LOCUS       NM_001316979            2129 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 45 (ZBTB45),
            transcript variant 3, mRNA.
ACCESSION   NM_001316979 XM_005259341
VERSION     NM_001316979.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027392.1 and BC024738.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001316979.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.471509.1, AK027392.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000594051.6/ ENSP00000469089.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1127              AK027392.1         12-1138
            1128-2129           BC024738.1         1351-2352
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2129
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /note="zinc finger and BTB domain containing 45"
                     /db_xref="GeneID:84878"
                     /db_xref="HGNC:HGNC:23715"
     exon            1..69
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1605
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /note="zinc finger protein 499"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     45"
                     /protein_id="NP_001303908.1"
                     /db_xref="CCDS:CCDS12984.1"
                     /db_xref="GeneID:84878"
                     /db_xref="HGNC:HGNC:23715"
                     /translation="MAAAEAVHHIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASL
                     RAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVVAQGEALQV
                     LTAASVLRIQTVIDECTQIIARARAPGTSAPTPLPTPVPPPLAPAQLRHRLRHLLAAR
                     PPGHPGAAHSRKQRQPARLQLPAPPTPAKAEGPDADPSLSAAPDDRGDEDDEESDDET
                     DGEDGEGGGPGEGQAPPSFPDCAAGFLTAAADSACEEPPAPTGLADYSGAGRDFLRGA
                     GSAEDVFPDSYVSTWHDEDGAVPEGCPTETPVQPDCILSGSRPPGVKTPGPPVALFPF
                     HLGAPGPPAPPPSAPSGPAPAPPPAFYPTLQPEAAPSTQLGEVPAPSAAPTTAPSGTP
                     ARTPGAEPPTYECSHCRKTFSSRKNYTKHMFIHSGEKPHQCAVCWRSFSLRDYLLKHM
                     VTHTGVRAFQCAVCAKRFTQKSSLNVHMRTHRPERAPCPACGKVFSHRALLERHLAAH
                     PAP"
     exon            70..1348
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..2129
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="ZBTB45"
                     /gene_synonym="ZNF499"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggcct tgtagtcggt caggaggaag cggccacggc agagcctggt gcctgaagag
       61 gagtcggaga tggcggctgc agaggctgtg catcacatac acctgcagaa cttctcacgc
      121 tctctgcttg agaccctcaa tgggcagagg cttgggggac acttctgtga cgtgactgtg
      181 cgcattcgtg aagcttcgct gcgtgcccac cgctgcgtgc tggcggccgg ctcacccttc
      241 ttccaagaca agctgctgct cggccactct gagatccgtg tgcctccggt ggtgcccgcg
      301 cagacagtgc gacagctggt agagttcctg tacagcggtt cgctcgttgt ggcgcagggt
      361 gaagccctgc aggtgctcac ggccgcgtca gtgcttcgca tacagacagt tatcgacgaa
      421 tgcacgcaga ttatcgcccg cgctcgagcc ccgggcacct ctgcgcccac gcccctgccc
      481 acccctgtgc ccccgccact cgcacctgcg cagctgcgtc accgcctgcg ccacctgctg
      541 gctgcacgtc ccccggggca ccccggtgct gcacacagcc gtaagcagcg ccagcccgcg
      601 cgtttgcagc tgccagcgcc cccaacacct gccaaggctg aggggcctga tgctgacccc
      661 tcactgtccg cggcccctga tgaccgaggt gacgaggatg acgaggaaag tgacgatgag
      721 accgatggcg aggatggcga aggtggcggc ccaggcgagg gccaggcacc tccttccttc
      781 ccagactgtg ctgctggctt cctcactgct gctgctgaca gcgcgtgcga ggagccccct
      841 gcacccactg gcctcgctga ctacagtggt gccgggagag attttcttcg gggagctggg
      901 tcagctgagg acgtatttcc agacagctat gtatccactt ggcacgacga ggatggcgct
      961 gtccccgaag gctgtcccac tgagacccct gtccagcccg actgcatact gtctggatcc
     1021 cgcccgcctg gtgtgaagac cccagggccg cccgttgcac tcttcccctt tcacttgggt
     1081 gcccctgggc cacccgcacc acccccttca gcaccatcgg ggccagcccc tgcgccccca
     1141 cccgccttct accccacact ccagcccgag gcagccccca gtactcagct gggggaggtc
     1201 ccggctccct ctgctgctcc caccacggcc ccctcaggca cccctgctcg caccccaggt
     1261 gctgagccac ctacgtatga gtgcagccac tgtcgcaaga cgttcagctc ccggaaaaac
     1321 tacaccaagc acatgttcat ccactcgggg gagaagccgc accagtgcgc cgtgtgctgg
     1381 cgatccttct ctctacgcga ctacctgctc aaacacatgg tcacgcacac cggcgtgcgc
     1441 gccttccagt gcgccgtctg cgccaagcgc ttcacgcaga agagctcgct caacgtgcac
     1501 atgcgcactc accggcccga gcgcgcgccc tgccccgcct gcggcaaggt cttctcgcac
     1561 cgcgcgctgc tggagcgcca cctggcggcg caccctgcgc cctgatggcg ctggggcctg
     1621 gcctcgccca cggtggatcc ggggcctccc gcacagtcgg ccacgcccgc tgcgggaccc
     1681 gtggttcccg ccactagacc acgctccctc ctgagcgcag gtcctctctc tcccttcacc
     1741 ctttctccat accagggcct aagtccgcct tactcctctc ctccatgtac ttgaaccctc
     1801 caggtggtgc cgggctgggg ctggggctgg ttagaccact tctgagaact ggactatttc
     1861 ctgcgtaaac cgggcgctca ggcgcttgga cccggcccaa gatttgactc cggttctcac
     1921 cccgccctct cctggggtgg tggtgggggc tggggggccg cttgcctgcc ccagggtcag
     1981 gctgggcaag gtccctagct ctctacccaa gctgttactc cctcatgggg cgcctaagga
     2041 gactcaagtg gacccatcat atatgggggc tgggcctcgg gactctcgct ctaataaagg
     2101 actgtaggcc atggggccta aaccacgaa
//
