LOCUS       NM_001256455            3606 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 7B (ZBTB7B),
            transcript variant 5, mRNA.
ACCESSION   NM_001256455
VERSION     NM_001256455.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Wang,M., Wang,T., Wang,J., Yang,Y., Li,X., Chen,H. and Liao,J.
  TITLE     ALDH1A1 promotes immune escape of tumor cells through
            ZBTB7B-glycolysis pathway
  JOURNAL   Cell Death Dis 15 (8), 568 (2024)
   PUBMED   39107297
  REMARK    GeneRIF: ALDH1A1 promotes immune escape of tumor cells through
            ZBTB7B-glycolysis pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   Cui,K., Yao,S., Liu,B., Sun,S., Gong,L., Li,Q., Fei,B. and Huang,Z.
  TITLE     A novel high-risk subpopulation identified by CTSL and ZBTB7B in
            gastric cancer
  JOURNAL   Br J Cancer 127 (8), 1450-1460 (2022)
   PUBMED   35941174
  REMARK    GeneRIF: A novel high-risk subpopulation identified by CTSL and
            ZBTB7B in gastric cancer.
REFERENCE   3  (bases 1 to 3606)
  AUTHORS   Xu,H.M., Xu,J., Yang,M.F., Liang,Y.J., Peng,Q.Z., Zhang,Y.,
            Tian,C.M., Nie,Y.Q., Wang,L.S., Yao,J. and Li,D.F.
  TITLE     Epigenetic DNA methylation of Zbtb7b regulates the population of
            double-positive CD4+CD8+ T cells in ulcerative colitis
  JOURNAL   J Transl Med 20 (1), 289 (2022)
   PUBMED   35761286
  REMARK    GeneRIF: Epigenetic DNA methylation of Zbtb7b regulates the
            population of double-positive CD4(+)CD8(+) T cells in ulcerative
            colitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3606)
  AUTHORS   Xia,L., Jiang,L., Chen,Y., Zhang,G. and Chen,L.
  TITLE     ThPOK transcriptionally inactivates TNFRSF12A to increase the
            proliferation of T cells with the involvement of the NF-kB pathway
  JOURNAL   Cytokine 148, 155658 (2021)
   PUBMED   34353698
  REMARK    GeneRIF: ThPOK transcriptionally inactivates TNFRSF12A to increase
            the proliferation of T cells with the involvement of the NF-kB
            pathway.
REFERENCE   5  (bases 1 to 3606)
  AUTHORS   He,X., Park,K. and Kappes,D.J.
  TITLE     The role of ThPOK in control of CD4/CD8 lineage commitment
  JOURNAL   Annu Rev Immunol 28, 295-320 (2010)
   PUBMED   20307210
  REMARK    Review article
REFERENCE   6  (bases 1 to 3606)
  AUTHORS   Widom,R.L., Lee,J.Y., Joseph,C., Gordon-Froome,I. and Korn,J.H.
  TITLE     The hcKrox gene family regulates multiple extracellular matrix
            genes
  JOURNAL   Matrix Biol 20 (7), 451-462 (2001)
   PUBMED   11691585
REFERENCE   7  (bases 1 to 3606)
  AUTHORS   Ghayor,C., Herrouin,J.F., Chadjichristos,C., Ala-Kokko,L.,
            Takigawa,M., Pujol,J.P. and Galera,P.
  TITLE     Regulation of human COL2A1 gene expression in chondrocytes.
            Identification of C-Krox-responsive elements and modulation by
            phenotype alteration
  JOURNAL   J Biol Chem 275 (35), 27421-27438 (2000)
   PUBMED   10856292
REFERENCE   8  (bases 1 to 3606)
  AUTHORS   Heegaard,A.M., Gehron Robey,P., Vogel,W., Just,W., Widom,R.L.,
            Scholler,J., Fisher,L.W. and Young,M.F.
  TITLE     Functional characterization of the human biglycan 5'-flanking DNA
            and binding of the transcription factor c-Krox
  JOURNAL   J Bone Miner Res 12 (12), 2050-2060 (1997)
   PUBMED   9421237
REFERENCE   9  (bases 1 to 3606)
  AUTHORS   Widom,R.L., Culic,I., Lee,J.Y. and Korn,J.H.
  TITLE     Cloning and characterization of hcKrox, a transcriptional regulator
            of extracellular matrix gene expression
  JOURNAL   Gene 198 (1-2), 407-420 (1997)
   PUBMED   9370309
REFERENCE   10 (bases 1 to 3606)
  AUTHORS   Galera,P., Musso,M., Ducy,P. and Karsenty,G.
  TITLE     c-Krox, a transcriptional regulator of type I collagen gene
            expression, is preferentially expressed in skin
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9372-9376 (1994)
   PUBMED   7937772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CV572166.1, AL451085.20,
            BC012070.1 and AI270090.1.
            
            On Jan 13, 2020 this sequence version replaced NM_001256455.1.
            
            Summary: This gene encodes a zinc finger-containing transcription
            factor that acts as a key regulator of lineage commitment of
            immature T-cell precursors. It is necessary and sufficient for
            commitment of CD4 lineage, while its absence causes CD8 commitment.
            It also functions as a transcriptional repressor of type I collagen
            genes. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (5) lacks two alternate exons in
            the 5' UTR and 5' coding region, and uses a downstream in-frame
            start codon, comapred to variant 3. The encoded isoform (1) is
            shorter at the N-terminus, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.2128.1,
                                           SRR18074969.230660.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535420.6/ ENSP00000438647.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               CV572166.1         133-635
            504-538             AL451085.20        143454-143488
            539-1563            BC012070.1         528-1552
            1564-3552           AL451085.20        144919-146907
            3553-3606           AI270090.1         13-66               c
FEATURES             Location/Qualifiers
     source          1..3606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3606
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /note="zinc finger and BTB domain containing 7B"
                     /db_xref="GeneID:51043"
                     /db_xref="HGNC:HGNC:18668"
                     /db_xref="MIM:607646"
     exon            1..142
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /inference="alignment:Splign:2.1.0"
     exon            143..1302
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1768
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /note="isoform 1 is encoded by transcript variant 5; zinc
                     finger and BTB domain containing 15; zinc finger protein
                     Th-POK; T-helper-inducing POZ/Krueppel-like factor;
                     krueppel-related zinc finger protein cKrox; zinc finger
                     protein 857B; zinc finger protein 67 homolog"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 7B
                     isoform 1"
                     /protein_id="NP_001243384.1"
                     /db_xref="CCDS:CCDS1081.1"
                     /db_xref="GeneID:51043"
                     /db_xref="HGNC:HGNC:18668"
                     /db_xref="MIM:607646"
                     /translation="MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLE
                     YRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSGTATGGAGAGVCELDFVGPEALGAL
                     LEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERAR
                     QYLEAFATATASGVPNGEDSPPQVPLPPPPPPPPRPVARRSRKPRKAFLQTKGARANH
                     LVPEVPTVPAHPLTYEEEEVAGRVGSSGGSGPGDSYSPPTGTASPPEGPQSYEPYEGE
                     EEEEELVYPPAYGLAQGGGPPLSPEELGSDEDAIDPDLMAYLSSLHQDNLAPGLDSQD
                     KLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDKLKIH
                     MRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQRHLK
                     GQNCLEVRTRRRRKDDAPPHYPPPSTAAASPAGLDLSNGHLDTFRLSLARFWEQSAPT
                     GPPVSTPGPPDDDEEEGAPTTPQAEGAMESS"
     exon            1303..3606
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3591..3596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /note="hexamer: AATAAT"
     polyA_site      3606
                     /gene="ZBTB7B"
                     /gene_synonym="c-KROX; CKROX; hcKROX; THPOK; vGAF; ZBTB15;
                     ZFP-67; ZFP67; ZNF857B"
                     /note="major polyA site"
ORIGIN      
        1 agcagcgagc ggcgagcaac tgaccgcggc cttctgacca ggaccggagc agggccccaa
       61 gcccccgggc ctggtggggg acgcgcttct tcccacactg tgagcctcag cagctccagc
      121 cagcggaccc gacggctgag aggagaagat ggggagcccc gaggatgacc tgattgggat
      181 tccattcccg gaccacagca gtgagctcct gagctgcctc aatgagcagc gccagctggg
      241 ccacctatgt gacctcacca tccggacgca gggccttgaa taccgcaccc acagggctgt
      301 gctagctgcc tgtagccact acttcaagaa gcttttcact gagggcggtg gcggagctgt
      361 catgggggcc gggggtagcg ggacggccac tgggggagca ggggccggtg tgtgtgagct
      421 ggactttgta gggccagagg cactaggcgc cctccttgaa tttgcctata cagccacact
      481 gaccaccagc agcgccaaca tgccagctgt gctccaggct gcccgcctgc tggagatccc
      541 gtgtgtcatc gctgcttgca tggagattct gcagggcagt gggctagaag ctcccagccc
      601 ggacgaggat gactgtgagc gagcccgcca gtatctggag gcctttgcca cagccacggc
      661 ctctggagtt cccaatggtg aagacagtcc tccacaggtg cccctcccac cacctccgcc
      721 accgccacct cggcctgttg cccgccgcag ccgcaagccc cggaaagctt tcctgcaaac
      781 caagggggcc agagcaaacc acctagtccc tgaggtgccc acagtgcccg cccatccctt
      841 gacctatgag gaggaggagg tggcgggcag agtgggcagc agtgggggca gtgggccggg
      901 ggacagctac agccctccca caggaactgc ctcccctcct gagggtcccc agagctacga
      961 accctatgag ggtgaggaag aagaagagga gctggtatat cccccagcct atgggctggc
     1021 gcagggtggc gggcccccgc tgtccccaga ggagctgggc tcagatgagg atgccatcga
     1081 tcctgacctg atggcctacc taagctccct gcaccaggac aacctggcac caggcctgga
     1141 cagccaagac aagctggtgc gcaaacgccg ctcccagatg cctcaggagt gccctgtctg
     1201 ccacaagatc atccatgggg caggcaaact gcctcgccac atgaggaccc acacaggcga
     1261 gaagcccttt gcctgcgagg tctgcggtgt tcgattcacc aggaacgaca agctgaagat
     1321 ccacatgcgg aagcacacgg gagagcgccc ctactcatgc ccgcactgcc cagcccgctt
     1381 cctgcacagc tacgacctca agaaccacat gcacctgcac acaggggacc ggccctatga
     1441 gtgccacctg tgccacaagg ctttcgccaa ggaggaccac ctgcagcgcc acctcaaagg
     1501 ccagaactgc ctggaggtgc gcacccgacg gcgccgcaag gacgatgcac caccccacta
     1561 cccaccaccc tctaccgctg ctgcatcccc cgctggcctc gacctctcca atggccacct
     1621 ggacaccttc cgcctctctc tagctcgatt ctgggagcag tcagccccca ctgggccccc
     1681 ggtctctacc ccagggcccc ctgatgacga tgaggaggaa ggggcaccca ccacacccca
     1741 ggctgaaggt gccatggagt cctcttaaag agggacgagg gccagactga agcagcacaa
     1801 ggccggggac acccatgcca agcagtggga gcacgcagga cagacacagc aggggtctgg
     1861 ggcacggagc cttgctggca tcagcatcag cccttcctcc cagagccctc attccaattc
     1921 caagctaaga aggtattggg gcagaggctc cccaaattgg ggtgatcccc caaggagtga
     1981 tacatatatt gtgtatatat ttacagctgt attgtaaaag tggggtccct gtccccagct
     2041 gctcctgggg agtagaagca ataatgtatt tctaatttgt gggtcccact tcggctatgc
     2101 gggtttctag ggggtggggg cttgggacca aagccttgcc ccgcccctat gccccttggg
     2161 ggttttggct gtgtaagggg gtgaaggact gcccctccct ttcgagaccc ctccttcctg
     2221 gtttctgttc ctttttcctg gcagtgaatt atgcaaaggg ggccggcaaa ggaagggtag
     2281 gtgggggaaa gccaggtgga agcttgaaag actgggggac tgggcctgta aggaaggagc
     2341 catcccagtc cccctccgcc ctgctcccgg cgctgagtca tggggtcgtg gagaaggggg
     2401 cggggtggcc tgattggctc gcctgcccct gggggcagta gaggggcccc gcccagctag
     2461 gggagccgct ccgttccact cccctcccta gccctccctc cccacggccc tgggcaggga
     2521 atgtcttgtt cccgccgctc cctccccggg gccagagggc agggcgggcc gggcggcgtc
     2581 ctaccctctt ctcctcctcc ccatctcctc cccgcccagg tgcgagccgg agccgccgcc
     2641 accgctgccg cccctgactc acgccgcccc cgggctggcg cagcgaaggg tgtgggacag
     2701 ggtaaggggt tggaagagcc ttgtggagag cgggcgagcc ggcgccatct ggcggccatg
     2761 ctctgagtgg gcgagcgccc cccgcggcca ctggagcgag ctgtcttcac gctcctcatc
     2821 caccccagct ggtgagcggc gcccccttgc caaggcagtg ggcacagaac ttctcgcttg
     2881 gccgcagggg aaggggctgc ggacctgtgg gaaagtgatc cccttcccag atccttgcca
     2941 gccgggcttc ctgtcaggca ggggagaata atccccactc tgctcttagg attgaatcca
     3001 cccccattct gtacatagcc tcttctgttg gtcttgttga aatctagttt cagattttta
     3061 actacccaat tctgctgggg gtgggggaca cccccccttc ctcgctgggt gctggacccc
     3121 ttttgcagcc tgggctctgc cttgcactat ttccccttcc tggcctgacg gctcctcccc
     3181 ctccttaaaa ggggcaggtt caggggcccg gtgctcttcc tcccttccat gcacccccat
     3241 gcccatttgc acagctgccc aggtacccct aacagtgggg aggggtcaca gggagggggt
     3301 agcgggacca gtccctgtta tctatttaaa aagtgatgat gtaatatatt ggggtggcgg
     3361 ggagatcggg ttgtcctggg cctcatctta gcatttcagg tgatgggggg agcccagggc
     3421 tggggagacc tggggcccag ccccagaaag tggggacaat gtggcctccc ttctccctac
     3481 tttcggcttt cccagtcagt gccttagggg gagaggcact ccccccctcc tattcccttc
     3541 cccccacccc aactccccca cctcgggtgt aagcgacagg aagaaataat aataatttaa
     3601 gattca
//
