LOCUS       NM_014870               8701 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 40 (ZBTB40),
            transcript variant 2, mRNA.
ACCESSION   NM_014870
VERSION     NM_014870.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8701)
  AUTHORS   Zhou,M., Cui,Y., Zuo,S., Peng,Q., Liu,Y., Li,X., Yang,Y., He,Q.,
            Yu,X., Zhou,J., He,Z. and He,Q.
  TITLE     ZBTB40 is a telomere-associated protein and protects telomeres in
            human ALT cells
  JOURNAL   J Biol Chem 299 (9), 105053 (2023)
   PUBMED   37454741
  REMARK    GeneRIF: ZBTB40 is a telomere-associated protein and protects
            telomeres in human ALT cells.
REFERENCE   2  (bases 1 to 8701)
  AUTHORS   Cushing,K.C., Chen,Y., Du,X., Chen,V., Kuppa,A., Higgins,P. and
            Speliotes,E.K.
  TITLE     Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of
            Both IBD and Adverse Bone Health Outcomes Highlighting Common
            Genetic Underpinnings Across Both Diseases
  JOURNAL   Inflamm Bowel Dis 29 (6), 938-945 (2023)
   PUBMED   36680554
  REMARK    GeneRIF: Risk Variants in or Near ZBTB40 AND NFATC1 Increase the
            Risk of Both IBD and Adverse Bone Health Outcomes Highlighting
            Common Genetic Underpinnings Across Both Diseases.
REFERENCE   3  (bases 1 to 8701)
  AUTHORS   Doolittle,M.L., Calabrese,G.M., Mesner,L.D., Godfrey,D.A.,
            Maynard,R.D., Ackert-Bicknell,C.L. and Farber,C.R.
  TITLE     Genetic analysis of osteoblast activity identifies Zbtb40 as a
            regulator of osteoblast activity and bone mass
  JOURNAL   PLoS Genet 16 (6), e1008805 (2020)
   PUBMED   32497039
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8701)
  AUTHORS   Hu,Y., Lao,L., Mao,J., Jin,W., Luo,H., Charpentier,T., Qi,S.,
            Peng,J., Hu,B., Marcinkiewicz,M.M., Lamarre,A. and Wu,J.
  TITLE     Armc5 deletion causes developmental defects and compromises T-cell
            immune responses
  JOURNAL   Nat Commun 8, 13834 (2017)
   PUBMED   28169274
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8701)
  AUTHORS   Zhang,L., Choi,H.J., Estrada,K., Leo,P.J., Li,J., Pei,Y.F.,
            Zhang,Y., Lin,Y., Shen,H., Liu,Y.Z., Liu,Y., Zhao,Y., Zhang,J.G.,
            Tian,Q., Wang,Y.P., Han,Y., Ran,S., Hai,R., Zhu,X.Z., Wu,S.,
            Yan,H., Liu,X., Yang,T.L., Guo,Y., Zhang,F., Guo,Y.F., Chen,Y.,
            Chen,X., Tan,L., Zhang,L., Deng,F.Y., Deng,H., Rivadeneira,F.,
            Duncan,E.L., Lee,J.Y., Han,B.G., Cho,N.H., Nicholson,G.C.,
            McCloskey,E., Eastell,R., Prince,R.L., Eisman,J.A., Jones,G.,
            Reid,I.R., Sambrook,P.N., Dennison,E.M., Danoy,P.,
            Yerges-Armstrong,L.M., Streeten,E.A., Hu,T., Xiang,S.,
            Papasian,C.J., Brown,M.A., Shin,C.S., Uitterlinden,A.G. and
            Deng,H.W.
  TITLE     Multistage genome-wide association meta-analyses identified two new
            loci for bone mineral density
  JOURNAL   Hum Mol Genet 23 (7), 1923-1933 (2014)
   PUBMED   24249740
REFERENCE   6  (bases 1 to 8701)
  AUTHORS   Liu,J.M., Zhang,M.J., Zhao,L., Cui,B., Li,Z.B., Zhao,H.Y.,
            Sun,L.H., Tao,B., Li,M. and Ning,G.
  TITLE     Analysis of recently identified osteoporosis susceptibility genes
            in Han Chinese women
  JOURNAL   J Clin Endocrinol Metab 95 (9), E112-E120 (2010)
   PUBMED   20554715
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8701)
  AUTHORS   Rivadeneira,F., Styrkarsdottir,U., Estrada,K., Halldorsson,B.V.,
            Hsu,Y.H., Richards,J.B., Zillikens,M.C., Kavvoura,F.K., Amin,N.,
            Aulchenko,Y.S., Cupples,L.A., Deloukas,P., Demissie,S.,
            Grundberg,E., Hofman,A., Kong,A., Karasik,D., van Meurs,J.B.,
            Oostra,B., Pastinen,T., Pols,H.A., Sigurdsson,G., Soranzo,N.,
            Thorleifsson,G., Thorsteinsdottir,U., Williams,F.M., Wilson,S.G.,
            Zhou,Y., Ralston,S.H., van Duijn,C.M., Spector,T., Kiel,D.P.,
            Stefansson,K., Ioannidis,J.P. and Uitterlinden,A.G.
  CONSRTM   Genetic Factors for Osteoporosis (GEFOS) Consortium
  TITLE     Twenty bone-mineral-density loci identified by large-scale
            meta-analysis of genome-wide association studies
  JOURNAL   Nat Genet 41 (11), 1199-1206 (2009)
   PUBMED   19801982
REFERENCE   8  (bases 1 to 8701)
  AUTHORS   Styrkarsdottir,U., Halldorsson,B.V., Gretarsdottir,S.,
            Gudbjartsson,D.F., Walters,G.B., Ingvarsson,T., Jonsdottir,T.,
            Saemundsdottir,J., Center,J.R., Nguyen,T.V., Bagger,Y.,
            Gulcher,J.R., Eisman,J.A., Christiansen,C., Sigurdsson,G., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Multiple genetic loci for bone mineral density and fractures
  JOURNAL   N Engl J Med 358 (22), 2355-2365 (2008)
   PUBMED   18445777
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8701)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   10 (bases 1 to 8701)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA787818.1, BC114607.1, DA248977.1 and AL035703.21.
            
            On Nov 22, 2018 this sequence version replaced NM_014870.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.215422.1,
                                           SRR1803612.220868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375647.5/ ENSP00000364798.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               DA787818.1         1-220
            221-1054            BC114607.1         93-926
            1055-1106           DA248977.1         132-183
            1107-1509           DA248977.1         185-587
            1510-2006           BC114607.1         1046-1542
            2007-2007           AL035703.21        120100-120100       c
            2008-3211           BC114607.1         1544-2747
            3212-3212           AL035703.21        109068-109068       c
            3213-3768           BC114607.1         2749-3304
            3769-8701           AL035703.21        98130-103062        c
FEATURES             Location/Qualifiers
     source          1..8701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..8701
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="zinc finger and BTB domain containing 40"
                     /db_xref="GeneID:9923"
                     /db_xref="HGNC:HGNC:29045"
                     /db_xref="MIM:612106"
     exon            1..154
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            155..920
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..3943
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger and BTB domain-containing protein 40"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 40
                     isoform a"
                     /protein_id="NP_055685.3"
                     /db_xref="CCDS:CCDS224.1"
                     /db_xref="GeneID:9923"
                     /db_xref="HGNC:HGNC:29045"
                     /db_xref="MIM:612106"
                     /translation="MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAA
                     ASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYTGKLPVGKHNFSKIISLADSLQM
                     FDVAVSCKNLLTSLVNCSVQGQVVRDVSAPSSETFRKEPEKPQVEILSSEGAGEPHSS
                     PELAATPGGPVKAETEEAAHSVSQEMSVNSPTAQESQRNAETPAETPTTAEACSPSPA
                     VQTFSEAKKTSTEPGCERKHYQLNFLLENEGVFSDALMVTQDVLKKLEMCSEIKGPQK
                     EMIVKCFEGEGGHSAFQRILGKVREESLDVQTVVSLLRLYQYSNPAVKTALLDRKPED
                     VDTVQPKGSTEEGKTLSVLLLEHKEDLIQCVTQLRPIMESLETAKEEFLTGTEKRVIL
                     NCCEGRTPKETIENLLHRMTEEKTLTAEGLVKLLQAVKTTFPNLGLLLEKLQKSATLP
                     STTVQPSPDDYGTELLRRYHENLSEIFTDNQILLKMISHMTSLAPGEREVMEKLVKRD
                     SGSGGFNSLISAVLEKQTLSATAIWQLLLVVQETKTCPLDLLMEEIRREPGADAFFRA
                     VTTPEHATLETILRHNQLILEAIQQKIEYKLFTSEEEHLAETVKEILSIPSETASPEA
                     SLRAVLSRAMEKSVPAIEICHLLCSVHKSFPGLQPVMQELAYIGVLTKEDGEKETWKV
                     SNKFHLEANNKEDEKAAKEDSQPGEQNDQGETGSLPGQQEKEASASPDPAKKSFICKA
                     CDKSFHFYCRLKVHMKRCRVAKSKQVQCKECSETKDSKKELDKHQLEAHGAGGEPDAP
                     KKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDEKPFSCEECGAKFAANSTLKNHLR
                     LHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCDAVFAQSIELSRHVRT
                     HTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEV
                     HSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHP
                     DVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPA
                     LLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTS
                     QAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQVFV
                     TLPDSQASQASSELVAVTVEDLLDGTVTLICGEAK"
     exon            921..1054
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1247
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1390
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1583
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1720
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1922
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2056
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2225
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2684
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2891
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3056
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3271
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3434
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3521
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3748
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..8701
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8215..8220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="hexamer: AATAAA"
     polyA_site      8239
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="major polyA site"
     regulatory      8629..8634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="hexamer: ATTAAA"
     polyA_site      8651
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
     regulatory      8680..8685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
                     /note="hexamer: AATAAA"
     polyA_site      8701
                     /gene="ZBTB40"
                     /gene_synonym="ZNF923"
ORIGIN      
        1 gatacccatt gcgcgccggc ctcaagatgg ccgccttctg gcgtctccgg cgctgttgaa
       61 tggcgaaagc tttattgttc ccttcgggca ggagtgttcg tgtcctctat ggcgctgtca
      121 ataaagaacg gcagtttgaa tcggtgctga acagggcctg tcctcccaaa gccaactcta
      181 aggagaggag aggaagagca gttcttgggg cagagttgac gcaatggagc tccccaacta
      241 cagccggcag ctgctgcagc agctgtacac tctgtgcaag gagcagcagt tctgtgattg
      301 caccatctcc attggtacca tttacttcag ggctcacaag cttgtcctgg ctgctgccag
      361 cctcctgttc aaaaccctgc tggataacac agataccatc tccatcgatg catctgtggt
      421 gagccccgag gagtttgcgc tcttgttgga aatgatgtac acgggcaaac tacctgtggg
      481 caagcacaac ttctccaaaa tcatctcctt agcagacagt ctacagatgt ttgatgtagc
      541 tgttagctgc aaaaatcttc tgaccagcct tgtaaactgc tcggttcagg gtcaggtggt
      601 aagggatgtc tctgcgccat cctcagagac attcagaaag gaaccagaga agcctcaagt
      661 agaaatcctt tcatctgaag gtgctggaga gcctcattct tccccagagc ttgctgccac
      721 tccagggggc cctgtgaaag ctgagactga ggaagcagcc cattcagttt cacaagagat
      781 gagtgtgaat tctcccacag cccaggagag ccagaggaat gcagaaaccc cagcggagac
      841 tcctactaca gctgaagctt gttccccctc ccctgctgtg caaaccttta gtgaggcaaa
      901 gaagacaagc acagaaccag gatgtgaaag gaaacactac cagctgaatt ttcttctaga
      961 aaatgaaggt gtcttctcag atgcactcat ggttacccag gatgttttaa aaaaactaga
     1021 aatgtgttca gaaattaaag gtccacagaa ggagatgata gtgaaatgtt tcgagggtga
     1081 aggaggacat tcagcattcc agagaatcct gggtaaagta agagaggaaa gcctggatgt
     1141 tcaaactgtt gtgtccctgt tgaggctgta ccaatattct aatcctgcag taaaaacagc
     1201 actattagac aggaagccag aagatgtaga cacagtgcag ccaaaaggga gcacagagga
     1261 gggaaagacc ttgtctgttc tgttactaga acacaaagag gacctgatac agtgtgtaac
     1321 acagctgaga cctattatgg agtccctgga aacagccaag gaggaattcc tgactggcac
     1381 tgaaaaaagg gtgattctga attgctgtga gggcagaaca cccaaggaga caatagaaaa
     1441 tttgttgcac agaatgactg aagagaagac gctgactgct gagggtttgg taaaactcct
     1501 ccaggctgtg aagacgactt tcccaaacct gggccttctg ctagagaagt tgcagaaatc
     1561 agccactttg ccaagcacca cagtccaacc aagccctgat gattatggga ctgagctatt
     1621 gagacgctat catgaaaacc tctctgagat tttcacagac aaccagattt tattaaagat
     1681 gatctcacac atgacaagtt tagcccctgg agaaagagag gtcatggaga agcttgtgaa
     1741 acgtgactct ggttcaggtg gtttcaattc tctgatatca gcagttctag aaaagcagac
     1801 tctctctgcc acagccattt ggcaactgct gctggtggtt caggagacaa agacctgtcc
     1861 attggacctg ctcatggagg aaatacgaag ggagcctggt gccgatgctt tcttccgggc
     1921 agtgaccacc ccagaacatg ccactttaga aacaatcctg aggcataacc agttgatctt
     1981 ggaggccatc caacagaaga ttgagtacaa gctctttacc tcggaggagg agcacctggc
     2041 agagactgtg aaagagattc tgagcattcc ctctgagaca gccagccctg aagcttccct
     2101 gagagcagtg ctgagcagag ccatggaaaa atcagtcccg gccattgaaa tatgccacct
     2161 cctgtgcagt gtccacaaat cttttccagg cctgcagcct gtcatgcagg agttggcata
     2221 cattggtgtc cttactaagg aagatggaga gaaggaaacg tggaaggtga gtaataaatt
     2281 tcaccttgaa gccaacaaca aagaagatga aaaggcagcc aaagaagaca gccagcctgg
     2341 ggaacagaat gatcaaggag agactggttc cttgccagga cagcaagaga aagaggcttc
     2401 agcctcccca gaccctgcca agaagagctt catctgtaag gcctgcgaca aaagcttcca
     2461 tttctactgc cgcctaaagg tgcacatgaa gcgctgccgg gtggctaaga gcaaacaggt
     2521 gcagtgtaag gagtgcagtg agaccaagga ttcaaagaaa gagctggaca aacatcagct
     2581 ggaggcccat ggtgcaggtg gagagcccga tgcccccaag aagaagaaga agaggcttcc
     2641 agtgacatgt gacctctgtg gcagagaatt tgcccatgcc tcaggcatgc agtaccataa
     2701 gctgacagag cacttcgatg agaagccttt ctcctgtgaa gagtgtgggg cgaagtttgc
     2761 agccaattcc accctgaaga accaccttcg ccttcacacc ggggaccgcc cgttcatgtg
     2821 caagcactgc ctcatgacct tcacccaggc ctccgccctg gcctatcaca ccaagaagaa
     2881 gcactcagaa gggaaaatgt atgcatgcca gtactgtgat gctgtgtttg cccagtctat
     2941 tgagctgtcc cgccacgtga ggacccacac cggggacaag ccctatgtct gcagagactg
     3001 tggcaagggc ttccggcaag ccaatggcct ctccatccat ctgcacacct ttcacaacat
     3061 agaagatcct tatgactgca agaagtgcag gatgagtttc cccactcttc aggatcaccg
     3121 gaagcacatc catgaggtgc actccaaaga gtaccacccc tgccccacgt gtgggaagat
     3181 cttcagtgcc ccgtccatgc tggagcggca cgtggtgacc cacgttggag ggaagccctt
     3241 cagctgcggg atctgcaaca aggcctacca gcaattgtct ggtttgtggt accacaatcg
     3301 aacccaccac cctgacgtat ttgctgctca gaaccaccga tcttccaagt tctcatcact
     3361 ccagtgcagc tcctgtgaca aaaccttccc caacaccatt gagcacaaga agcacatcaa
     3421 agcagaacat gcagatatga agttccatga atgtgaccag tgtaaggagc tcttccccac
     3481 gccagccttg ctgcaggttc atgtcaagtg ccagcattca gggtcccagc cattccggtg
     3541 cttgtactgt gctgctactt tccgttttcc tggagcattg cagcaccatg tcaccacgga
     3601 gcacttcaag cagtcagaga ccaccttccc ctgtgagctc tgtggggaac tcttcacctc
     3661 ccaggcccag cttgacagtc acctggaatc tgagcaccca aaggtgatga gcacggaaac
     3721 ccaggccgca gcctcacaga tggcgcaggt gatccaaacc ccagagccgg tggccccgac
     3781 agagcaggtg atcactttgg aggagaccca gcttgccggg tcgcaggtgt ttgtgacgtt
     3841 gccagattct caggcatctc aggccagctc tgagctcgtg gcggtgactg tggaggactt
     3901 gctggatggc acagtgacgc tgatctgtgg tgaggccaaa tgagcagcct ttcatccggc
     3961 agagccttcc tgcgtttgca gcagagagga ggccccacag cttgcccttt gccctccatc
     4021 cctggctgtc ctgagtggtg agcatcttag cttagcacca accaacacag tctcacctag
     4081 aaaacagatg gaagcttcgt tgttctcata gaaccaacag catctgagcc ctcaacacca
     4141 acagcaccat cctctgtagc agacaggcct ccctccccac aggcccgctg ctgcggcctc
     4201 tatgacactg tccatcccca agtgacatgt ggcttcagaa gtagagtctg aaagagcagt
     4261 gggatgggag ctggtgacca gggtacccca ggaggcatga tgtgccgaca gcgctcagtg
     4321 ggcagaatgg cagttagata tgggacttgg cccacagtgg gggctgcaaa tgctgccact
     4381 gcctctggcc atttaaagtg agaggggcac caacagacaa ttcggggacc ttaggcccct
     4441 tcctgaggca cacttggccc cttcctcggt cctatcatcc taccctctgc tggggttccc
     4501 cctccaccca gtggccacgc ccagcaccct attgatggct ataggacagg tagccctcat
     4561 ttccatgcct gataacccct tgtcagttgt cagctcttcc caaaacaaag ctctggagtt
     4621 tctgctggaa gtgtttaatg tgaggcatca gctgctagac agtgtctgcc tttccaggac
     4681 attcttcttg gtattcctta cctgaagcct ggttcccaca gctcttccgt gtcatcttca
     4741 tccccttcct ttaatcaaag gctgaaatct ctgcctgacc tggcagcctg gctccctctg
     4801 ggtcatatgg tgcagactgt gaccagcacc aggcaggcag tcctgtctgc gtgtggagga
     4861 gcagccgtga ctgcccgtgg ctctgctgcc gcccactccc tgccttgtga gtggcctgct
     4921 gcctcacctc ccgcaggccg ccacacttat tgcaggtcag tgatcctttg gagtttgaat
     4981 ttcacaaagc tttttttatc ttcagttcct aaaatataat ctgataatta atggtttgtg
     5041 gaatccatta tgaagtgcaa ttagatagat gtaggttcct gccgtttgga gagaatgact
     5101 agcatttatc ttcttttcct tccatgccaa aggttggagt ctgctggtgc ggtgtttaca
     5161 caccaggcag ggctgtctgc caccttgtgt ggcttgaccc cctgtggagg ggagtgcctg
     5221 gttggatccc acactggcag agatggggcc accccttcct tccaggcaca tctcacattg
     5281 ccatgtacag aggcaggagt cacgtttggt caccatggaa gcttttattg ctcccacatg
     5341 gtcaggtctc accctgcttg aagcgcagaa ggcacagcct tactgaccag cacgcccact
     5401 gactggcatc tgccggcttt gtgcaggcag ccccgacggt ttccacagcg agcgccagct
     5461 ccggccagcc tgggacagct catcccagcc gactacacct gcttctggtc ctgtccacat
     5521 tttgatacgc agatcacttg agcttgtcaa ttagggttct gccattctga aataaatgaa
     5581 gtttctaaag cagagtcggc ctcagaagcc aaaaactgac cagaagatgg tgctcaaacc
     5641 tttaagactt catctccatg tgaagggctc actgtttcta ccaaggctgt gcctgtatta
     5701 aggcttttcc gtcctgggaa ctgtcagtct gggagagctc ttgatctgca ggtggcaaaa
     5761 tggcactgaa tatccccttg gcagcagaga aaacccactg aaagatcgta gagtggcaca
     5821 tgcttacagg gcattggtgc caagtccagt ggatgagaat ccagcccctc acaagctgtg
     5881 ggatggggct tgggagttgc agtgaatgtc attaaaattt cttccaaaac aaaactagaa
     5941 ataattgctg agggcttata gggaagtgat ttaaaaagaa aaaacaaaca acaacaaaaa
     6001 aaactcttcg gaataaagag ggctgtaaat tttgaattcc agtgtcagat cctttcaagc
     6061 actgagaaat tctttctcag gtttcttttt ttgggggaga cagggtcttg ctctgtcacc
     6121 cagactggaa cacagtggca cgatcttggc tcactgcaac ctctgcgggc tcacgcaatc
     6181 ctcctgccac agcttcccaa gtagctggga ccacaggcgt gagccaccac tgctggccag
     6241 tttttgtatt tttttttttt tttgtagaga cagggtctcg ccatgttgcc caggctggtt
     6301 taaaactcct gagctcaagc agttctccca cctgggcctc ccaaagtgct aggattacag
     6361 acatgagcca ctacgcctgg ccaggtttct gttggagacc cagattgtga caagacattt
     6421 gttttcttcg gaatcaccag atttgcagct tactgtgccg agagtggact ggctgccggg
     6481 gcccatcaga tgccctctgg cccatggcac actcagcaga aggcacaaac ccagtgctgg
     6541 ttctcatcaa gaaagagggg aaggcccttc ccgagtttac tgtctgctct gagtgggctc
     6601 cgcactggct gactgatttt atagtcttgc tctctagaga agcccaggca tggatcttat
     6661 aggaaaactt tctgactctg cttggccatt ttatcctttt ctcctacttc tgcccaagag
     6721 acctgaattg ctgccataga ggacagtgtt tgtgtggtct cctgagtcca catcgctcgc
     6781 ttccatgggg tcccggtgtt gtttttgcct cgttccccat aggctgctgc ccttatggcc
     6841 tctggactga actctggggc ctttggggtg gtgtgaagga gtctgtgggc ttcttggaac
     6901 acatggatct gttcggtggg tccccagacc tctgctccca gagctcatgg cccaggtggt
     6961 gaggagggaa aggcagtcag attccaggct ggagtgtgat tctgtgggaa tactggggtc
     7021 agttatggaa caggacttgc ccatcatagg taagtgagac agcaaataga tgattcaaga
     7081 gcaaggatta ctgcgggaag gtgagactcc tactgtccac gcgcatgagc agaacctgga
     7141 accagagggg cagggaccag gggtctttac tcatttattt tatgggtaaa gagacatgaa
     7201 gagacagcct ctctcttctg tctcagaagc tctgtgtttg ggaaactttg agcccagtga
     7261 gtagcagggt ctgcagtgtg agtaccaggt ttccctggca atccaggtct cctctgagga
     7321 agcattctga cttcccactg accacggaag gcatgtcagc ttcatgcctc gggctagagt
     7381 tctgataatc ggggctgagg ggtgaaaaga aatccagtca gacagacagt ggggagacag
     7441 gtccctgccc tttatttgcg ggatcaatca gggactccca gaaaggaagg agaatggtga
     7501 gaagggccct aagagttcgt ctctcacctg ggggctggtg acgtggtcac cacaagctga
     7561 agacaggcta atggggtggc gggtgtgtgt ttaaacctca cgtgcctgga agctgcacat
     7621 tgaccaaagg agggagggaa gtgctaacca tgtatagagt gggcaggcgg ttccagggag
     7681 acaagcagca tgttattaaa ttgggcctag gcagttggac gataatggag aaaaagcagg
     7741 gatgctataa tgagtcctcc ccaagggtga gttcagcacc ccagccctgt tctgcttgta
     7801 tcccagtgat acttgggagg taggaagaaa atgggagtaa gagaacaatt tggggctgaa
     7861 gggagtgtca gaggcacgtt gatccttgtt ttgttgtcat ggaaacttcg gggctggtgg
     7921 gacttaggcc aaaagctcag aggcacagcc aaaatttaga agcttgctac tcctacgact
     7981 cggcctataa ggaagagaga agctgtctgt actttgggga ctacattgct gaaggaaaaa
     8041 aatcactccc tggctaatta agattgcttc caaattgggg gaatgtgtgt catttccttt
     8101 accaaggcca gtcatccctg cttccaccca tggtcaggac agtcagccac tacgtgatgc
     8161 tgtataaatt ggattacaaa ccatattctt gttcagcttg cactaatcta tataaataaa
     8221 atatgtactt tgaaaaaaat taggctacat gagtttcaaa tggactgtga tgttatagac
     8281 ctgctttctc tttggttctg ggccagtgtc agacggggac aggggtgata ggcctggtgt
     8341 cctaggggcc atttgtgtac cttgaggccg tgttaacatg gcctggggga aagaaagctc
     8401 tcctgtcact tggagtctca ttcctaaacc ctccttccca gggagcaagt gtggggcagg
     8461 gtttcagagc acaggctttg gtgtccagcc tgggtacatc cagctgtccc gctgtctaac
     8521 tgacattgtg tgagatgctt actctctctg agctccctcc tcctggctcc caactttatt
     8581 ataaaatggg gaaaatgatt gtgcttgccc tacagaattg tagtatgaat taaaagtctg
     8641 gatttaatgt atttaatata gaaaatttta gcttttatta ataaaagttt ttggcataca
     8701 a
//
