LOCUS       NM_001099270            6590 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 34 (ZBTB34),
            transcript variant 1, mRNA.
ACCESSION   NM_001099270 XM_928961 XM_937669
VERSION     NM_001099270.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6590)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6590)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6590)
  AUTHORS   Qi,J., Zhang,X., Zhang,H.K., Yang,H.M., Zhou,Y.B. and Han,Z.G.
  TITLE     ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential
            transcriptional repressor
  JOURNAL   Mol Cell Biochem 290 (1-2), 159-167 (2006)
   PUBMED   16718364
  REMARK    GeneRIF: This present work as the first report about the functional
            exploration of the novel ZBTB34 gene would be contributed to
            profound understanding of the transcriptional regulation via
            BTB/POZ protein family.
REFERENCE   4  (bases 1 to 6590)
  AUTHORS   Ohara,O., Nagase,T., Mitsui,G., Kohga,H., Kikuno,R., Hiraoka,S.,
            Takahashi,Y., Kitajima,S., Saga,Y. and Koseki,H.
  TITLE     Characterization of size-fractionated cDNA libraries generated by
            the in vitro recombination-assisted method
  JOURNAL   DNA Res 9 (2), 47-57 (2002)
   PUBMED   12056414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354944.22 and AL160169.12.
            
            On Aug 25, 2021 this sequence version replaced NM_001099270.3.
            
            Sequence Note: This RefSeq contains an in-frame start site 4 codons
            upstream from the currently annotated site but is not being
            annotated as a start site since it is in a weak Kozak sequence
            context and there is a lack of evidence for use of the upstream
            AUG.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB082524.1, SRR11853567.30903.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319119.5/ ENSP00000317534.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL354944.22        24079-24179
            102-6416            AL354944.22        42830-49144
            6417-6590           AL160169.12        1997-2170
FEATURES             Location/Qualifiers
     source          1..6590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..6590
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /note="zinc finger and BTB domain containing 34"
                     /db_xref="GeneID:403341"
                     /db_xref="HGNC:HGNC:31446"
                     /db_xref="MIM:611692"
     exon            1..101
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /inference="alignment:Splign:2.1.0"
     exon            102..6590
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1626
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 34"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 34
                     isoform 1"
                     /protein_id="NP_001092740.2"
                     /db_xref="CCDS:CCDS48023.2"
                     /db_xref="GeneID:403341"
                     /db_xref="HGNC:HGNC:31446"
                     /db_xref="MIM:611692"
                     /translation="MSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQG
                     QPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKD
                     VVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEENPESRNGVKDSSF
                     FANPVEISPPYCSQGRQPTASSDLRMETTPSKALRSRLQEEGHSDRGSSGSVSEYEIQ
                     IEGDHEQGDLLVRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNV
                     GSYGSVLQHAYSYSQAASQPTNVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHL
                     HSDLQGLVQGSDSEAMMNNPGYESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLD
                     RHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQH
                     LRKNHPGVAEVRSRIESPERTDVYVEQKLENDASASEMGLDSRMEIHTVSDAPD"
     regulatory      6539..6544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /note="hexamer: AATAAA"
     regulatory      6568..6573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /note="hexamer: AATAAA"
     polyA_site      6575
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
     polyA_site      6590
                     /gene="ZBTB34"
                     /gene_synonym="ZNF918"
                     /note="major polyA site"
ORIGIN      
        1 gcgggctggg gcggcagccg gagcggcggg gactggcctg gcgccggcgg cggcggaggg
       61 ggcgccgcgg gcgggcgatg tgagcgcggc gctctggaca gagtacgctt catgtcagta
      121 gaaatggaca gcagcagttt tattcagttt gatgtgcccg agtacagcag caccgttctg
      181 agccagctaa acgaactccg cctgcagggg aaactatgtg acatcattgt acacattcag
      241 ggtcagccat tccgagccca caaagcagtc cttgctgcca gctccccata tttccgggac
      301 cattcagcgt taagtaccat gagtggcttg tcaatatcag tgattaaaaa tcccaatgtg
      361 tttgagcagt tgctttcttt ttgttacact ggaagaatgt ccttgcagct gaaggatgtt
      421 gtcagttttc tgactgcagc cagctttctt cagatgcagt gtgtcattga caagtgcacg
      481 cagatcctag agagcatcca ttccaaaatc agcgttggag atgttgactc tgttaccgtc
      541 ggtgctgaag agaatcccga gagtcgaaac ggagtgaaag acagcagctt ctttgccaac
      601 ccagtggaga tctctcctcc atattgctct cagggacggc agcccaccgc aagcagtgac
      661 ctccggatgg agacgacccc cagcaaagct ttgcgcagcc gcttacagga ggaggggcac
      721 tcagaccgcg ggagcagtgg gagcgtttct gaatatgaga ttcagataga gggagaccat
      781 gagcaaggag acctattggt gagggagagc cagatcaccg aggtgaaagt gaagatggag
      841 aagtccgacc ggcccagctg ttccgacagc tcctccctgg gtgacgatgg gtaccacacc
      901 gagatggttg atggggaaca agttgtggca gtgaatgtgg gctcctatgg ttctgtgctc
      961 cagcacgcat actcctattc ccaagcagcc tcacagccaa ccaatgtatc agaagctttt
     1021 ggaagtttga gtaattccag cccatccagg tccatgctga gctgtttccg aggagggcgt
     1081 gcccgccaga agcgggcttt gtctgtccac ctgcacagtg acctgcaggg cctggtgcag
     1141 ggctctgaca gtgaagccat gatgaacaac cccgggtatg agagcagtcc ccgggagagg
     1201 agtgcgagag ggcattggta cccgtacaat gagaggttga tctgtattta ctgtggaaag
     1261 tccttcaacc agaaaggaag ccttgatagg cacatgcgac tccatatggg aatcaccccc
     1321 tttgtgtgca agttctgtgg gaagaagtac acacggaagg accaactgga gtaccacatc
     1381 cggggccata cagatgataa accattccgc tgtgagatct gcgggaagtg ctttccattc
     1441 caaggtaccc tcaaccagca cttgcggaaa aaccacccag gcgttgctga agtcaggagt
     1501 cgcattgagt cccccgagag aacagatgtg tacgtggaac agaaactaga aaatgacgca
     1561 tcggcctcag agatgggcct agattcccgg atggaaattc acacagtgtc tgatgctccc
     1621 gattaagatg gtaaagaagt gcacccaaac aaagcacatt aatcaatgca tatttgtgat
     1681 ttgctttgtt gtaatctttg gttttcccaa ccatctggaa atctcttggt ctcttggcag
     1741 tttttctaaa gtttctggat ggaacacttc gttgtgttta tcctttcccc tgccctccct
     1801 ccccgaagga gctcaaagca tgaagggcaa cgcatccagg gaaaacacag gctgacagta
     1861 ttcctctttg gctgaactct taatccaaaa tctgccagtg atttagctat gccaactggt
     1921 tgaccctcca ttctctgcca agaggcatac tctttctcat tgtgtgcgct ggcagcagtg
     1981 cacttccacg gagggagatt aggatgccgt cagctgatac aaatgggtaa ccttttctaa
     2041 tttaaaattc cttttagggg gtagttagac aatttatata tatatataat aaaactatta
     2101 ttatatatat agtatatata cattttcaaa tttgatttta ttctggttga ggtgaatgta
     2161 agaggaatat ataatttaat acaatgtgaa cagggcttct gagtctatct catccctacc
     2221 taatatgtta gggttttgcc ccttcatttc ccttacaaaa gaatgttagt aggtttatat
     2281 taatcattgt gtccaaaagc aagcaaagca aatcacagtg ttcacagctc tgcttcataa
     2341 caaatacata aaccaaatgc cataaaattt cttcaactct agttggaaac cgtttggaat
     2401 ttttgttagt tgtccagcag gtaagctgga tgacctgtgg tgctgacctt tttacatagt
     2461 gtagtgttat attagccaac cccaaaggag cagtggtttt caaggttttt actggcctac
     2521 aaatctacct tcattccgta ctgtagaaac atacatacca ggtaactaaa tcgaatcact
     2581 ctctatcatg agttagtact cactcgcact taaggaaagg gatttgtagt tctgtctaca
     2641 aaattctcca agcagtgttg tggttttttt tgtttttgtt ttttttcttt ctcttttcaa
     2701 acagccagtt caggtgcaca gcaacttttt ctacatgcag ttcccaggga aactgcagaa
     2761 cttagaattt gtactttttg taaagctata ctctatggga attgcaagca atatatctat
     2821 cttagtattg tgtgtgctaa tgagagcctc agtggctccc ccactctctc agtgtttcct
     2881 gcttaaagaa ccaacagttt aaaagccctc taagatactc tgtgtgtcac caaatctgtg
     2941 tgtcaccatt ttttggtcat gtggtgctat ttttgttaag tgtcttttta ggtcagtata
     3001 gttgtagaaa atgtgaaatc tgatggtaat aatgaattat aattgttttc ctctcttgag
     3061 ttcatagctt gaaaagagac ctcaaaagca tgtgctggca aacacgttac tgtatgaaaa
     3121 catacctgag tccatttgaa taatgtttta ttagtacttt cggaaatgtc ttcagttctg
     3181 tattgtgttc acatacacaa acaggcttta caagattgct tcggtactgt aaactctggc
     3241 agagagtaat tttgtaggca gtttggtggt gagtttgtgc tgcaggctgc ctgtgggatg
     3301 tcagcgttct ggtatctgcc tgagaacctg ggctctgaga cgcacaacca gtgcacctcc
     3361 ataggagaac agtgcagcca cctaaaagaa aaacgaacga aggaccagcc tcagaggcta
     3421 gaagttaaag gaatacagaa ttagatgttt gctggttttc tgtgcttttt tggctcctaa
     3481 aataccaatg gtggatttgt ttttgttttt gttttttgtt ttgagaaata aaaagtcatt
     3541 caagcccttt gtgtgtaata gcccccaggg gtggcagctg tgcagtcgca tctctttggc
     3601 acacaggatc tgttcacgtg tgaactgctg cgctacacat cagtgttaac tccctacaga
     3661 ttacactcta atcccgctgc tcccgaggag cggctttgct aaatcgggta tatagtatat
     3721 gcctttttcc tcgtcaaact gcctaagtag gggttcgttc tctccctgaa gcacttgttc
     3781 aactcctgtt aaagccgcgt gcctcaaggg gaggctggac cccaagtgtt tacccactta
     3841 aatatgttct ggggtttcag gtaaatgttt gtgggttttt ttttccttac atgaataagt
     3901 ttggttttga ttttttttta attgaatgca aaaaatttgt gttgtgatac aaattaagtt
     3961 tgtgacaaga aatgcccaaa tccaaggaca taagaggtca agctcaggga aggaacctcc
     4021 ttttcactca ggcttggggc ctccagcgag gtttccagag cattccatgg tatgagagac
     4081 agtgaggagg gagggcacct ggcgcgggca cttccagcgt cctggctctt ggcattgtcc
     4141 gtcttaacct tatttacatg gagttctttg tatttgtgaa tctgtttaac tggtttgagt
     4201 ttaccaaaga gtgacttatc caaaattgtc tttgacaaaa atatccattg ctttgattgt
     4261 acagttcagg ttcaaacatt gtaatgggac tgttaagggg cagaaaattg attgagtttc
     4321 tctctaagaa tcatgattcc acattttgca agttccactt gctcccattc gtgttgctaa
     4381 cactttaccc tttccactgc tcgcagtgtt aagaatgaat tctcaagcca taacacagta
     4441 ctgtaaagtt ccgcagggct tcgagggagg cagcgcctag gccagcacgg agctgtgtag
     4501 cctctctgag cgttcgcact gtcatgcttc ccaggggtgt gactggtgag agattaactc
     4561 cattcagatc gggcagcagc aattaattgt gccttgccgc atgaggatgt gtcaggagga
     4621 ttaacatgac cacagaaccg aaacattctc tccctgaagt tcacttcacg tctccgcaga
     4681 cgaagtacgc tgtgtaactc cttagagcaa ctctttttgg aaagcaaagt ccctatttct
     4741 gtacagtttt aggttaggtg tttcatttat aacagatgca gaaatcaatt aagataaagt
     4801 gatatgtgaa gaaatctttt acagtaaaat atatcctgaa ttcatatagg cttgttcata
     4861 attgagtctc ttcttgagct accttttcaa tattagacaa tgtgaagaca gtgacagcgt
     4921 ccttttctag agatatttag cctgttatta caaactgtga agacaaagaa ttttatactt
     4981 ttactaatgt ttgtggtttt aaacagttat tttcattcta atcagttctc taccctctaa
     5041 tttctactaa agctgtaaat acatttagaa attatatttg taaatacagt atatggagac
     5101 aagttaattt tttggtcagt ggaaaaagcc tcccaaccaa ttggccctgc cttggcagtt
     5161 gtgttttttg ttgttgttgt tgttgtttta gtttagtttt tttttttaaa cagcagaaag
     5221 gatactgtcg gttcactgtt gagcagaata tactgtagaa cgaaaatgat aatttttaaa
     5281 tcttccagag catgagtaaa tgtcttttct aatgatagca aatataacca actctttgtt
     5341 tttcccttag cccagaccat atagacctgc gtattttgtg tgtggttttg tttttatttt
     5401 tgttcttaca gcctagaccc taggaaaaat ttgcaggaac acgaaacaag ggctgggggg
     5461 aaaatcatct atgtgaatga gctttacttt aaagagatca atgtatttta ttttatcaac
     5521 tttttctctt agttactgtg atttttgttg ttgttgtcct cgttattgtt aaattctgta
     5581 atggtttcct gtgaagcctc cactgaaagg gactcaaata tgcaacacct aaactatttt
     5641 ccaagggcac atgccccttg aatggtgctt ctagactggt cagggttatt tattaaattt
     5701 tatatatgaa agtattgggg aattatgtaa attctttata tgaaactatc tagttcataa
     5761 atcatagatt tcatattact cagtgcaact gaactaaaag ttcagaaaag tcattcacat
     5821 tgttccaaat ttgtaatggt tgtcacatgt cacatgcgtc tttttcagta agtgccagag
     5881 tgttcccact gtttctgccc agtgcttgac ttctcggccc ggaagagaac ctgctttctc
     5941 tggtttcctt cctgagtctg gcacagacgg ggctattgta gttcttgatc aagtcctgga
     6001 gtcagccttg cctggctctc cttgtagcag attcagtcca cagacctctt gctgcccctc
     6061 agtgacaagt atgctgtgaa ttcaaccttt ggacttgctg cccaagcctt tggttgctgc
     6121 cctgactatt gtaagaggta aacttacctg gtttgtttga gaatgaccat tttcctaatg
     6181 tgaaaaccat ctctctcacc acttttatta gtagggctaa catttttttc cgttataaat
     6241 ggttgagcaa tttgaatgac ttaacacagt gtcattatct tgcaatataa actggtaacc
     6301 tcacaactcc acacttcatc accatatgaa gtaaatgaag ctagctaagc ggatgctgta
     6361 tcaactagta acttgccatt aaggattatt ttatagcatg aatttaagac tatttattca
     6421 aatgatattt tactcttgta ttcactttgt tttagatttg tgacatgaat atttcagtgc
     6481 tgcttaattt tgttctgaat tcttgtttct tgcttgtaaa tggctttttt atggtataaa
     6541 taaagtcaat ggacattgct gtttgtaaat aaaaatgctg ctagagcaaa
//
