LOCUS       NM_014383               2037 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 32 (ZBTB32),
            transcript variant 1, mRNA.
ACCESSION   NM_014383 XM_005258739
VERSION     NM_014383.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 2037)
  AUTHORS   Jash,A., Wang,Y., Weisel,F.J., Scharer,C.D., Boss,J.M.,
            Shlomchik,M.J. and Bhattacharya,D.
  TITLE     ZBTB32 Restricts the Duration of Memory B Cell Recall Responses
  JOURNAL   J Immunol 197 (4), 1159-1168 (2016)
   PUBMED   27357154
  REMARK    GeneRIF: ZBTB32 is a novel negative regulator of antibody recall
            responses.
REFERENCE   3  (bases 1 to 2037)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2037)
  AUTHORS   Lambert,B., Vandeputte,J., Remacle,S., Bergiers,I., Simonis,N.,
            Twizere,J.C., Vidal,M. and Rezsohazy,R.
  TITLE     Protein interactions of the transcription factor Hoxa1
  JOURNAL   BMC Dev Biol 12, 29 (2012)
   PUBMED   23088713
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2037)
  AUTHORS   Stogios,P.J., Cuesta-Seijo,J.A., Chen,L., Pomroy,N.C. and
            Prive,G.G.
  TITLE     Insights into strand exchange in BTB domain dimers from the crystal
            structures of FAZF and Miz1
  JOURNAL   J Mol Biol 400 (5), 983-997 (2010)
   PUBMED   20493880
  REMARK    GeneRIF: confirmed that the promyelocytic leukemia zinc finger
            (PLZF) BTB dimer is strand exchanged in solution, while the FAZF
            BTB dimer is not
REFERENCE   6  (bases 1 to 2037)
  AUTHORS   Han,S.H., Jeon,J.H., Ju,H.R., Jung,U., Kim,K.Y., Yoo,H.S.,
            Lee,Y.H., Song,K.S., Hwang,H.M., Na,Y.S., Yang,Y., Lee,K.N. and
            Choi,I.
  TITLE     VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3
            inhibits tumor cell growth by blocking cell-cycle progression
  JOURNAL   Oncogene 22 (26), 4035-4046 (2003)
   PUBMED   12821938
REFERENCE   7  (bases 1 to 2037)
  AUTHORS   Dai,M.S., Chevallier,N., Stone,S., Heinrich,M.C., McConnell,M.,
            Reuter,T., Broxmeyer,H.E., Licht,J.D., Lu,L. and Hoatlin,M.E.
  TITLE     The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle,
            apoptosis, and proliferation are differentiation stage-specific
  JOURNAL   J Biol Chem 277 (29), 26327-26334 (2002)
   PUBMED   11986317
  REMARK    GeneRIF: results suggest an essential role for FAZF during the
            proliferative stages of primitive hematopoietic progenitors,
            possibly acting in concert with (a subset of) the Fanconi anemia
            proteins
REFERENCE   8  (bases 1 to 2037)
  AUTHORS   Tsuzuki,S. and Enver,T.
  TITLE     Interactions of GATA-2 with the promyelocytic leukemia zinc finger
            (PLZF) protein, its homologue FAZF, and the t(11;17)-generated
            PLZF-retinoic acid receptor alpha oncoprotein
  JOURNAL   Blood 99 (9), 3404-3410 (2002)
   PUBMED   11964310
  REMARK    GeneRIF: can interact with GATA-2 and can modify GATA-2
            transactivation capacity
REFERENCE   9  (bases 1 to 2037)
  AUTHORS   Hoatlin,M.E., Zhi,Y., Ball,H., Silvey,K., Melnick,A., Stone,S.,
            Arai,S., Hawe,N., Owen,G., Zelent,A. and Licht,J.D.
  TITLE     A novel BTB/POZ transcriptional repressor protein interacts with
            the Fanconi anemia group C protein and PLZF
  JOURNAL   Blood 94 (11), 3737-3747 (1999)
   PUBMED   10572087
REFERENCE   10 (bases 1 to 2037)
  AUTHORS   Lin,W., Lai,C.H., Tang,C.J., Huang,C.J. and Tang,T.K.
  TITLE     Identification and gene structure of a novel human PLZF-related
            transcription factor gene, TZFP
  JOURNAL   Biochem Biophys Res Commun 264 (3), 789-795 (1999)
   PUBMED   10544010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY027719.1 and AF130255.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014383.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF130255.1, SRR1163657.542969.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392197.7/ ENSP00000376035.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                HY027719.1         73-149
            78-2037             AF130255.1         1-1960
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2037
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /note="zinc finger and BTB domain containing 32"
                     /db_xref="GeneID:27033"
                     /db_xref="HGNC:HGNC:16763"
                     /db_xref="MIM:605859"
     exon            1..66
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     exon            67..183
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     exon            184..1168
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1751
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis zinc finger protein; repressor of GATA; zinc finger
                     and BTB domain-containing protein 32; FANCC-interacting
                     protein; fanconi anemia zinc finger protein; zinc finger
                     protein 538; myoneurin"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 32
                     isoform 1"
                     /protein_id="NP_055198.1"
                     /db_xref="CCDS:CCDS12471.1"
                     /db_xref="GeneID:27033"
                     /db_xref="HGNC:HGNC:16763"
                     /db_xref="MIM:605859"
                     /translation="MSLPPIRLPSPYGSDRLVQLAARLRPALCDTLITVGSQEFPAHS
                     LVLAGVSQQLGRRGQWALGEGISPSTFAQLLNFVYGESVELQPGELRPLQEAARALGV
                     QSLEEACWRARGDRAKKPDPGLKKHQEEPEKPSRNPERELGDPGEKQKPEQVSRTGGR
                     EQEMLHKHSPPRGRPEMAGATQEAQQEQTRSKEKRLQAPVGQRGADGKHGVLTWLREN
                     PGGSEESLRKLPGPLPPAGSLQTSVTPRPSWAEAPWLVGGQPALWSILLMPPRYGIPF
                     YHSTPTTGAWQEVWREQRIPLSLNAPKGLWSQNQLASSSPTPGSLPQGPAQLSPGEME
                     ESDQGHTGALATCAGHEDKAGCPPRPHPPPAPPARSRPYACSVCGKRFSLKHQMETHY
                     RVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCSLCGAGCPSLASMQAHMRGH
                     SPSQLPPGWTIRSTFLYSSSRPSRPSTSPCCPSSSTT"
     exon            1169..1242
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1311
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1476
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..2037
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2009..2014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /note="hexamer: AATAAA"
     polyA_site      2037
                     /gene="ZBTB32"
                     /gene_synonym="FAXF; FAZF; mynn; Rog; TZFP; ZNF538"
                     /note="major polyA site"
ORIGIN      
        1 actcggcctt aagccgtcct gggtgtatgt gaggctgaaa gggaaggagg aacagggtct
       61 gggccgctgt gtgctctgcc gtcatctcta agaaacaacc ataccactga atgctactgt
      121 gtacttacaa accacactca tattcgtcac gtcatttcat cttcaccccc acctccaaat
      181 gaggcttgaa atgagatgag atgttcctcc ctcccctttc aaccatggac ctcacactgt
      241 ggacttcctc ttagagcctc tgagttaggt acccaagcca aggcacaatg tccctgcccc
      301 ccataagact gcccagcccc tatggctctg atcggctggt acagctagca gccaggctcc
      361 ggccagcact ctgtgatact ctgatcaccg tagggagcca ggagttcccc gcccacagcc
      421 tggtgctagc aggtgtcagc cagcagctgg gccgcagggg ccagtgggct ctgggagaag
      481 gcatcagccc ttctaccttt gcccagctcc tgaactttgt gtatggggag agtgtagagc
      541 tgcagcctgg agagctaagg ccccttcagg aggcggccag ggccttggga gtgcagtccc
      601 tggaagaggc atgctggagg gctcgagggg acagggctaa aaagccagat ccaggcctga
      661 agaaacatca ggaggagcca gagaaaccct caaggaatcc tgagagagaa ctgggggacc
      721 ctggagagaa gcagaaacca gaacaggttt ctagaactgg tgggagagaa caggagatgt
      781 tgcacaagca ctcgccacca agaggcagac ccgagatggc aggagcaacg caggaggctc
      841 agcaggaaca gaccaggtca aaggagaaac gcctccaagc ccctgttggc caaaggggag
      901 cagatgggaa gcatggagtg ctcacgtggt tgagggaaaa tccagggggc tctgaggaaa
      961 gtctgcgcaa gctccctggc ccccttcccc cagcaggctc cctgcaaacc agcgtcaccc
     1021 ctaggccctc gtgggctgag gccccttggt tggtgggggg ccagcctgcc ctgtggagca
     1081 tcctgctgat gccgcccaga tatggcattc ccttctacca tagcaccccc accactggag
     1141 cctggcagga ggtctggcgg gaacagagga tcccactgtc cctaaatgcc cccaaagggc
     1201 tctggagcca gaaccagttg gcctcctcca gccctacccc aggttccctc ccccagggcc
     1261 ccgcacagct cagccctggg gagatggaag agtctgatca ggggcacaca ggcgcacttg
     1321 caacctgtgc gggtcatgag gacaaggcag gctgcccacc tcgcccgcac cctcccccgg
     1381 cccctcctgc tcggtctcgg ccctatgcgt gctctgtctg tggaaagagg ttttcactca
     1441 agcatcagat ggagacgcac taccgagtcc acacaggaga gaagcccttc tcctgtagcc
     1501 tttgtcctca gcgctcccgg gacttctcgg ccatgaccaa gcacctgcgg acacacgggg
     1561 ccgctccgta ccgctgctcc ctgtgcgggg ccggctgtcc cagcctggcc tccatgcagg
     1621 cgcacatgcg cggtcactcg cccagccaac tcccgcccgg atggaccatc cgctccacct
     1681 tcctctactc ctcctcgagg ccgtctcggc cctcgacctc tccctgttgt ccttcttcct
     1741 ccaccacctg acggggtgtc ggtagcgtct tagccaagag tccaattaaa gaacgaaaag
     1801 cgggccggct cggcttctga cctggcaccg ctgctacggc ggcctagcaa attccgcccc
     1861 agaagcgccc caggaagggc gccgagtgcc ctctcctgga cgatcgcggg tcgcagaagc
     1921 ccaggccagc gagccctaca gagtgaggac actgaagtgt gcaggagcga aggttaacag
     1981 taggggagat tgtcgatctc atcaccataa taaagagttt cctgtgccct cccttca
//
