LOCUS       NM_006977              10365 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25),
            transcript variant 2, mRNA.
ACCESSION   NM_006977
VERSION     NM_006977.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10365)
  AUTHORS   Lear,T.B., Boudreau,A.N., Lockwood,K.C., Chu,E., Camarco,D.P.,
            Cao,Q., Nguyen,M., Evankovich,J.W., Finkel,T., Liu,Y. and Chen,B.B.
  TITLE     E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection
            through ubiquitination of the main viral protease MPro
  JOURNAL   J Biol Chem 299 (12), 105388 (2023)
   PUBMED   37890782
  REMARK    GeneRIF: E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus
            infection through ubiquitination of the main viral protease MPro.
REFERENCE   2  (bases 1 to 10365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 10365)
  AUTHORS   Madhavan,A., Arun,K.B., Pushparajan,A.R., Balaji,M. and Kumar,R.A.
  TITLE     Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a
            Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its
            Inhibition Clears Pathogen by Autophagy
  JOURNAL   mSphere 6 (1), e00036-21 (2021)
   PUBMED   33627504
  REMARK    GeneRIF: Transcription Repressor Protein ZBTB25 Associates with
            HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected
            Macrophages, and Its Inhibition Clears Pathogen by Autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10365)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 10365)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 10365)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 10365)
  AUTHORS   Benita,Y., Cao,Z., Giallourakis,C., Li,C., Gardet,A. and
            Xavier,R.J.
  TITLE     Gene enrichment profiles reveal T-cell development,
            differentiation, and lineage-specific transcription factors
            including ZBTB25 as a novel NF-AT repressor
  JOURNAL   Blood 115 (26), 5376-5384 (2010)
   PUBMED   20410506
  REMARK    GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor
            of activated T cells (NF-AT) activation, such that RNA interference
            mediated knockdown resulted in enhanced activation of target genes.
REFERENCE   8  (bases 1 to 10365)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   9  (bases 1 to 10365)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 10365)
  AUTHORS   Chardin,P., Courtois,G., Mattei,M.G. and Gisselbrecht,S.
  TITLE     The KUP gene, located on human chromosome 14, encodes a protein
            with two distant zinc fingers
  JOURNAL   Nucleic Acids Res 19 (7), 1431-1436 (1991)
   PUBMED   2027750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035804.1, AL049869.6, BQ446833.1, DA328137.1, BX479957.1 and
            AL122035.6.
            
            On Jun 2, 2019 this sequence version replaced NM_006977.4.
            
            Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035804.1, SRR14038192.1961618.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608382.6/ ENSP00000476746.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                BC035804.1         8-101
            95-95               AL049869.6         176139-176139
            96-1579             BC035804.1         103-1586
            1580-2016           BQ446833.1         16-452              c
            2017-2103           DA328137.1         385-471
            2104-2178           BX479957.1         205-279
            2179-3079           AL049869.6         193646-194546
            3080-10365          AL122035.6         1299-8584
FEATURES             Location/Qualifiers
     source          1..10365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..10365
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="zinc finger and BTB domain containing 25"
                     /db_xref="GeneID:7597"
                     /db_xref="HGNC:HGNC:13112"
                     /db_xref="MIM:194541"
     exon            1..178
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:2.1.0"
     exon            179..358
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1493
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger and BTB domain-containing protein 25; zinc finger
                     protein KUP; zinc finger protein 46"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 25
                     isoform a"
                     /protein_id="NP_008908.2"
                     /db_xref="CCDS:CCDS9765.1"
                     /db_xref="GeneID:7597"
                     /db_xref="HGNC:HGNC:13112"
                     /db_xref="MIM:194541"
                     /translation="MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAA
                     FSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFL
                     HADYLSHIATEMNQVFSPETVQSSNLYGIQISTTQKTVVKQGLEVKEAPSSNSGNRAA
                     VQGDHPQLQLSLAIGLDDGTADQQRACPATQALEEHQKPPVSIKQERCDPESVISQSH
                     PSPSSEVTGPTFTENSVKIHLCHYCGERFDSRSNLRQHLHTHVSGSLPFGVPASILES
                     NDLGEVHPLNENSEALECRRLSSFIVKENEQQPDHTNRGTTEPLQISQVSLISKDTEP
                     VELNCNFSFSRKRKMSCTICGHKFPRKSQLLEHMYTHKGKSYRYNRCQRFGNALAQRF
                     QPYCDSWSDVSLKSSRLSQEHLDLPCALESELTQENVDTILVE"
     exon            359..10365
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6847..6852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="hexamer: AATAAA"
     polyA_site      6871
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="major polyA site"
     regulatory      6908..6913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="hexamer: TATAAA"
     polyA_site      6931
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
     regulatory      10343..10348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="hexamer: AATAAA"
     polyA_site      10365
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
ORIGIN      
        1 ctctttcccc tgctaccaga cacgcggtca cgtggggcca tcgcgggctg ccggcgcggg
       61 aagccgcgcg agaggcggcc gaggggtgcg tgagccggcg ccactgcttg cagtgcgcgg
      121 cttgggagcc cgcccctcct gcacggagga gtcggcctgc cgccgcggcg gcatctggaa
      181 ccacaatgga cactgccagc catagccttg ttcttctcca gcagctgaac atgcagcgag
      241 aatttggttt tctgtgtgat tgcacagttg caattggaga tgtttacttc aaagcccaca
      301 gagcagtgct tgctgctttt tctaactatt tcaagatgat atttattcac caaacaagtg
      361 aatgcataaa aatacaacca actgacatcc aacctgacat attcagctat ttgttgcaca
      421 ttatgtacac ggggaaaggg ccaaaacaga ttgtggatca tagtcgtttg gaggaaggga
      481 ttcgatttct tcacgccgac tacctttctc acattgcaac tgaaatgaat caagtgttct
      541 caccagagac tgtgcagtcc tcaaatttat atggcattca gatctcaaca acccaaaaaa
      601 cagttgtcaa acaaggactg gaggtcaaag aagctccttc cagtaacagt ggaaacagag
      661 ctgctgtcca gggtgaccac ccccagttgc agttgtctct tgctattggt ctggatgatg
      721 gcactgcaga ccagcagagg gcctgtcctg ccacccaggc cctggaggag caccagaagc
      781 ccccagtttc catcaagcag gagagatgtg acccagaatc tgtgatctcc cagagccacc
      841 cctcaccctc atcagaggtg acaggcccca cttttactga aaacagtgtc aaaatacact
      901 tatgccatta ctgtggggaa cgttttgatt cccgtagtaa cctaaggcaa catctccata
      961 cacatgtgtc tggatccctg ccattcggtg tccctgcttc cattctggaa agtaatgacc
     1021 ttggtgaagt gcatcccctt aatgaaaaca gcgaggccct tgaatgccgc aggctcagct
     1081 ccttcattgt taaggagaat gaacagcagc cagaccacac caaccggggt accacagagc
     1141 ctttgcagat cagtcaagta tctttgatct ccaaagacac agagccagta gaattaaact
     1201 gtaatttttc tttttcaagg aaaagaaaaa tgagctgtac catctgtggt cataaattcc
     1261 ctcgaaagag ccaattgttg gaacacatgt atacacacaa aggtaaatct tacagatata
     1321 accgatgcca aaggtttggt aatgcattgg cccagagatt tcagccatac tgtgacagct
     1381 ggtctgatgt ctccctgaaa agttctcgct tgtcacaaga acacttagac ttgccttgtg
     1441 ccttagagtc agagctcaca caagaaaatg tggatactat cctagttgag tagcagcttc
     1501 tctttcagaa tttttatacc aattctgaaa aagaaaattt gcgtggcatt tttaattcat
     1561 aaattatttt cctcctcaag tttcattgac tttttttctt cacagcttat ccatggtttt
     1621 aaggttgtat atattagatc ttctcataag acatattaat atgtggctat taaaatgtaa
     1681 cattcaatta ctactgtgaa cttttcacaa acgaaataac aatttagaaa tcagaaatca
     1741 atgtagaaat atggaaacct taaatagtta tttatagaat tctaagtttt tccagttata
     1801 gaatcagtaa aatcaaattg aatataaagt aaatgaaatc tgttttaaag catattctaa
     1861 actatcactt ctgcctacat ttcacatgaa ttcactccta ccaggattat ttttaaatat
     1921 tttcttccat ataggaaatt aatagttact ttaatgcata actgtatgtt atacatatgt
     1981 tataatgtat aaaaatttat tttaagatat accaaatcat gagtagtttt attttttaac
     2041 tactagctcc acaacatctt acctacatgg cttctcttta ctttttaaca ttgagtatac
     2101 ctcttttttt ttttgagaca gagtctctct gtgtcgccca ggctggggcg cagtggcgcg
     2161 atctcggctg actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc
     2221 tgagcagctg ggactacagg cgcccgccac cacgcccagc taattttttt gtattttttt
     2281 agtagagacg gggtttcacc gtgttagcca ggatggtctc gatctcctga cctcgtcatc
     2341 tgcccgcctt ggcctcccaa agtgctggga ttacagatgt ggtatatctc atttttaata
     2401 aaaaaaacag ttaaagggag aagagtcaga gagacattaa aaaatattta agaaacagta
     2461 agatatacac acatagataa ataagcatgc agagacagag actgagctag aactgcattg
     2521 actaaaaacc ccagggttgt taacttggtc tagagtgttt tcttagacac cttaaaaagt
     2581 aatttgagat tttatgacca gaggtttaca tgagttgaaa gagaatgatg ataaaatata
     2641 aatcatgttt ctaccctcag cgtcaggatt tttggggctt cctgggttga ttttaatttt
     2701 ctaaaaatca ctgaaaaagt aatttttcag tggcacagtt ttcacttttt tcctgatcca
     2761 taaaaccagc aaagtggata cattcagtgt tctataacta catttaagat ccatgatgtt
     2821 agcttttcct ctataaatca acttaactct cttttataat ggtgacactt acaaagctaa
     2881 aaccccagga aaattaaagt tgatgaaaga aataacagat tccccggctc tatatacctg
     2941 ggaaatagct ggttaagctt caccacaaag gatagatcta aattgtttct gaaatgttta
     3001 aatttcaaac cccgcatagt caaggataat aaaacagact catctttttt tgccctcttg
     3061 ttaaattcta agcttcacgg gcatttgaat acatctaaaa aatttggttt gtgagcctta
     3121 gaatttaacc acttacaaaa ctcttgagct ccctccactt ctgaggacgt ttcctgacac
     3181 attcaacagc atcagcgtcc aatcaggagg gagctcaaag agtaatccag ctaattctaa
     3241 ggacacaaag gttttctcta ggtaaacagt ttaggtaaat tacaaagtgg taagtttttc
     3301 ttgaggattg aatgaagaaa gctactggat attgtgtaag gcagttgagt ttctgcctta
     3361 aacaagtgag taaaggctcc tatggttaag actgatgtgt gttgagagca catctaactt
     3421 gataagatca attgtattgg gagtaattaa aacaaatgta tgttctttgg ggtcagaact
     3481 ttgtctaatc ttaaactttt ttctaccaat tcacttaagc aactattgaa atttgtactg
     3541 ccctcaaaaa tatcatctca ttggaagaac acaagtatta acattgattt tttgtatttt
     3601 aggctagtta agatatattt cctagccttc ttcaattcaa attctattgt tcttattaag
     3661 ataatttttc tcctctatat tcttccctgt ttgcctactc attattatta tttttttaat
     3721 ttaatttttt tttaagatgg agtttcaccc ttgttgccca ggctggagtg caatggcgtg
     3781 atctcggctc actgcaatct ctgctgcctg ggttcaagcg attctcctgc cttagcctcc
     3841 caagtagctt gggattacag gcatgcacca ccatacccag ctaattttgt gtttttagca
     3901 gagacagggt ttcaccatct tggtcaggct ggtctggaac tcctgacctc aggtcatgca
     3961 ccagcctcgg cctcccatag tgctgggatt acaggtgtga gccaccgtgc caggcccact
     4021 cattattctt tgacacagga aatccttgta tatagctaaa gggtggaggt agagttgtac
     4081 atggttggtt ggataagaca gcaagtgcct cagggcagag tttggataaa tggtaagagt
     4141 ttgctagcag ctgattggcc gtgatagaca acactcattt aaagcagaaa tatatctgtt
     4201 cgttgagagt taagaaaata gtggttaact gtatttctat tcttatagtt ccttttaata
     4261 ttagaaattc aaagcaaatg ctctttcctt gttccttaaa acattcattc tgtttaggaa
     4321 gtgggaaaat atcaacttca ttttatagaa aaaaaatccc aaaagctgaa ttccagagat
     4381 gcagtgaata gtggtgtggg actgaccccc agtttttgtt attgttgttt tcatttattc
     4441 tgcaggcttt tttttttttt tttttttttt tttttgagac agtcgtgctg tgtcgccagg
     4501 ctggagtgca gtggtgcaat ctcagctcac tgcaacctcc gcctctcgaa ttcaagtgat
     4561 tctcctgcct cagcctcctg agcatgtgcc accatgccca gctaattttt gtatttttag
     4621 tagagacagg gtttcaccat gttggccagg atggtctcga gctcctgacc tcatgatctg
     4681 cctgcctcag attacaggca tgagccaccg cgcccgggtc tgcaggcatt ttttaaagta
     4741 actgtcatat gcctaacact gtgccctgag tattattttt taaagacatg attgctcact
     4801 gagaaaattt gctttgtatt ttaaaagttc ttccagctag gccaggcgtg gtggctcatg
     4861 cttgtaatcc cagcactttg ggaggccgag gcgggcgggt cacgaggtca gaagatccag
     4921 accatcctgg ctaacacagt gaaaccgcgt ctctactaaa aatacaaaaa attagccggg
     4981 tgtggtggca cacacctgta atcccagcta ctcgagaggc tgaggcagtg gaatagcttg
     5041 aacccgggag gcagaggttg cagtgagcgg agatcgcacc actgcactcc agcctgggtg
     5101 acagagcgag actccatctc aaaaaaaaaa aagttcttcc agctaaaacc tttatttttt
     5161 gactacatct ccacaaaatg gagctatact gttagccagt atcctaatag tatagtgcag
     5221 tttgcataat gattaccaag cttgaaactg gaaatgtcat atgcactttc gtgtgtatca
     5281 ggcagatact aaacattttc cccttgagtc agcttaaaat ttttccttct tttgaaatct
     5341 cacgcagttg ttttctggag aaaaatagag actgttttag tatttgttct tattagcgta
     5401 tcatcagaac tcagcacagt ctgccttata agaaaacaaa aaattttttt atttataact
     5461 cttgagattg ttacttcttg ctctttctga tttcccatcc gtaaagtggg tgtaagcaat
     5521 acttacctca caggggtgtt gtgaggattt atattaaacg tgttaagttc tctcagtatt
     5581 attgattaaa atcaaccata taaacgacat ttattctgta gctagaccta ttaactttag
     5641 tatttcagcc tataaattct aaaatgttct taaaagcagt aatgtactat ctaatattca
     5701 ataactaatt gacagaactc attgttattt tttacaaata actagaaaca atactgttgc
     5761 tagaattcct gttctactgt aatttaatca tcactgtttc tttttagcct tcagtaagga
     5821 ggatactagt tctttggcat tattgggaat aaaactttgt caatttcagc tttattgaaa
     5881 gttctcccaa atatattgtt tttgtttaca caaaggaaaa ggaacaaaaa caataaataa
     5941 atacctttgt ttttttttct tttttgagac ggagtctcgc tctgttgccc aggctggagt
     6001 gcagtggtgc gatctcggct cactgcaacc tccgcctccc aggttcaagc gattcttctt
     6061 cctcagcctc ccgagtagct ggaactatag gcacgcacca ccacacccag ctaatttttg
     6121 tatttttagt agagatgggg tttcatcatg ttggcaaggc tggtttcgaa ctcctgacct
     6181 tgtgatctgc ctatctcagc ctcccaaagt gctgggatta caggtatggg ccactgggcc
     6241 cagcctattt ttatttcttt gatgtaggtg atctaaatag tagatgagga caggaaatgg
     6301 ggtgaaggta ataatagtat tattagaaaa gtcttcactg aaaattgaag gaaatacata
     6361 ttaatcgtgg aaaaagatag tgtgaaaaat gtgtaatttc gttaacattt atttgtacag
     6421 gcacattctt gatgttgtga gtcagatact tgataaatgt ccattttttg tagtaattga
     6481 tgtaaaaatg ggccatgtga agaattttca taatgtaatt tgtgtctttg tatattttga
     6541 actacatata gatttgtggc acttaaatta ttaatttttg atttcttaag agtgaagtct
     6601 gtaaatgatt tctctctgct gtacttctgt gtttgtatgg ttggacattt tgaaaactgg
     6661 tgagattgca cagtcccaaa cctggatgtc ttaaatacaa ggaattacaa actgtgattt
     6721 ttgtcttgaa gacctggaag aattcattgt gcttcagtat gtatttgtac tgcacttgat
     6781 taattagtta agtattggtc tggtgcaatt gacattaact gtcatcaact cctctatttt
     6841 gtgctaaata aagtcattta gtcagaatgg atcaaatata aacttatact ttaaaataaa
     6901 cttagattat aaaaacttgt tcaataaaaa agacccactg aaaaatcttc aaagtacatg
     6961 taacacatag ctaatacagg agaccaaaat caataataca ttgtgtggct aaactcatcc
     7021 acctaatgta ctgtgaattt gcttcagaaa cattctttta gaaagttgtg tatctgccgg
     7081 gcatggtgcc tcatgcctgt aatcccagca ctttgggagg ccaaggccca ggagtccgag
     7141 accagcctgg gcaatatagt gagacctcat ctctgccaaa aattttggcc aggggcagtg
     7201 gctcacgcct gtaatcccag cactttggga ggtcgaggtg ggcggatcac cagaggtcag
     7261 gagttcaaga tcagcctggc taacatggcg aaaccctgtc tctactaaaa atacaaaaat
     7321 aagccaggtg tggtggtgcg cgtctgtagt cccagctact tgggaggctg agacagaatc
     7381 atttgaaccc gggagatgga ggttgcagtg agccgagatt gcgccattgc actccagcct
     7441 gggcgacaga gtgagactcc gtctcaaaaa aaaaaaggca gggtgtggtg gctcacacct
     7501 gtaatcccag cactttggga ggccaaggcg ggcggattat gaagttagga gatcgagacc
     7561 atcctggaca acatggtgaa accctgtctc tagtaaaaca caaaaaatta gctgggtgtg
     7621 gtggcacgtg cctgcagtcc cagctactag gggggcagag gcagaggaat tgcttgaacc
     7681 cgggaggcgg aggttgcagt gagccgagat tgcgccactg cactccagcc tggcgacaga
     7741 gcaagaaaca atgaatttca tatattttat caagacaaat taatgtgact taatcaaaaa
     7801 caagtttatt agcttagctt atagaatgtg ttcttatttt acatcagtgt ttgccaaatg
     7861 ttgtgttcct agtgttgagg caagtagtct ttgtactggg taacattttg gaggtgtgat
     7921 gcaaaaatgc atttgtggac ctaattctta ccgaccataa tctgtgttaa tcgaaaattg
     7981 acgtcctaat caaatgcttt ccaactgctg tctctggaaa gaaaggtagt atttcgtcat
     8041 ttcccagaag tttcttgctt tgcttcttct tttttttttt tttttttttt tttgagatgg
     8101 agtcttgctc tgttgcccag gctggagtac agtggagtga tctcggctca ctgcaacctt
     8161 cacatcccag gttcaagcta ttctcctgcc tcagcctccc gagtagctga gattacaggt
     8221 tcccaccact acactcggct aattttttgt atttctagta gagacggagt ttcaccatgt
     8281 tggccaggct ggtctcgaac tcctgacctt gtgattcacc tgcctcagcc tcccaaagtg
     8341 ctgggattac aggcgtgagc caccgcgccc agctgcttct ttcttctcta tttacagtct
     8401 actgtatcgc cttttgcccc cagtaacatg atccacaata gtagttctca actgaggtat
     8461 attagtcagg attctccaga aaaagaaaga aacaacaggt agaactgaga gagagaaaga
     8521 gattgattga ttataaggaa taggttcatg taattatgga ggctgagaag tcccaagatc
     8581 tgcagttggg aggctgagag gctggggagt cagtgatgtt ccaatctgaa tttgaagacc
     8641 tgagaaccag gagagcttat ggcataagtt ccagtccaaa agctggcagg cttgaaactc
     8701 aagaagagct gatgtttcca tttgggtcca aagggaagaa aagaccgata attgcagctc
     8761 aagcagtcag gccagagaaa gtctcttttt ttattatatt ctggccttca actgatggaa
     8821 tgagagccac ccacatcagg gagggtgatc ttctttacgc agtctactga ttcagatttt
     8881 gtctccctcc agaacaccct cacggacaca cccagaataa tgtttgacta actattgggg
     8941 cagcccatgg cccagtcatt tggacacata aaattaaaca ttacacaggg ctatcccccc
     9001 ccatagagac atttgacgat gtggagatgt ttttggttgt cacagttggg tgggcgatga
     9061 gggaggctgc tgctggcatc tagtaggtgg aggccaggga tgctgctaaa catctcagtg
     9121 cagaggacag cctcccgcaa tacagaatat gtacctcaaa atgtcattag agctgaggtt
     9181 gaccaaccct tctgagacct taaagtaagt tttgtgatgg ctgtcaggaa taaaagaata
     9241 caaagaaacc caatttgggg gatttctatt ctagtcatgt ttagagcaag tattggagta
     9301 tgagatgtgt tcagaattaa attctatttg tattatcctt gatcccagct tttaaaagat
     9361 aaaaatgtga ttattagaaa taaaaggaaa aaatgtgatt attaaaaatc agagatgtat
     9421 taatcagcaa gacagttttg aatctattca tataatgttt gaactaaata attgtctccc
     9481 caaagaggtc tcttcatgaa attgagattg taggttataa tttctgtgaa tttttaatct
     9541 ggccaaaagg tggcaccagt gtacctttaa aaaaatgttc attatacttg aattcagcat
     9601 tactattaat agtaaatatt atttagggct tagctacttt tggatcatgc tttatagagt
     9661 caagactaat gagaattttc ttaaaatttc ataaggtact gcaatatctt gacatccctc
     9721 tttaatcaag atgcttctga tttacatgta catatctcag cagataactt tttaaaatat
     9781 cacattattg tgctacattg agcatttctg aagatttttc caagccatta actgtgaggc
     9841 cttggaattt gggctctttt aatcaggcat cacactcagt ttttggtgtt ctgcctggtc
     9901 aagacataga ttgaaggaca tttgagtaaa tacgctccct tgctcctttc ttgccttttg
     9961 ttcatttttt gtacatccac aatctatgag gtatgttacc tactgaaatt tactttcttt
    10021 tccaactgtg gttcaacaac tgactttctt ctctcatact ttccaaccca ttccattctg
    10081 aataagttaa gagttttctt accttcagct cttctcacct tccaatacta agtgaataca
    10141 gcctgcctcc cccttcattt ctgattacaa tattattctc atcatcctag gactttgtac
    10201 ctaatcacca gttgcttctc ctaagtttat tttacagctg ataagccaac ttggaaaatg
    10261 agcccactct ccctcagata cattctcttc cgctgtttga aacgtttttc attgaaacaa
    10321 tttggtgata ttgtatcaaa ataataaagt attaagctac tggaa
//
