LOCUS       NM_001376113            8014 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 38 (ZBTB38),
            transcript variant 5, mRNA.
ACCESSION   NM_001376113 XM_024453431
VERSION     NM_001376113.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8014)
  AUTHORS   Marchal,C., Defossez,P.A. and Miotto,B.
  TITLE     Context-dependent CpG methylation directs cell-specific binding of
            transcription factor ZBTB38
  JOURNAL   Epigenetics 17 (13), 2122-2143 (2022)
   PUBMED   36000449
  REMARK    GeneRIF: Context-dependent CpG methylation directs cell-specific
            binding of transcription factor ZBTB38.
REFERENCE   2  (bases 1 to 8014)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8014)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 8014)
  AUTHORS   Jing,J., Liu,J., Wang,Y., Zhang,M., Yang,L., Shi,F., Liu,P. and
            She,J.
  TITLE     The role of ZBTB38 in promoting migration and invasive growth of
            bladder cancer cells
  JOURNAL   Oncol Rep 41 (3), 1980-1990 (2019)
   PUBMED   30569128
  REMARK    GeneRIF: Study findings suggested that ZBTB38 promoted migration
            and invasive growth of bladder cancer cells through facilitation of
            the Wnt/betacatenin signaling pathway.
REFERENCE   5  (bases 1 to 8014)
  AUTHORS   Hudson,N.O., Whitby,F.G. and Buck-Koehntop,B.A.
  TITLE     Structural insights into methylated DNA recognition by the
            C-terminal zinc fingers of the DNA reader protein ZBTB38
  JOURNAL   J Biol Chem 293 (51), 19835-19843 (2018)
   PUBMED   30355731
  REMARK    GeneRIF: the mechanism by which this ZF domain of ZBTB38
            selectively recognizes methylated CpG sites
REFERENCE   6  (bases 1 to 8014)
  AUTHORS   Oikawa,Y., Matsuda,E., Nishii,T., Ishida,Y. and Kawaichi,M.
  TITLE     Down-regulation of CIBZ, a novel substrate of caspase-3, induces
            apoptosis
  JOURNAL   J Biol Chem 283 (21), 14242-14247 (2008)
   PUBMED   18375381
REFERENCE   7  (bases 1 to 8014)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
  REMARK    GeneRIF: There was strongest association with SNPs in the ZBTB38
            gene and adult human height.
REFERENCE   8  (bases 1 to 8014)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
REFERENCE   9  (bases 1 to 8014)
  AUTHORS   Sanna,S., Jackson,A.U., Nagaraja,R., Willer,C.J., Chen,W.M.,
            Bonnycastle,L.L., Shen,H., Timpson,N., Lettre,G., Usala,G.,
            Chines,P.S., Stringham,H.M., Scott,L.J., Dei,M., Lai,S., Albai,G.,
            Crisponi,L., Naitza,S., Doheny,K.F., Pugh,E.W., Ben-Shlomo,Y.,
            Ebrahim,S., Lawlor,D.A., Bergman,R.N., Watanabe,R.M., Uda,M.,
            Tuomilehto,J., Coresh,J., Hirschhorn,J.N., Shuldiner,A.R.,
            Schlessinger,D., Collins,F.S., Davey Smith,G., Boerwinkle,E.,
            Cao,A., Boehnke,M., Abecasis,G.R. and Mohlke,K.L.
  TITLE     Common variants in the GDF5-UQCC region are associated with
            variation in human height
  JOURNAL   Nat Genet 40 (2), 198-203 (2008)
   PUBMED   18193045
REFERENCE   10 (bases 1 to 8014)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
  REMARK    GeneRIF: ZBTB38 binds methylated methylated CpGs in vitro and in
            vivo and represses transcrption.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010184.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 8, 2019 this sequence version replaced XM_024453431.1.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcriptional activator that binds methylated DNA. The encoded
            protein can form homodimers or heterodimers through the zinc finger
            domains. In mouse, inhibition of this protein has been associated
            with apoptosis in some cell types. [provided by RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3764122.1,
                                           SRR14038193.2289163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321464.7/ ENSP00000372635.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC010184.18        171005-171305       c
            302-376             AC010184.18        169863-169937       c
            377-439             AC010184.18        158322-158384       c
            440-505             AC010184.18        152872-152937       c
            506-610             AC010184.18        135778-135882       c
            611-8014            AC010184.18        90017-97420         c
FEATURES             Location/Qualifiers
     source          1..8014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..8014
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:253461"
                     /db_xref="HGNC:HGNC:26636"
                     /db_xref="MIM:612218"
     exon            1..301
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            302..376
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            377..439
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            440..505
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            506..610
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     exon            611..8014
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..4198
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="protein phosphatase 1, regulatory subunit 171"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001363042.1"
                     /db_xref="CCDS:CCDS43157.1"
                     /db_xref="GeneID:253461"
                     /db_xref="HGNC:HGNC:26636"
                     /db_xref="MIM:612218"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQE
                     TVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITN
                     GPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTL
                     AEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSD
                     SATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPA
                     AEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQI
                     CMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHM
                     VKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEI
                     WHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLY
                     RLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNT
                     LTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAV
                     SSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSSVIMHSNAIAAMTSSN
                     HRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKTTSHTRGEIPEESNYVADP
                     GGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGS
                     KLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMSEVFDDASDQDSTDK
                     PWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDCAVGKAPQDKPFE
                     EEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQSPSTLKMHMR
                     CHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNETLKIHERIH
                     TGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAALGMHQKK
                     HLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL"
     regulatory      6903..6908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: ATTAAA"
     polyA_site      6924
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="major polyA site"
     regulatory      7106..7111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: AATAAA"
     polyA_site      7130
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
     regulatory      7995..8000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
                     /note="hexamer: AGTAAA"
     polyA_site      8014
                     /gene="ZBTB38"
                     /gene_synonym="CIBZ; PPP1R171; ZNF921"
ORIGIN      
        1 agttggggag tggcactcgc agctgcagca aatctcaaaa taaagaggca acggcctttc
       61 tcttcctctc catctcccta tagcacacct tttatttctt ttcttctttt ttttaagcct
      121 cacgaaagat tttacttgta gatcaacttt caaaatgtag gaagtcagaa tgggtgacat
      181 catcagaaaa atatgtggag ctgatcacaa gaagtgaaga acccagagca cgaaagcggt
      241 tgtgactcct gggcccaggg agttgacagc gtctgggttt cagaggagcc agcgcctccg
      301 agttgtcttg aagtgaggct ctgctgtagt cctgttcttc tggctctaag atctgaatgt
      361 tgtgaccact aatttgctct ttcctggaga gtaaccccag tttggtccac aaggcttgct
      421 gcccaatctt tgccaacagt tgaaccaaga ctctgaggct gatatgcaat gtcacttaca
      481 acattaatca gatactgcat ttaagatctt gatgtggaag aaatggagga ctcagaacca
      541 aggatttcca agtgatttct tccaaagcac aggaatctca ctctgttaaa gctggtctgt
      601 tctaactgag atgacagtca tgtccctttc cagggacctc aaggacgact ttcacagtga
      661 cacggtactc tccatcttaa atgagcagcg cattcggggc attttatgcg atgtcactat
      721 cattgtggaa gataccaaat ttaaagccca tagcaatgtt ctggcagctt caagcctgta
      781 ttttaaaaat atcttttgga gccatacaat ctgtatttcc agccacgtcc tggagctgga
      841 cgatctcaaa gctgaagtgt ttactgaaat acttaattat atctacagtt ccacagtcgt
      901 tgtcaagaga caggaaacag tcactgatct cgcagctgca ggaaaaaagc tgggaatatc
      961 gttcttggaa gaccttactg atcgcaactt ctcaaattcc ccgggtccct atgtattctg
     1021 tattactgaa aagggagtgg ttaaagaaga aaaaaatgaa aaaaggcatg aagaaccagc
     1081 catcactaat gggccaagga tcacaaatgc attttccatc atcgaaacag aaaatagtaa
     1141 taacatgttt tccccgctgg acttgagggc aagtttcaaa aaggtctccg actccatgag
     1201 aacagctagc ctttgcctgg agaggacgga cgtctgccac gaggcagagc ctgtccgcac
     1261 acttgccgag cactcatacg ctgtttcttc cgtagctgaa gcttacagaa gtcagcctgt
     1321 acgtgaacat gatggcagtt cacctggtaa cacagggaaa gaaaattgtg aagcccttgc
     1381 agcgaaaccg aaaacatgcc ggaagccaaa gacattctcc ataccacagg attcggattc
     1441 agccacagaa aatataccac cccctccagt atccaactta gaggttaatc aagaaagaag
     1501 tccacaacca gctgctgttc tcactcgttc aaaatctcca aacaatgaag gagatgtcca
     1561 tttttccagg gaagatgaaa atcaatcttc tgatgttccc gggccgccag ccgcagaggt
     1621 tccacctctg gtgtacaatt gtagctgctg ttccaaagcc tttgacagca gcactctgct
     1681 cagtgcccac atgcagcttc acaagccaac ccaggagcct ttagtgtgca agtattgcaa
     1741 caaacaattc accaccctga acaggttgga tcggcatgaa cagatctgca tgaggtcaag
     1801 ccacatgccc attcctggag gaaaccaacg ctttttagaa aactatccta ccattggaca
     1861 aaatggaggt tcattcacag gtccagaacc tttattatct gaaaatagga ttggtgaatt
     1921 ttccagtacc ggaagtactt tgccagacac ggaccacatg gttaaatttg ttaatgggca
     1981 aatgctctac agttgcgttg tgtgcaaacg tagttatgtg accttatcta gcctccgaag
     2041 acatgcaaat gttcactcct ggagaagaac atatccttgc cattactgca acaaagtatt
     2101 tgcattggct gagtacagga caaggcatga aatttggcat acgggagaaa gacgatatca
     2161 gtgcattttc tgtcttgaaa ctttcatgac ctactatata ctcaaaaatc atcagaagtc
     2221 tttccatgcc atcgatcata gactttccat cagtaaaaaa acagcaaatg gaggcttgaa
     2281 gcctagtgtc tatccgtata aactttatag gctactgcct atgaaatgca agagagcccc
     2341 ttataagagc taccgaaatt cttcctatga aaatgcacga gaaaacagtc aaatgaatga
     2401 gtctgcacct ggtacctatg ttgttcagaa tccacacagc tctgaattac caacgctgaa
     2461 tttccaagat actgtaaaca ccctgaccaa cagtccagcc atcccattgg aaacatctgc
     2521 atgtcaggac atacccactt ctgccaatgt acaaaatgca gagggtacca aatggggaga
     2581 ggaggcattg aaaatggatc ttgacaataa cttttattca actgaggtgt cagtttcttc
     2641 cactgaaaat gctgtcagtt ctgacctccg ggcaggggat gtacctgttt tatctttgag
     2701 taatagcagt gagaatgccg cctctgtgat cagctacagt ggctctgcac cctcggtcat
     2761 tgtacacagc agccagtttt catcggtgat catgcacagc aatgccattg ctgccatgac
     2821 cagcagcaac cacagagcct tttcagaccc agctgtcagt cagtccctga aagatgacag
     2881 taagcccgag ccagataaag tgggtaggtt tgcaagcaga cccaaaagca ttaaggagaa
     2941 aaagaaaact acatcacata ccaggggaga aataccggag gagtcaaact atgttgctga
     3001 tcctggagga tcactgagca aaaccacaaa tattgctgaa gaaaccagca aaattgaaac
     3061 ctacattgca aaacctgctc tgccgggaac ctccacaaat agtaatgttg cacccctttg
     3121 ccaaataaca gtgaaaattg gaaacgaagc cattgtgaaa aggcacattc taggatctaa
     3181 attgttttat aaaagaggga gaagacccaa gtatcagatg caggaggagc ctttgccaca
     3241 ggggaatgac ccagaaccca gtggagacag cccactcggg ctttgccaat ccgagtgcat
     3301 ggagatgagt gaagtgttcg atgacgcaag tgaccaggat tccactgaca aaccgtggcg
     3361 cccttactac aactacaaac ccaaaaagaa atccagacag ttgaaaaaaa tgaggaaagt
     3421 caactggagg aaggagcacg gaaacaggag cccgagccat aaatgtaaat acccagcaga
     3481 actggattgc gccgtgggga aggctcctca ggataaaccc tttgaggaag aagaaactaa
     3541 agagatgccc aagctgcagt gtgaactctg tgatggagac aaagcagtgg gggctggaaa
     3601 ccaaggaagg ccccaccgac atcttacttc tcggccatat gcctgcgagc tctgcgccaa
     3661 gcagttccag agcccttcca cactcaaaat gcacatgaga tgtcacaccg gggagaagcc
     3721 ataccagtgc aagacctgcg gacggtgctt ttcggtgcaa ggaaacttac agaaacatga
     3781 acgcatccac ctgggcttga aggagttcgt ctgtcagtat tgcaacaagg cattcacctt
     3841 gaatgagacc ctcaaaatcc atgaaagaat ccatactgga gaaaagcgtt accactgtca
     3901 gttctgcttt cagagatttt tgtatctctc caccaaaagg aatcacgagc agaggcatat
     3961 tcgggagcat aatgggaagg gctatgcctg cttccagtgc cccaaaattt gcaaaacagc
     4021 tgctgccctt ggaatgcacc aaaagaaaca cttattcaaa agcccaagtc agcaggagaa
     4081 aataggtgac gtgtgccacg aaaactcaaa tcccttggag aatcaacatt tcattggttc
     4141 agaagacaat gaccaaaagg ataacataca aaccggtgtg gaaaatgttg tcctttgagt
     4201 ggcaagaatt agaaaaatct tcaaaaatat agttggtggt ttttttagtt atgatttaag
     4261 tttagtttca ttttgtccat gtgacagtca tgaaggagtg aaattaaaaa aaaaaaaaac
     4321 tcatttgtga aaattccaga aaaaggatcc taatatctac tttgggtttt agcattaact
     4381 ttatgcaaag tgcacaaaaa caaaatagct gactcctcca atatcccaag tttcttgtga
     4441 aagttaataa aattcttagc tgtggtattt ctaccagtga aaaaaggagt ttaattttag
     4501 cctagtttaa aactttctaa taattgctaa taagaactgg ctgctgaact gtctttagtc
     4561 actggagaaa ataagggtca gatatcctga agatggcatc ttcgtaaata tgttacgtgg
     4621 taataagctg tgtgacggtc tttattccca tctggcttct gcactattaa aatttgttta
     4681 aattaatgga tacacatgaa atacttaaac aatataactg aaattatgtg cataatgagt
     4741 aacctaaagt aggacattca tacattatgt agaactactt ttctgcaaca caaaccttgt
     4801 aaaatacata tataaatcac tataactttt aactgtccat atcccctgta gagaattatg
     4861 aggagcaata gatctgcaaa taatgaggac tgatgtaaaa atcaatagaa agcattttga
     4921 atatgattta agagcatgtg aatgctttta gatggaatgc tgttcccttg aagttatggc
     4981 tgagctgttc ttagaactgg tctactcaat tcacagaaaa cataggtcat gccttatcta
     5041 tgggggaaca ccctcccaga atttacctgt gattacctgt gctgcatatt actttgcaat
     5101 ggcctcatct cagagaatga aagagggtca cattgttctg aaactctctg cagtcttcca
     5161 accaccacaa ggccatggat gtgggggtct attccagaca gacttaaggg ctcaagtgga
     5221 acctgccatc tcccattcca ctgaaggact gtccaagaga tttagtgcaa ggtacactgc
     5281 agtagtgaat tcccaggcac ttgaaagtga ctgcctaatc cctacaatta ctagccttgt
     5341 tggagattat gcagcccaca agtacagact agtataaagc aaaaggacaa aggaaccccc
     5401 accctccacc ccacccatta atgacttgag tgggcaagaa gaagtgatgg ccttccttgc
     5461 ctaaaacagt agctttgttt ttagggggtg ggaaggtagg atgtggagtg acatggttct
     5521 atcctttact tatgagactc agaaatatat ctacaaagcc agatgctctg tcttcatatt
     5581 tgcagacatc tagacccctt gctaaaaacc cactgaagtt ttttttttat gttctttgac
     5641 ccacaccatc aacactaccc tcaaatctaa ttgccctaca gcatattcta tcatgtggac
     5701 taggttcctg gaaagccgga actcatgatt ctttttcaaa ctgccagaat agaagggaga
     5761 gagaaaacat ttctaccctt tgatcaccag tgtgaacaga atccggaatg cagtttcagc
     5821 gtgacctgca gtcattcatg ttcattggat ttgacagatg gaaacccaag gttatcgaag
     5881 attggaaggt tatcattgtg aagaagtagc tcaaaggact ccggtttctg tctacaagtg
     5941 tgatgtctcc atgaagaaga cttagtatgg atttgggtgg gtaagaaagc atttaaacgc
     6001 ccaggaaagg acatgattaa agttgacctt ttaatactgt agtaccttgc tgttaagtaa
     6061 ccccactatt gtatctgcat ttatcttttg ttcatctact ttcacttaca tacagtatta
     6121 tataagtaga gaaaaatggg aaaatgcaag caaattcaac tttattttat acattgtata
     6181 tatgtacacc ctacactatt catttgggtt ttattaaaga gatagtcaca aagggcttac
     6241 gaaaatcatt tttgaattga taattagaat attgaataag caatcctatg atccactaat
     6301 ttgttttatc agttaataat attaatcaaa gacatttact gtatattcta gtcattttga
     6361 tttgagttaa ccccaaatat aaaattacct gtagtgatgt ctctctccca gcccttatat
     6421 gtggatattt tttaagtgga cttgtatgct gataattcta gaccaaagta aatatggcag
     6481 aatatttata catgaaaaaa taattttgca aatattttct ataattgtat tcatttaaaa
     6541 tgttgatagc ttgtgttagt ttcagggagg ggtgtatatt ttgataaaaa aatacttgac
     6601 tttgtaattc tgtatattct atacaattta tagcagagcc gttttaagac agccttgtca
     6661 catttttttg ttaattgtga aaattttatt gagtgatgtt taagtatgca ttgagtacat
     6721 gaccaactag aattaaagta agtgtaaaca gtgaacatac tgtatgctgt acaagatata
     6781 atgtaacttg ctgttttagc atctgtattt tggttagaag atattattaa atgcagatgt
     6841 taaggattgg aaaagtctaa ttttattttt agaaataatg gatataaatt tgtttttgct
     6901 tgattaaaat agcttattcc tacattaagt ctctttttaa atgttttcat gttatttctt
     6961 ttgtgcagct atttcatctg tgtgagtcac agctttgttt ccacgtatta ttcagtttat
     7021 ttctgtttcc ttacttgttt acattccgtg gtacctactt acatgcttag gagtcaaatg
     7081 gattatgaca ttaggaaaaa agcagaataa aagagattga agtcttctga tgattgagtg
     7141 ttttggatag gcctgatctt ataatgataa atcagagaat gaaatgctct ccaggaagca
     7201 ttctgctcca ctcatccgtg ggaaacaaat tacatttatt gagtaccagg cactgggcaa
     7261 tgtctttaca taggctattt cattaacaca cacgcaccag aattcgacct cattatcctc
     7321 gttttatagt gactttgaga aggtctcaca accagacaaa gccaggatgc taacctaggt
     7381 ctgcctgact ccaaagccca tgtttttgtt ccttctcaac actgtagaga aaaatcattt
     7441 atagaaactg aacagagtat gaggaaagga gatatgataa agtaatgcag ctttaggatg
     7501 gcagttagtg actgccctgg aacaggatta aaggaggctg tgtcaggttc agcttcccct
     7561 gaattgggct tcccttatat ctcaggagat tgccctataa aatcagtaaa atttgtgcac
     7621 ttttttaagg atatggagta aaattgtaat agcattataa gctggtaatt ttcacacaaa
     7681 gaaaaaaata cgttccgtcg tcacagactc tactcctaaa cttagctaac taactatctt
     7741 gcaaatgcct gcagtttgtc ccagtgggca atgtgagagg ggatgtcggt ggctcaggca
     7801 gcacagtcca tcaccaacac agagaaaatt actgccaggc ctaccggtgg ctggccagta
     7861 gcatcaattt tgtattggaa gggcaatcca aaccagattc accaaaaatt tgataactgt
     7921 tatctgctaa aactaacttc attatgtaca agaacaacag atttaatatt gaaagcatct
     7981 gtaacaattg ggaaagtaaa agcataaaac aaaa
//
