LOCUS       NM_001376175            7995 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 38 (ZBTB38),
            transcript variant 43, mRNA.
ACCESSION   NM_001376175
VERSION     NM_001376175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7995)
  AUTHORS   Marchal,C., Defossez,P.A. and Miotto,B.
  TITLE     Context-dependent CpG methylation directs cell-specific binding of
            transcription factor ZBTB38
  JOURNAL   Epigenetics 17 (13), 2122-2143 (2022)
   PUBMED   36000449
  REMARK    GeneRIF: Context-dependent CpG methylation directs cell-specific
            binding of transcription factor ZBTB38.
REFERENCE   2  (bases 1 to 7995)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7995)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7995)
  AUTHORS   Jing,J., Liu,J., Wang,Y., Zhang,M., Yang,L., Shi,F., Liu,P. and
            She,J.
  TITLE     The role of ZBTB38 in promoting migration and invasive growth of
            bladder cancer cells
  JOURNAL   Oncol Rep 41 (3), 1980-1990 (2019)
   PUBMED   30569128
  REMARK    GeneRIF: Study findings suggested that ZBTB38 promoted migration
            and invasive growth of bladder cancer cells through facilitation of
            the Wnt/betacatenin signaling pathway.
REFERENCE   5  (bases 1 to 7995)
  AUTHORS   Hudson,N.O., Whitby,F.G. and Buck-Koehntop,B.A.
  TITLE     Structural insights into methylated DNA recognition by the
            C-terminal zinc fingers of the DNA reader protein ZBTB38
  JOURNAL   J Biol Chem 293 (51), 19835-19843 (2018)
   PUBMED   30355731
  REMARK    GeneRIF: the mechanism by which this ZF domain of ZBTB38
            selectively recognizes methylated CpG sites
REFERENCE   6  (bases 1 to 7995)
  AUTHORS   Oikawa,Y., Matsuda,E., Nishii,T., Ishida,Y. and Kawaichi,M.
  TITLE     Down-regulation of CIBZ, a novel substrate of caspase-3, induces
            apoptosis
  JOURNAL   J Biol Chem 283 (21), 14242-14247 (2008)
   PUBMED   18375381
REFERENCE   7  (bases 1 to 7995)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
  REMARK    GeneRIF: There was strongest association with SNPs in the ZBTB38
            gene and adult human height.
REFERENCE   8  (bases 1 to 7995)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
REFERENCE   9  (bases 1 to 7995)
  AUTHORS   Sanna,S., Jackson,A.U., Nagaraja,R., Willer,C.J., Chen,W.M.,
            Bonnycastle,L.L., Shen,H., Timpson,N., Lettre,G., Usala,G.,
            Chines,P.S., Stringham,H.M., Scott,L.J., Dei,M., Lai,S., Albai,G.,
            Crisponi,L., Naitza,S., Doheny,K.F., Pugh,E.W., Ben-Shlomo,Y.,
            Ebrahim,S., Lawlor,D.A., Bergman,R.N., Watanabe,R.M., Uda,M.,
            Tuomilehto,J., Coresh,J., Hirschhorn,J.N., Shuldiner,A.R.,
            Schlessinger,D., Collins,F.S., Davey Smith,G., Boerwinkle,E.,
            Cao,A., Boehnke,M., Abecasis,G.R. and Mohlke,K.L.
  TITLE     Common variants in the GDF5-UQCC region are associated with
            variation in human height
  JOURNAL   Nat Genet 40 (2), 198-203 (2008)
   PUBMED   18193045
REFERENCE   10 (bases 1 to 7995)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
  REMARK    GeneRIF: ZBTB38 binds methylated methylated CpGs in vitro and in
            vivo and represses transcrption.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010184.18.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcriptional activator that binds methylated DNA. The encoded
            protein can form homodimers or heterodimers through the zinc finger
            domains. In mouse, inhibition of this protein has been associated
            with apoptosis in some cell types. [provided by RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2194876.1,
                                           SRR18074968.1303509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC010184.18        151922-152162       c
            242-486             AC010184.18        143306-143550       c
            487-591             AC010184.18        135778-135882       c
            592-7995            AC010184.18        90017-97420         c
FEATURES             Location/Qualifiers
     source          1..7995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..7995
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:253461"
                     /db_xref="HGNC:HGNC:26636"
                     /db_xref="MIM:612218"
     exon            1..241
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            242..486
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            487..591
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            592..7995
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..4179
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="protein phosphatase 1, regulatory subunit 171"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001363104.1"
                     /db_xref="CCDS:CCDS43157.1"
                     /db_xref="GeneID:253461"
                     /db_xref="HGNC:HGNC:26636"
                     /db_xref="MIM:612218"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQE
                     TVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITN
                     GPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTL
                     AEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSD
                     SATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPA
                     AEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQI
                     CMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHM
                     VKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEI
                     WHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLY
                     RLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNT
                     LTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAV
                     SSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSSVIMHSNAIAAMTSSN
                     HRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKTTSHTRGEIPEESNYVADP
                     GGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGS
                     KLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMSEVFDDASDQDSTDK
                     PWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDCAVGKAPQDKPFE
                     EEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQSPSTLKMHMR
                     CHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNETLKIHERIH
                     TGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAALGMHQKK
                     HLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL"
     regulatory      6884..6889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: ATTAAA"
     polyA_site      6905
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="major polyA site"
     regulatory      7087..7092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: AATAAA"
     polyA_site      7111
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
     regulatory      7976..7981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: AGTAAA"
     polyA_site      7995
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
ORIGIN      
        1 gcagtctcag aaaaaccttg gatgagaaac ttcttttttc aatcctgttt tcctgttgat
       61 aaattcagtt ctgtgatcac agttcattca agctgttctg cgtatgattt ttgtgtgtat
      121 gtgacaattg catctaaaac ttgtgagcaa gaagacagag aaatcagttg gtctccatcg
      181 ctttacataa aaatggctga gtgtcttgtc atgctagcac tgcattaagt gatgcataca
      241 ggttcacagt gtcttcacct ggaatagatt ccacctcaag aaaccagttt ctttgctcat
      301 ccataagaag caactcctca tctgatcaag ttttataata agattgcaga aattcagtct
      361 catctttagg ctccacttct agttcttatg ctatttccac cacatctgca gttacttcct
      421 ccactgaagt cttgaatctc tcaaagtcat ccatgagggt tggaaccaac atcttccaaa
      481 ctcctgatct tgatgtggaa gaaatggagg actcagaacc aaggatttcc aagtgatttc
      541 ttccaaagca caggaatctc actctgttaa agctggtctg ttctaactga gatgacagtc
      601 atgtcccttt ccagggacct caaggacgac tttcacagtg acacggtact ctccatctta
      661 aatgagcagc gcattcgggg cattttatgc gatgtcacta tcattgtgga agataccaaa
      721 tttaaagccc atagcaatgt tctggcagct tcaagcctgt attttaaaaa tatcttttgg
      781 agccatacaa tctgtatttc cagccacgtc ctggagctgg acgatctcaa agctgaagtg
      841 tttactgaaa tacttaatta tatctacagt tccacagtcg ttgtcaagag acaggaaaca
      901 gtcactgatc tcgcagctgc aggaaaaaag ctgggaatat cgttcttgga agaccttact
      961 gatcgcaact tctcaaattc cccgggtccc tatgtattct gtattactga aaagggagtg
     1021 gttaaagaag aaaaaaatga aaaaaggcat gaagaaccag ccatcactaa tgggccaagg
     1081 atcacaaatg cattttccat catcgaaaca gaaaatagta ataacatgtt ttccccgctg
     1141 gacttgaggg caagtttcaa aaaggtctcc gactccatga gaacagctag cctttgcctg
     1201 gagaggacgg acgtctgcca cgaggcagag cctgtccgca cacttgccga gcactcatac
     1261 gctgtttctt ccgtagctga agcttacaga agtcagcctg tacgtgaaca tgatggcagt
     1321 tcacctggta acacagggaa agaaaattgt gaagcccttg cagcgaaacc gaaaacatgc
     1381 cggaagccaa agacattctc cataccacag gattcggatt cagccacaga aaatatacca
     1441 ccccctccag tatccaactt agaggttaat caagaaagaa gtccacaacc agctgctgtt
     1501 ctcactcgtt caaaatctcc aaacaatgaa ggagatgtcc atttttccag ggaagatgaa
     1561 aatcaatctt ctgatgttcc cgggccgcca gccgcagagg ttccacctct ggtgtacaat
     1621 tgtagctgct gttccaaagc ctttgacagc agcactctgc tcagtgccca catgcagctt
     1681 cacaagccaa cccaggagcc tttagtgtgc aagtattgca acaaacaatt caccaccctg
     1741 aacaggttgg atcggcatga acagatctgc atgaggtcaa gccacatgcc cattcctgga
     1801 ggaaaccaac gctttttaga aaactatcct accattggac aaaatggagg ttcattcaca
     1861 ggtccagaac ctttattatc tgaaaatagg attggtgaat tttccagtac cggaagtact
     1921 ttgccagaca cggaccacat ggttaaattt gttaatgggc aaatgctcta cagttgcgtt
     1981 gtgtgcaaac gtagttatgt gaccttatct agcctccgaa gacatgcaaa tgttcactcc
     2041 tggagaagaa catatccttg ccattactgc aacaaagtat ttgcattggc tgagtacagg
     2101 acaaggcatg aaatttggca tacgggagaa agacgatatc agtgcatttt ctgtcttgaa
     2161 actttcatga cctactatat actcaaaaat catcagaagt ctttccatgc catcgatcat
     2221 agactttcca tcagtaaaaa aacagcaaat ggaggcttga agcctagtgt ctatccgtat
     2281 aaactttata ggctactgcc tatgaaatgc aagagagccc cttataagag ctaccgaaat
     2341 tcttcctatg aaaatgcacg agaaaacagt caaatgaatg agtctgcacc tggtacctat
     2401 gttgttcaga atccacacag ctctgaatta ccaacgctga atttccaaga tactgtaaac
     2461 accctgacca acagtccagc catcccattg gaaacatctg catgtcagga catacccact
     2521 tctgccaatg tacaaaatgc agagggtacc aaatggggag aggaggcatt gaaaatggat
     2581 cttgacaata acttttattc aactgaggtg tcagtttctt ccactgaaaa tgctgtcagt
     2641 tctgacctcc gggcagggga tgtacctgtt ttatctttga gtaatagcag tgagaatgcc
     2701 gcctctgtga tcagctacag tggctctgca ccctcggtca ttgtacacag cagccagttt
     2761 tcatcggtga tcatgcacag caatgccatt gctgccatga ccagcagcaa ccacagagcc
     2821 ttttcagacc cagctgtcag tcagtccctg aaagatgaca gtaagcccga gccagataaa
     2881 gtgggtaggt ttgcaagcag acccaaaagc attaaggaga aaaagaaaac tacatcacat
     2941 accaggggag aaataccgga ggagtcaaac tatgttgctg atcctggagg atcactgagc
     3001 aaaaccacaa atattgctga agaaaccagc aaaattgaaa cctacattgc aaaacctgct
     3061 ctgccgggaa cctccacaaa tagtaatgtt gcaccccttt gccaaataac agtgaaaatt
     3121 ggaaacgaag ccattgtgaa aaggcacatt ctaggatcta aattgtttta taaaagaggg
     3181 agaagaccca agtatcagat gcaggaggag cctttgccac aggggaatga cccagaaccc
     3241 agtggagaca gcccactcgg gctttgccaa tccgagtgca tggagatgag tgaagtgttc
     3301 gatgacgcaa gtgaccagga ttccactgac aaaccgtggc gcccttacta caactacaaa
     3361 cccaaaaaga aatccagaca gttgaaaaaa atgaggaaag tcaactggag gaaggagcac
     3421 ggaaacagga gcccgagcca taaatgtaaa tacccagcag aactggattg cgccgtgggg
     3481 aaggctcctc aggataaacc ctttgaggaa gaagaaacta aagagatgcc caagctgcag
     3541 tgtgaactct gtgatggaga caaagcagtg ggggctggaa accaaggaag gccccaccga
     3601 catcttactt ctcggccata tgcctgcgag ctctgcgcca agcagttcca gagcccttcc
     3661 acactcaaaa tgcacatgag atgtcacacc ggggagaagc cataccagtg caagacctgc
     3721 ggacggtgct tttcggtgca aggaaactta cagaaacatg aacgcatcca cctgggcttg
     3781 aaggagttcg tctgtcagta ttgcaacaag gcattcacct tgaatgagac cctcaaaatc
     3841 catgaaagaa tccatactgg agaaaagcgt taccactgtc agttctgctt tcagagattt
     3901 ttgtatctct ccaccaaaag gaatcacgag cagaggcata ttcgggagca taatgggaag
     3961 ggctatgcct gcttccagtg ccccaaaatt tgcaaaacag ctgctgccct tggaatgcac
     4021 caaaagaaac acttattcaa aagcccaagt cagcaggaga aaataggtga cgtgtgccac
     4081 gaaaactcaa atcccttgga gaatcaacat ttcattggtt cagaagacaa tgaccaaaag
     4141 gataacatac aaaccggtgt ggaaaatgtt gtcctttgag tggcaagaat tagaaaaatc
     4201 ttcaaaaata tagttggtgg tttttttagt tatgatttaa gtttagtttc attttgtcca
     4261 tgtgacagtc atgaaggagt gaaattaaaa aaaaaaaaaa ctcatttgtg aaaattccag
     4321 aaaaaggatc ctaatatcta ctttgggttt tagcattaac tttatgcaaa gtgcacaaaa
     4381 acaaaatagc tgactcctcc aatatcccaa gtttcttgtg aaagttaata aaattcttag
     4441 ctgtggtatt tctaccagtg aaaaaaggag tttaatttta gcctagttta aaactttcta
     4501 ataattgcta ataagaactg gctgctgaac tgtctttagt cactggagaa aataagggtc
     4561 agatatcctg aagatggcat cttcgtaaat atgttacgtg gtaataagct gtgtgacggt
     4621 ctttattccc atctggcttc tgcactatta aaatttgttt aaattaatgg atacacatga
     4681 aatacttaaa caatataact gaaattatgt gcataatgag taacctaaag taggacattc
     4741 atacattatg tagaactact tttctgcaac acaaaccttg taaaatacat atataaatca
     4801 ctataacttt taactgtcca tatcccctgt agagaattat gaggagcaat agatctgcaa
     4861 ataatgagga ctgatgtaaa aatcaataga aagcattttg aatatgattt aagagcatgt
     4921 gaatgctttt agatggaatg ctgttccctt gaagttatgg ctgagctgtt cttagaactg
     4981 gtctactcaa ttcacagaaa acataggtca tgccttatct atgggggaac accctcccag
     5041 aatttacctg tgattacctg tgctgcatat tactttgcaa tggcctcatc tcagagaatg
     5101 aaagagggtc acattgttct gaaactctct gcagtcttcc aaccaccaca aggccatgga
     5161 tgtgggggtc tattccagac agacttaagg gctcaagtgg aacctgccat ctcccattcc
     5221 actgaaggac tgtccaagag atttagtgca aggtacactg cagtagtgaa ttcccaggca
     5281 cttgaaagtg actgcctaat ccctacaatt actagccttg ttggagatta tgcagcccac
     5341 aagtacagac tagtataaag caaaaggaca aaggaacccc caccctccac cccacccatt
     5401 aatgacttga gtgggcaaga agaagtgatg gccttccttg cctaaaacag tagctttgtt
     5461 tttagggggt gggaaggtag gatgtggagt gacatggttc tatcctttac ttatgagact
     5521 cagaaatata tctacaaagc cagatgctct gtcttcatat ttgcagacat ctagacccct
     5581 tgctaaaaac ccactgaagt ttttttttta tgttctttga cccacaccat caacactacc
     5641 ctcaaatcta attgccctac agcatattct atcatgtgga ctaggttcct ggaaagccgg
     5701 aactcatgat tctttttcaa actgccagaa tagaagggag agagaaaaca tttctaccct
     5761 ttgatcacca gtgtgaacag aatccggaat gcagtttcag cgtgacctgc agtcattcat
     5821 gttcattgga tttgacagat ggaaacccaa ggttatcgaa gattggaagg ttatcattgt
     5881 gaagaagtag ctcaaaggac tccggtttct gtctacaagt gtgatgtctc catgaagaag
     5941 acttagtatg gatttgggtg ggtaagaaag catttaaacg cccaggaaag gacatgatta
     6001 aagttgacct tttaatactg tagtaccttg ctgttaagta accccactat tgtatctgca
     6061 tttatctttt gttcatctac tttcacttac atacagtatt atataagtag agaaaaatgg
     6121 gaaaatgcaa gcaaattcaa ctttatttta tacattgtat atatgtacac cctacactat
     6181 tcatttgggt tttattaaag agatagtcac aaagggctta cgaaaatcat ttttgaattg
     6241 ataattagaa tattgaataa gcaatcctat gatccactaa tttgttttat cagttaataa
     6301 tattaatcaa agacatttac tgtatattct agtcattttg atttgagtta accccaaata
     6361 taaaattacc tgtagtgatg tctctctccc agcccttata tgtggatatt ttttaagtgg
     6421 acttgtatgc tgataattct agaccaaagt aaatatggca gaatatttat acatgaaaaa
     6481 ataattttgc aaatattttc tataattgta ttcatttaaa atgttgatag cttgtgttag
     6541 tttcagggag gggtgtatat tttgataaaa aaatacttga ctttgtaatt ctgtatattc
     6601 tatacaattt atagcagagc cgttttaaga cagccttgtc acattttttt gttaattgtg
     6661 aaaattttat tgagtgatgt ttaagtatgc attgagtaca tgaccaacta gaattaaagt
     6721 aagtgtaaac agtgaacata ctgtatgctg tacaagatat aatgtaactt gctgttttag
     6781 catctgtatt ttggttagaa gatattatta aatgcagatg ttaaggattg gaaaagtcta
     6841 attttatttt tagaaataat ggatataaat ttgtttttgc ttgattaaaa tagcttattc
     6901 ctacattaag tctcttttta aatgttttca tgttatttct tttgtgcagc tatttcatct
     6961 gtgtgagtca cagctttgtt tccacgtatt attcagttta tttctgtttc cttacttgtt
     7021 tacattccgt ggtacctact tacatgctta ggagtcaaat ggattatgac attaggaaaa
     7081 aagcagaata aaagagattg aagtcttctg atgattgagt gttttggata ggcctgatct
     7141 tataatgata aatcagagaa tgaaatgctc tccaggaagc attctgctcc actcatccgt
     7201 gggaaacaaa ttacatttat tgagtaccag gcactgggca atgtctttac ataggctatt
     7261 tcattaacac acacgcacca gaattcgacc tcattatcct cgttttatag tgactttgag
     7321 aaggtctcac aaccagacaa agccaggatg ctaacctagg tctgcctgac tccaaagccc
     7381 atgtttttgt tccttctcaa cactgtagag aaaaatcatt tatagaaact gaacagagta
     7441 tgaggaaagg agatatgata aagtaatgca gctttaggat ggcagttagt gactgccctg
     7501 gaacaggatt aaaggaggct gtgtcaggtt cagcttcccc tgaattgggc ttcccttata
     7561 tctcaggaga ttgccctata aaatcagtaa aatttgtgca cttttttaag gatatggagt
     7621 aaaattgtaa tagcattata agctggtaat tttcacacaa agaaaaaaat acgttccgtc
     7681 gtcacagact ctactcctaa acttagctaa ctaactatct tgcaaatgcc tgcagtttgt
     7741 cccagtgggc aatgtgagag gggatgtcgg tggctcaggc agcacagtcc atcaccaaca
     7801 cagagaaaat tactgccagg cctaccggtg gctggccagt agcatcaatt ttgtattgga
     7861 agggcaatcc aaaccagatt caccaaaaat ttgataactg ttatctgcta aaactaactt
     7921 cattatgtac aagaacaaca gatttaatat tgaaagcatc tgtaacaatt gggaaagtaa
     7981 aagcataaaa caaaa
//
