LOCUS       NM_014797               5501 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger and BTB domain containing 24 (ZBTB24),
            transcript variant 1, mRNA.
ACCESSION   NM_014797 XM_376525
VERSION     NM_014797.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5501)
  AUTHORS   Ruan,H., Dai,Z., Yan,J., Long,X., Chen,Y., Yang,Y., Yang,Q.,
            Zhu,J., Zheng,M. and Zhang,X.
  TITLE     ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents
            recurrent spontaneous abortion by promoting trophoblast
            proliferation, differentiation and migration
  JOURNAL   Bioengineered 13 (2), 2777-2790 (2022)
   PUBMED   35038951
  REMARK    GeneRIF: ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents
            recurrent spontaneous abortion by promoting trophoblast
            proliferation, differentiation and migration.
REFERENCE   2  (bases 1 to 5501)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5501)
  AUTHORS   Helfricht,A., Thijssen,P.E., Rother,M.B., Shah,R.G., Du,L.,
            Takada,S., Rogier,M., Moritz,J., IJspeert,H., Stoepker,C., van
            Ostaijen-Ten Dam,M.M., Heyer,V., Luijsterburg,M.S., de Groot,A.,
            Jak,R., Grootaers,G., Wang,J., Rao,P., Vertegaal,A.C.O., van
            Tol,M.J.D., Pan-Hammarstrom,Q., Reina-San-Martin,B., Shah,G.M., van
            der Burg,M., van der Maarel,S.M. and van Attikum,H.
  TITLE     Loss of ZBTB24 impairs nonhomologous end-joining and class-switch
            recombination in patients with ICF syndrome
  JOURNAL   J Exp Med 217 (11) (2020)
   PUBMED   32865561
  REMARK    GeneRIF: Loss of ZBTB24 impairs nonhomologous end-joining and
            class-switch recombination in patients with ICF syndrome.
REFERENCE   4  (bases 1 to 5501)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5501)
  AUTHORS   Chouery,E., Abou-Ghoch,J., Corbani,S., El Ali,N., Korban,R.,
            Salem,N., Castro,C., Klayme,S., Azoury-Abou Rjeily,M.,
            Khoury-Matar,R., Debo,G., Germanos-Haddad,M., Delague,V.,
            Lefranc,G. and Megarbane,A.
  TITLE     A novel deletion in ZBTB24 in a Lebanese family with
            immunodeficiency, centromeric instability, and facial anomalies
            syndrome type 2
  JOURNAL   Clin Genet 82 (5), 489-493 (2012)
   PUBMED   21906047
  REMARK    GeneRIF: A novel deletion in the ZBTB24 gene was responsible for
            causing immunodeficiency, centromeric instability and facial
            anomalies syndrome type 2 in this family.
REFERENCE   7  (bases 1 to 5501)
  AUTHORS   de Greef,J.C., Wang,J., Balog,J., den Dunnen,J.T., Frants,R.R.,
            Straasheijm,K.R., Aytekin,C., van der Burg,M., Duprez,L.,
            Ferster,A., Gennery,A.R., Gimelli,G., Reisli,I., Schuetz,C.,
            Schulz,A., Smeets,D.F.C.M., Sznajer,Y., Wijmenga,C., van
            Eggermond,M.C., van Ostaijen-Ten Dam,M.M., Lankester,A.C., van
            Tol,M.J.D., van den Elsen,P.J., Weemaes,C.M. and van der
            Maarel,S.M.
  TITLE     Mutations in ZBTB24 are associated with immunodeficiency,
            centromeric instability, and facial anomalies syndrome type 2
  JOURNAL   Am J Hum Genet 88 (6), 796-804 (2011)
   PUBMED   21596365
  REMARK    GeneRIF: These data indicate that ZBTB24 is involved in DNA
            methylation of juxtacentromeric DNA and in B cell development
            and/or B and T cell interactions.
REFERENCE   8  (bases 1 to 5501)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   9  (bases 1 to 5501)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5501)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB007901.1, BC117374.1 and
            BX648883.1.
            
            On Dec 4, 2019 this sequence version replaced NM_014797.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007901.1, SRR14038192.774819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230122.4/ ENSP00000230122.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AB007901.1         19-618
            601-3288            BC117374.1         487-3174
            3289-3368           BX648883.1         2483-2562
            3369-5011           AB007901.1         3387-5029
            5012-5099           BX648883.1         4116-4203
            5100-5350           AB007901.1         5118-5368
            5351-5501           BX648883.1         4457-4607
FEATURES             Location/Qualifiers
     source          1..5501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..5501
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /note="zinc finger and BTB domain containing 24"
                     /db_xref="GeneID:9841"
                     /db_xref="HGNC:HGNC:21143"
                     /db_xref="MIM:614064"
     exon            1..122
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1102
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2244
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /note="isoform 1 is encoded by transcript variant 1; POZ
                     (BTB) and AT hook containing zinc finger 2; zinc finger
                     protein 450"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 24
                     isoform 1"
                     /protein_id="NP_055612.2"
                     /db_xref="CCDS:CCDS34509.1"
                     /db_xref="GeneID:9841"
                     /db_xref="HGNC:HGNC:21143"
                     /db_xref="MIM:614064"
                     /translation="MAETSPEPSGQLVVHSDAHSDTVLASFEDQRKKGFLCDITLIVE
                     NVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHAS
                     EKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPTTLNTAGAPVVVISNKKNDPPKR
                     KRGRPKKVNTLQEEKSELAAEEEIQLRVNNSVQNRQNFVVKGDSGVLNEQIAAKEKEE
                     SEPTCEPSREEEMPVEKDENYDPKTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQEDH
                     GSAKRICGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQK
                     HSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQNRQ
                     LKSHYRVHTGHSLPECKDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQ
                     THIRIHRGEKPYSCGICGKSFSDSSAKRRHCILHTGKKPFSCPECNLQFARLDNLKAH
                     LKIHSKEKHASDASSISGSSNTEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFM
                     PGPSQGISIVTAESSQNMTADQAANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIE
                     SQMGPSQTEPVHVITLSKETLEHLHAHQEQTEELHLATSTSDPAQHLQLTQEPGPPPP
                     THHVPQPTPLGQEQS"
     exon            1103..1270
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1354
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1438
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1520
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..5501
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5475..5480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /note="hexamer: ATTAAA"
     polyA_site      5501
                     /gene="ZBTB24"
                     /gene_synonym="BIF1; ICF2; PATZ2; ZNF450"
                     /note="major polyA site"
ORIGIN      
        1 gtggctgtgg ctgcggcggc ggcgcaggag cagaaaccgg tgcggcgcag aagccccaga
       61 ggcgggcggg gcggagcgga gggccagcgg gccccggcgt gggtctcccg ccaggccgcc
      121 ggatttaacc cttagtggct tctgaagaaa atggcagaaa catcgccaga gccttctggg
      181 cagcttgttg tacactcaga cgctcacagt gacactgtgc tggccagttt tgaggatcag
      241 aggaagaaag gcttcctctg tgacattact ttaatcgtgg agaatgtaca tttccgggcc
      301 cacaaagcct tacttgctgc cagtagtgaa tacttctcaa tgatgtttgc agaagagggg
      361 gaaatcggcc aatccattta tatgctggaa ggcatggttg cagacacctt tggtatcctg
      421 ctggaattta tctacacagg ttatctccat gccagtgaga aaagtacaga acaaatcctg
      481 gctactgctc agttcttaaa agtctatgac ctggtaaagg cttacacaga cttccaaaat
      541 aatcatagct ccccaaagcc aacaactttg aacactgctg gtgccccagt ggttgttatc
      601 tctaataaga aaaacgatcc tccaaagcgg aaacggggaa gaccaaaaaa agtcaataca
      661 ttgcaggagg agaaatcaga actggctgca gaggaagaaa tacagttaag agtgaacaat
      721 tcagttcaga atagacaaaa ctttgtggtt aaaggagaca gtggtgtact gaatgagcaa
      781 attgcagcaa aagaaaagga agaatcggag cctacttgtg agccaagtag agaggaggaa
      841 atgccagttg aaaaagatga gaactatgat cccaagaccg aggatggcca ggcaagccag
      901 agtcgataca gcaagcggag gatttggaga tccgtcaaac ttaaagatta caaacttgtt
      961 ggggatcaag aggaccatgg ttcagccaag aggatctgtg gaaggagaaa gcgccctgga
     1021 ggccctgagg cccgctgtaa agactgtggc aaggtcttta agtacaatca ctttttagca
     1081 atccaccaga ggagccacac aggggagcga cctttcaaat gtaatgagtg tggaaaaggc
     1141 tttgcccaga agcactcgct acaggtccac accaggatgc acacaggcga gcggccgtac
     1201 acctgcaccg tgtgcagcaa ggctctgacc accaagcact cactgctgga gcacatgagc
     1261 ctgcactcag gacagaagtc ttttacctgt gatcaatgcg gaaaatattt cagccagaac
     1321 agacagctaa agagccatta ccgagttcat acaggccact cattaccgga atgcaaagac
     1381 tgccatcgca aattcatgga tgtgtctcag ctaaagaaac atctgcgaac acacacaggt
     1441 gagaagccat ttacttgtga aatctgtggc aaatctttca cagcaaagag ttctcttcag
     1501 acccacatca gaatccatcg aggagaaaag ccatactcct gtggcatttg tggcaaatcc
     1561 ttctctgact ccagtgccaa aaggagacac tgcattctac acactggcaa gaagcctttc
     1621 tcctgccctg agtgtaactt acagtttgct cgcttagaca acttgaaggc tcacttgaaa
     1681 attcatagca aggagaagca tgcttcagat gccagcagca tttctggcag tagtaataca
     1741 gaagaggtca ggaatattct tcagctacag ccatatcaac tctctacctc gggagagcag
     1801 gaaattcagc ttctcgtaac cgattctgta cataacatca atttcatgcc cggtcctagc
     1861 cagggaatca gcattgtgac tgcagagagt tcccaaaaca tgactgcaga ccaggctgct
     1921 aatcttaccc tgctcacgca gcagccagag caactgcaga atttaattct ttcagctcaa
     1981 caggagcaaa cagaacacat tcagagcctc aatatgattg aaagccagat ggggccctca
     2041 caaacagagc cagtgcacgt gatcactctg tccaaggaaa cactggaaca tcttcatgcc
     2101 catcaagagc aaacagagga gctccattta gctacaagta cttcagatcc agctcagcac
     2161 ctgcagctga cacaggagcc tggtccgcca ccacccactc accacgtgcc ccagccaacg
     2221 ccacttggcc aggagcagag ctgacctgta aacacgtttg actgcttgat tgggctcttc
     2281 ttataagcca gctctgactg gattttgaac gcttgaaatc aggctctcca caccattgac
     2341 ttgcagatgc ttctgtgaga gctgtgatgg ctaactgatg tttataatgc cctccatcca
     2401 ggtagcaaga tgtgtgtatg tcttgtctaa ggtactgatt tgtattgagc atttcaatat
     2461 tattgaatgg ttttcatttt aatctgcaat gtctcataaa gactcgggta gtttttcttt
     2521 gggggcattg atctcagttt ttctgtaagg tttaaatgtt cacagccata ggttatggtc
     2581 ttgccaacct ccccagttat gtttttttgt tttctaggac aaagggagtc attttggttg
     2641 aactgggcag aatggtttgt tctattttct tatttttctt aggcaacaca gttgttacca
     2701 caagacaagt cagggctaaa tatgacagat cacaatgtat ggggaatttg cccttttaat
     2761 aatttccagt cccctaagac aaagtaaccc tcaacgtttt atctttatgc agtacagtgg
     2821 gcttattgtg ttaacacttc agaaagattc aaactcataa actcagtatt ttaactcaaa
     2881 attcatgtaa caagatagcc aaaagcatag gatttcttaa aattctgaat tcgtcttttc
     2941 tgagaaacat aaatttacat atttttcaac agaaggctat caaaatttta attaagttta
     3001 aaatacaaaa ttggatcaag acattcaccc taaattctga atttttgtca gaaaagagat
     3061 ttgattttca tgaaggtaaa gctttcttca ctattctgga acataaaact ttattcagtg
     3121 taatttaagt cttatatata ctctactgaa ttctaactga tctcctgaaa atgttgatct
     3181 acgtgttgtg tctgataact ttctggagat ggaagcttat aattcatttt tattgcagac
     3241 tagttaaatc ccacaaagtg aatatcttct cctaatcttt ccttttttag agacagggtc
     3301 tcactgtatc acccaggcca gagtgtagtg gcacaatcat tgctcactgt aacctcgaat
     3361 tcctgggctc aagcaaccct cccaccttag cctccctagt agctgggact acagggatgt
     3421 accaccacac ccagctaatc ttcatctaat cttaaaactt tgagcctcag agactttgta
     3481 gccagcatgt gtctgtaatt gtatgatttt taaatcatca tcaaaagatt aaattatgtt
     3541 tgggttaggt tttcaagcta agcttattga attcttttac cactttcatg taagctggta
     3601 ggggattttt gagaaaagaa ggtgggcact agtatatcta aattaacaat gctgatgggg
     3661 agtagggggt aatctactct aaaattaata gagcctttcc atcaattgtt ttgttttaga
     3721 catccttgat ttctccctaa atcaaataag ttatttggag gttagagtaa tagagaattc
     3781 ttcaggtttg agagaagata aaaacatttt ggttgcatat ttgctaagct atattttatt
     3841 atatgtaatt cacaaaactt ccaaaatgat atatatctta tatgtatcaa ccaaactaat
     3901 gttaaatcag gcctgactag agcaaagata acaatttttt acaaacactg ttaagcccta
     3961 agtattattt caggttctcg tttaaactgt ttaattttat tcttaaaaca caaagttttt
     4021 accaactttt caaagcccac caatccacat tttctccagg aaattaaata tttaagtaag
     4081 tgagtgttta ctcactctgg atagctaggt gattattcag aaaatacggt tacatagcta
     4141 tttataagtc aagtttcact ggctctataa cagtctacct ctacactaag agaactataa
     4201 catgaacaac ataggtcact ttaaatgttc tagtagcaac ttttaaaaac ataaaaagaa
     4261 gcaggtgaaa atgttaataa aagtttattt aatccaacat ttgccaaata tttcaacata
     4321 taaaaatata ttagtgagac attttacatt ctctttttca tactaagctt tcgaaatctg
     4381 gtgtgtattt tacactttct gcacatctcc atttggatgc taatgttcat tggacatact
     4441 tgatctgtat ttagatttca tacaacttac agttgaaaac agattctcat atcaagtagc
     4501 taagacaaaa gtttttttca agaattgaaa taagtatcag tttaaaaatt tatattaaat
     4561 ttattaaaat taaaatccag ttccttgttg catgggacac agtgcaaatg cttgataagc
     4621 acatgtggct agtggctgct atattggaca gcatgggcca cctgtttcta acttgagcat
     4681 cagtcctagc tatgcctgaa ttatttgacc agctgtcaaa gagaaacaag gaaatgatag
     4741 ctttgttaat ctagcctctt tctttgtccc acatatacat tctacccctt tgaataaaaa
     4801 agttcaatga cgccgggcgt ggaggctcat gcctgtaatc ccagcacttt gggaggccaa
     4861 ggtgggcgga tcacgaggtc aggagttcga gggcagcctg accaacatag tgaaacccca
     4921 tctctactaa aaatacaaaa attagctggg cgtggtggtg tacccctgta atcccagcta
     4981 ctcgggaggc tgagacagga gaatcacttg aacccaggag gcggaggctg cagtgagctg
     5041 agatcacgcc attgcactca agcctggcga cagagcgaga ctccgtctca aaaaaaaaag
     5101 ttaaatgact tgagtaccca aaagaaatgt cgtgaacatg aaagtacttc tcatgtgtcc
     5161 ttgagaaatg atgttgctag tgcagtgttt cacaattcat tttctactaa atgtgtacca
     5221 ttttttaaat tgttttaaca gaaatataga gtgtgtttct taggaaatag aatgttatgc
     5281 tttggggctc ctgaaacacc tcgttttgaa ggtgaatctt tggttttctc ccagaagagg
     5341 gtctgccttg ggatgattgg agctcttacc atcaaaatca gttattcaag tgcttgccca
     5401 gtgcttcttg aaactcacct ctactctgta ttttctacag ttggttcttg tgttataaat
     5461 gttgtgagca acagattaaa tgatgctgag gaatgaaaaa a
//
