LOCUS       NM_001370809            2950 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 3 (ZBTB3),
            transcript variant 1, mRNA.
ACCESSION   NM_001370809
VERSION     NM_001370809.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Wang,Z., Liang,Q., Qian,X., Hu,B., Zheng,Z., Wang,J., Hu,Y.,
            Bao,Z., Zhao,K., Zhou,Y., Feng,X., Yi,X., Li,J., Shi,J., Liu,Z.,
            Hao,J., Chen,K., Yu,Y., Sham,P.C., Lu,W., Wang,X., Song,W. and
            Li,M.J.
  TITLE     An autoimmune pleiotropic SNP modulates IRF5 alternative promoter
            usage through ZBTB3-mediated chromatin looping
  JOURNAL   Nat Commun 14 (1), 1208 (2023)
   PUBMED   36869052
  REMARK    GeneRIF: An autoimmune pleiotropic SNP modulates IRF5 alternative
            promoter usage through ZBTB3-mediated chromatin looping.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Lim,J.H.
  TITLE     Zinc finger and BTB domain-containing protein 3 is essential for
            the growth of cancer cells
  JOURNAL   BMB Rep 47 (7), 405-410 (2014)
   PUBMED   24856827
  REMARK    GeneRIF: Suppression of ZBTB3 activates a caspase cascade,
            including caspase-9, -3, and PARP leading to cellular apoptosis,
            resulting from failed ROS detoxification.
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001160.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025249.1, SRR1660803.135261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000394807.5/
                                                ENSP00000378286.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AP001160.4         31265-31461         c
            198-2950            AP001160.4         28264-31016         c
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2950
                     /gene="ZBTB3"
                     /note="zinc finger and BTB domain containing 3"
                     /db_xref="GeneID:79842"
                     /db_xref="HGNC:HGNC:22918"
     exon            1..197
                     /gene="ZBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            198..2950
                     /gene="ZBTB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1823
                     /gene="ZBTB3"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 3"
                     /protein_id="NP_001357738.1"
                     /db_xref="CCDS:CCDS8034.2"
                     /db_xref="GeneID:79842"
                     /db_xref="HGNC:HGNC:22918"
                     /translation="MEFPEHSQQLLQSLREQRSQGFLCDCTVMVGSTQFLAHRAVLAS
                     CSPFFQLFYKERELDKRDLVCIHNEIVTAPAFGLLLDFMYAGQLTLRGDTPVEDVLAA
                     ASYLHMNDIVKVCKRRLQARALAEADSTKKEEETNSQLPSLEFLSSTSRGTQPSLASA
                     ETSGHWGKGEWKGSAAPSPTVRPPDEPPMSSGADTTQPGMEVDAPHLRAPHPPVADVS
                     LASPSSSTETIPTNYFSSGISAVSLEPLPSLDVGPESLRVVEPKDPGGPLQGFYPPAS
                     APTSAPAPVSAPVPSQAPAPAEAELVQVKVEAIVISDEETDVSDEQPQGPERAFPSGG
                     AVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPHLPYHLLPGAGQYHRGLVTSPLP
                     APASLHEPLYLSSEYEAAPGSFGVFTEDVPTCKTCGKTFSCSYTLRRHATVHTRERPY
                     ECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEVGPLLGVQPLPGSPTADRQSSS
                     GGGPPKDFVLAPKTNI"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB3"
                     /note="hexamer: CATAAA"
     regulatory      2931..2936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB3"
                     /note="hexamer: AATGAA"
     polyA_site      2940
                     /gene="ZBTB3"
     polyA_site      2950
                     /gene="ZBTB3"
                     /note="major polyA site"
ORIGIN      
        1 ggagctcgcc ctgtggctgc tcggtggtgg gtgaggtatc agctttctcc gctagttccc
       61 accctggtag tccttagccc ctggaatgcg tgagggagat gcttagggag ttctcgaagt
      121 ggggcgtaga ggcatcgcct ggcaaggcct gggagcgaaa aagatctcta cttcgtggag
      181 ccgttggacg ctaccgggga gccactggtg gggacctttt ttgggccccc tttccttcgt
      241 ggggtactat ggagttccca gaacacagtc agcagctgct gcagagcctc cgggagcagc
      301 ggtcccaggg tttcctttgt gactgcaccg tgatggtggg tagtacccag ttcttggccc
      361 atcgggctgt gctggcctcc tgcagcccat tcttccagct tttctacaag gagcgggaat
      421 tggacaagag ggatctggtg tgtattcaca atgaaattgt cacagcccca gcctttgggc
      481 tgcttctgga ctttatgtat gctggccagc tgaccctgag aggggatacc cctgtggagg
      541 atgtgctggc agctgccagc tacttgcaca tgaatgacat cgtcaaggtg tgtaagcggc
      601 ggcttcaagc ccgggccctg gcagaggcag acagtaccaa gaaggaggag gaaaccaact
      661 cacagcttcc tagtttggag tttttgtcta gtacttcccg tggcacccaa ccttcgttgg
      721 catctgctga gacatcaggc cactggggca aaggggaatg gaaaggctct gctgctccct
      781 cacctactgt ccgtcctcca gatgagccac caatgtctag tggggctgac actacacagc
      841 ctggcatgga ggttgacgca ccacatctgc gggcacctca tccaccagtg gctgatgtct
      901 ctcttgccag ccctagtagc tccactgaga ccattcctac aaactacttc tcttctggca
      961 tctcagcagt ttcattggag ccactgccat ctcttgatgt gggtcctgag agtctgaggg
     1021 tggtggaacc aaaggatcct ggaggaccac tgcaaggctt ctatccccca gcctcagccc
     1081 caacgtcagc cccagcccct gtctcagctc cagttccatc ccaggctcca gccccagctg
     1141 aagctgagct ggtccaggtg aaagttgaag ctattgtgat ctctgatgaa gagactgatg
     1201 tgtcagatga acagcctcag ggtcctgaga gagctttccc atctggagga gcagtgtatg
     1261 gggcacagcc ctcccagcca gaggcttttg aagacccagg ggcagcagga ctggaggagg
     1321 tggggccaag tgaccacttc ctgccaacag accctcatct accctaccat ctgctgccag
     1381 gtgcagggca gtatcatcga ggactggtga cctcacctct gcctgcaccc gcatccctgc
     1441 atgagccact ttacctgtct tctgagtacg aagcagctcc aggaagcttt ggggttttta
     1501 ctgaggatgt tcccacctgc aagacatgtg ggaagacctt ctcatgctct tacacactac
     1561 ggcgacatgc cacggtgcac acacgtgagc gaccctatga gtgccgctac tgcctgcgga
     1621 gctacacgca gtcaggggac ctctaccgcc acatccgcaa ggctcacaat gaggacctgg
     1681 ccaaacgcag caaaccagat ccagaagtgg gaccccttct aggggtgcag cctctccctg
     1741 gctccccaac agcagacaga cagagcagca gtggtggagg gccacctaaa gattttgtat
     1801 tggccccaaa aactaacatc taagggagca tgagctgatg ctaggctgct cttaccatcc
     1861 ttagatggca gctcagaagg ttggtggcac cttatcaccc ctgctgggtg acaagaataa
     1921 aggctctgcc caggctgaaa gttcctaccc tttttttttt ttaatctttt atttttttga
     1981 gacagagtct cactctgtca cccagactgg agtgcagtgg cgcgatctcg gctcactgca
     2041 agctcagcct ccccgattca cgccattctc ctgcctcagc ctcccgagta gctgggacta
     2101 caggcgccta tcaccatgcc tggctaattt tttttgattt ttagtagaga cagggtttca
     2161 ccgtgttagc caggatggtc tcgatcttct gacagatctg acctcgtgat ccgcccatct
     2221 ccacctcccg cagtgctggg attacaggca tgagccaccg cgcccagctg cctttttttt
     2281 tttgagtctt gctctgtcac tgaggctgga gtgcagtggc gcaatttcag ctcactgcaa
     2341 cctctgcctc ccaggttcaa gcgattcctt tttttttttt tttttttgag acagagtctc
     2401 actctgtccc ccaggctgga gtgcagtggc gcgatcttgg cccaccacgc ccgcctaatt
     2461 ttttgtattt tttagtagag acggggtttc accgtgttag tcaggatggt ctcgatctcc
     2521 tgacctcgtg atccacccgc ctcagcctcc caaagtgctg ggattacagg cttgagccac
     2581 cgtgcctggc ctcaagcgat tctcttaact cagcctcttg agtagctggg attacaggaa
     2641 cgcgccacca cgcccagcta attcctgtat ttttagtaga gacagggttt caccatgttg
     2701 gccaggctgg tctcaaattc ctgaccccag gtgatctgcc caccttggcc ttaaaaagtg
     2761 ctgggattaa aggcgtgagc caccatgccc agcctcctac ccttttcttt gcccagccag
     2821 ataagcagga ctttatgggg caaagcctat gtcagctctc tccaagggca ctgggaattt
     2881 tcctgaggtg taatcgcttc tcactgtatg ttctggaaca taaagctagc aatgaaggta
     2941 tttctttgaa
//
