LOCUS       NM_014872               4690 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 5 (ZBTB5), mRNA.
ACCESSION   NM_014872 XM_376832
VERSION     NM_014872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4690)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4690)
  AUTHORS   Choi,S.H., Koh,D.I., Ahn,H., Kim,J.Y., Kim,Y. and Hur,M.W.
  TITLE     Cell fate decisions by c-Myc depend on ZBTB5 and p53
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1247-1254 (2020)
   PUBMED   33051058
  REMARK    GeneRIF: Cell fate decisions by c-Myc depend on ZBTB5 and p53.
REFERENCE   3  (bases 1 to 4690)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4690)
  AUTHORS   Koh,D.I., Choi,W.I., Jeon,B.N., Lee,C.E., Yun,C.O. and Hur,M.W.
  TITLE     A novel POK family transcription factor, ZBTB5, represses
            transcription of p21CIP1 gene
  JOURNAL   J Biol Chem 284 (30), 19856-19866 (2009)
   PUBMED   19491398
  REMARK    GeneRIF: ZBTB5 directly repressed transcription of cell cycle
            arrest gene p21 by binding to the proximal GC-box 5/6 elements and
            the two distal p53-responsive elements (bp -2323 to -2299; bp -1416
            to -1392)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158155.24, DB457364.1, BC010007.2, AB002352.1 and AW075599.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014872.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002352.1, SRR1803613.14829.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307750.5/ ENSP00000307604.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL158155.24        191769-191808       c
            41-196              DB457364.1         1-156
            197-980             BC010007.2         1-784
            981-981             AL158155.24        168169-168169       c
            982-2550            BC010007.2         786-2354
            2551-3003           AB002352.1         2500-2952
            3004-4678           AB002352.1         2957-4631
            4679-4690           AW075599.1         5-16                c
FEATURES             Location/Qualifiers
     source          1..4690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..4690
                     /gene="ZBTB5"
                     /note="zinc finger and BTB domain containing 5"
                     /db_xref="GeneID:9925"
                     /db_xref="HGNC:HGNC:23836"
                     /db_xref="MIM:616590"
     exon            1..236
                     /gene="ZBTB5"
                     /inference="alignment:Splign:2.1.0"
     exon            237..4690
                     /gene="ZBTB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2274
                     /gene="ZBTB5"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 5"
                     /protein_id="NP_055687.1"
                     /db_xref="CCDS:CCDS6610.1"
                     /db_xref="GeneID:9925"
                     /db_xref="HGNC:HGNC:23836"
                     /db_xref="MIM:616590"
                     /translation="MDFPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAA
                     CSTHFRALFSVAEGDQTMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDVLLA
                     ASHLHLNSVVKACKHYLTTRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNS
                     SQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKRKQSAEERARQRLRPSIDESAISDVT
                     PENGPSGVHSREEFFSPDSLKIVDNPKADGMTDNQEDSAIMFDQSFGTQEDAQVPSQS
                     DNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLGEKEHMRVVVKSEPL
                     SSPEPQDEVSDVTSQAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSSTDRVGDI
                     HILEVTNNLEHKSTFSISNFLNKSRGNNFTANQNNDDNIPNTTSDCRLESEAPYLLSP
                     EAGPAGGPSSAPGSHVENPFSEPADSHFVRPMQEVMGLPCVQTSGYQGGEQFGMDFSR
                     SGLGLHSSFSRVMIGSPRGGASNFPYYRRIAPKMPVVTSVRSSQIPENSTSSQLMMNG
                     ATSSFENGHPSQPGPPQLTRASADVLSKCKKALSEHNVLVVEGARKYACKICCKTFLT
                     LTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHSKTTCLRWQSSNLPSTLL"
     regulatory      4659..4664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB5"
                     /note="hexamer: AATAAA"
     polyA_site      4690
                     /gene="ZBTB5"
                     /note="major polyA site"
ORIGIN      
        1 gtcacttccg cttatcctcg ggcgccgccg ccgtgttctc agagtgctgc ggcgaactgg
       61 ctggaggagc taggggacta gaggcggggt gggagggggg cgggtggaag ggggaggaag
      121 tcccgtaacg gagacgctgg tcaggacgtt cccacctcct ctgacactgc cgagtccgat
      181 cggagagggg tcaccgcctc cttcagcgag gaggaggggg gcggagcccg actcaggatc
      241 atggattttc ctggtcactt tgaacaaatc ttccagcagc tgaactacca gagacttcat
      301 ggccagctct gtgattgtgt cattgtagtg gggaatagac actttaaagc ccaccgctcc
      361 gtgctggcag catgcagcac gcatttccga gccctgttct cagtggcaga aggagatcag
      421 accatgaaca tgatccagct ggatagcgag gtggtgacag cagaggcctt tgctgcactg
      481 attgacatga tgtatacctc caccctcatg ctgggggaga gcaatgtaat ggatgtctta
      541 ttggcagcct ctcacctgca tttgaactct gttgttaagg catgtaaaca ttacttaacg
      601 acaaggacgc tgcccatgtc tccccccagt gagcgcgttc aggagcagag cgcccgcatg
      661 cagcgctcct ttatgctaca gcagctggga ctaagcatcg tgagctcagc cctcaattcc
      721 agccagaatg gcgaggagca gccagccccc atgagctctt ccatgcgcag taacctggat
      781 cagcgcacgc ccttccccat gagacgcctt cataagcgca agcagtctgc agaggagcgg
      841 gccaggcagc gcctccgacc ctccatagat gagtctgcca tttcagatgt tacaccggag
      901 aatgggcctt caggggttca ttctcgggag gagttctttt caccagattc tctgaaaatt
      961 gtggataatc ctaaagctga tggaatgact gataaccagg aagatagtgc gatcatgttt
     1021 gatcagtctt ttggcactca agaagatgcc caggtgccca gccagtctga taacagtgct
     1081 ggcaacatgg cacagttgtc catggcctct cgtgcaactc aggttgagac tagttttgat
     1141 caggaagctg cacctgagaa aagtagtttt cagtgtgaaa accctgaggt tggccttggt
     1201 gagaaggagc acatgagagt ggtggttaaa tctgagcccc tgagctcacc tgagcctcag
     1261 gatgaagtga gcgatgtgac ctcacaagca gaaggcagcg agtctgtgga agtggaagga
     1321 gttgtggtca gtgccgagaa gatagacctc agccctgaaa gcagtgatcg gagtttttca
     1381 gatccccagt ctagcacaga cagggtaggt gatatccata ttttggaagt cacaaataac
     1441 ctagagcata agtccacttt tagtatttcg aattttctta acaagagcag aggaaataac
     1501 tttactgcaa atcagaacaa tgatgataat attccaaaca ccactagtga ctgcaggctg
     1561 gagagtgagg ccccctattt gttgagtcca gaggctgggc ctgcaggtgg gccctcctct
     1621 gcccctggct cccatgtaga gaacccattt agtgaacctg cagactccca cttcgtcagg
     1681 cctatgcagg aggtgatggg cctgccgtgt gtgcagactt caggctacca aggaggagaa
     1741 cagtttggga tggacttttc caggtctggt ttgggcctcc actcctcctt ctccagggta
     1801 atgataggtt ccccaagggg aggagccagt aactttcctt actaccgccg catagctccc
     1861 aaaatgccag ttgtaacttc cgtcaggagc tcacagatcc cagaaaactc taccagttct
     1921 cagctaatga tgaatggagc tacgtcctca tttgaaaatg gccatccttc ccagcctggc
     1981 cctccacagt tgaccagggc atctgcagat gttctgtcaa agtgcaagaa ggccttatca
     2041 gagcacaatg ttttggttgt agagggagct cgcaagtatg cctgcaaaat ctgctgcaaa
     2101 acttttctga ctttgacaga ttgcaagaag cacatccgtg ttcacacagg tgaaaagcct
     2161 tacgcctgcc tgaagtgtgg caagaggttt agtcagtcca gccacctgta taagcactca
     2221 aagactacct gcctgcgctg gcagagcagc aatcttccca gcactttgct ctagctgttt
     2281 gtccttacaa gacaacgctg aggccagttg tcagactgaa tttcttttgg taagcagtta
     2341 atgcctttgg gttcgaggct tccagctgcc cagtggctct taaacagttt agcaactaat
     2401 aaccggagaa ctaacatgta gtatttgtgc tgctgcattt ctgagtgaag tgcacgtctt
     2461 gggaaaggga tgcaatccct gaaaccaggt gcttccttgg ggttgagtaa tgcagtcaga
     2521 aagtagtttg taattgatat taaaagtggc acatttaaaa atttaaaaat tgaagtgcaa
     2581 aaaaaatttt ttagcaattt ttgtaaaact gtgtagcatt taaatttcct ataccttctg
     2641 atgggagtat tatatccctg tatagtgatg caaaatgcac ttatgtgtaa ccagtggtga
     2701 tttggtgcct gtcttaaagg aaggcctttg aggacacacc tgtctgccac aaatgcttta
     2761 aagtgtatca tgagctagtc ctaggcctca aagtactgta ttttttattt ttacctgatt
     2821 tgcagtcata aacactgcac tttggtgctg acactgggtc cagagtgagc attctcttgg
     2881 actattagat gtatatactt ttgaatacat cactgttgga tagatgtttt aacagttttt
     2941 tctggtttaa aaaccaaatt gtaaatggag tgtgtacttg tagagagtga caaggtattg
     3001 tttccctatg tgctgtttga gcagtatttt aaccaacttg tattacagat gttacagttc
     3061 catgttagga agtcagaaaa gacttgtgtt tgtctttgtt ctgctgatgt ggagtcatgt
     3121 tttgtggggt cttccatggc acatttacct gttgctccgt ccagatgttg agggccagtc
     3181 taggctgaca catcctaccc gaggacaagc ctgttctcca tttcttcact ctcccctccc
     3241 catatagcaa ctctcccagg tttagattac cgttttcgac gacagattaa ccaaaaatgc
     3301 cccacacagg ttttattact gttatatact atacttttaa cagtacagac cctaaatttt
     3361 attatttgtt gctcccccaa tctgatacca aatgtttaaa gttgtttgaa atccaaacat
     3421 ggtagtgttc atgggtaaat attttctagg ctatgtaaga gttagcagcc catagcatag
     3481 aagtaatcaa gtagcatctg agactgttgg aggcactagg gcctctctgg gccctacagc
     3541 ctcacttccc cagcctcacc ttgctgtcct ctgacactgc catcagggct gttagtggca
     3601 cctgtatgag gccaagtgtg cgtccagggg aacagcacag gttaatgcgt ctccctagaa
     3661 ctcatgaagt cagtttaatt catgcatgaa catgagttca ttttatgttt tatatagctt
     3721 tcttagacat accaaaccat cattcataaa tcagataaat tattcagttt ttgtgtttag
     3781 aaagctaagt atgtgtagct ggaaacaaaa atgagcgtgt tttctctcct gttaatctag
     3841 agtgtgcagt tacacatgtg tggataattt catgttccag gggcgcttgg catctcccat
     3901 ggactgattc ccaggaagaa aagcccaaag ggaaacccac gattcctttc gagtagatgt
     3961 gggaaagagc ccattggagg atatgaggtc ctgtgaaatt cagttgtgtg tgtggctcct
     4021 tgttagcagt catgttgaca tggtgttagg aggctcccca tccacccttt acatgatgta
     4081 gggaccagtg tcttgtgaga ttaaccttgg gacacagtgg gttagcctgg agaaaatgag
     4141 aggccctgcc tggacccagg gagaggagcc agtgacacag gcagagcggt gcagccctcc
     4201 ttcccttcca tttggaggag gtggtgccag gagcctgccc gcttacctct gctgaagcat
     4261 aagtggactt tgcttttggg gcttatctct gatacatgct ggagccctgc ctctccactg
     4321 ctagatggaa cctggaatct ctcatctacc tcttagtctg tcagtttcta cgtgtgagaa
     4381 gcaagcttgt gggccagtgt ccttgtacat gctgtagcac ttaaaaaata attccagggt
     4441 tccctggaaa accagtccca gggttcctat gatctgtagt ttctacctgg attataactg
     4501 gttttgggta cctgaatttt gattggttag ccttaattat agtctggcgt gatcatgtag
     4561 aatcttttct ggtgaacaga tcataaagtt ctatcaagga gttctatcaa ggcatccatg
     4621 tcagtggtgc tatgctggtt acaacttgag atttttgaaa taaaaaattt gtcatattca
     4681 tgcctctaaa
//
