LOCUS       NM_001122770           19183 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 37 (ZBTB37),
            transcript variant 1, mRNA.
ACCESSION   NM_001122770 XM_005245546
VERSION     NM_001122770.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19183)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 19183)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136170.14 and KF455104.1.
            
            On Apr 22, 2019 this sequence version replaced NM_001122770.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302696.1, SRR1660803.259660.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367701.10/ ENSP00000356674.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL136170.14        11016-11041
            27-222              AL136170.14        11561-11756
            223-1171            AL136170.14        12836-13784
            1172-1271           AL136170.14        16103-16202
            1272-10892          AL136170.14        28272-37892
            10893-11195         KF455104.1         1-303
            11196-19183         AL136170.14        38196-46183
FEATURES             Location/Qualifiers
     source          1..19183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..19183
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /note="zinc finger and BTB domain containing 37"
                     /db_xref="GeneID:84614"
                     /db_xref="HGNC:HGNC:28365"
     exon            1..26
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /inference="alignment:Splign:2.1.0"
     exon            27..222
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /inference="alignment:Splign:2.1.0"
     exon            223..1171
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1760
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 37"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 37
                     isoform a"
                     /protein_id="NP_001116242.1"
                     /db_xref="CCDS:CCDS44278.1"
                     /db_xref="GeneID:84614"
                     /db_xref="HGNC:HGNC:28365"
                     /translation="MEKGGNIQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQAFR
                     AHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTGRICLQLADIISY
                     LTAASFLQMQHIIDKCTQILEGIHFKINVAEVEAELSQTRTKHQERPPESHRVTPNLN
                     RSLSPRHNTPKGNRRGQVSAVLDIRELSPPEESTSPQIIEPSSDVESREPILRINRAG
                     QWYVETGVADRGGRSDDEVRVLGAVHIKTENLEEWLGPENQPSGEDGSSAEEVTAMVI
                     DTTGHGSVGQENYTLGSSGAKVARPTSSEVDRFSPSGSVVPLTERHRARSESPGRMDE
                     PKQPSSQVEESAMMGVSGYVEYLREQEVSERWFRYNPRLTCIYCAKSFNQKGSLDRHM
                     RLHMGITPFVCRMCGKKYTRKDQLEYHIRKHTGNKPFHCHVCGKSFPFQAILNQHFRK
                     NHPGCIPLEGPHSISPETTVTSRGQAEEESPSQEETVAPGEAVQGSVSTTGPD"
     exon            1172..1271
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..19183
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /inference="alignment:Splign:2.1.0"
     regulatory      19164..19169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /note="hexamer: ATTAAA"
     polyA_site      19183
                     /gene="ZBTB37"
                     /gene_synonym="D430004I08Rik; ZNF908"
                     /note="major polyA site"
ORIGIN      
        1 attccggccc atttccaccc ccggagctct cacccctcca gtgccgacgg tagcgaaaga
       61 ctttcctcca ggggcttcct cactggggaa ttgccggaaa gagcaaacaa aaaaggcgct
      121 ggtgtaggct ccaaaataaa cacatctgaa ttcatgatgg catcgacaga ggctcttatt
      181 ggattaaaag tttcaaaaca aacaataacg ctttggaaaa agggttgaat gcaccctcag
      241 gcacgaccat ggagaaaggt gggaacatac aattggagat tcctgacttc agcaactctg
      301 tcctgagcca tctaaaccag ttgcgcatgc agggccgtct ctgtgatatt gtggtcaatg
      361 tgcaaggaca agcttttcgg gctcacaaag tggtgctggc tgccagctcc ccctatttcc
      421 gggatcacat gtccttgaat gagatgagta cagtctccat ttcagtcatc aagaacccta
      481 ctgtttttga acagctcctt tctttctgtt acacagggcg gatatgcctg caactggcag
      541 atatcatcag ctacctaaca gctgccagtt ttctgcaaat gcagcatatt atagacaaat
      601 gtacacagat cctggagggc attcatttca aaattaatgt ggctgaggtt gaagcagaat
      661 taagtcaaac aaggacaaag catcaagaga gacctccaga gtctcacagg gttacaccaa
      721 atctcaaccg ctcccttagc ccacgacata ataccccaaa gggaaaccgg cgaggtcagg
      781 ttagtgctgt gctggatatc agagagctaa gtcctcctga ggagtccacc agccctcaga
      841 tcattgaacc aagttctgat gtagagagcc gggagcccat tcttcggatc aaccgagcag
      901 gacagtggta tgtggagaca ggagtggcgg accgtggggg tcggagtgat gatgaagtta
      961 gagttcttgg agcagtacac atcaaaactg aaaatctgga ggagtggctt gggcctgaga
     1021 atcagccttc tggagaagat gggagtagtg cagaggaagt aacagccatg gtgattgata
     1081 ccacaggcca tggttctgta ggacaggaaa attatacttt agggtcttca ggagccaagg
     1141 tggctcggcc aacaagcagt gaagttgaca gatttagccc ctccggcagt gttgttccct
     1201 tgacagagag acacagagcc agaagtgagt ctcctgggag aatggatgag cctaagcaac
     1261 ccagctccca ggtagaagag tcagcaatga tgggagtaag tggctatgtg gagtatctcc
     1321 gagagcagga agtatctgag cggtggttcc ggtacaaccc tcgtctcacc tgcatctatt
     1381 gcgccaaatc tttcaaccag aagggaagcc tggaccgcca catgcgccta cacatgggga
     1441 tcacaccatt cgtctgccgc atgtgtggca agaagtatac ccggaaagat cagctggagt
     1501 atcatatccg caagcacaca ggcaacaagc cctttcactg tcatgtctgt ggcaaaagtt
     1561 tccccttcca ggccatcttg aatcagcact ttcgcaaaaa ccaccctggc tgtatacccc
     1621 tggaggggcc tcacagcatc tcccctgaaa caactgtcac atctcgagga caagctgagg
     1681 aagagtcacc ttcacaggaa gagacagttg ctcctgggga agctgtccag ggctctgtgt
     1741 ccaccactgg gccagactga aacatccagg gggagggggc tgaccctctt cccctatgag
     1801 ccataagcag ccagcatcag agccatgggc tgatacttag attcacaaaa tgccacatca
     1861 ctaggccaga agatgctccc aagatgttgc caaactggag gatcagcaac ttacacaaaa
     1921 gcactaaagg ctcctccctt cttattgccc gcctcacact ttggaaaata atcaagcaaa
     1981 tcaactttct aattcaggga tcaacagcct tggtttgtta actttataag aaaaaaggtt
     2041 ttttaacaaa acgatgatga taaatggtca tttatctatc agtcatgttt gaacactgta
     2101 ctttggtcca tatcatcttg gtggctataa ttgcccggat ctaaaaaatg cagcaggagc
     2161 ctcaaccatc cgaagcagcc aaccgcaaga gaggaggtag tcatgatggt gatgaggagg
     2221 agaaatttct cctcttcctt ccctggcata acatgcattt ttgtgtttca agaaaaaaat
     2281 gaatactggt ggttcttatt ttgaaaggtt aggctttatc tttcccctga ctaggcatct
     2341 aatactttgc ctggttattt catataatca gccatcttga agcagtattc tagtggacaa
     2401 catcacctga agcacttggc aactgggagt gaaatgagca gcaaagtgta tgcaataggt
     2461 actgctacat ttggggggct tgagtgttgt gttgaggaag aggagagcag ggagggaagt
     2521 gtttttatgt tttgcaaata tcaaacagca cagagccgtt ctgcaacttc ctgactggta
     2581 tttgtaaacc atagtgctac acatccttgg gtaatggctc tagttcaggt gaattaatgt
     2641 gttaggctga ctaccaaagt ttcatctagt ctctttggct cctattttca cgttcagcaa
     2701 tattgtaatc aaaaatgtca ctttccagtg aaatgagcct ggattgtatt tttaaatcca
     2761 caggtctcca tatttgataa cttttatatg aagttttaaa catgtttttt ctgcagtatt
     2821 gtggttgaag aaattcaaca ctatggttct tactgcaacc acaatttcat ttccttatac
     2881 atatgtaata gtttatattt tcaggcatat agaaggacct cacttaaaac tatgtctcgg
     2941 gtctgcaaac ctagtaattc ataaaccaac catcagcaaa ccatagctgg tgactccaag
     3001 agctttgctt tttaataata tactacaggg cacttatcag aaaacatcat gcagaatcat
     3061 gttgcaataa atgatcaaag gatcaatttt ggtcaggttt ggttacttag tcattcctaa
     3121 gatttttaaa acttcaaggg acccttttag taattctggg tatttctaag attcttaatc
     3181 cagcactgag agaaagaact tagcaaacat gtagagcttt ggataccccg tctttcatga
     3241 agtgagagaa ggaggaatat taagggatgc cggcaaatag atgcttataa cttacagtgc
     3301 aagttgaaaa atctctagct tctgttgacg gagcactagt tgttggggtt cttttaagta
     3361 tgtaatggtt taagaaattg tttcagtgca gaggcataga tgactgtaaa agagatttgg
     3421 cagagggaca ggttgtacct gcactggtga accatctgtg agaatgttag tcatgtgctc
     3481 ctttcctgag attgctttgt ggtatgtgaa aaggtgggta gaaaagaaag aaatctcttt
     3541 gagataagaa attagaatgc aaagggtaga tcttaagcaa tctgagaatt gtacatgtac
     3601 ataaagctgc accctctcac aagagaaagg ttattttatc ttctgaaaaa gcatagaaat
     3661 gcatctttta tgggaagata atgatgctac catttaataa gagcctaccc ttaaaggcag
     3721 cattgaaact gtattttgtc tttagaagac atagactggt gcatcctccg ctttagttag
     3781 acaacagcat gataaggaaa aaactgtctt ctaaagccat ctttagggac tggctgtgct
     3841 ctgtggcata gaaaaggtaa agttgaatta gccaaaaatc cttagggaaa caactggtaa
     3901 taaggttttc agtggacaga ttttgtcatt actaaatagg cagtgaggtg agaagtacag
     3961 attatgctgc tttggatgga gcctttaagc ctaccaaaaa acttttaagt ccatcctact
     4021 tttgagaaat agtatgctag aaagttctgt ttttcttttt cttctttttt atatttttta
     4081 gagactgtgt cttcctcttg tcacccaaac cagagtgcag tggtgcaatc atagctcact
     4141 gtaatcttga actcctaggc tcaagtgatt gacctgcctc agcctccagg tagctaggac
     4201 tataggcatg caccaccatg tctagctaat ttttaaattt ttttgtagag acggtgtctc
     4261 tacaaaattt gcctaggttg gtcttgaact cctggcctca agtaatccta ccaccttgac
     4321 ctcccgaagt gctaggatta caggcatgag ccagtgaact tggcctggag aaagaattct
     4381 ttgttgcttt gttagtttct tagattatat gtgagaaaat ggagcttttt aaactattac
     4441 caaattttaa aggtgaagtg cagtaatttc tgtaaagaga aactttgcag catttgtcaa
     4501 ttctccttcc agggttagca acaaacaaat gaggtaggga ctatctcatt catgtggaaa
     4561 tgctatgaat gtttggtggg tttcccctcc cttttctttt cattcacttt aaatagcctt
     4621 ttcctatatt gatactgtga atagggtgct tcctggtcat ctaggaccac tttagcacaa
     4681 tcatgtttgc tggttctctc aattggccta gccagagcca caaaattcat gaaaatttaa
     4741 ggcaggctag cttttaaaca aattaaaact tctgaaaaca atttcagctt tttcgttaaa
     4801 agagatgttg ttattctaaa taactgtcca agactcttac ccacatacac tgtgacattg
     4861 tcctagttct tagctaacaa cacattggtc ataggagtta ctgatgttct atctacatta
     4921 atgaacagct attggtgtat gcacagagga tacctcttaa ggatgtacta aatggacttt
     4981 gtttggttga tgctgaaaat taattaccaa atcttaactt gcacgtgtta ccttgtgaag
     5041 ggaactgcat tagcaatgag agctacatca tcatgaagta ctttaatgcc atgaaattgc
     5101 aaacactggg actgttttca tttattgagt ggcacttagt agcaaaggag ctatccagta
     5161 ttctcagcaa agaagagaga cggaagtata ttaatctatt ttcatactaa gatgttcctt
     5221 tattctgtct gaactctaat accagtataa aatatagcat tggcatgaac agttaatgct
     5281 gtacttaggc agaaaggctc cttctaatga cttgttctct ctttactcag aaccgtattt
     5341 acctctgaac caagttgaat tttattttat ccaagttgca aactacccca tgccattttt
     5401 attataatag agggttaaat ctaatctcaa atacataaag gtaaattagt tcatagagga
     5461 taaagtttgg gaatgaagag agcagttaag gaaaatttta ttttttgtca ttttttaaat
     5521 gtttccagtt ccctctacat cagtgaaaca gggttttcca aagatggttt gaagatagaa
     5581 aaaacttttt ccccccgact tcatagttga catctggtat tggttggaat tggtctggtg
     5641 gcagagtgaa gtagggaact tcattttttt cttttttttc ttaaaggcag ggtctcacta
     5701 tgttgcccag gctggtctca aactcctggg ctcaagtggt cctccttcct cagcctcctg
     5761 aggagctggg actacaggcg tgtgaccaca cctggctgta aatgtcattc ttaatagctg
     5821 aataatcttt ggtcaagaag taacttttcc agagttttag ctgttacttg acattaattg
     5881 ggtttctttt aactggtgaa aactgtattt attttgtttg accagactgt ctaacttaaa
     5941 tgaaagcaat ggataatgga aaggaaactg aacaaagaca aaagtcttct tcatcatagt
     6001 gaaaggcatt taatcaggaa gagttggaat cctggaagtt tttctttttt tcaggtacaa
     6061 gaggcatgat ttttttctct tcctaaaatg tccttcccct tatctgtgta cttattagtt
     6121 caaggaataa caaatgagtc ttaattgaac ttagtctttg gaaattgagc tctttattta
     6181 ggttatatgt gaaagagttt aaaatattga aatactttgg ttgctaagca gatttagaaa
     6241 agcaacaagc aattgtcggg caaatcccta ggtttgagaa gatgtcctca gcaaaatata
     6301 cccttaggac ttacggaatt agatcagggt tcagcaaaca gtagtttcca ggccaaatgc
     6361 tgaggctact tgcttgtgta aagaaaatta taatggaata gggccacact tacttgttta
     6421 ggtattgttt atgccttctt tctactacaa tggcaaagtt gagtacttgt gacaaagatc
     6481 acgtggctac aaagcttgaa aatatttact gtctggtact tgttagaaaa aatttgccaa
     6541 ctccaagaaa gaattacctc ctaaagttgt tactcatgac attttgcctt tataatagtt
     6601 tggttgaagt tttaaattca tgttgtcaca tatacatgtt ttcttgaaag agtttgccaa
     6661 ctttttctag atcctcttat cataactctt tttgtgctcc ttcatgattt ttttgtgctc
     6721 cttcatgatt cccattactt taaaagcatt tagaattggc ctgttgtttg tccttgtctt
     6781 aatggtgccg gtattttaaa gtttagttgt aagtaagttt tgccattcct ctgagttaac
     6841 ttgaactggt ttgcataatg gtgacaagaa tgaatttttt cccaagtgga ttaaaaacta
     6901 atttcattat gaagaagtat tttgattcat atccaaagta ctgtttttct ggattagaac
     6961 ccctaccttt tccctttgca atgtatctta attttaactt ctttaaactt actctgttcc
     7021 atgtagagca gtaaaaagcc aagtttttct tccttttttc ctggatgttt tgaaacataa
     7081 tgaaacatct gaggatttca aattcttttt agacctatct tcccatttct gttattgtct
     7141 ataattcttc taaatacata ttggaccatt aacatgtttg ctttgtgaat gttcattctt
     7201 agtgttcaga tagcctactt atactcgatg tgggaaaaat gggaaatgtt agggggttca
     7261 taaacagaaa tccttgcagg aagccgggtg tgacagcaga cacctataat cccagctact
     7321 tgggagactg agctgagagg cccacttgag gccaggaatt taaggaccag cctgggcaac
     7381 atagacctta tctctaaaac aaaaaaaaat ccttgcaaga agagagaata attgcttccc
     7441 atttggaaat gatataggga cttttgaatt agatctatct tgacaaagtt ttctaggcca
     7501 tgctgataca gtatagggag tttgaatctg ttgtgagcgc tgtcaacata gacaaagttc
     7561 aagtgagtaa ctagctttct ataataggga ctctcttcac taggtatttt aaagttgctg
     7621 ctttctaatt ggatattagg aagttttata tgatataccc tctgagtaat agataatcct
     7681 catctataaa gttccagaat atttgcctag gttagatctc ccctggctta gagcagttat
     7741 acctatagta acagtaggtt tttgagattt tggagtatta cttttctgat taacctagga
     7801 ttctgattaa cctggaaggt gggacttgtg aaagaaattg gattttgtta gcccagtgaa
     7861 tcatctgcat cccactctat ttgaggtctt ggtaatagat gtcaatttaa atatgcatct
     7921 attgaaagca atggagtttt ccaagcatta tgacttcctt gataattttc agtcttatct
     7981 tttttcgtat tttctagtct ctttccctgt ctttagtctt cttcctctta aatggtgctt
     8041 ttcccagggc cagtctttct actttctaag caagcaggct tttttgttca ggataagcca
     8101 gagttagata ttatgaatac tttgaaacat ctgaatatgt tacattccaa agtatgtaat
     8161 tattgatagt agtatcaaaa cctggaagat attggtgcag attattcagt tttgctgtgt
     8221 aggcaggctg tctttctcct caactgtgac acagcagtga cttgagaagg caaatattac
     8281 ttgaaacccc cattatcttt atagagggta cgtatataaa ttttcttacc tgacattttt
     8341 accattatca atatatcagt agctcacatc ttaacataga agaagcccat tagctcaaat
     8401 actggaaact tcaaacaagg aaataaatta caaaagcaaa gcagttaatg aaaaaaactt
     8461 gtctattgcc tgcgtctttc atgtctactc aataggtcct gttgaggagg ctagaataca
     8521 ccatccggtt aagaaagggg ttgttttgtt ttgtttaaga cagagtcttg gtctgtcttc
     8581 caggctggag tgcagtggct caatcttggc tcactgcaat ctccacctcc ttggttcaag
     8641 caattcttgt gcctcagcct cccaaatagc tgagattaca ggcgtgtgcc accatgccca
     8701 gctaattttt gtatttttag tagagatggg gtttcaccat gttggccagg ctggtcgtga
     8761 actcctggcc tcaattgatc ctcctgcttc ggcctcccaa agtgctggac ttagaggcat
     8821 gaaccactgc acccagcccc atttaagaga gttttatatt cagcatctca tatggcctac
     8881 accatgattt taatatactg tgaatcttag gatttcagtt aatccataat gccaggagtt
     8941 aaggtatttc atgggaacat gtttcctctt ctatgaaatc acctgtctgc agtgataggt
     9001 aatgtataag agaatgtttc attaagtaaa tattaagtac tttttgatac cagacaacat
     9061 gcttgggatt tgtataataa aactggtttt agacatagtt tagacatgat gtgtcttcct
     9121 atacttgaga gtcctaagcc cacttggttg gcgtctggga tgtattgctt ttgaaaagcc
     9181 tgcacttttt actgtagaga taaaagatca aaaaggggac agaattagct ttattaagtg
     9241 ctttatcgtc ataactgtgg ttaagacaat aatactatga ggtaataaca gtaatgttaa
     9301 aaataactaa ctttttttga atgcttacta tgtgccaggc acagttctat gtgcttcaca
     9361 ttgattaact catctaatcc ttatgacaat cccatgaggg tagataacat cctcatttta
     9421 gatgggaaga aacagacaca actgactcag gctaacacta gagttgcctc tagtaggtgt
     9481 aattatatca tattttatag atgaggaaac tgatgaaccc aaggttacat aactggtaaa
     9541 ttacagagcc aatatttacc aatcttgatt ccaaagccca gactatctgc atgatgtcat
     9601 attgactcca tttacttatc aagagttgaa gttgactgga atatacagta gccaggaaca
     9661 gtactgcttt ttgtgaatgt gtaattcaag agtaagtgat tagaaggttc ttcaaaagct
     9721 gatgcagttg atctctgagc agagttgaat agtgaatatt ttcagtggat attgcccact
     9781 gattcaaggg agtcacccgt gtggttaggt ctaatagtga gtgaggtact atcaaggcaa
     9841 aaattgaaag agttccagtt acctattgct gtgtaacaaa cttaattaaa attaagtaat
     9901 tttaattact taaaatcaac catttcctat atcatggttt tgtgaatcag aaaatccagg
     9961 aagggcttgt ctgggcaatt ctcctccctg tgacaacgac tcaggtcacc tggtggtatt
    10021 cagcaggtgg ttagacaagt ctggaaggag tgtccaagat gatcgatctt acatacctga
    10081 cactttggtg gggagactag aaggatggac tcagcaggtc tcctctttct ctccatgaag
    10141 tctaaggact ctccatgtgt tctcttcatc aaggtagtca gatttactac gaggacagct
    10201 aaggcctctg aaaggctggg cagaagaatc tagtcaactt aaaggccagg cctagaatta
    10261 tcatacagcc accactgtac tcttggtcga agaacttaat ggtaagatga cagcaagaat
    10321 gaagggggaa aaaagaactc aatggtcagc ccaaatttaa ggagagaaga aataccctac
    10381 cactttatgg aaggcatgtc caggacttgg ggctattttt aatgtgttaa tgtttttttt
    10441 gttttgtttt gttttttgtc ttgactcttt ggtgtttatt catcagttgt ttgtgctgta
    10501 gaaaccattt attatgtcta ccatgggtca ctaaaggagc tagaaggaga atgagacaaa
    10561 tatctggagc atacttcatt tgctgccctc tccctccaag tttcatttat cttatagcaa
    10621 aattttcatt ttgtactgtg ttccaagttg tgaacatttg cctggttttg ctctgaagcc
    10681 acggtaactg catgcggagc tagaaatact ctagagggag taaaaagctt acattttttt
    10741 tgtttgtttt ttgttttagg acagagtttc actctgtcac ccaggctgga gtgcagtggt
    10801 gcaatcacag ctcactgcag cctcaacctc ctggactcaa gcaatcctcc tacctcatcc
    10861 tcccaagtag ctgggactcc agacgtgtgc cactacacct ggctaatttt tgtgtatttt
    10921 tagagacggg atctcaccat gttgcctggg ctggtcttga actcctggac tcaagagatc
    10981 caccttcctc ggcctcctga agtgctggga ttacaggcat gagccaacgt gcctggcccg
    11041 gaaagcttac tattaaataa tttgatttct tggagatatc agttgtattt taagtttaca
    11101 aataggtgaa tactcttgtg gtatggaaac attgcatggc tgctgaatct ctttcaacag
    11161 gagtttctat tgggtggcta catggatcat attcttgaga tagtgaaaag ttttacctac
    11221 ttatcttaat cccattctac ctctacacct ccagcatgat tttgtgctcg aagatgaatc
    11281 aattcctttc attcttgtta cctttcatac aggaaaattc atcgcccaat tttatatgtt
    11341 gttaatcttt taaaattggc agttgttacc agcctctctc atttaaaata acagatcatt
    11401 gaagtttttt gatttttggt tagatgtgtc agatttagga tgccttattt aaactcgtgc
    11461 tgtcttacta gactgttcct gctctgagaa gaaatatgga cagagaatga atttcattgt
    11521 ccatattgat gaaccccaaa tcaatacact tcttaagaaa ggtttgagat tatccagtcc
    11581 atgtgcaatg aatccttgga gcattagctg tgtggccttc ctactgataa tctgcagtta
    11641 tcacagtaaa gagatctctg ttcctaggtc aggccttagc aattacaaat acaggaaata
    11701 aaggggtact caatgctgaa gacttaattt tgggtaccta caaagtcctg ggaagggaaa
    11761 aagaagacct tggcatttgt atttgcataa ccagagatgg aatgtttgag gcttttaggc
    11821 ataaagatta attagatttt atcatataaa gattagggca aattattttt ttttccagtt
    11881 cattcttaac atgttaaggg acaaatttta atgaataaaa atttaaaggc cttaaaactt
    11941 tcttttggat tcacatttcc actctggtat aatccactct ggtgtagtct gccctttatg
    12001 acagagaaag cctttgaaaa tattgtccca gggaatgaaa aatcttaatg atgatctatg
    12061 gaaatgtctc tcattctcta ttacagccct ttgggccctc ctatagattc tctgtgaatt
    12121 taagtttgaa atcatttggt gtttgcatga aaaataattc ttactattca tttaaataat
    12181 tcttaaatgt ggtcttaaat tgcaagagag aacaaagcca gaaaaagggg aaccttgtag
    12241 attgaccaaa tatttattct ttattttcag catcacaaat ctaaaccatt tcaagctaat
    12301 acaacaacct gagtgagtag aaattcctta aggtttagat ttctgctttt agtcacatct
    12361 tgaagcagat gtttatgaca tatttgaaga tgatccactg agtttcctat aaagtaatag
    12421 aatcctaact atagtggttc tttaagaacc actgaaaaaa cagaattgca gtgcagggaa
    12481 caaagcttaa aatgtgtttc ctctggaagc caagatgcta aaaaaggggt cactaatagt
    12541 gtgactgaag tccgtctcta gaatggctat ctgttagata gcagaaatat ttagaatgta
    12601 tatggcattt ctaatatttt tacaaaaata attttaaatc atgtaactcg aatttttttt
    12661 aaaaagtctg ttttcttttt ggaaaactgg cacaataaaa ataacactaa tataattcca
    12721 ttgtatatgc atgtgcattg aacccagagt gggtatacta aagatagttc atgcaaataa
    12781 cttatgggaa gtttggctat tttttcatgt atgtttataa atatatttag tcatctactg
    12841 tgaccttggt agcacagaag cattttgtta gctgtatcat taattctaaa aatcaaattc
    12901 ttggcatagt aggctatgag agctttttgt tacttggtat tttggctaag aaaattattt
    12961 cttgcacttt ctatttgtaa agatgttata acacaatgca cccacttaat gcagcttttc
    13021 tttagagaaa aaagatgtag gtgtaaaagt gaaatgtatg ttttcaaacc tggcaaaagg
    13081 agggacctca aaaaaataaa tttggcttgc catctacctg agtagggttg gggattaata
    13141 taaaacttag gttgaaagtg gctgttggga taggtatact gttgctgtga attgcaatat
    13201 tgctgtgagt tgccagctat gtatgtgtaa gtttatgtgt gtatgtgaga aaaaggtatt
    13261 tcgtgaaggc ataaaagtca gtgtagaata tcctacctcc cactagagac tgagcatatt
    13321 caagattgct ctgtagtccc ttgggcagga agctggattc ctcagccact gtctacccca
    13381 ttcttctcta tactcacttc agctcctcta cctctgagca cttggctgaa gaaagagtat
    13441 agctttctgt agcaagcaaa ggaaagccag acccaaaata gagaggctgc agtatctgaa
    13501 attcttatca tgttcagata tcaatattta attttgttgc ccaaatcaaa caatgtcaga
    13561 acacttgagt ttagtgcttt tttttctctc tctgtctcct acagacttct cccggtttac
    13621 tgcttttatc cactggcttc tgtttggcag gagtagccag tggaggtcaa gtctgttttt
    13681 aaagactaaa acacctaatt ccttttaatg atgtgtaaca tttgtttgaa tccccaactt
    13741 cttttttttt ggggggcagg ggtagagatg gagtctccct atgttgccca gtctcgtctt
    13801 aaacatctag gtttggttgg atgcagtggc tcacacctgt aatcccagca ctttgggaag
    13861 ctgaggtagg cggatcacct gatgtcagga gttcgagacc agcctggcca acattgtgaa
    13921 accccgtctc tactaaaaat acaaaaaatt agctgggtgt ggtggcggca tctgtaatcc
    13981 cagctactcg ggaggctgag gcaggagaat cgcttgaact cgggaggtgg aaattgcagt
    14041 gagccgagat cacacggttg cactccagcc tgagcaacaa gagcgagact ccatctcaaa
    14101 aaaaaaaaaa aaaagtctgg gctcaagcga tcctaccacc tcagcctccc caaagtgata
    14161 ggattacagg tgccagtcac cacacctggc ccatgatgga ttttcagatg acctctttta
    14221 cttctaatct ctccaaagag agatattctt gtttttaagg tcaatattgt cataatagtc
    14281 atgatgtcct cacctgaatg ttgtaggtgt cagaaagttg tttcaatagt aatatgccac
    14341 caggcagacc acctaatctt taaatccagt tgtagcactc aatttatttt ctgtttgggg
    14401 cactagtgca ctgagccaag tcaacttgtc cacttttcta atatttctta cagctaagga
    14461 ggaactgttg gtcctttgat atcctagaat gctttctact tgtggaaatg ctttttaccc
    14521 taatacactg attatattgt ctaaatgtct aaacagggat tctctggtta gaagtgaaat
    14581 gagagagtga cccattttca gatttttaga gattggctcc cgtattttag gaactagctg
    14641 ataagtattt agtttcctgg tgactttgga tacggcaagt ggagatgcag agaatgtgaa
    14701 attccaaata ataagacaag cattactcac aaataacaac tgatacagta atttctgccc
    14761 aaatgcagta agaatcttgt agggagatga agtggtaaaa ttaaattata tgaatctttt
    14821 taccacgact attttttttt ttctacctgt agcatagttc tctgcctata agccatgcta
    14881 atatcctaga cccaggaatt aattcctgct taggaaaatt tttccttctg gcttatcttt
    14941 tgtttgtgcc cagagttttg tcctaggcct gtcccctgat cttttgctat aacacatact
    15001 taaggtgcag ccttcttacc taaatcagta ctttactgtt gctgttgctg cctattacag
    15061 ccagttattt atttaaaaag tagtgaaaaa atgcctaggt agtttgattg cagcatgtta
    15121 aatccataaa tctggacaga agccatggag tcttaccttt tctctctcta gcttggatga
    15181 acaccggcct tatgctttct attacaggac tagttgaccc agttcttcat attggttgca
    15241 cattagaatt gcataggacc ccctctagac atttacattt tattggtctg ttgtgcaacc
    15301 tgggctttag gtgattctaa tgtgcagcca aggttgagaa tcactcccta tgtaatccct
    15361 agtggtcatg gcaggataac ctcaatccag tcctctttga cctgaaaata tctttattga
    15421 tattccatgc atggctctca attcaaagtg tacagtgggt caaggcttag gtagtaaaat
    15481 ggatcatcca tttgtcctca gaataattct ggagggagat attgtcatcc atccagtttc
    15541 ctctctatac caaatacaaa gtacacataa ataagcaaaa caaattttca aagttccttc
    15601 tctagaatcc tctttctttt gcatatgtag tttcagtgga gatttctcaa ctagctgaaa
    15661 tggagcactt gaatatatta aaagagccca aactgcttac agcaatttct atttgtaaaa
    15721 taaacaggtg gcattgttaa tggagaaaag gaaggatcct gcctgtggtg atggtaatat
    15781 gtttgattat ttatctctta gcctgtcttc taagtgggat ttcagtgtca gttaactttc
    15841 acttttcttg gattgttttt ttgtgaatga aatgaactag ttaaggctta agtatttctg
    15901 aataatatat gaaatgtgaa atgagtcatt ttaggatctt tcttctggga tgtcaaagac
    15961 ctaaccaagt aactcccaaa tgaggttcca gattcatttt tctcatccca ggtagtaaac
    16021 gtgttttaat gggtttgttt cttgcccatg gcaacctcaa cacagagggg agaactgttt
    16081 tattacccta aaatagtgag aaccactgtt caaactaact agctaccaag tgacttctaa
    16141 ctcatgaaga aaatttgtat ttaagagcaa gttcaaatgt agcaggctct cttctgagag
    16201 tattctggat accacggaaa gtttcattta tatattgctt acaagtacgt ggtaatttga
    16261 acttcagtag gtgatatgtg caaggagaaa aagtaggtca aggagaaagt tggttagtgc
    16321 agaggactga cttagcatca gtctgtgaaa tttcattaaa gtagcactaa ggcctggctg
    16381 tttgcttagc atgtaaatgc tgcagtgtcc aagaaaatgc ctcctatgcc ttagaaaatt
    16441 tgctgaaggc ttcctgttac tggtggagta gaaaagcaat agcctttgag actccaaaga
    16501 gagtagcccc cttagggttt tcatactgaa gaaccttgtg gagtactgtg aaacattgtt
    16561 gaactttatg caaattatac tgcactggat tttaagattt tatggggaga gagtagagca
    16621 gagtggggaa gtaatgataa aagataaata cgtaaacttg tactatattt taagcaagga
    16681 atgaaacaaa ttccctaaca ggaattccct gtcagcactg tgaagtttgg tcaagttctg
    16741 cctaatgggt tggcttgctg attcctctta aacctctagg aaatcctttc taagacagca
    16801 aaacaaacgt tagtttgagt actactattt caccaccctg ctccatcccc ctactctcaa
    16861 cgaaagaaaa gcattcccaa actataggca aaagaaatgt gttctcagtc cattaatttt
    16921 tcatctgcta tgatctctgt tcacagtttt agcacattgc attattttgt aatctgatag
    16981 cagaacatca ggaactaatg gcttccttcc ctttaagaaa tcttaaagtt agaacttttt
    17041 tttttttttt tttttttgag acagggtctt gatctgtcac ccaggctgga gtacagtggt
    17101 gcaattatag ctcactgcag cctccacctc ctggactcta tcctcctgcc tcagcctccc
    17161 aagtagctgg aactacaggc atgtgccacc acgcccagct aaattttcta ttttctttta
    17221 gagacagagt ctcactatgt tgcccaggct ggtctcaaac tcctgggctc aagcgatcct
    17281 cccacctagg actcctaaag ttacaggtgt gagccactgt gcttggccta gaactctgtt
    17341 tttggcattt ctttctaaat gagtacattg gaagaacatt taggtttcca ggctcctcat
    17401 aatttctgaa tgggacccgc tctgctctgc ctctgaaagg aggagaaaag gctgagggtt
    17461 caaagacaga aaagtcaatg tagcagaaat ttgatttcct tcagatggac atagtctgaa
    17521 agaaatctat ccagctgttc tctatggtgc ttatatgatg ggtgacagct gtccccatct
    17581 acctgtccct ggcactgtgc cttcacactg gtcactgtga aaagcagatc acactggact
    17641 cagaggccag aatccaggac aagatccccc ttctcatctt gagcccatca catctttgta
    17701 tagctgttaa tgtagcattt acttctctat gggaaactct tgggttttta acccaagaag
    17761 aaattgtaaa gcatttaaac tagtcagaaa ataagattct gatggtagcg atcaaataaa
    17821 ggaaaatttc acttcctctc agttgatatt gattgatagc aaggatcaac tatgcccacc
    17881 tcttcctaag tttctaaagg ctaccataat atttgtaaac aacaaattta tctaatattt
    17941 tttacaactt gctaatcaag gaggattcat attaaaacag acaatcagtt tctaaaatgt
    18001 tatccctgaa agggaatgga atagagtatt tttagctgta agaacctacc agtctgtttt
    18061 ttccctttga aaaaaactaa tgtttgagat ttgtgtcttt tcatctgaag cagttactcc
    18121 attaatagta aagatgcctc gggaaagtca gtgaaccaga atagtgctct tgcaccactg
    18181 agggtgctag actggctttg tgcatcttat ttcctaagaa tatcagtttt tattatgacc
    18241 ttaattataa atacctatat ataggagtag gattttctct cacccaaccc tactttaatc
    18301 attatcactt aagtgtaaac ctccacctcc ccctctttcc ctttaccgaa aaaaaatgca
    18361 ctttaattcc taaggagagt ggctgttcct ggccctgaaa ccagattact tcaggaggag
    18421 agttaaggag ggagagctct taccagaccc tgtgaaatga accaaatttc ttaatgtaaa
    18481 cacacaagta ataacatcca cttttaagtg gcccccactc catgccaaag ggaaaaagaa
    18541 ccgccaaatt gaaaaagggt tctaaatacc tgtcctgatt ttggaagttt cactggggaa
    18601 aaactaccta agattatttt cacagctacc aatttgtcag aaactttggt ggtgttttgt
    18661 gggaggctga gattttttaa attaaaaatc aagtgaaaac acaaagactc taagacacga
    18721 tcctgatttg tgtcatttct aagtatcaga tttgttctcc cttcatttga caggtgttct
    18781 cagtctctcc tcctgtaaga ttctgtcctt cccctgatga caagccaata gttcttggtg
    18841 gggttgcatg tctcctagag ccccaggacc cctgtcgtgt cggggaaggg gggagggcag
    18901 gagggtgggc agagactcgg gttgggggag ggagttcaaa gaaagagtga aaatatgggt
    18961 ttatataaac atatttaaag cagtttagca aaagctttct cgttgaacag ctttaagaac
    19021 aatgtgaatg aaatcttagc aacttggtta gtaatctgaa aagtctatta atgtatactt
    19081 gaaattctgt ttgtataaaa atgcattttc ccctttattt taacactgtg taaaagaaca
    19141 ttatgcatgt gagtggtttg agaattaaat ggtttaatac tca
//
