LOCUS       NM_001301098            7399 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 44 (ZBTB44),
            transcript variant 1, mRNA.
ACCESSION   NM_001301098 XM_005271524
VERSION     NM_001301098.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7399)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 7399)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7399)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 7399)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   5  (bases 1 to 7399)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002986.2, AC019227.4, BC030580.1, AP001183.6 and BC049375.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001301098.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357899.9/ ENSP00000350574.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AP002986.2         1-58                c
            59-437              AC019227.4         151725-152103       c
            438-2084            BC030580.1         117-1763
            2085-2085           AP001183.6         137667-137667       c
            2086-2770           BC030580.1         1765-2449
            2771-6154           AP001183.6         128714-132097       c
            6155-7399           BC049375.1         2608-3852
FEATURES             Location/Qualifiers
     source          1..7399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..7399
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /note="zinc finger and BTB domain containing 44"
                     /db_xref="GeneID:29068"
                     /db_xref="HGNC:HGNC:25001"
     exon            1..543
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1617
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     CDS             600..2312
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /note="isoform 1 is encoded by transcript variant 1; BTB
                     (POZ) domain containing 15; zinc finger and BTB
                     domain-containing protein 44; BTB/POZ domain-containing
                     protein 15; zinc finger protein 851"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 44
                     isoform 1"
                     /protein_id="NP_001288027.1"
                     /db_xref="CCDS:CCDS73414.1"
                     /db_xref="GeneID:29068"
                     /db_xref="HGNC:HGNC:25001"
                     /translation="MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRA
                     HKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENII
                     DVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENNSNCNFTSRDGSI
                     SPVSSECSVVERTIPVCRESRRKRKSYIVMSPESPVKCGTQTSSPQVLNSSASYSENR
                     NQPVDSSLAFPWTFPFGIDRRIQPEKVKQAENTRTLELPGPSETGRRMADYVTCESTK
                     TTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEQVQEDLLISP
                     QSSSIGSVDEGVSEGLPTLQSTSSTNAPPDDDDRLENVQYPYQLYIAPSTSSTERPSP
                     NGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDRCGKKFTRAYSLKMHRLKHE
                     GKRCFRCQICSATFTSFGEYKHHMRVSRHIIRKPRIYECKTCGAMFTNSGNLIVHLRS
                     LNHEASELANYFQSSDFLVPDYLNQEQEETLVQYDLGEHGFESNSSVQMPVISQYHSK
                     GKEP"
     exon            1618..1702
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1866
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2167
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2285
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2360
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..7399
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /note="hexamer: AATAAA"
     polyA_site      3130
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
     regulatory      7369..7374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /note="hexamer: ATTAAA"
     polyA_site      7399
                     /gene="ZBTB44"
                     /gene_synonym="BTBD15; HSPC063; ZNF851"
                     /note="major polyA site"
ORIGIN      
        1 attgtgggac acaaacaaag tgcccccaaa caggctggag tgagcggagc ggcaacggcg
       61 gcggcgccgg ccgcacgcgc gcggcggcgg ctccctccca acctccccct cccctcccct
      121 cagtcccctt ccccttcccc accccgcccc gctgggaaca cgcgagccgt cgccgcgctc
      181 cccaaacaac cgcctgccct cggccaaccg tccccaacgg tcgccagcgc gcggctcccg
      241 ggccccctcg ctcctcccct ctggcccctc cgagcgctgg gggtgcttcc ctccccgcct
      301 cctcgcactc ccactcgcgg gcacgccggt ggctgtgccg ccatgcccca ccacaggctg
      361 ctcacgggcc taggcgcggc ggcccgagat aggggcccct gagcctcccg ggggaggaga
      421 gaggcagcga gccgcgctcc gccccctccc cccgggccgc cgccgccgcc gcctcgccgc
      481 cccagcctgg cgggagaagg aggaggagca gcaggcctcc gggcccggcg ccgccgcccg
      541 caggacattt ctgatttatt tgcatccttg aagagcatct gtagaagagg aagtaaaaga
      601 tgggtgtgaa aacatttact catagctcct cttcccacag ccaggaaatg cttggaaagc
      661 taaatatgct gcgaaatgat ggacattttt gtgatatcac tattcgtgtc caggacaaaa
      721 tcttccgggc acataaggtg gtactagcag cttgcagtga tttctttcgc accaaacttg
      781 taggccaagc cgaggatgag aacaagaatg tgttggatct gcatcatgtt acagtgactg
      841 gctttatacc tcttttagaa tatgcttaca cagccactct atcaattaac acagaaaata
      901 ttattgatgt tctagcagca gccagctata tgcaaatgtt cagtgttgcc agcacctgct
      961 cagagttcat gaaatcaagc attttatgga atacacccaa cagccaacct gaaaagggtc
     1021 tagatgctgg acaagaaaat aattctaact gcaattttac ttctcgagat gggagcattt
     1081 ctcccgtgtc ctcagagtgc agtgtggtag aaagaaccat tcctgtctgc cgagaatccc
     1141 ggagaaagcg caaaagctac attgttatgt ctcctgaaag tcctgtaaag tgtggcacac
     1201 aaacaagctc accccaggta ttgaattctt cagcttccta ctcagaaaat agaaaccaac
     1261 cagttgactc ttccttagct tttccttgga cttttccttt tggaattgat cgaaggattc
     1321 agcctgagaa agttaagcaa gcagaaaata cccggacttt agaattacct ggcccatctg
     1381 agaccggtag aagaatggct gattatgtga cttgtgagag cacaaaaact accttgcctt
     1441 taggtaccga agaagatgtc cgggtcaaag tagaaagatt aagtgatgag gaggtccatg
     1501 aggaagtgtc ccagcctgtc agtgcatctc agagttcgct gagtgatcag cagacagttc
     1561 caggaagtga acaagtccaa gaggaccttc tgattagtcc acagtcttcc tctataggct
     1621 cagtagatga aggcgtttct gagggcttgc ctacacttca aagcacgtct agcactaatg
     1681 ctcctccgga tgatgatgat cgattggaaa atgttcagta tccctaccaa ctctacattg
     1741 ctccttccac cagcagtaca gagcgaccaa gtccaaatgg tcccgacaga ccttttcagt
     1801 gtccaacctg cggggtgcga ttcacccgta ttcagaacct aaagcagcac atgctcatcc
     1861 actcaggaat taaaccattt cagtgtgacc gctgtgggaa aaagttcacc agggcttact
     1921 cgctaaagat gcatcgccta aagcatgaag gtaaacgctg tttccggtgc cagatatgta
     1981 gtgccacttt cacttccttc ggggaatata aacaccacat gagggtttcc cggcacatta
     2041 tccgcaagcc tcggatttac gagtgcaaaa catgtggcgc catgttcacc aactctggaa
     2101 atttaatcgt gcacctgagg agtctgaacc atgaagcatc agagctagca aactacttcc
     2161 agagcagtga tttcctagta ccggactact taaaccagga acaagaagag acccttgttc
     2221 aatatgatct tggagaacac ggttttgaaa gcaactcctc tgttcaaatg cctgtcattt
     2281 cacagtacca ctccaaaggc aaggaaccat gattgacaac agtcaagctg tggatgaaat
     2341 gaccaggaac ggagaatgaa ttccaagagg tggtttttga aagagcaaga ggaaagaaaa
     2401 aagaaaagaa ggaaagaaga ataaagaaga gaaacgtgta agaatggttt gcagattgat
     2461 tggttaaaag tgtttttagc acatccccaa ccctgaaaac ttcgcattaa gagccaagca
     2521 caatgttggt agctccaaga tattctgact gtgttctcag aatgagggat tacccatcac
     2581 tgggtattcc ttcccaagta gaaactttag attttcactg gtaatacaca ttgccaagtt
     2641 ttatgggaaa tctgaatata ctgtgaaaat gcatatctgg ttagttgtct gctgcccaga
     2701 tcttatcaat accagtaact aaccagtatt taacataaaa tgatacaaat aaaggccttt
     2761 ttctatttca gtgagggtac atttttcttg atatatatgt actttaagga tattggatct
     2821 gtttatggat ctgttttagg aaacagattt gcaagggata attgtatata tagtagtatt
     2881 taggtttatt tcaaattcat cttagggatg cctagatgca taatttttac caggacatat
     2941 tgaaaatatt gcaaagagat agccagttat attatcccat tcattagaaa ttaccagtgt
     3001 aactaaacat aaatattcca gtttagagtg cttaaacgta gctatctttc ttaaggccag
     3061 gagggtaact ttgtggtatc taaagggctt aaatttcaga atgcagaata aattgccttt
     3121 ttaaaaccaa gcattttgta caagctttta ttttcagttt tttaactacc aaataggtgt
     3181 gatgtacttt agaagtaaac aaagatgttc acccatgata atggatgtta aagctcctgc
     3241 agttgttctt ttcgtgttta aagggtatat tctaatagtg gaagcatcaa acatgtcagt
     3301 gatttcatct cattcagaaa taaagagatt aatattggtc tttatttttt ggcattttaa
     3361 gttttatata aatggatgca gatggagatt atcacccaca aatatattta aatggatttt
     3421 tcttaatttg aatttcaagt aatcttttta tttcaagtaa ttagttacgc atttagttac
     3481 attgccagtt tttttttttt atcaatttca gtaagacaaa atatactaaa atgtttaaat
     3541 agcctcattc aatcttacat tttgacattt cagcaatcat tctggcttac agtaattaga
     3601 tcccctgtta cgacacatgc cctttgttct taataactag caaaaaaaaa aaaaaaaaaa
     3661 aactttcatc ttgttaaaat actttgccaa atgaaataga ctagtcaata catctgatgt
     3721 ccataattat tggtaactca gttaccttct aactaatagg ctggttcagg agactctccc
     3781 agtttataaa tggttctctt gggagccttt ggaagctgta ttaaatcttt cagtctttta
     3841 tttctaattt tttctcttaa tctaaataga ggccagttat ctattttatc agcttttatt
     3901 cttgaagatt ctcagattat gttttagtcc cttttagctt taatagtcct tgaaaaatac
     3961 attactgtat aatgtggcaa ttctgtaaca gagacttatt acttgaatga ataatcctaa
     4021 aattttaata ttttagctga agtttgagat ttgtggaatg aacaaaagaa ttagaaactt
     4081 tcatatgtta ctttgtttca gtcatctgca aagtatgaag ctgtaattct gaaatacaca
     4141 tccaagtgaa tgagaattaa aaattttcta aatattaata ctaactggga aaaaaaaact
     4201 agtgtgaagt ttacagttag aagaaacaga cccaaagttg ccagaaggta ataaataaat
     4261 gtagttttca ctgtaagtaa gttattgacg taagatgctt tatttgtaat atatttagat
     4321 tttgaaagtt attgagagat gaatgtataa aagctaaatt ttcttttctg aagcagtgaa
     4381 acaaaattgg ggtaacaagg aagctctgtt gtggcaaaca tgtctatgag gaatattaaa
     4441 actaagcata ctcccacagg ctttaaactc aaactatgaa catttaaatt aagttgttcc
     4501 ttattttgcc tatacccatt tttatctttc attgtcgttt ttgcttgaca gtatggtgac
     4561 agagtatttt tatttggaaa gtcctcagca agatgaatta gccaaaagca ataatggttc
     4621 agattaaaca ataaagtgga attgattcaa tcccaggctc aactaagaac agtcgctctc
     4681 tggatgtttc attttagacg atagataagt tgagatgttg taatatttat ggggggttaa
     4741 gcctgtgtca gttatgggat gaagacttgt agtaccagta ccatcagtgg tcatactttt
     4801 ttttaacttt ttactaaact aatacagtta gacatttcca ctctatcgtg attatatttt
     4861 tatgatggga aaataaaaac acttccatgt ttttataaat agtctctgca aagatttcag
     4921 atgttattgg tatctcggtt tggcagtatc tgaaaaattg agattgtctt tgaaatgttt
     4981 gtgctacttt tacttaagta aacccccact gtgcaagacc caggccggct tcagctaata
     5041 ccaaggtttc tgtgtgcata atagtttaca gagaacttaa gagtaaggac tgcggattaa
     5101 aaacaaaact ttttttaact ttaaaatttt tagtttttgt tcaaagtacc tggtttataa
     5161 agtcaaattc ttttattagt tcctttctcg tttaaattga ctgatgttgc tgatgaagct
     5221 taaagtccca ggcacggttg tggcgatata ctgataaaat tggtgcctag tggtgggagg
     5281 agctccagtg tcaggacttt tattaaaagg cccttgtttt cccaaatgcc aatctagcca
     5341 catttagatt tcattattca ataaaacaga tgaaaaatca tcccataaat gaatgttgag
     5401 gttaccaaag tacatcacct gctgaggaag gataaatctt cctgctttaa gggagccctg
     5461 tcatctctcc tcttaatgca cgtttccctt ggtattagtg gaagctgtgt tcaagatggg
     5521 aagcctttcc tgcagttctt agaaacacct gctttctaag gagagccttt tctaggatta
     5581 gcttatgtgt gttttctcta ggcgattttt tatttcagtt accaatttaa ttttcaagtt
     5641 gacagatgct gtgtaaagtc tctcataatg agagtagtcc attaaattgt tgaaagttgc
     5701 actgcttttc atctttcagg tacctgaaat gagtgacatc aggtatttgg aaggagtaag
     5761 atcataaact gtattcattt tcttccttgt acaaagtgat gacttctaat gcttatatct
     5821 caaggtattt tttaaaaaag caacggtccc taatagagta aaatttggtt ttggtccaag
     5881 ttcccaataa tgtatttaat gtttctgttg tttactggtg cctcccgttg catcaggtag
     5941 agattgcctg cctctttgta gggcagcctt gtggcacctt atgtccaact tggaggatag
     6001 tatatggctt ctttgtgcct ctactatctt ttcaaaagcc attttataaa aatcctaggt
     6061 agcctatttt aatatttaaa tatatatatt tgtgaaagaa cttttagaac agaccttttc
     6121 tttttacttt aaaattcctg tatttccatt tttaagagta aatttaatct ccaggattta
     6181 gaagtgtctt tccagagaag cataatgaga aagtcagact gaggtaataa gaccagaatt
     6241 aagtgataga agaaactgtt gtttggttaa aggacacaga tttgaaggaa aaaaattttg
     6301 atgtaacaat tttttaaata aaattttgtt tttctgtaat gtcatatttg ctgctacagt
     6361 agctcaatat tttacagggc taacataaag ctggctccat ttaaaaactg gagtacttcc
     6421 tagtgcagcc agcctaggcg gaaactgtac accatggtct tccagatggg tgactgatgg
     6481 ctttgggtag ctgatgcatg ctttaatatt tgcctatagc ccggcagcaa ggaagtcggg
     6541 gcggggggac ttttttaccc tgccagttat agcattgtga ttctttctgg gcactggcat
     6601 tttgtgaaac tctcaaggga aggtgatgca ggggagaaaa tgtgaattaa attacataga
     6661 tgggtgtttt tatgtcttct acccctttcc tagaattagt acaactctta actgtgccag
     6721 tccccagttc accagctttg tatccagtcg tcatctcatt caagtatggc tttacttggt
     6781 gacactggcc atagctaagt taacttggca tgtttgactt ttgacaataa caaaaatggt
     6841 tttggatttt gttttatttc caaaaaatgt atacaatatc agaacttcac attttatata
     6901 ctagtatctg gctattagta ttttacagga accatagttc ttggtgacta catatatata
     6961 tatatttttg tgaccttttt tgtaaactaa gtgccgtttc aacgttacaa tcatttttag
     7021 ggttattgta atcaatgtga atatcatgtt ttttcaaatc tgttctgagc ctatagtgtt
     7081 tgctttgtga acatgtgtat tgtatatatt ctgtatagtt atattgtact gaaattagct
     7141 tgtttgatat aaggaaaata tgtattgagt acctttttgc tagcctgatt gtttaatctt
     7201 tttaaaaaag gtttaaactt tttttaaaaa aaaaatcttt aaactggcct ttattacatg
     7261 gtcacacata aagttgcagt taggaaaggg atgggcaggg aaaaactagt tttgagtgtc
     7321 tttagataga aacatgagac taaggtttga ttttgttttc gttttctcat taaaatatct
     7381 tatgctttat ggaataaaa
//
