LOCUS       NM_014007               5940 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 43 (ZBTB43),
            transcript variant 1, mRNA.
ACCESSION   NM_014007 XM_376910
VERSION     NM_014007.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5940)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 5940)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   7  (bases 1 to 5940)
  AUTHORS   Zhu,X., Feng,T., Li,Y., Lu,Q. and Elston,R.C.
  TITLE     Detecting rare variants for complex traits using family and
            unrelated data
  JOURNAL   Genet Epidemiol 34 (2), 171-187 (2010)
   PUBMED   19847924
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 5940)
  AUTHORS   Schoenen,F. and Wirth,B.
  TITLE     The zinc finger protein ZNF297B interacts with BDP1, a subunit of
            TFIIIB
  JOURNAL   Biol Chem 387 (3), 277-284 (2006)
   PUBMED   16542149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA864775.1, BC008828.2, AL161731.20 and AL354944.22.
            
            On Nov 22, 2018 this sequence version replaced NM_014007.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.111042.1,
                                           SRR1803611.166438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373464.5/ ENSP00000362563.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA864775.1         37-78
            43-1345             BC008828.2         1-1303
            1346-4290           AL161731.20        177509-180453
            4291-5940           AL354944.22        1-1650
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..5940
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /note="zinc finger and BTB domain containing 43"
                     /db_xref="GeneID:23099"
                     /db_xref="HGNC:HGNC:17908"
                     /db_xref="MIM:618676"
     exon            1..93
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /inference="alignment:Splign:2.1.0"
     exon            94..216
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /inference="alignment:Splign:2.1.0"
     exon            217..5940
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1643
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /note="zinc finger protein 297B; zinc finger and BTB
                     domain-containing protein 22B"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     43"
                     /protein_id="NP_054726.1"
                     /db_xref="CCDS:CCDS6867.1"
                     /db_xref="GeneID:23099"
                     /db_xref="HGNC:HGNC:17908"
                     /db_xref="MIM:618676"
                     /translation="MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIF
                     RAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVS
                     YLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSG
                     GHTDFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEG
                     ASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTV
                     QTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNL
                     IGHRQEAALAAGYSENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMS
                     MHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSC
                     TKSYEAAKAEQNTTEAN"
     regulatory      5912..5917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /note="hexamer: AATAAA"
     polyA_site      5940
                     /gene="ZBTB43"
                     /gene_synonym="ZBTB22B; ZNF-X; ZNF297B"
                     /note="major polyA site"
ORIGIN      
        1 gaatctgttg cggcagctga ggctacaaca ggcctgcgcc ggcggcagag aggatatctt
       61 gggcggggga tgtgagcgct gagcccttgg cagaagtcaa tgtgatttta atttgaagca
      121 aaactgaaat gggttcttct tcctcattct attcatgttg ctttttgatg gccatggcat
      181 aaggaactct atcccaggaa tacagctttg cattagcacc gaacaagatt tgtgatgaaa
      241 tggagcctgg aacaaactct tttcgggtag aatttcctga tttttccagc accattctac
      301 agaaactgaa ccagcagcgc cagcaaggac aattatgtga cgtctccatt gttgtccaag
      361 gccacatttt ccgggcacac aaagccgttc ttgctgccag ttcaccctac ttttgtgacc
      421 aggtactcct gaaaaacagc aggagaattg ttttgcctga tgtgatgaac ccaagagtgt
      481 ttgagaacat tctcctatct agttatacag gacgtctagt aatgcccgct ccagaaattg
      541 ttagttactt gacagcggca agcttcctcc agatgtggca tgtggtagac aaatgcactg
      601 aagttttaga gggaaaccct acagtccttt gtcagaagct aaatcatggc agtgaccacc
      661 agtcaccaag cagcagtagt tataatggcc tggtagagag ctttgagctg ggctctgggg
      721 gtcatactga ttttcccaaa gcccaagaac tgagagatgg tgaaaatgaa gaggagagca
      781 ccaaagacga gctgtcatcc cagctcaccg agcacgaata cctgcccagc aactcgtcca
      841 cagagcatga ccgcctgagc acggaaatgg caagccagga tggggaggag ggcgccagcg
      901 acagcgccga gttccactac acccggccca tgtacagcaa gcccagcatc atggctcaca
      961 aacgctggat ccacgtgaag cccgagcgct tagaacaggc ttgcgagggc atggatgtgc
     1021 acgcgaccta cgacgagcac caggtcacag agtccatcaa caccgtgcag acagagcaca
     1081 cggtgcagcc ttcgggagtg gaggaggact tccacatcgg ggagaagaaa gtggaagctg
     1141 agtttgatga acaggctgat gaaagcaatt atgatgagca ggtggatttc tatggctctt
     1201 ccatggaaga gttttccgga gagaggtcag atgggaatct aattgggcac agacaggagg
     1261 ctgccctcgc agcaggttac agtgagaata ttgaaatggt aacagggatt aaagaagaag
     1321 cttcccactt aggattctca gccactgaca agctgtatcc ttgtcagtgt gggaaaagtt
     1381 tcactcacaa gagtcagaga gatcggcaca tgagcatgca cctcggtctt cggccttacg
     1441 gctgtggggt ctgcggtaag aaattcaaaa tgaagcacca tctcgtgggc cacatgaaaa
     1501 ttcacacagg cataaagccg tatgagtgta atatctgtgc aaagaggttt atgtggaggg
     1561 acagtttcca ccggcatgtg acttcttgta ctaagtccta cgaagctgca aaggctgagc
     1621 agaatacaac tgaggctaac taaaaatagg atctggccct tgagtggcat gcacaaaaat
     1681 aaactatggt aattaatgca aatctgggca cagatgatgc gtgctacttg ctattatgag
     1741 agaagcttaa aaaaaaaaag gaagatattt ctgaaagacc agctctaagt aggccaatta
     1801 aaaaaatcta attcctcaaa tttgtgtgtt ccagtcctgg cctggaatgg gtaatggggt
     1861 gagttaaccc accgcccagc tggcaaggga aaccttctga ctggttgtga tcgaaacagg
     1921 tggacagaga cacctgcact tggaactgga ctccacccac cagttccatt ttgggtggca
     1981 gcagctttgg atcactcatt attacaaggt catgctgaaa ttttattttg ctcttgctat
     2041 agatacttag gtaatgtgga tttgttttgg tagctatttc actgaaggaa gtgctactta
     2101 tataaaagct agaaataatg tgattcctag gatgagaaat tggttaacag agctctgttg
     2161 tctggtttta gtctttctaa aggatatttt aactaaaact atggagatgc taagagagtg
     2221 actttctaaa tatgaaacag ataatttacg gtacaaggct gacatagtgc ccttgtcagt
     2281 ttctgtaaga tgccactact gtcacaaggt gtttcagact cttgataagg cagtgttttg
     2341 tattttagtt ctaacattga gtttggacaa ttttatctaa ttgtaattct ctagggtgcc
     2401 agagataggt atttctcatt ggtttgcttt cccaaatcct gtttggttaa ttgtagcctc
     2461 catacagtgg ggtcttctct gtggctggta gacaccaagc tgctgtgact gaccacggta
     2521 ccacgggctg ccacagcccc tgctctgtct tagattatgg tgctttacaa agagagtggt
     2581 ccatgaccac acttagtgag aaggagccac aagttgtggc tgagagttcc ctgtgaactt
     2641 gagtagttca tagagtgcta aggtgacact ccaccaacca gagtgagagg gcagataggc
     2701 aggattctat gagtggttat acttaagggg gacaaaactg cccaagaaga atcttgagaa
     2761 tacactcttt caaggtgggg gagatactct ttagagggta cactgagcta atactaccag
     2821 ttctttatga gcactggaat gtgtttgtaa aaggagtcct aagtttagca aggtagtcta
     2881 cagaaccatg ctcccacatt atagataaag ctgcttaaac ttaaaagtcc acaaagctac
     2941 gccgaccaga aaaaaaaaat taaaaaaaca aacaagaaaa gcaactattc tgagaccttt
     3001 tctgcccatc agttagatga tttaggttaa aaagaaaggt aatattgcac atgcttttaa
     3061 gctgtgtaac atacctgagg ttatcaccag ggtaggacag ggtgctacta ccatgtcatc
     3121 ttttccacaa tcgtactggg ttatttactt ctaaatagaa actttttttt cttaaaataa
     3181 aaataatttt tcttggattt ggggtgaaat tttatttgaa aagtttggct ttgctgtaat
     3241 gtaatagaca ttgctggcaa tggcctctga ttctcaagct cctaacacca gggtgtttac
     3301 ttgttgaaca ttgtctggaa agaggaaaga aaatacttat ttaccagtta actcttgtaa
     3361 gcaagattac aaacagggat ttattcacaa cactgtatca ttctcgatat ataaaaagca
     3421 ctttgtattt aaaactttat tataaatata tatatatatt gttttttttt aaacctagaa
     3481 actagatatt acctcttggt tgtttgccac attaatagct tctcttagta ttgaaacgtt
     3541 actggttagc agtcttttct ctgtgtacct gacacacgta tactgagggg attgtacaat
     3601 caagcctatt gtctcctttt ctttcactca tggtagaggc cagtgggttt taggtatgat
     3661 cctagccatt atatttgagg agaaattgtt ctattactcc tactaatttc agtactaagg
     3721 tggtgatgcc attttgttct gccaaaaact gatcaccctc tcccatggta ttagcagagc
     3781 attttctgcc tgtttggaag gtttgatgtc ctgtttctca ttgaagacta tttacatgat
     3841 cattaggaca ttgcaggaga agtctgagag gtaaaaatac agatattctg ggagagtcgt
     3901 ggtccttcag ttctgctgaa atcagcatag tgcccttgtc atgaggaaga gtttctgttc
     3961 agccaagagt ggtggcacgc ttgggtggta gttttggaag cagtcagttg tgctaggact
     4021 tatttaatat gttgtgaaga gaagagtgtc ttcttgaaag ccttatgtgt ccatcagcta
     4081 ctaaatgtag aacttaaata agttgctcac atctgttctt ttagtgtttt gtggtatttg
     4141 aggttttggc aaaaattggg atttttttat caggcagcca gagcctggga ggtggtaggg
     4201 tgtctgaaat gctggccatg ttcagagagg caggagaagg gggttgcttt catttgaata
     4261 ttaaaagtga atttttgtaa actctggttt ttaccttttt ttcatcccca cgttgagttg
     4321 gaggaatagt ctcttctctt cacctcaata tagctttaga aaatctttat ccttcctaat
     4381 aagtttggat ggttgtgggt aacattgttc aaacaatctt tcagggatca cgtcaatggc
     4441 ctacaaccaa gctatttgtc ccctactttg agtcttaact gtggtttttc ttcaatcccc
     4501 atgggaaagg gcttcaaggc accaccagtg gtatttaata ttcatacttg gggccaggca
     4561 tggtggctca cgcctgtaat cccagcactt tgggaggccg agatgggtgg atcacctgag
     4621 gtcaggagtt tgtgaccagc ctgaccaaca tagtgaaacc ccatctctac taaaaataca
     4681 aaaattagcc aggcgtggtg gcgcacacct gtaatcccag ctactcggga ggcggaggca
     4741 ggagaatcac ttgaacctgg gaggcggagg ttgcagtgag ccgcgattgc accaccacac
     4801 tccagcctgc gcgacagatc gagactctgt ctcaaaaaaa aaaaaaaaat tcatacttat
     4861 gccatgcttt tacctttaga tacacacgtt acagtaatcc acgtggtgaa gtgcatgtca
     4921 ccgttaacta aggaaggact gcggtaactt accctgcagg gctgtaggtt gcctgcaggc
     4981 gctccaggcc cccagcctgt tgattccgat ttctaggtct catcttcctc tggtcccttt
     5041 tggccactac tttaaaagct tgcccaaagg gatcccctcc attctagtgg gcatttgctg
     5101 aactaacctg cccctaaggc tggcttctaa ccaccgggga aagctgctta gcctccaggg
     5161 ctccctcctt gagaggctca cacaccccca agctgctgtg gagtgaattt gagacggagc
     5221 agaagctgca aagctgtgct ttccctgggg aaggggatgt gctgcggcct cctgggtggg
     5281 cgtggagagg gcgccatcac aacgagtcca ggtttttgct tttggaaggt ctctgataat
     5341 ttaggggtgc tggaaaccag cactgtgtta tccccaatcc ctcctgtgcc accagttttg
     5401 tgatttaggt tgctttagtg ggtgactaac ttttgttcag tgaaaccagg gtttgtttgg
     5461 ggtttttttc tttgctactt acatatttaa aggtacaagt ttcttatttc aaatctctac
     5521 tgatagtgcc ctatggggag atgctggaac acattttgca aatgtgactt tttttttttt
     5581 ttttaatttt tgcttgaagc ctgtgtcatg ttagttgctg ctgccttctt tccttttgtg
     5641 aggttcccaa tgtttcgtcc agaaaagtac tttatttatg caagtcaggt gactcttagg
     5701 ccacaaaacc atttgatgat aaacagatta tcattaggtg catatcttat tgatattttg
     5761 tgaaatgtta tgcctatgtt gcaaaagttg aatagttttg tctttatata ttgctgtctt
     5821 cagtgtacag catggtttta cttaattgaa tgttaatgtt taatattttc ttcttataga
     5881 agagatcatg cccttttgta tgacatgttt taataaatgt tatctgtcaa ctttgtaaaa
//
