LOCUS       NM_005341               2347 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 48 (ZBTB48),
            transcript variant 1, mRNA.
ACCESSION   NM_005341
VERSION     NM_005341.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Nabeel-Shah,S., Pu,S., Burke,G.L., Ahmed,N., Braunschweig,U.,
            Farhangmehr,S., Lee,H., Wu,M., Ni,Z., Tang,H., Zhong,G., Marcon,E.,
            Zhang,Z., Blencowe,B.J. and Greenblatt,J.F.
  TITLE     Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the
            telomeric zinc finger protein ZBTB48
  JOURNAL   Genome Biol 25 (1), 246 (2024)
   PUBMED   39300486
  REMARK    GeneRIF: Recruitment of the m[6]A/m6Am demethylase FTO to target
            RNAs by the telomeric zinc finger protein ZBTB48.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Jung,S.J., Kil,S.H., Lee,H.W., Park,T.I., Lee,Y.H., Kim,J. and
            Lee,J.H.
  TITLE     Clinical Characteristics of TZAP (ZBTB48) in Hepatocellular
            Carcinomas from Tissue, Cell Line, and TCGA
  JOURNAL   Medicina (Kaunas) 58 (12), 1778 (2022)
   PUBMED   36556980
  REMARK    GeneRIF: Clinical Characteristics of TZAP (ZBTB48) in
            Hepatocellular Carcinomas from Tissue, Cell Line, and TCGA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Kim,G.J., Lee,J.H., Chae,M. and Lee,D.H.
  TITLE     Prognostic Value of Telomeric Zinc Finger-Associated Protein
            Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
  JOURNAL   Medicina (Kaunas) 57 (11), 1223 (2021)
   PUBMED   34833441
  REMARK    GeneRIF: Prognostic Value of Telomeric Zinc Finger-Associated
            Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of
            Lung.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Park,W.J., Park,J.H., Shin,H.Y. and Lee,J.H.
  TITLE     Clinical and Prognostic Significance of TZAP Expression in Cervical
            Cancer
  JOURNAL   Medicina (Kaunas) 56 (5), 207 (2020)
   PUBMED   32344888
  REMARK    GeneRIF: Clinical and Prognostic Significance of TZAP Expression in
            Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2347)
  AUTHORS   Maris,J.M., Jensen,J., Sulman,E.P., Beltinger,C.P., Allen,C.,
            Biegel,J.A., Brodeur,G.M. and White,P.S.
  TITLE     Human Kruppel-related 3 (HKR3): a candidate for the 1p36
            neuroblastoma tumour suppressor gene?
  JOURNAL   Eur J Cancer 33 (12), 1991-1996 (1997)
   PUBMED   9516840
REFERENCE   8  (bases 1 to 2347)
  AUTHORS   Maris,J.M., Jensen,S.J., Sulman,E.P., Beltinger,C.P., Gates,K.,
            Allen,C., Biegel,J.A., Brodeur,G.M. and White,P.S.
  TITLE     Cloning, chromosomal localization, physical mapping, and genomic
            characterization of HKR3
  JOURNAL   Genomics 35 (2), 289-298 (1996)
   PUBMED   8661141
REFERENCE   9  (bases 1 to 2347)
  AUTHORS   Sugawara,M., Scholl,T., Ponath,P.D. and Strominger,J.L.
  TITLE     A factor that regulates the class II major histocompatibility
            complex gene DPA is a member of a subfamily of zinc finger proteins
            that includes a Drosophila developmental control protein
  JOURNAL   Mol Cell Biol 14 (12), 8438-8450 (1994)
   PUBMED   7969177
REFERENCE   10 (bases 1 to 2347)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY047768.1, BI913659.1, L16896.1, BC013573.2 and AA765826.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005341.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279858.3258.1, SRR1803617.38210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377674.9/ ENSP00000366902.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                HY047768.1         4-26
            24-62               BI913659.1         1-39
            63-811              L16896.1           6-754
            812-2283            BC013573.2         674-2145
            2284-2347           AA765826.1         16-79               c
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..2347
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /note="zinc finger and BTB domain containing 48"
                     /db_xref="GeneID:3104"
                     /db_xref="HGNC:HGNC:4930"
                     /db_xref="MIM:165270"
     exon            1..143
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            144..902
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..2279
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /note="GLI-Kruppel family member HKR3; zinc finger and BTB
                     domain-containing protein 48; krueppel-related zinc finger
                     protein 3; zinc finger protein 855; telomeric zinc
                     finger-associated protein"
                     /codon_start=1
                     /product="telomere zinc finger-associated protein"
                     /protein_id="NP_005332.1"
                     /db_xref="CCDS:CCDS84.1"
                     /db_xref="GeneID:3104"
                     /db_xref="HGNC:HGNC:4930"
                     /db_xref="MIM:165270"
                     /translation="MDGSFVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVL
                     ACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAAREL
                     RVPEAVELCQSFKPKTSVGQAAGGQSGLGPPASQNVNSHVKEPAGLEEEEVSRTLGLV
                     PRDQEPRGSHSPQRPQLHSPAQSEGPSSLCGKLKQALKPCPLEDKKPEDCKVPPRPLE
                     AEGAQLQGGSNEWEVVVQVEDDGDGDYMSEPEAVLTRRKSNVIRKPCAAEPALSAGSL
                     AAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKPFECPKCGKCYFRKENL
                     LEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKD
                     LQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNG
                     LQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASL
                     DKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLR
                     VHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLIIEDEKMV
                     VVALQPPAELEVGSAEVIVESLAQGGLASQLPGQRLCAEESFTGPGVLEPSLIITAAV
                     PEDCDT"
     exon            903..1144
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1256
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1349
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1436
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1591
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1728
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1893
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1982
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2347
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /note="hexamer: AATAAA"
     polyA_site      2347
                     /gene="ZBTB48"
                     /gene_synonym="HKR3; pp9964; TZAP; ZNF855"
                     /note="major polyA site"
ORIGIN      
        1 acgctttgac gtcacgtccg gcgcggagac ggtggagtct ccgcactgtc ggcggggtac
       61 gcatagccgg gcactaggtt cgtgggctgt ggaggcgacg gagcaggggg ccagtggggc
      121 cagctcaggg aggacctgcc tgggagcttt ctcttgcata ccctcgctta ggctggccgg
      181 ggtgtcactt ctgcctccct gccctccaga ccatggacgg ctccttcgtc cagcacagtg
      241 tgagggttct gcaggagctc aacaagcagc gggagaaggg ccagtactgc gacgccactc
      301 tggacgtggg gggcctggtg tttaaggcac actggagtgt ccttgcctgc tgcagtcact
      361 ttttccagag cctctacggg gatggctcag ggggcagtgt cgtcctccct gctggcttcg
      421 ctgagatctt tggcctcttg ttggactttt tctacactgg tcacctcgct ctcacctcag
      481 ggaaccggga tcaggtgctc ctggcagcca gggagttgcg agtgccagag gccgtagagc
      541 tgtgccagag cttcaagccc aaaacttcag tgggacaggc agcaggtggc cagagtgggc
      601 tggggccccc tgcctcccag aatgtgaaca gccacgtcaa ggagccggca ggcttggaag
      661 aagaggaagt ttcgaggact ctgggtctag tccccaggga tcaggagccc agaggcagtc
      721 atagtcctca gaggccccag ctccattccc cagctcagag tgagggcccc tcctccctct
      781 gtgggaaact gaagcaggcc ttgaagcctt gtccccttga ggacaagaaa cccgaggact
      841 gcaaagtgcc cccaaggccc ttagaggctg aaggtgccca gctgcagggc ggcagtaatg
      901 agtgggaagt ggtggttcaa gtggaggatg atggggatgg cgattacatg tctgagcctg
      961 aggctgtgct gaccaggagg aagtcaaatg taatccgaaa gccctgtgca gctgagccag
     1021 ccctgagcgc gggctcccta gcagctgagc ctgctgagaa cagaaaaggt acagcggtgc
     1081 cggtcgaatg ccccacatgt cataaaaagt tcctcagcaa atattatcta aaagtccaca
     1141 acaggaaaca tactggggag aaaccctttg agtgtcccaa atgtgggaag tgttactttc
     1201 ggaaggagaa cctcctggag catgaagccc ggaattgcat gaaccgctcg gaacaggtct
     1261 tcacgtgctc tgtgtgccag gagacattcc gccgaaggat ggagctgcgg gtgcacatgg
     1321 tgtctcacac aggggagatg ccctacaagt gttcctcctg ctcccagcag ttcatgcaga
     1381 agaaggactt gcagagccac atgatcaaac ttcatggagc ccccaagccc catgcatgcc
     1441 ccacctgtgc caagtgcttc ctgtctcgga cagagctgca gctgcatgaa gctttcaagc
     1501 accgtggtga gaagctgttt gtgtgtgagg agtgtgggca ccgggcctcg agccggaatg
     1561 gcctgcagat gcacatcaag gccaagcaca ggaatgagag gccacacgta tgtgagttct
     1621 gcagccacgc cttcacccaa aaggccaatc tcaacatgca cctgcgcaca cacacgggtg
     1681 agaagccctt ccagtgccac ctctgtggca agaccttccg aacccaagcc agcctggaca
     1741 agcacaaccg cacccacacc ggggaaaggc ccttcagttg cgagttctgt gaacagcgct
     1801 tcactgagaa ggggcccctc ctgaggcacg tggccagccg ccatcaggag ggccggcccc
     1861 acttctgcca gatatgcggc aagaccttca aagccgtgga gcaactgcgt gtgcacgtca
     1921 gacggcacaa gggggtgagg aagtttgagt gcaccgagtg tggctacaag tttacccgac
     1981 aggcccacct gcggaggcac atggagatcc acgaccgggt agagaactac aacccgcggc
     2041 agcgcaagct ccgcaacctg atcatcgagg acgagaagat ggtggtggtg gcgctgcagc
     2101 cgcctgcaga gctggaggtg ggctcggcgg aggtcattgt ggagtccctg gcccagggcg
     2161 gcctggcctc ccagctcccc ggccagagac tgtgtgcaga ggagagcttc accggcccag
     2221 gtgtcctgga gccctccctc atcatcacag ctgctgtccc cgaggactgt gacacatagc
     2281 ccattctggc caccagagcc cacttggccc cacccctcaa taaaccgtgt ggctttggac
     2341 tctcgta
//
