LOCUS       NM_001369741            5231 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 46 (ZBTB46),
            transcript variant 1, mRNA.
ACCESSION   NM_001369741
VERSION     NM_001369741.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Wen,Y.C., Liu,C.L., Yeh,H.L., Chen,W.H., Jiang,K.C., Tram,V.T.N.,
            Hsiao,M., Huang,J., Chen,W.Y. and Liu,Y.N.
  TITLE     PCK1 regulates neuroendocrine differentiation in a positive
            feedback loop of LIF/ZBTB46 signalling in castration-resistant
            prostate cancer
  JOURNAL   Br J Cancer 126 (5), 778-790 (2022)
   PUBMED   34815524
  REMARK    GeneRIF: PCK1 regulates neuroendocrine differentiation in a
            positive feedback loop of LIF/ZBTB46 signalling in
            castration-resistant prostate cancer.
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Carrera,C., Carcel-Marquez,J., Cullell,N., Torres-Aguila,N.,
            Muino,E., Castillo,J., Sobrino,T., Campos,F., Rodriguez-Castro,E.,
            Llucia-Carol,L., Millan,M., Munoz-Narbona,L., Lopez-Cancio,E.,
            Bustamante,A., Ribo,M., Alvarez-Sabin,J., Jimenez-Conde,J.,
            Roquer,J., Giralt-Steinhauer,E., Soriano-Tarraga,C.,
            Mola-Caminal,M., Vives-Bauza,C., Navarro,R.D., Tur,S., Obach,V.,
            Arenillas,J.F., Segura,T., Serrano-Heras,G., Marti-Fabregas,J.,
            Delgado-Mederos,R., Freijo-Guerrero,M.M., Moniche,F., Cabezas,J.A.,
            Castellanos,M., Gallego-Fabrega,C., Gonzalez-Sanchez,J.,
            Krupinsky,J., Strbian,D., Tatlisumak,T., Thijs,V., Lemmens,R.,
            Slowik,A., Pera,J., Kittner,S., Cole,J., Heitsch,L., Ibanez,L.,
            Cruchaga,C., Lee,J.M., Montaner,J. and Fernandez-Cadenas,I.
  TITLE     Single nucleotide variations in ZBTB46 are associated with
            post-thrombolytic parenchymal haematoma
  JOURNAL   Brain 144 (8), 2416-2426 (2021)
   PUBMED   33723576
  REMARK    GeneRIF: Single nucleotide variations in ZBTB46 are associated with
            post-thrombolytic parenchymal haematoma.
REFERENCE   3  (bases 1 to 5231)
  AUTHORS   Chen,W.Y., Wen,Y.C., Lin,S.R., Yeh,H.L., Jiang,K.C., Chen,W.H.,
            Lin,Y.S., Zhang,Q., Liew,P.L., Hsiao,M., Huang,J. and Liu,Y.N.
  TITLE     Nerve growth factor interacts with CHRM4 and promotes
            neuroendocrine differentiation of prostate cancer and castration
            resistance
  JOURNAL   Commun Biol 4 (1), 22 (2021)
   PUBMED   33398073
  REMARK    GeneRIF: Nerve growth factor interacts with CHRM4 and promotes
            neuroendocrine differentiation of prostate cancer and castration
            resistance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5231)
  AUTHORS   Wang,Y., Sun,H.Y., Kumar,S., Puerta,M.D.M., Jo,H. and Rezvan,A.
  TITLE     ZBTB46 is a shear-sensitive transcription factor inhibiting
            endothelial cell proliferation via gene expression regulation of
            cell cycle proteins
  JOURNAL   Lab Invest 99 (3), 305-318 (2019)
   PUBMED   29884909
  REMARK    GeneRIF: In vitro results using endothelial cells (ECs) showed that
            cell confluence and laminar shear stress, both known physiological
            conditions promoting EC quiescence, led to upregulation of ZBTB46
            expression.
REFERENCE   5  (bases 1 to 5231)
  AUTHORS   Chen,W.Y., Zeng,T., Wen,Y.C., Yeh,H.L., Jiang,K.C., Chen,W.H.,
            Zhang,Q., Huang,J. and Liu,Y.N.
  TITLE     Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes
            neuroendocrine differentiation of prostate cancer
  JOURNAL   Cancer Lett 440-441, 35-46 (2019)
   PUBMED   30312731
  REMARK    GeneRIF: ZBTB46 is inversely correlated with SPDEF and is increased
            in higher tumor grades and small-cell NE prostate cancer (SCNC)
            patients, which are positively associated with PTGS1. Findings
            suggest that the induction of ZBTB46 results in increased PTGS1
            expression, which is associated with NEPC progression and linked to
            the dysregulation of the AR-SPDEF pathway.
REFERENCE   6  (bases 1 to 5231)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 5231)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5231)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   9  (bases 1 to 5231)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   10 (bases 1 to 5231)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158091.31 and AL121845.20.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1894249.1,
                                           SRR14038197.903707.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245663.9/ ENSP00000245663.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL158091.31        13877-14044         c
            169-1138            AL121845.20        93418-94387         c
            1139-1423           AL121845.20        79275-79559         c
            1424-1599           AL121845.20        56283-56458         c
            1600-5231           AL121845.20        47267-50898         c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..5231
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /note="zinc finger and BTB domain containing 46"
                     /db_xref="GeneID:140685"
                     /db_xref="HGNC:HGNC:16094"
                     /db_xref="MIM:614639"
     exon            1..168
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /inference="alignment:Splign:2.1.0"
     exon            169..1138
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1971
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /note="zinc finger protein 340; BTB (POZ) domain
                     containing 4; BTB/POZ domain-containing protein 4; BTB-ZF
                     protein expressed in effector lymphocytes"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     46"
                     /protein_id="NP_001356670.1"
                     /db_xref="CCDS:CCDS13538.1"
                     /db_xref="GeneID:140685"
                     /db_xref="HGNC:HGNC:16094"
                     /db_xref="MIM:614639"
                     /translation="MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKA
                     HKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNV
                     IEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISA
                     VMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWP
                     GDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNK
                     ETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELY
                     AQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDG
                     SLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEI
                     CGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRG
                     MAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDK
                     DEEDSPRPRSPPGGPDKDFAWLS"
     exon            1139..1423
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1599
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..5231
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4353..4358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /note="hexamer: AATAAA"
     polyA_site      4381
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /note="hexamer: AATAAA"
     polyA_site      5231
                     /gene="ZBTB46"
                     /gene_synonym="BTBD4; BZEL; dJ583P15.7; dJ583P15.8; RINZF;
                     ZNF340"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgccggc ctgacggacc gacggacgga cggacggacc gagcagcccc ggcgagcgcg
       61 cagctcggac ccgcccggac gcagcgccct cccggcggcg gcggcgatca ccggcgccgg
      121 cccggcggcc gcggcgcccg ccctcgcccg cgccccatgg ggtcacagag tctgtagaag
      181 aggcgacacc agggcttcca aatgaacaac cgaaaggaag atatggaaat cacgtcccac
      241 taccggcacc tgctgcggga gctcaacgag cagaggcagc acggcgtcct gtgcgacgtc
      301 tgcgtggtcg tggagggcaa ggtcttcaag gcgcacaaga acgtcctgct gggcagcagc
      361 cgctacttca agacgctcta ctgccaggtg cagaagacgt cggagcaggc cacggtcacg
      421 cacctggaca tcgtcacggc ccagggcttc aaggccatca tcgacttcat gtactcagcg
      481 cacctggcgc tcaccagcag gaacgtcatc gaggtgatgt cagccgccag cttcctgcag
      541 atgacggaca tcgtgcaagc ctgccacgac ttcatcaagg cggcgctgga catcagcatc
      601 aagtcggacg cctcagatga gcttgcggag ttcgagatcg gcgcctcgtc cagcagcagc
      661 acggaagctc tcatctcggc cgtgatggct gggaggagca tctccccgtg gctggcacgg
      721 cgaacgagtc ctgccaattc ttccggagac tcggccatcg ccagctgtca cgacggaggg
      781 agcagctacg ggaaagagga tcaggagccc aaggccgatg gccctgatga tgtttcttca
      841 cagcctctat ggcctggaga cgtgggctac gggcctctgc gcatcaagga agagcaggtt
      901 tcaccgtctc agtacggagg gagcgagctg ccttctgcca aggacggtgc agtacagaac
      961 tctttctcag agcagagtgc tggtgatgcc tggcagccca cgggccgaag gaagaatcgg
     1021 aaaaacaaag agaccgtccg gcacatcaca cagcaggtgg aagatgacag ccgggccagc
     1081 tccccggtgc cgtccttcct gccgacgtcg gggtggccgt tcagcagccg agactcaaat
     1141 gcggacctgt ccgtcaccga agccagcagc tccgacagcc gaggagagag ggccgagctc
     1201 tatgcacagg tggaggaggg tctcctggga ggagaagcca gctatctggg ccctcccctc
     1261 accccagaga aggacgacgc cctgcatcag gccaccgcgg tggccaacct gcgcgcggcg
     1321 ctcatgagta agaacagcct gctgtcgctg aaggccgacg tgctggggga tgacggctcc
     1381 ctgctgttcg agtacctgcc cagaggggcc cactcgctgt ccctgaatga gttcacggtg
     1441 atcaggaaga agttcaagtg tccgtactgc agcttctcgg ccatgcacca gtgcatcctc
     1501 aagcgacaca tgcgctcgca cacgggagag cggccctacc cctgcgagat ctgcgggaag
     1561 aagttcacgc ggcgcgagca catgaagcgc cacacgctgg tccacagcaa ggacaagaag
     1621 tatgtgtgca aggtgtgcag ccgcgtcttc atgtccgccg ccagcgtggg catcaggcat
     1681 ggctccaggc gccacggtgt gtgcaccgac tgtgctggcc gcggcatggc cgggcccctg
     1741 gaccatggcg gcggaggcgg cgagggctct ccagaggcgc tgttcccagg cgacgggccc
     1801 tatctggagg accctgagga cccacgaggg gaggcggagg agctgggcga ggacgacgag
     1861 ggcctggccc ctgaggatgc gctgttggcg gacgacaagg atgaggaaga ctcgccgcgg
     1921 ccgcgcagcc ccccaggagg ccctgacaag gacttcgcct ggctctccta ggcccgcccg
     1981 ccggcagggt cggtggctgc ctcgctccgt ccacccgtgt gtgtgtccgg tgggtctcca
     2041 ctgcggggcc agggccacgc tcacccctct cgcggcccct cctctgcttc cccctgaacc
     2101 caccccccac ggaaaccagc cctgcgggct aagcaggtgc gaccccagca agaggggtgc
     2161 tctgggacca gacatgaagt gagttggggg agggcacagg gtgggtttga gtgaagggag
     2221 agcacggtcc taagtcccca gcaggtggtg cgggtgtgtg agtggcccct gtgatggcca
     2281 gcctggcttg gacacgtgat gggcctgtgg ccgggtccag tgggcactgg gcggggtggt
     2341 gtgttcggcc cagaggcccc tggcctgagc aggtgcagag ttttacagac acccggtcag
     2401 cccggctgga gcccgccctc ccctccccta gcagccaggt cactgcctgt ggctgcagcc
     2461 gtggcccgtg gtgcagccgt ggcccatggc agcctgtaga atccaggtgc acagagagcc
     2521 ctgccaccgt cttacctctg ggctttggtg cttaacacac aacacagctg cagaccctgc
     2581 tggaggccga gggctccagg tgctatctta ggtggacaca gccctggggg ctccttccag
     2641 gaggggaccc tcagccctgt gccccccacc acttcaggcc acaccaggtt ccctctgcaa
     2701 gggcctcggc tcagtcgtgt gcacttcctc ggagagcctt gggctgccac gtccaccccg
     2761 ggctctgccc gtcctgttct gcccatggcc cagcccggcc gctcctgctg acccctcctg
     2821 gacgggctgg agctgggctc ctgcctttgc tgctaacact ggaggcggtg ttcctaactg
     2881 cagtgtgctg cttacacctc cccgcgtggg taaccaaatt tttaagtagt cagagacata
     2941 tcgaggtagt tacataaaat tattttgttt ggcattattt ttctcactcg aagaaactat
     3001 atagggttgt ttttccttta gcttgtgctc aagtcctctt gctgtgtttt cagaagcact
     3061 cacatgttct ttcttttcct gagtgaaaag caaaggtccc acggtgtgtg ctgtggtgca
     3121 ccgcctggct ttgggggtcc cggaggcagg ctgcctagac tcacagcctc gggaccgttg
     3181 ccacggcctg tcttctcgtt caggcctgcc tctgacagca ctcaccatga ggacattcca
     3241 tccttcaccc cctcctctgg cacaggccac cactgcggtg ctgtgccttc agatgggagg
     3301 tgggcgcggt ggcctcctcc ttccctccag gacctgcccg tgtgaagacc ccccggagtg
     3361 ctgagcttca gggctgcgtg gaaagagttt ttactctctt tttctagcct gtataccagg
     3421 cttttcccca cattgtcagg tagagcacca gcttccctga ccgctgctgc tcggggaggg
     3481 ctggggctgg ccgggggtcc tgtggaggag tacatggagg actccaggta cagcgcagga
     3541 gtcacggctt ttgttttttg acattggccc ccggttctac caatgacagg gtgccctggc
     3601 tggagctgtc atcacacaca cccctcagct cggaggctgt gggctcctca aagctggaga
     3661 aagaggccaa gatttttctg cacacggagt gtggggatag gagccgggcc aagcgctggc
     3721 ccctcagcgg tgagccctgc ccactcttac cgagcaaggt gggtggctct ggcacgagtc
     3781 ccccaggggg agagcatggc taccagggag ctgcagcgga gccctccagc cctcacccca
     3841 ggccagcccc accccggcct ctttgagaat tctcagaact ttgtaccttt cccctgattt
     3901 ttaaaccctt tttctaaaca gactgacttt cttacaaaat gcatttggaa accagacctt
     3961 tgctacccac caatgtctct gggttttgta ccagtccctg ctctcaggcc accctgccca
     4021 ggacccaggc ccgcctcccc ctccacactc aggatgtcct gctccatctg gccggctcac
     4081 tccgtgtggc ctgcctttgc tgaccgtttt ggggttcccc gccggagcta caggggcatt
     4141 ttcttcccta aaaccaacag tgtcccactg acctccccaa gtgtttgctg cgtggcagat
     4201 ttcctgttct tgttcgcagt ttgccgactg aagagtgtgg gatttccgag gcccaggtga
     4261 gcacgtccat ctcaggaggc gtggagggaa aagacatgtc atgaagggtt ttttttatgt
     4321 gactgatttt tttttaaatc gatgttcaaa ctaataaata tttttttatg aagaggaaaa
     4381 atgtgtagat tacatttcac attttgtatt tttgtttgtg tctgtttgta ttttggtgtt
     4441 tacaacacca aagtgggaaa tacagtccat tggggatggt gttatttggg ggcggggagg
     4501 gggcagggac accacgattt ttctgtcaag ctctggatcc tgaccaggtt gtacactggg
     4561 gctctctgag ctttgggaca caggacactg ccagggctac gtagggaact gactcagaag
     4621 acgcagctta ctgcttccaa ctttgcacat cttcctcttt aaaaaactga gaaaatgcaa
     4681 aaactggaac tttttgcaat attataaaag aagtaatctt attttagctc attctgtgac
     4741 atgtgcgact cttaagaaag ccatacttaa tggtggtggt tttttttaga tcttatattg
     4801 tgttttgtat gcagcccttt tagaactact tgtagtgagg gtgctgtgtg tgcttttctt
     4861 aaatatttat ttttttcaac atgctttcaa cctgtcaaca aaaacaaaac acacaaaaaa
     4921 agggcagtgt ttgaagattg ttgatttttt tctggggata atctatatta tattgacttc
     4981 ctattactta ttataaacct gtgtttgtat tggagatgtg tctactattg ggggaagagg
     5041 ttctcgtaat cgctcggtgg gaaatcatgg ctctgccgtc ctgcctctct gtggccgtgg
     5101 gttcacgtgg cctctgcggt gagtctccaa gtttctgcct aggcgcctgt gcgtttcctt
     5161 tctgtgacgg gattagctta gacatccttg caaagcgatc actttcaata aattgggaaa
     5221 ttgctgctcc a
//
