LOCUS       NM_001184742            5253 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 33 (ZBTB33),
            transcript variant 1, mRNA.
ACCESSION   NM_001184742
VERSION     NM_001184742.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5253)
  AUTHORS   Ahmed,S., Khan,S., Qureshi,M.A., Bukhari,U., Anis,M. and
            Mughal,M.N.
  TITLE     Expressional variations of Kaiso: an association with pathological
            characteristics and field cancerization of OSCC
  JOURNAL   BMC Cancer 22 (1), 990 (2022)
   PUBMED   36115941
  REMARK    GeneRIF: Expressional variations of Kaiso: an association with
            pathological characteristics and field cancerization of OSCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5253)
  AUTHORS   Tian,W., Yuan,H., Qin,S., Liu,W., Zhang,B., Gu,L., Zhou,J. and
            Deng,D.
  TITLE     Kaiso phosphorylation at threonine 606 leads to its accumulation in
            the cytoplasm, reducing its transcriptional repression of the
            tumour suppressor CDH1
  JOURNAL   Mol Oncol 16 (17), 3192-3209 (2022)
   PUBMED   35851744
  REMARK    GeneRIF: Kaiso phosphorylation at threonine 606 leads to its
            accumulation in the cytoplasm, reducing its transcriptional
            repression of the tumour suppressor CDH1.
REFERENCE   3  (bases 1 to 5253)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5253)
  AUTHORS   Nikolova,E.N., Stanfield,R.L., Dyson,H.J. and Wright,P.E.
  TITLE     A Conformational Switch in the Zinc Finger Protein Kaiso Mediates
            Differential Readout of Specific and Methylated DNA Sequences
  JOURNAL   Biochemistry 59 (20), 1909-1926 (2020)
   PUBMED   32352758
  REMARK    GeneRIF: A Conformational Switch in the Zinc Finger Protein Kaiso
            Mediates Differential Readout of Specific and Methylated DNA
            Sequences.
REFERENCE   5  (bases 1 to 5253)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5253)
  AUTHORS   Kondapalli,J., Flozak,A.S. and Albuquerque,M.L.
  TITLE     Laminar shear stress differentially modulates gene expression of
            p120 catenin, Kaiso transcription factor, and vascular endothelial
            cadherin in human coronary artery endothelial cells
  JOURNAL   J Biol Chem 279 (12), 11417-11424 (2004)
   PUBMED   14699141
  REMARK    GeneRIF: differential expression of p120(ctn) and Kaiso mRNA was
            observed in human coronary artery endothelial cells depending on
            how laminar shear stress was applied in relation to the wounding
            process
REFERENCE   7  (bases 1 to 5253)
  AUTHORS   Yoon,H.G., Chan,D.W., Reynolds,A.B., Qin,J. and Wong,J.
  TITLE     N-CoR mediates DNA methylation-dependent repression through a
            methyl CpG binding protein Kaiso
  JOURNAL   Mol Cell 12 (3), 723-734 (2003)
   PUBMED   14527417
REFERENCE   8  (bases 1 to 5253)
  AUTHORS   Prokhortchouk,A., Hendrich,B., Jorgensen,H., Ruzov,A., Wilm,M.,
            Georgiev,G., Bird,A. and Prokhortchouk,E.
  TITLE     The p120 catenin partner Kaiso is a DNA methylation-dependent
            transcriptional repressor
  JOURNAL   Genes Dev 15 (13), 1613-1618 (2001)
   PUBMED   11445535
REFERENCE   9  (bases 1 to 5253)
  AUTHORS   Daniel,J.M., Ireton,R.C. and Reynolds,A.B.
  TITLE     Monoclonal antibodies to Kaiso: a novel transcription factor and
            p120ctn-binding protein
  JOURNAL   Hybridoma 20 (3), 159-166 (2001)
   PUBMED   11461664
REFERENCE   10 (bases 1 to 5253)
  AUTHORS   Daniel,J.M. and Reynolds,A.B.
  TITLE     The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain
            zinc finger transcription factor
  JOURNAL   Mol Cell Biol 19 (5), 3614-3623 (1999)
   PUBMED   10207085
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB468333.1, AK312321.1,
            BC042753.1 and AC002086.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001184742.1.
            
            Summary: This gene encodes a transcriptional regulator with bimodal
            DNA-binding specificity, which binds to methylated CGCG and also to
            the non-methylated consensus KAISO-binding site TCCTGCNA. The
            protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc
            finger motifs. It recruits the N-CoR repressor complex to promote
            histone deacetylation and the formation of repressive chromatin
            structures in target gene promoters. It may contribute to the
            repression of target genes of the Wnt signaling pathway, and may
            also activate transcription of a subset of target genes by the
            recruitment of catenin delta-2 (CTNND2). Its interaction with
            catenin delta-1 (CTNND1) inhibits binding to both methylated and
            non-methylated DNA. It also interacts directly with the nuclear
            import receptor Importin-alpha2 (also known as karyopherin alpha2
            or RAG cohort 1), which may mediate nuclear import of this protein.
            Alternatively spliced transcript variants encoding the same protein
            have been identified.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.81070.1,
                                           SRR1803613.273544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557385.2/ ENSP00000450969.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               DB468333.1         58-432
            376-2289            AK312321.1         375-2288
            2290-5251           BC042753.1         2251-5212
            5252-5253           AC002086.1         101361-101362
FEATURES             Location/Qualifiers
     source          1..5253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..5253
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /note="zinc finger and BTB domain containing 33"
                     /db_xref="GeneID:10009"
                     /db_xref="HGNC:HGNC:16682"
                     /db_xref="MIM:300329"
     exon            1..166
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /inference="alignment:Splign:2.1.0"
     exon            167..268
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /inference="alignment:Splign:2.1.0"
     exon            269..5253
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2289
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /note="kaiso transcription factor; WUGSC:H_DJ525N14.1;
                     zinc finger and BTB domain-containing protein 33"
                     /codon_start=1
                     /product="transcriptional regulator Kaiso"
                     /protein_id="NP_001171671.1"
                     /db_xref="CCDS:CCDS14596.1"
                     /db_xref="GeneID:10009"
                     /db_xref="HGNC:HGNC:16682"
                     /db_xref="MIM:300329"
                     /translation="MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFR
                     AHKNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELI
                     KSGQLLGVKFIAELGVPLSQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNG
                     ATIMPIITESFSLSAEDYEMKKIIVTDSDDDDDDVIFCSEILPTKETLPSNNTVAQVQ
                     SNPGPVAISDVAPSASNNSPPLTNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHL
                     TPNIILLNQTPLSTPPNVSSSLPNHMPSSINLLVQNQQTPNSAILTGNKANEEEEEEI
                     IDDDDDTISSSPDSAVSNTSLVPQADTSQNTSFDGSLIQKMQIPTLLQEPLSNSLKIS
                     DIITRNTNDPGVGSKHLMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKD
                     DPDEGEARLENEIPKTSGSEMANKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTS
                     LRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMS
                     SHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYLSDRSSTIPAMKDDGIGYKVDTGKE
                     PPVGTTTSTQNKPMTWEDIFIQQENDSIFKQNVTDGSTEFEFIIPESY"
     regulatory      5233..5238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /note="hexamer: AATAAA"
     polyA_site      5253
                     /gene="ZBTB33"
                     /gene_synonym="ZNF-kaiso; ZNF348"
                     /note="major polyA site"
ORIGIN      
        1 gtagcagcgt tggcggcagg aggcggcggc cgcgtcgacg tcgacccaga ctggagcgac
       61 gtttaaagaa ggggcagaat cgctggggag tgcggcttct tcttgttggg ggactcccag
      121 ccttccgcgc gtccggagga ggagaagcgg cggcgccggg aagcagtgtc tgttgacttc
      181 acttggcact gtttaacatt ccacctctgg aaattgtaaa gatggagaga tgaggggaag
      241 ggacaagggg atgaagaaag aggaaagggc atggagagta gaaaactgat ttctgctaca
      301 gacattcagt actctggcag tctgctgaac tccttgaatg agcaacgtgg ccatggactc
      361 ttctgtgatg ttaccgttat tgtggaagac cgaaaattcc gggctcacaa gaatattctt
      421 tcagcttcta gtacctactt ccatcagctc ttctctgttg ctgggcaagt tgttgaactg
      481 agctttataa gagcagagat ctttgcagaa attctcaatt atatctatag ttctaaaatt
      541 gttcgtgtta gatcagattt gcttgatgag ttaattaaat cagggcagtt attaggagtg
      601 aaatttatag cagagcttgg tgtcccattg tcacaggtta aaagcatctc aggtacagcg
      661 caggatggta atactgagcc tttacctcct gattctggtg acaagaacct tgtaatacag
      721 aaatcaaaag atgaagccca agataatggg gctactataa tgcctattat aacagagtct
      781 ttttcattat ctgccgaaga ttatgaaatg aaaaagatca ttgttaccga ttctgatgat
      841 gatgatgatg atgtcatttt ttgctccgag attctgccca caaaggagac tttgccgagt
      901 aataacacag tggcacaggt ccaatctaac ccaggccctg ttgctatttc agatgttgca
      961 cctagtgcta gcaataactc gcccccttta acaaatatca cacctactca gaaacttcct
     1021 actcctgtga atcaggcaac tttgagccaa acacaaggaa gtgaaaaatt gttggtatct
     1081 tcagctccaa cacatctgac tcccaatatt attttgttaa atcagacacc actttctaca
     1141 ccaccaaatg tcagttcttc acttccaaat catatgccct cttcaatcaa tttacttgtg
     1201 cagaatcagc agacaccaaa cagtgctatt ttaacaggaa acaaggccaa tgaagaggag
     1261 gaggaggaaa taatagatga tgatgatgac actattagct ccagtcctga ctcggccgtc
     1321 agtaatacat ctttggtccc acaggctgat acctcccaaa ataccagttt tgatggatca
     1381 ttaatacaga agatgcagat tcctacactt cttcaagaac cactttccaa ttccttaaaa
     1441 atttcagata taattactag aaatactaat gatccaggcg taggatcaaa acatctaatg
     1501 gagggtcaga agatcattac tttagataca gctactgaaa ttgaaggctt atcgactggt
     1561 tgcaaggttt atgcaaatat cggtgaagat acttatgata tagtgatccc tgtcaaagat
     1621 gaccctgatg aaggggaggc cagacttgag aatgaaatac caaaaacgtc tggcagcgag
     1681 atggcaaaca aacgtatgaa agtaaaacat gatgatcact atgagttaat agtagatgga
     1741 agggtctatt atatctgtat tgtatgcaaa aggtcatatg tctgtctgac aagcttgcgg
     1801 agacatttta acattcattc ttgggagaag aagtatccgt gccgttactg tgagaaggta
     1861 tttcctcttg cagaatatcg cacaaagcat gaaattcatc acacagggga gcgaaggtat
     1921 cagtgtttgg cctgtggcaa atctttcatc aactatcagt ttatgtcttc acatataaag
     1981 tcagttcata gtcaagatcc ttctggggac tcaaagcttt atcgtttaca tccatgcagg
     2041 tctttacaaa tcagacaata tgcatatctt tccgatagat caagcactat tcctgcaatg
     2101 aaggatgatg gtattgggta taaggttgac actggaaaag aacctccagt agggaccact
     2161 acatctactc agaacaagcc aatgacctgg gaagatattt ttattcagca ggaaaatgat
     2221 tcaattttta aacaaaatgt aacagatggc agtactgagt ttgaatttat aataccagag
     2281 tcttactaaa ctcctttgaa atactagaaa gttttgtttt ggatgatggg gcaggggttt
     2341 cagaagatct gtaaaacaaa ttaaggtgcg aacaagttaa tttgatctgc cacattatct
     2401 gaaggaagtg tagtgggatt tttgttgata atttttagaa gcaaattttc ctgaaagttt
     2461 tgagtagagg tgagaccccc tccccaagta tctgtttata tagttagttt tcagctcatt
     2521 taaaagaggc aaaaattaaa agcttggaga gatagtttcc tgaatagaat ttgaagcagt
     2581 ctgaatgttc tttgaaaata actggagtta ttagcatacc ctagtacatc ttacagcttt
     2641 ccccttccat gttagcactt tactgctgaa ttctcaattt tcttaacatt gagacaataa
     2701 atgtgtgttt tgtcttgtat atggcataaa gagtaaataa gttttagagt tgttctggaa
     2761 aatgtcagaa taagtcagta cttgggttgt gtaatctgct agtccaagcg aacagcaacc
     2821 tcctgctacc ctccctctat gaaaatagcc atgcagacaa gtctctcatc tgaagaacaa
     2881 attagattta gctaattaga attaatcctg gctttcattg ccatagtctg taaaagactt
     2941 tggtggctag accactttat accttcgcag tgtggtctct gggggcaaaa aactaatgaa
     3001 aacaatctct gtaatggcag ataggaggag atgaaaagtt ctgttgcatg gatttttaat
     3061 tctctggcta ccacatagta gagaatggaa tgaagatttc cttttggctt cttaaggtta
     3121 aaaatattcc catgaacatg aaaattttca aattttgaat ctgaaagcca ccaaatgtat
     3181 ctttatgtat aaatccttgt aaatgataga ttccatgggt gagactttac atattttggg
     3241 tgggaggcta ctggcatata tttttaaatg ttcatattgc gtagaatctc cactaggaag
     3301 tctttatttg aaatagttga atcagtgatc tagtattttc ctttcggcaa gatttgttag
     3361 gtttttaccc cttctaaaat aagttttatt ccatctgcaa attgctgcaa tattatagta
     3421 atcagaaact acataaggaa tgttatatag gcttgtcagt tcccattttt cttgacaaca
     3481 ataaatacca cttttaaaaa tgacacatat ttaaacactt agaaaataaa gttaacactt
     3541 actgaagtgc tagtactaaa ctgtgctagt actaaaagaa aacaggttgg aacatacata
     3601 tagcctagca tttataacag aattgttgaa cgtctgtaaa tgattttttt tttttttgca
     3661 aaggaaaaaa ttgatactgg aaaagattgt tgtgcatagt tattagtcat ttgtaacctt
     3721 gcttaagtat ttcttagtcc aacatagata ttttctttct cctgaccatg tattttaaaa
     3781 tatagtctat ttcttgactt tgaacttaaa gctttaatca taatttctca tgtatacatc
     3841 gttcttctga tggtaagctg gatttgaagg tagtggtttc agtgtttctt aagttggtag
     3901 ctgagggtat caggcatcag ttcatgcaat aatacaagaa aaaaaatcct ttgcttgcca
     3961 agaggtagag tgatgtgcat ttatctgttt tctgttctgt aagtctagac cttcaaacca
     4021 tttgtaaact aacccctggg aaatttgaaa ttacctgata acttaagact ctgtgatctc
     4081 tggaatcacc atatgtttct tttttgtgta gatattaata acattactct ttgactatag
     4141 tgtgcactct gaaatgtact cagtgaaaat ttgttttgag tttcattaat gctatttcac
     4201 cagttagaca taattacttc taccgatgtg aatgatacgg atgccggcag agcttccaga
     4261 tctttcagac tcaactgcta ggtcaattag tttgtcataa taaaacttgg cagattctac
     4321 aagtctatta tgacaaacca ggaactaatt ctataatgga aaactatcca ttctgaataa
     4381 taggtatgta attatttgct gctgctgctg tgctctgtaa attctgaata tgacatttaa
     4441 actctgtgcc tactaaaggt atcttctgga gtttttggga ggagagaaac tggaaaatta
     4501 aattgtattt ttgccagaag actcttactt gcatgtgtct cagggtcttc agtttttcta
     4561 taagtttcca tatccaaagt tcagaattca tgtgaaatac ttctttgggg caaaagtcct
     4621 tcattcctgg tatttattgg attggaaatc tgtagcaaga tgctgtttaa aattaccata
     4681 ttgttttttt atcttatact tagctctctg gctattgaac ttccttttct tgtttgaagt
     4741 tagcttcaaa tttgctccta tgctaaatta cctgtaaata ttctggatag gaactacttg
     4801 aaatagtaat ttgttaaaag atatgacaaa atgaaaatgc ttaaactaca gaaatttaaa
     4861 aatgccataa caatcttgcg agactaactt taaaatatac tttaaatgat tattatgatt
     4921 ttggtggtaa cgatccccca cacacaacca ctatgaagaa ataatgccgc atttttcccc
     4981 cattgtacca aaaagataaa aaaatggtaa acactgatca aggtattttg tattgtcaag
     5041 gcatgcatat tctaaagaat taaatgctaa cttaacagca ctggctttct ggctggtcaa
     5101 ctatatgaaa ccttgttcat tcctccgagt actgtaatgt tcacacttgt acaatcttcc
     5161 ctgtcatgac tttaagttct acttttcatt aaccatggcc tgatattagt tcttagagct
     5221 tcttgtggca aaaataaaat gatttaattc tga
//
