LOCUS       NM_001128833            5860 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger and BTB domain containing 4 (ZBTB4),
            transcript variant 2, mRNA.
ACCESSION   NM_001128833
VERSION     NM_001128833.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5860)
  AUTHORS   Yang,Z., Chen,F., Wang,F., Chen,X., Zheng,B., Liao,X., Deng,Z.,
            Ruan,X., Ning,J., Li,Q., Jiang,H. and Qin,S.
  TITLE     Identification of ZBTB4 as an immunological biomarker that can
            inhibit the proliferation and invasion of pancreatic cancer
  JOURNAL   BMC Cancer 23 (1), 263 (2023)
   PUBMED   36949454
  REMARK    GeneRIF: Identification of ZBTB4 as an immunological biomarker that
            can inhibit the proliferation and invasion of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5860)
  AUTHORS   Chen,C., Zhang,Q. and Kong,B.
  TITLE     miRNA-576-5p promotes endometrial cancer cell growth and metastasis
            by targeting ZBTB4
  JOURNAL   Clin Transl Oncol 25 (3), 706-720 (2023)
   PUBMED   36538280
  REMARK    GeneRIF: miRNA-576-5p promotes endometrial cancer cell growth and
            metastasis by targeting ZBTB4.
REFERENCE   3  (bases 1 to 5860)
  AUTHORS   Jiang,H., Zhu,M., Wang,H. and Liu,H.
  TITLE     Suppression of lncRNA MALAT1 reduces pro-inflammatory cytokines
            production by regulating miR-150-5p/ZBTB4 axis through JAK/STAT
            signal pathway in systemic juvenile idiopathic arthritis
  JOURNAL   Cytokine 138, 155397 (2021)
   PUBMED   33341002
  REMARK    GeneRIF: Suppression of lncRNA MALAT1 reduces pro-inflammatory
            cytokines production by regulating miR-150-5p/ZBTB4 axis through
            JAK/STAT signal pathway in systemic juvenile idiopathic arthritis.
REFERENCE   4  (bases 1 to 5860)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5860)
  AUTHORS   Fan,H., Jin,X., Liao,C., Qiao,L. and Zhao,W.
  TITLE     MicroRNA-301b-3p accelerates the growth of gastric cancer cells by
            targeting zinc finger and BTB domain containing 4
  JOURNAL   Pathol Res Pract 215 (11), 152667 (2019)
   PUBMED   31585814
  REMARK    GeneRIF: miR-301-3p was highly expressed in gastric cancer
            contributed to tumor progression via attenuating ZBTB4
REFERENCE   6  (bases 1 to 5860)
  AUTHORS   Yamada,D., Perez-Torrado,R., Filion,G., Caly,M., Jammart,B.,
            Devignot,V., Sasai,N., Ravassard,P., Mallet,J., Sastre-Garau,X.,
            Schmitz,M.L. and Defossez,P.A.
  TITLE     The human protein kinase HIPK2 phosphorylates and downregulates the
            methyl-binding transcription factor ZBTB4
  JOURNAL   Oncogene 28 (27), 2535-2544 (2009)
   PUBMED   19448668
  REMARK    GeneRIF: Results show that overexpressing HIPK2 causes the
            degradation of ZBTB4, whereas overexpressing a kinase-deficient
            mutant of HIPK2 has no effect.
REFERENCE   7  (bases 1 to 5860)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 5860)
  AUTHORS   Weber,A., Marquardt,J., Elzi,D., Forster,N., Starke,S., Glaum,A.,
            Yamada,D., Defossez,P.A., Delrow,J., Eisenman,R.N., Christiansen,H.
            and Eilers,M.
  TITLE     Zbtb4 represses transcription of P21CIP1 and controls the cellular
            response to p53 activation
  JOURNAL   EMBO J 27 (11), 1563-1574 (2008)
   PUBMED   18451802
  REMARK    GeneRIF: These data suggest that Zbtb4 is a critical determinant of
            the cellular response to p53 activation and reinforce the notion
            that p21Cip1 can provide an essential survival signal in cells with
            activated p53.
REFERENCE   9  (bases 1 to 5860)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 5860)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
  REMARK    GeneRIF: ZBTB4 binds methylated methylated CpGs in vitro and in
            vivo and represses transcrption.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113189.11.
            
            On Nov 22, 2018 this sequence version replaced NM_001128833.1.
            
            Transcript Variant: This variant (2) has an altenate 5' UTR, as
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040971.2, AY302699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380599.9/ ENSP00000369973.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC113189.11        129539-129714       c
            177-247             AC113189.11        117340-117410       c
            248-1347            AC113189.11        115794-116893       c
            1348-5860           AC113189.11        109461-113973       c
FEATURES             Location/Qualifiers
     source          1..5860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..5860
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /note="zinc finger and BTB domain containing 4"
                     /db_xref="GeneID:57659"
                     /db_xref="HGNC:HGNC:23847"
                     /db_xref="MIM:612308"
     exon            1..176
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /inference="alignment:Splign:2.1.0"
     exon            177..247
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /inference="alignment:Splign:2.1.0"
     exon            248..1347
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..3298
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /note="KAISO-like zinc finger protein 1"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 4"
                     /protein_id="NP_001122305.1"
                     /db_xref="CCDS:CCDS11107.1"
                     /db_xref="GeneID:57659"
                     /db_xref="HGNC:HGNC:23847"
                     /db_xref="MIM:612308"
                     /translation="MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAH
                     RSVLAASSPFFREALLTSAPLPLPPATGGAAPNPATTTAASSSSSSSSSSSSSSSSAS
                     SSSSSSSSSPPPASPPASSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAV
                     AEIGALGRRLGISRLQGLGEGGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRA
                     EAQAPDLQCSLPRRPLPCPQCGKSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPG
                     GPAGVDASALPPPVGFRGGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWR
                     RKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISP
                     GLLASEKTPNGGYKPKLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPTLNTPAPVA
                     MPASPPPGPPPAPEPGPPPSVITFAHPAPSVIVHGGSSSGGGGSGTASTGGSQAASVI
                     TYTAPPRPPKKREYPPPPPEPAATPTSPATAVSPATAAGPAMATTTEEAKGRNPRAGR
                     TLTYTAKPVGGIGGGGGPPTGAGRGPSQLQAPPPLCQITVRIGEEAIVKRRISETDLR
                     PGELSGEEMEESEEDEEEEDEEEEEEDEEESKAGGEDQLWRPYYSYKPKRKAGAAGGA
                     SVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRARTERRHRCGDCAQTFTTLRK
                     LRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAALSRHGQRHAAERPGGTPTP
                     VIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEEASETASLQDPIISGGE
                     EPPVVASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVGAGEGDRMEGIGAAK
                     VTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGAGALPFLPGVFGYAV
                     NPQAAPPAPPTPPPPTLPPPIPPKGEGERAGVERTQKGDVG"
     exon            1348..5860
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5182
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
     regulatory      5838..5843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /note="hexamer: AATAAA"
     polyA_site      5860
                     /gene="ZBTB4"
                     /gene_synonym="KAISO-L1; ZNF903"
                     /note="major polyA site"
ORIGIN      
        1 gatgatgtca gcggcggcgg cggcggcggc agcggggccg ggccggggcc aggcgctggg
       61 ggggccaggg ccggagctgg agccggagcc ggagctggag gcgggcaaaa ccggagcggc
      121 cgggggcggc cacggtgatg agccgggcct ggcggacgcg gcgccatcgc agtcagaagg
      181 aagaggccca gcagaaggga ctcgctgagc caccccccgc cccactccat gttggctgtg
      241 ctctcaggct ggcaccatgc ccccccctgc agaggtgacg gacccgtccc atgcccccgc
      301 cgtcctgcgc cagctcaatg aacagcggct ccgtggcctc ttctgtgacg tcaccctcat
      361 agccggagac accaagttcc ctgctcaccg cagcgtcctg gctgcttcaa gtcccttctt
      421 cagagaggcc ctgctcactt cagccccact accccttcca ccagctactg ggggcgccgc
      481 acccaaccct gccaccacca cagctgcctc ttcctcctcc tcctcttcct cgtcttcttc
      541 ctcttcttcc tcctctgctt cttcttcttc ttcctcttcc tcttcctctc cccctccagc
      601 ctctccccct gcttcttccc caccccgggt cctggagttg ccaggagtcc cagcagctgc
      661 gttttctgat gtcctcaact tcatctacag cgcccggctc gcactgcctg gtggtggagg
      721 ggacggggca gctgtagcag agattggagc tttggggcgc cgtctgggca tctcccgcct
      781 tcagggcctg ggggagggag gtgatgcctg ggtacctcct accccagccc ccatggccac
      841 ctcgcagcct gaagaggaca gctttgggcc cgggcccagg ccagctgggg agtgggaggg
      901 tgacagggct gaggcccagg cccctgactt gcagtgctcc ctgccccggc ggcccctccc
      961 ctgcccccag tgtggaaaaa gcttcatcca tcccaaacgg ctgcagaccc atgaggccca
     1021 gtgccgacga ggggccagca cgcgggggtc tacagggctg ggagctgggg gcgctggccc
     1081 tggtggtcct gcaggggtgg acgcctcagc cctgcctcca ccagtgggct tccgaggggg
     1141 ccccgagcac gtggtgaagg tggtgggcgg ccacgtgctg tatgtgtgcg cggcctgcga
     1201 gcgttcctac gtgaccctgt ccagtctgaa gagacacagc aatgtacact cgtggcggag
     1261 gaagtacccc tgccgctatt gtgagaaagt gtttgctctg gcggagtacc gcacgaagca
     1321 tgaagtgtgg cacacggggg agcgcaggta ccagtgcatc ttctgttggg agacctttgt
     1381 cacttactat aacctgaaga cccaccagcg agccttccac ggcattagcc cgggcctcct
     1441 tgccagtgag aagacaccca atggaggcta caagcccaag ctcaatacac tcaagctcta
     1501 ccgcctgctc cccatgcggg cagccaagcg gccctacaag acctacagcc agggagcccc
     1561 ggaggctccc ctttctccaa ccctcaacac accggcccct gtggcaatgc cagccagccc
     1621 gccgcctggg cctccacctg ccccagagcc tggccctcca ccctctgtca tcacttttgc
     1681 ccacccagcc ccctctgtca ttgtccatgg gggcagtagc agtggtggag gggggagtgg
     1741 gacggccagc acaggagggt cccaagctgc ctcggttatc acttacactg ctcccccgag
     1801 gccacccaag aaacgagaat acccacctcc tccccctgag cctgcagcca cacccaccag
     1861 cccagccaca gcagtcagcc cagccaccgc tgcagggcca gccatggcca ccaccacgga
     1921 ggaggccaag ggccggaatc cacgggctgg aaggactctg acttacacag ccaagccagt
     1981 gggcgggatt ggtggaggtg ggggtccccc cacaggggct ggccggggcc cctctcagct
     2041 gcaggctcca cctccactgt gtcagatcac tgtgcgaata ggggaggagg ccatcgtcaa
     2101 gcgccgcatc tcagagactg acctgcgtcc tggggagctg agcggagagg agatggagga
     2161 gagtgaggag gacgaagagg aggaggacga agaggaggag gaggaggatg aggaggaatc
     2221 aaaggctggt ggggaggacc agctctggag gccctactac tcctacaagc ctaagcgcaa
     2281 ggctggagct gctggaggtg ccagtgtggg gggcagtggg ctgccccgag gccgccggcc
     2341 accacgttgg aggcagaagc tggaacggag gagctgggag gaaaccccag cggccgagag
     2401 cccagcggga cgtgcccgca cagagcggag gcaccgatgc ggggactgtg cccagacctt
     2461 caccaccctg agaaagctgc ggaagcacca agaggcccac ggtgggggct cccacagctc
     2521 ccgggccgga cggaggccct ccacccgctt tacctgcccc cactgcgcca aggtgtgcaa
     2581 gaccgcagct gccctgagcc gccacgggca gaggcatgct gctgagcggc ccgggggcac
     2641 cccaacccct gtcattgcct attccaaggg cagcgctggc accaggcccg gggatgtcaa
     2701 ggaggaagcc ccccaagaga tgcaagtctc ctcatccagc ggtgaggcag gtggcgggag
     2761 cactgctgct gaggaagctt ccgagaccgc ctcactccag gaccctatca tttcaggggg
     2821 tgaggagccc ccagtagtgg caagcggggg cagctatgta tacccacctg tgcaggaatt
     2881 tccactggcc ttgattgggg gcggccggga acctggcggt ggcaggggaa aatctgggag
     2941 tgaagggcca gtgggggctg gtgaggggga ccggatggag gggatagggg ctgccaaagt
     3001 cactttctac cctgagccct acccgctcgt ctatggcccc cagctccttg ccgcctaccc
     3061 ttacaacttc agtaacttgg ccgctctccc ggttgctctc aacatggtcc tacctgatga
     3121 gaagggtgcg ggggcccttc ccttcctacc aggggtcttt ggctacgcag tgaatcctca
     3181 agcagcaccc cctgccccac caacaccacc tcccccaact cttcctccac caattccccc
     3241 taagggagaa ggggaaaggg caggggttga gagaacccag aagggcgatg tggggtgaac
     3301 cctggggctc aatccccctt tcaccagatg ccaccctccc tgaacccccc accactacca
     3361 gctccctggc ctccctgccc cttgggagcc ccttcacact cttgtgcagg gacttggggg
     3421 cccctggagc tcaggggtca ggctgctttg tgtgagatgt agttttccca tctcctggga
     3481 agggatcttt cgaggttccc ctctcagtct tcctccaggg aatggcctcc atgaggggca
     3541 gggccagctt ccatcccttc tccagccctt ggggcaactg agcaatatac ttaacctgaa
     3601 tctctactca cagcccccac cagctctgaa tgtctaacct gctcccctga ttcgtaaacc
     3661 taggggaaac catctctctc acctaatgac ccgccttgtt ctgaagcttt ctctaagccc
     3721 ttcccagttg cttcctagca cattccattc tttgtggccc agggcctgga ccagaccatt
     3781 gtgatacctg accccgccca cctgggagtg tggctttggg tttcatcctt ccccagcgtg
     3841 ggtctctacg tccctgtttc ccttgtatca agacaccttc ctcagcttcc atgcctttgg
     3901 atcttccatg ttcctcccca tattcctgga cttcggagat ggcctctccc aagccaggtc
     3961 aaggaggttt gggggagggt tgcccctctg cccctctgtt ctgtggctga gcactttccc
     4021 agtccagggc agggaaatat tggccctatc ttgaccccca aatccagtga gctccagatt
     4081 cttccaaggc aaaagaggta agcagatcac acctctttct gcctctacat atggcctatt
     4141 ctgggctaga ccagatttgg gggccaggag ggaagaactc catatgggat ggagaaggga
     4201 atctactttc tccctgtttt tttttcctga tggtttctcc cagactagac caaatagcca
     4261 gaaaaatgat aggggtcgga tgggtgggta agcccaggat ttgcacatga ccttccatcc
     4321 ttacctgtat tcccatctcc ccagtgtcac tcccctcacc aatcactcca gatggttttg
     4381 ggggaaccat tctactcttc tggtgggctt tggggtatcc ccaccaactt tcccttcaaa
     4441 atagcacctt acaccccatc tttgactcag ttccccacac ccaaagatcc cagcctaggg
     4501 atggggtaca gggactttaa atagtcccta atccctaatt tgcactagtt aaccctggtc
     4561 agggtccctg tatttccttc cagtggggga gataaatgtt tgctcctaat tctctttgaa
     4621 aactgggcct ccctgctctg tgattggata aatatttccc atcccaccca cctcccccca
     4681 aaaaatagct cacaagggga gagccagtat gggggagcaa atttgacaaa tgggaattag
     4741 aggagtgcag ttttaaaagg aaaagttgct gtcatcaaaa tggcagcctt ttccccagct
     4801 actgtttttg gggccaagat ggctgcccta gcagcaatca ctgccaaggg caagatcatg
     4861 gcttttggag ggaggtgagt ttagggaggg ccaggaccat cctcctaccc ctcataccct
     4921 cccagcatat acaaaagggg aggttttaga caggctccct gaatgttaac cacagaggag
     4981 tcactccttc attcctcctc tgtctctttg cacttttctt ggtcttggcc acagcctgag
     5041 tgacgaattt cctactgaat gtaccaagtt ccaattttta agggggggaa aggtttcaaa
     5101 tggggaaaaa cacacaaaaa aaaaaatcac taaaaattcc cacaaatctt gtttctggca
     5161 ctttagaaaa actgcaaaaa aatacgtaat aaagaataca tatatatata tctacacaca
     5221 aattatatat ctatctatct atacagcgga accacaagag agactgagga aggcctggag
     5281 gcaggggcag aggtgacgac agtgccccta tatccttaac ccatactcct ctgaggcaaa
     5341 caggcatggg aaaatggaag ggttgaggat ggaccggaga attggaactt cagaataggt
     5401 caaaattcca aaaccatgga catttttttt tgggagaatt gagattgtag acattttttt
     5461 tttcttaaat atgatcaagg aaaatagctt ccagaatgtg gtggttctgg gcaacaaatg
     5521 agattgtggc gacgtggaga ttaaaatata tgtatttgag ctggggaatt tgaatattgt
     5581 gagtttcaga tgttggaaat ttgggatttt gcagttttgt cttttgaaaa tgatcaagtc
     5641 ttgtcagttc gtgccctctt tccccatgtt ccctgggaag acgggtggtg gcagagtgag
     5701 aaggccactg gttctgtgcc gcagcacgca aaatttagaa ttctacagac tagctctata
     5761 cgtagtgagg acccagattt agagaaactg accaatattt atctccgcat ttgtgtgtgt
     5821 gtccaactct gtaggccaat aaaccaacaa gacaaatgaa
//
