LOCUS       NM_020924               4455 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 26 (ZBTB26),
            transcript variant 1, mRNA.
ACCESSION   NM_020924
VERSION     NM_020924.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4455)
  AUTHORS   Vick,P., Eberle,B., Choukair,D., Weiss,B., Roeth,R., Schneider,I.,
            Paramasivam,N., Bettendorf,M. and Rappold,G.A.
  TITLE     Identification of ZBTB26 as a Novel Risk Factor for Congenital
            Hypothyroidism
  JOURNAL   Genes (Basel) 12 (12), 1862 (2021)
   PUBMED   34946811
  REMARK    GeneRIF: Identification of ZBTB26 as a Novel Risk Factor for
            Congenital Hypothyroidism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4455)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4455)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 4455)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4455)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY066289.1, BC018748.1, AK058083.1, BM682342.1 and AC007066.4.
            
            On Nov 22, 2018 this sequence version replaced NM_020924.3.
            
            Transcript Variant: This variant (1) and variants 2 and 3 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018748.1, SRR1660803.136412.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373656.4/ ENSP00000362760.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                HY066289.1         41-52
            13-1752             BC018748.1         1-1740
            1753-1966           AK058083.1         1319-1532
            1967-1992           BM682342.1         374-399
            1993-4455           AC007066.4         126807-129269
FEATURES             Location/Qualifiers
     source          1..4455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4455
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /note="zinc finger and BTB domain containing 26"
                     /db_xref="GeneID:57684"
                     /db_xref="HGNC:HGNC:23383"
                     /db_xref="MIM:620164"
     exon            1..76
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /inference="alignment:Splign:2.1.0"
     exon            77..4455
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1412
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /note="zinc finger protein 483; zinc finger protein 481;
                     zinc finger protein Bioref"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     26"
                     /protein_id="NP_065975.1"
                     /db_xref="CCDS:CCDS6847.1"
                     /db_xref="GeneID:57684"
                     /db_xref="HGNC:HGNC:23383"
                     /db_xref="MIM:620164"
                     /translation="MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEV
                     QGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVN
                     YLTAASFLQMSHIVERCTQALWKFIKPKQPMDSKEGCEPQSASPQSKEQQGDARGSPK
                     QDSPCIHPSEDSMDMEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQH
                     SLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMASKDVFGPNIRGVDKGLQWHHQCP
                     KCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKT
                     FSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQD
                     LTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN"
     regulatory      4435..4440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /note="hexamer: AATAAA"
     polyA_site      4455
                     /gene="ZBTB26"
                     /gene_synonym="bioref; ZNF481"
                     /note="major polyA site"
ORIGIN      
        1 ctcccccttc ccggagcccc gaggggccgg agctcctggc ggtgccggat cctgacggcg
       61 gccttccccc gggtctgtct gccaaaatgt ctgaaagatc agatctcctt cacttcaagt
      121 ttgaaaatta tggagattca atgttacaaa aaatgaacaa attaagagaa gagaataaat
      181 tttgtgatgt tacagttctc atagatgata ttgaggtaca gggacataaa attgtgtttg
      241 ctgcaggttc ccccttctta agagaccaat ttttactgaa tgattccaga gaggtgaaaa
      301 tctccatatt acagagttcc gaagtgggga gacaattgct cttatcctgt tatagtggtg
      361 tgctggaatt ccctgagatg gaactggtaa attacttgac tgctgcaagt tttcttcaga
      421 tgagccacat tgtagaacgg tgcacacagg ccctgtggaa gtttataaag ccaaaacaac
      481 caatggatag taaagaggga tgtgaaccac agagtgcttc tccccagtca aaagaacagc
      541 agggagatgc cagaggctcc ccaaagcagg actcaccttg tattcatcca tctgaagaca
      601 gtatggatat ggaggacagt gatattcaga ttgttaaggt agaatctatt ggggatgtat
      661 cagaggttag aagtaaaaaa gatcagaacc agtttatttc ttctgaaccc actgctttac
      721 attcatcaga gccccagcac tccctgataa attcaactgt ggaaaacaga gtaagtgaaa
      781 tagaacaaaa ccatctccac aattatgccc tttcttatac aggcagtgat aacatcatca
      841 tggcctcaaa agatgtcttt ggccctaata ttcgaggtgt agacaaaggc ctacagtggc
      901 atcaccagtg cccaaagtgt accagggtgt ttcgtcacct ggagaactac gccaaccatt
      961 taaaaatgca caaactcttt atgtgtctac tctgcggcaa gactttcact cagaaaggca
     1021 accttcatcg acacatgcgt gtgcatgccg gaattaaacc tttccagtgt aaaatctgtg
     1081 ggaaaacctt ttctcagaag tgttccttac aggatcatct taaccttcac agtggagata
     1141 agccccataa atgtaactat tgtgatatgg tttttgcaca taaaccagtt ttgaggaaac
     1201 accttaaaca gctgcatggc aaaaacagct ttgataatgc caatgagaga aatgtacaag
     1261 acctcacagt ggattttgat tcttttgcat gtacaacagt cacagactct aaagggtgtc
     1321 agccacaacc cgatgcaaca caggtcctgg atgcaggtaa actggcccaa gctgtcctga
     1381 acttaagaaa tgatagtact tgtgtgaatt gagtaggggc ttcatgctca caactcgaac
     1441 tgactgacaa tgtggcaata gtcttagtct ttttaggagt gattttgcta gtttgacttc
     1501 tccaaagcct ctgtgtaggt ggtagggagt gagtcaaagc actaatagac caggcaactt
     1561 accacttgga gtggatttgc cttacttttg ccctctccca ttttctgttt tgagttattt
     1621 atcttgtaaa gtctgttttc ctttcccaag gaataattcc ttttgtctac ctaacattga
     1681 cttatgtctt agactgacac tgttttaggc ttttcactag gcacattccg aaggtaccaa
     1741 caagttaata acgtcaccta ctctccacta atagatgcta tgctaagaga agtgaataat
     1801 ctttctttgg tagaaaatag gctgagatat aaggtgatat tgctattgac ctgaaaatgt
     1861 gatagaactt ctggttgcct attgattatt cctccatgtc tgataaatga atctgcttcc
     1921 taccatttgt acttgtcttg gagctggcta taaagaagta tgctggtttg ttatgtactc
     1981 ttttcaacag tatcatagcc caacttcatc tcattgaatt gttcacatat accagagtac
     2041 tctctcttga ggaacacctg caggcagata gttagggatg accatgagga gcataatcaa
     2101 cagggataga agtacactta tacaacagca cttacatggg cggtttctct ggtagcatgt
     2161 cccataagag gccatatgct tataattaat gtgtaacttg ttgatgcttt tgagatcagg
     2221 actgctccag gcacgctaaa aatgtgctaa agtatagtgg gctctctaaa aagaggctat
     2281 ttgggagtct ctgaattttg tttcagagtt tagccatcag aaaggtgagt ttggccatca
     2341 gagttttgtc ctgtgcacca taaaagtctc tgaattttcg tttcctcatg taccttaatt
     2401 tctaaaacgg atgataaaag ttaggttgga cacagaaggg gcaatcaaat ttctgtattc
     2461 agatacctct taaaggtaca ctgtgccacc ttgctgcctt tgattgcaaa tacaaagtta
     2521 attttcaaaa aggaaaaaca aaacagctct ttttcctaaa acacatgttg tacttcagac
     2581 ctaaaattct aagtcttatt tgtttctcac ccatgagtta gatttaggta atagtattag
     2641 tagagtcctt agagaatctt aagaggtcat ttactccacc tctttcattt taaattgggg
     2701 tatccaaagc ctgaagaggt ggcctggcca atattgacca aggtataact aaatatgagc
     2761 tagcatcttc ttccttcttc tcgctatccc ttggctttaa aagatttagt acatgaagaa
     2821 taatgcatta gcaaaaagct cctagtttgt gtttcccctt tgtgtctccc tgttggcttt
     2881 ctgagacaac ctgaattttg ccaacaaaat atcgcagagg gatttatatt aattattttt
     2941 tagttagatg aatattatat tcttcccatc caagtgagtg atttgctagg tttgtttagg
     3001 gagggaaaaa gcaagaataa tgtgagaaga atctaaatgc gaagttgatt ttgtgtggaa
     3061 aactgtttat tagtttccat caggattttc tgtttttatt tttgagctat gagagtgcat
     3121 gcagatttga aaaattaggc ttgcatagtc agaggggatc ttcaattgtt atatttgata
     3181 cgtttacatg tatcattgtt atcatatgta aattatcatc atgtgagtca gatgtgaagt
     3241 atgatttttg tcttttgttc aaatatttaa aatgataata cagttgagtg gtaagactaa
     3301 taggtacctt atgcctaaca tcactcatta tatggtctaa tgatgcttcc tagcattgtg
     3361 atttttacat gatccagcca aagagtacca attctatgca atagtgagac tctaccctgt
     3421 caaccaaaca gcattttttg gtattttctg tcaacatcat ttcttcacag ggaaatttca
     3481 agttggagtg cttcgtttgc tcacattcat gtcttgtttt tgttactggt ttgaagacta
     3541 aaaggcacgg gttcaaataa gattggtctc tttggttgga gactatttct gggttcattc
     3601 agttgttcaa gaaacattag ttaagcacct actgttgcta gacactatgc tagatactga
     3661 ggataatgaa ggtaagattg atatagtccc tgccctcatg gagcttatag tctcatgtgg
     3721 tcttagtgaa acaaagtctc aatttgcttt tatactagaa ataataaaga aagctgcctt
     3781 gctgtattcg atcagttaaa atcagcaact ttgtgctttt gtatcagtaa aacatttagt
     3841 tctcaccttt tgaaaatgca aaccactgaa gtgatttaca gtctcctcca tttttggctg
     3901 gagaggtgtt ctgtttctgt gagacatttt tctaattttt gtggaacttc actttcctcc
     3961 ttctttgctt atacgtgttt gttagattat attgcaaaga agtcaagtta ctgatatcca
     4021 gtattttaca gaggaagatg actttcaaaa ctagtcatat ttctgtagag gaggaagatt
     4081 tttaaaacct ttatcattca gcatttgtat tttatggatc cccaggagaa ctaaaaagga
     4141 gatgactctc taccatagtt tggtttaaaa aaaaattact ctgtcagtta tttatttatt
     4201 atttaatact aaactccaaa ctgaagtggc tctgaggtaa atcagatatg attttaattt
     4261 aagtttcttt attagcagat ctataaatgg aaggtgacca atgtcactgc ttctaaaata
     4321 ctgtcctaaa caacccagaa gattttattt cagctcatga atagctgttc taaatctgtt
     4381 gtatgttaga catactatga actacctctt cacttattat ggggaagttt ccttaataaa
     4441 agtgtgacga ttaaa
//
