     MCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQC
                     EFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPAPDKAAFVMP
                     PALGEVGGHLGGAAVCLPGPSPAKHFLAAPKGALSLQELERQFEETQMKLFGRAQLEA
                     ERNAGGLLAFALAENVAAARPYFPLPDPWAAGLAGLPGLAGLNHVASMSEANN"
     exon            1670..4909
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="hexamer: TATAAA"
     polyA_site      4313
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="major polyA site"
     regulatory      4672..4677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="hexamer: ATTAAA"
     regulatory      4695..4700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="hexamer: ATTAAA"
     polyA_site      4700
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
     polyA_site      4717
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
     regulatory      4884..4889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
                     /note="hexamer: AGTAAA"
     polyA_site      4909
                     /gene="ZBTB7C"
                     /gene_synonym="APM-1; APM1; ZBTB36; ZNF857C"
ORIGIN      
        1 atacccgccg gcgcagcccc gccacgagac tctgacagcg gcgcggccgg cgaggctcgg
       61 gcgcgcaggg accggcggac accggcggcg aaggaggacg ccaggactgc gtcccggagc
      121 caagtgcggg aggcgcgcag ggccggcggc gcgcggagat cccctctgag cagctgggag
      181 ctcagaagct ctgtccaacc ctgaggagtg ggtcagccac aagagcaaga agtgatggcg
      241 tggagtccac ccagggcctg aggcatgagc agaatccacg cccattagac ctggagcctg
      301 ggcgtttggg gctgcactgc tggggagatc caagaagaat caatgctttg gcccctggtg
      361 acatgtacat ggtgtaatga caggaaatga gcagatttgc agaaaaactg gtgtcctgaa
      421 atttaaaact aaggcatcgg tgcttggctc tggctgagaa catggccaat gacattgatg
      481 agctcattgg cattcccttc cccaaccaca gcagtgaggt cctgtgcagc ctcaatgagc
      541 aacggcacga tggcctgctg tgtgacgtgc tcctggtggt gcaggagcag gagtatcgga
      601 cccaccgctc cgtcctggct gcctgcagca agtacttcaa gaagcttttc acagccggca
      661 ccctagccag ccagccctac gtctatgaga tcgactttgt ccagcctgag gctctggctg
      721 ctatcctgga gttcgcctac acctccacgc tcaccatcac cgctggcaat gtcaagcaca
      781 tcctcaacgc agccaggatg ctggagatcc agtgcatcgt gaacgtgtgc ctggagatca
      841 tggagcctgg gggggacggg ggggaggagg atgacaagga ggacgatgac gacgacgaag
      901 atgatgatga tgaggaggac gaagaggagg aggaggaaga ggaggaggat gacgatgatg
      961 acacggagga ctttgctgac caagaaaact tgcctgaccc ccaggacatc agctgccacc
     1021 aaagcccttc caagacagac catctcacag agaaggccta ttcagacacc cccagggact
     1081 tccctgactc cttccaggct ggcagtcctg gccatctggg ggtgatccgg gacttctcca
     1141 tcgaatctct gctaagggag aacctgtacc ccaaggccaa catccccgac aggagaccct
     1201 ccttgtctcc attcgccccg gacttctttc cacacctctg gccaggggac ttcggtgcct
     1261 ttgcccagct gcctgagcag cccatggaca gtgggccact ggatctggtc atcaagaatc
     1321 ggaagatcaa ggaggaggag aaggaggagc tgcccccacc cccaccgcca cccttcccta
     1381 atgacttctt caaggacatg ttccctgacc tgccgggggg gcctctggga cccatcaagg
     1441 cggagaacga ctacggtgcc tatctcaact tcctgagtgc cacccacctg ggaggcctct
     1501 tcccaccctg gcccctggta gaagagcgca agctgaagcc caaggcctct cagcagtgcc
     1561 ccatctgcca caaagtcatc atgggggccg ggaagctgcc gcggcacatg aggacccata
     1621 ccggggagaa gccatacatg tgcaccatct gcgaggtccg cttcaccagg caggacaagc
     1681 tgaaaatcca catgcggaag cacacagggg agcggcccta cctgtgcatc cactgcaacg
     1741 ccaagttcgt gcacaactac gacctcaaga accacatgcg catccacacg ggcgtgcggc
     1801 cctaccagtg cgagttctgc tacaagagct tcacgcgctc tgaccacctg caccgccaca
     1861 tcaagcgcca gagctgccgc atggcacggc cccgacgcgg ccgcaagcct gctgcgtgga
     1921 gggccgccag cctgctcttc gggcccggcg gcccggcccc cgacaaggcg gccttcgtga
     1981 tgccccctgc gctgggcgag gtgggcggcc acctgggcgg cgcagctgtg tgcctcccgg
     2041 gccccagccc cgccaagcac ttcctggcag cgcccaaggg cgccctgagc ctgcaagagc
     2101 tggagcggca gttcgaggag acacagatga agctgttcgg gcgcgcgcag ctggaggctg
     2161 agaggaacgc ggggggcctc ctggccttcg cgctggccga gaacgtggcg gcggcgcggc
     2221 cctacttccc gctgcccgac ccttgggccg ccggcctggc cggcctccct gggctcgccg
     2281 gcctcaacca cgtggcctcc atgtccgaag ccaacaacta ggctggtccc tgtcggctcc
     2341 agcccaccag ccctccagtc cttctccctc caggcccact ctaccctacc ccatggatct
     2401 gaacttttca ttttaaaaac acaaagggaa aatgggaaaa taataataat actatcagtg
     2461 atggcatttt cccgggctcc taaagcagct gcctcctttt gctggtctga gacgggcatc
     2521 ttttcccaaa aggccaggag cccgggcctc cctccctgtc tctctggctc tcatatagaa
     2581 acttgcaccg gcccatgcca caaagaactg ggtgcccagg ggcacttagg agctgggtga
     2641 gtcatgaggg gtcagggggt ggttggcctg gtgcccagcc agccacagca ggaggaggta
     2701 ggggctgggc atgcaccttg gttaagcccc accccctatg gcaaagtctc tgccaacact
     2761 cctctgaggg ctcattttcc agtctccagt ggccccgggg tctttttgag aactacccac
     2821 ctgccacata gaaagaaatg ctctgttggc agggaggcct cctggaacca gtcaggaacc
     2881 aggctctgga aggcccgggc catttcttcc ctgacctgtc ctgtgacctt gacaggtcag
     2941 ccctctgtag ctcagtgtca cctggctatg gaaggggctg gtaactgagg tttccgccct
     3001 ccacctctaa acacatacac acctatcccc ccagagaatc acagagatgg tagaagcttt
     3061 gtactcccca agtccatggg gaaacagttt atctttctgg acttagtttt atcacatcca
     3121 gctctatatt agcatattag cataggtgag aaatatggcc agactagaca gagatcaggt
     3181 catcagggga gcttccgagc ttcagcaaag cccacaggta gctctgcgaa ctcagaatgc
     3241 taccctacct tccctgcagg ccgctgttca tgtctggact cctgggggcg ctatttaatg
     3301 tttaccccca tctccagtgc cccctccaag gctgtgcagt gtcttggggc tctcagggcc
     3361 aacatcgaag agatgggggc cacctcttaa cacctggcaa cagtctcccc tcatcctgat
     3421 tcctgacaac agacaaaaca ccggtttcta gggtttatct gtttgttttt tgagttgagg
     3481 gttcctcagg gccttggcat tgctagtgat ggtccccttt gctgtgtgag aaccccctca
     3541 accccttcct cctccctctg gggatgaagt gggagtattt ggctccccat ttttgacaaa
     3601 agggctcagt gcagggaggt ggaggcctct gaggtttgaa gggctctgtg agttagagtt
     3661 gtcacatgtt ctcctggttc ttgaatttgc agcaggtcct gaaaaggaag gctctgctgg
     3721 ccccgtgcct tcctgacctt ctctctcctt ccctcccctc tcttttcttg ccaagtttgc
     3781 tttggtttct gagcagccca gagaggagga gggttcgtcc ccagggagag cccagggctg
     3841 gagtccccaa tccctgtgct atgggcacaa agagacttca gctcttcctg ttgccttggc
     3901 tttttcctga gcaaaaacac aacaaacaaa aaggccagag aagagcacag actctgtccc
     3961 tctcacaact ctccagaaga gaccccctga ttcttcacac caccggatgc cactccagcc
     4021 agcaggattg ctacacacac cctctgttct cagaagtcat ctgcctgggc agccgcctct
     4081 cagattcctg tcttcgtttc agacactttt ctctgaagca tgcccatgtc caccagccaa
     4141 cgtgcccccg tgttcccccc catcagccaa gtgattgggg ctgaaccaga ctttaaaaga
     4201 gaggaaaaaa aaaaaaaaag gaaacatgaa taaattggaa tccagtggtg ttggggcttt
     4261 tgtttttatt ttgtaaaggt gatgacttct tataaactca atttttcaga tgactggtta
     4321 gttctttctg ttttttcttg gctgcagttt ggaattgtac attgtaaaat atccaaagat
     4381 gttgagtact gtatgatcaa gaacttgaag caaatgggtt gtggggggag gggtggttgt
     4441 gtttttgttt tgcttcaatt tttttttttt tttgatgttt caatttccct gtctgtctgt
     4501 gggagaactt tggaattttt tctatttata actctttttt tatgtgattg ctctacgtaa
     4561 aatgacactc aacaaagttt gccttagtga ttcaagggac aatcttccat aacttcggtc
     4621 gcacgccaca tcccgccgag aaaaactctc agctaatttt ctggcctatt tattaaacag
     4681 tattaattga cttgattaaa ttatattgag agttgcactt ctgtgagatg tgacttctga
     4741 aagttcacag gacagcaaca agccagtctt aaggttttta attgttgggt gtcataaact
     4801 taaaataatg tcaaagacac cttaacaaag aaaaaaaaaa aaacctttga cccttatttt
     4861 atactttaaa ggacagtgtt ttgagtaaaa gtgagctatg cttgcttaa
//
