LOCUS       NM_006626               4099 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 6 (ZBTB6), mRNA.
ACCESSION   NM_006626
VERSION     NM_006626.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Bardwell,V.J. and Treisman,R.
  TITLE     The POZ domain: a conserved protein-protein interaction motif
  JOURNAL   Genes Dev 8 (14), 1664-1677 (1994)
   PUBMED   7958847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU600946.1, BX641237.1, BC037282.2 and BX390688.1.
            
            On Nov 25, 2018 this sequence version replaced NM_006626.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037282.2, SRR1660809.155653.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373659.4/ ENSP00000362763.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BU600946.1         9-9
            2-43                BX641237.1         8-49
            44-1382             BC037282.2         51-1389
            1383-1383           BX390688.1         584-584
            1384-4099           BC037282.2         1391-4106
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4099
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /note="zinc finger and BTB domain containing 6"
                     /db_xref="GeneID:10773"
                     /db_xref="HGNC:HGNC:16764"
                     /db_xref="MIM:605976"
     exon            1..73
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /inference="alignment:Splign:2.1.0"
     exon            74..4099
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1357
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /note="zinc finger protein with interaction domain; zinc
                     finger protein 482"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 6"
                     /protein_id="NP_006617.1"
                     /db_xref="CCDS:CCDS6846.1"
                     /db_xref="GeneID:10773"
                     /db_xref="HGNC:HGNC:16764"
                     /db_xref="MIM:605976"
                     /translation="MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEF
                     QGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLK
                     YLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKD
                     CEIIEISEDSPVNIDFHVKEEESNALQSTVESLTSERKEMKSPELSTVDIGFKDNEIC
                     ILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQDQGLF
                     CENTEGSYGTVSEIQNLEEGYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKT
                     FTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFK
                     HKSALKKHLTSVHGRSSGEKLSRPDLKRQSLL"
     polyA_site      2629
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
     regulatory      4077..4082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /note="hexamer: AATAAA"
     polyA_site      4099
                     /gene="ZBTB6"
                     /gene_synonym="ZID; ZNF482"
                     /note="major polyA site"
ORIGIN      
        1 cttccaggct aagtccatct tccggcttgg gcagacgctg ccgcggaatc cttgactcta
       61 gttttctgag tcgattgtga tcatggctgc tgagtctgat gttctgcatt tccagtttga
      121 acagcaagga gatgtggtct tgcagaaaat gaatcttttg agacagcaga atttattttg
      181 tgatgtatca atttacatta atgacactga gttccagggg cacaaggtga ttttggctgc
      241 ttgctccact tttatgagag atcagttttt actcacacag tcaaaacatg tcagaatcac
      301 catcttacag agtgcagaag ttggcagaaa attgttactg tcttgctata ctggagcact
      361 tgaagttaaa aggaaagagc ttttgaaata cttgactgct gccagttacc ttcagatggt
      421 tcacattgtg gaaaagtgca cagaagcttt gtcaaagtat ctggaaattg atctttctat
      481 gaaaaacaac aaccaacaca ctgacctgtg tcagtcttct gatcctgatg ttaagaatga
      541 agatgaaaat tctgataaag actgtgagat aattgaaatt tcagaagata gtcctgtaaa
      601 catagatttc catgttaaag aagaggaaag caatgctttg cagtctacag tagagagtct
      661 gacatcagag agaaaggaaa tgaagtcacc agagctgtct acagtagaca taggttttaa
      721 agacaatgaa atttgtatcc ttcatgtaga atccatcagt acagctggtg tcgaaaatgg
      781 gcagttttca cagccttgta cctcttcaaa agcaagcatg tatttctctg aaacacagca
      841 ttcattgatc aattctacag ttgagagcag agtggctgaa gttcctggga atcaagatca
      901 gggcttattt tgtgagaata ctgaaggaag ttatggtaca gtgagtgaga ttcagaatct
      961 ggaggaaggt tattcactga ggcaccagtg ccccaggtgt cctcgaggct ttcttcatgt
     1021 tgaaaactat ctgcgccacc ttaaaatgca taaactattc ttatgcttac agtgcggaaa
     1081 aacatttaca cagaagaaaa atctcaaccg acacatccga ggacacatgg gcatacggcc
     1141 ctttcagtgt actgtgtgct tgaagacatt tactgccaaa agcacacttc aggaccactt
     1201 gaacatacac agtggggatc ggccatacaa atgccactgt tgtgatatgg atttcaagca
     1261 caagtctgct ctcaaaaagc acttaacctc tgtccatggc agaagcagtg gtgaaaaact
     1321 atctaggcct gatctcaaaa ggcaaagtct actataatta taatcacaga cttgttatat
     1381 aaagtttgta ttattctatt acgcaagtct ttctgtagag atgcagcatt tgtaatattt
     1441 catcccccca atctttgttt cttatatttt gtcggcttac acataatcat tctttctgaa
     1501 cttctaacag ttccaaagtt atgggaggca cagtaaagct gatgggattc tgtctcatct
     1561 cataccttac atataagtct cagtagtatc cctagagaaa tagtgttcct ctcttatata
     1621 ttcttgattc tagtgacaaa ggatccagca gtatttgcag attccgattt ggagtctcta
     1681 ggtaattgat ttaagtataa aatccaatca tataaaaact ttaatgaatt aggataacaa
     1741 gaagagaaaa taaaggtaaa aacactatta cctgtttcta gtcactttag aacagatggc
     1801 actaaaaaaa ttttttttta actttttacc agctgttctt ggattccaaa ctaaacacca
     1861 agatactttt cattttaaaa tgtataaagt aacaattcag attcacttgg gaatagcaga
     1921 atttttttat acagggttaa taatccttaa aatactttta tttccatgcc ttattagtat
     1981 acatacttaa gaaatggttc attgggcccg agtttcttga ttttatttaa tacaatcgga
     2041 tttaataatt ttgtggccag taaaattata ccattggcat gaagctgtga aaaatgagaa
     2101 attctacctt taccagggat atctgttcta ctgttttaaa agttcctctc tattttattt
     2161 tttatttaac atgaagtaaa attgaaattt cttcttggtg tatagttctg tgaattttaa
     2221 cagaaagatt tgtgcaccac tactgcagtc ggtacagaac agttccttca ctcccaatag
     2281 ctctcttatg ctgtcccttt gtagtcagct ccttctagct ctaatcctgg caacagttct
     2341 ccgtcactat tattttgcct tttctggact gtcatataaa cagaatctta tagtacgttc
     2401 cctcttgaaa tgctttttca cccagcataa tgactttgag gttcatccat gtcattttaa
     2461 attttgaatt ggcaatatat attctagctg ttactagatg agcaatttaa aaaggtgtag
     2521 ctattagtgt tgtatttttt catttacatt aatgtaattt ccattcacta tgtgttgata
     2581 aaaatcttaa ccatccctag agttttatat ttccaaaaat atgccaaaag gaaaactatg
     2641 actgtatgat tattttagcg agagtcatat ttgagatggt gttctgagcc atagttctct
     2701 aacatctccg tctacatata acacaaaact tttataaatt attttaacaa agattaaaat
     2761 atactgcagg gcaaataata ttctctaaaa cacaggaact gcttttcgta aagaagactg
     2821 actagatgca tctttctttg aagctgttct agtcctcctc tagttaactt agctttatgt
     2881 agaatttcta ctgtatttaa tttctattga agcccttctg tattttaaaa tgtaatatac
     2941 tttgtaccat ttataaaaat tgtgtgatga atgaatcaca tgttcgttgt tataagtgtt
     3001 aacctttttt tgacaatttt gtgggaaaga cattctccac tgaattttaa ctttccttga
     3061 gactttcaag aatgcaggtc tcgtttgatg aaaaaaccga cttcataacc caatgttact
     3121 agttagcgac attgtgctga atttctcctt gaacttttta actttatatg taaaataact
     3181 ttgatcttgg tcatttgaaa gatcatttcc aggtctaaaa ttccatgatt ttgtatttaa
     3241 ttcttcctga gaacagaaga ggggaaagca agagaggacg gttttgtgtc tttatgaact
     3301 ttgttactta agtactccat tggagacata atttttctaa ttagtggatc tttttccact
     3361 ggaaagtgtg atagctcatt gctaattttt cattcatagt tcattgcttc catttgacct
     3421 aagattggcc atttgttggt gtgaaaatat tttcttttca gaaatagttt actagtgatt
     3481 gaagtacttt tcttattttt gcttcctatt ataaaatggc gtggggggaa gggggaagga
     3541 tggagatggg aggagagggt aaaagaatag tactctgatt ttttaagaat tagtatctac
     3601 tatcttggat atttgaaaaa aaattggttg aaactatgtt taagttttat gtgtgccttg
     3661 taagattgtt gtaaaatttt ttgtgagcac tttgagattt ttgctggggg aggggtgttt
     3721 tgtgaaagtg atggttatta tttatattat ttattcctgt tcagtagcac ggaatgatct
     3781 ccaaacattc ctaggagagt gtctgtttgc atgatatgtc taaaaatttt caggaaaatg
     3841 gaatcttttt ttaaagttca ggtatgacaa agtatagaat ttattcattt aacatattca
     3901 catttagttt atgtttctga tatgacagaa aaatgaaaag tgtttgagtt cagcctcttc
     3961 atttactcca tttacatata aaagatcttg aaaaggtagt tgttacttcg ttgtcagaga
     4021 aaaacacttg ccctttttcc tgggatgtaa ctatcttaca tgtttacata agaaataata
     4081 aactggaggt gggaatgga
//
